Clinical trials: Blinking
Essential Tremor
Pathophysiology of Tremor-modulating Mechanisms of Propranolol and Primidone in Essential Tremor
Pathophysiology of tremor-modulating mechanisms of propranolol and primidone in essential tremor (ET) will be studied using accelerometry with electromyography (EMG), transcranial magnetic stimulation (TMS), and eyeblink…
- Trial name
- NCT04692844
- Testing
- Propranolol, Primidone
- Where
- Slovenia
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Dry Eye
Study of Blinking as a Function of Tear Film Quality
The goal of this study is to better understand how eye blinking behavior is linked to the stability of the tear film, in adults aged 18 to 65 years, with or without symptoms of dry eye.
- Trial name
- WINK (NCT07499193)
- Testing
- Blink behaviour
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Essilor International
Disorders of Consciousness
Spontaneous Eye Blinking in Disorders of Consciousness
Differential diagnosis between Unresponsive Wakefulness Syndrome (UWS) and Minimally Conscious State (MCS) is complicated due to severe cognitive and/or sensorimotor deficits in these patients.
- Trial name
- Blink-DoC (NCT06323031)
- Where
- 8 sites in Belgium, Germany and 2 more
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Migraine Disorders, Brain, Healthy Adult Participants
Effect of Atogepant on the Vestibulo-Ocular Reflex in Healthy Adults and Adults With Migraine
Researchers want to find out how a substance in the body called CGRP affects balance. CGRP (calcitonin gene-related peptide) is a small protein involved in migraine. Several approved migraine medicines work by blocking it.
- Conditions
- Migraine Disorders, Brain, Healthy Adult Participants, Vestibulo-Ocular Reflex
- Trial name
- VOR-GRIP (NCT07826910)
- Testing
- Atogepant 60 mg
- Where
- Switzerland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Konrad Peter Weber
Blepharospasm, Blepharospasm, Benign Essential
Effect of Non-psychoactive Cannabidiol as an Adjunct to Botulinum Toxin in Blepharospasm
The planned study is a prospective analysis of non-psychoactive Cannabidiol (without THC) as an adjunctive therapy for blepharospasm in a masked double cross-over study.
- Conditions
- Blepharospasm, Blepharospasm, Benign Essential, CBD
- Trial name
- NCT04423341
- Testing
- Cannabidiol Oral Solution [Epidiolex]
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Silkiss Eye Surgery
Healthy, Schizophrenia
Eye Blink Response in Healthy Volunteers and Adults With Schizophrenia
The purpose of this study is to explore how the brain works during particular memory tasks in people with schizophrenia and healthy volunteers.
- Trial name
- NCT00001920
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Cognitive Performance
Effects of Transcranial Magnetic Stimulation to the Cerebellum on Cognition
Functional neuroimaging studies have shown that the cerebellum is active during cognitive performance. The investigators hypothesize that stimulation of the cerebellum with transcranial magnetic stimulation will produce brief…
- Trial name
- NCT00740701
- Testing
- Cerebellar transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Idiopathic Generalized Epilepsy
Blinking and Yawning in Epilepsy: The Role of Dopamine
The objective of the present study is to assess dopaminergic reactivity with behavioural markers (i.e. yawning and blinking) in patients with idiopathic generalized epilepsy compared to matched healthy controls, after injection…
- Trial name
- BYE BYE DOPA (NCT01432821)
- Testing
- Apomorphine (Experimental product)
- Where
- France
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Autism Spectrum Disorder
Duration of Moment in Autism
This study investigates the temporal dynamics of perception and attention in children with Autism Spectrum Disorder (ASD), focusing on two key phenomena: the Temporal Integration Window (TIW) and the attentional blink.
- Trial name
- DOMA (NCT07384819)
- Testing
- Temporal Integration Window task, Attentional Blink task
- Where
- 2 sites in France
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Autism, Ocular Surface Disease
Ocular Function in Autism Spectrum Disorder
This study will investigate the visual function in individuals with ASD, with a particular focus on the ocular surface condition and visual function assessment.
- Trial name
- NCT04010422
- Testing
- no intervention
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cannabis, Psychotic Disorders
Cannabinoids and Cerebellar-Motor Functioning
The purpose of this study is to characterize the dose-related effects of delta-9-tetrahydrocannabinol (∆9-THC) in healthy individuals on cerebellum-dependent motor functions.
- Trial name
- NCT01853020
- Testing
- THC
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Yale University
Eyelid Movement Disorders
Eyelid Movement Sensor Device- Blinking Characterizing
The investigators have developed a simple to use device that facilitates the monitoring of the upper eyelids motion, acquires the eyelid vertical movement and enables analysis and graphic presentation of the results.
- Trial name
- NCT02309814
- Testing
- eyelid motion sensor device (Hall-probe)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Well-being, Emotion Regulation
Cognition and Emotion in Meditation: A Comparison Between Mindfulness and Compassion Standardized Programs
The study is aimed at comparing the differential effects of two widely used standardized meditation programs: Mindfulness-Based Stress Reduction (MBSR) and Compassion Cultivation Training (CCT) in general population samples.
- Conditions
- Well-being, Emotion Regulation, Cognitive Control, Attention
- Trial name
- NCT03920241
- Testing
- Mindfulness-Based Stress Reduction, Compassion Cultivation Training, Control Group
- Where
- Spain
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Spinocerebellar Ataxias
Use of a New Smartphone Application to Determine Changes in Eyeblink Conditioning From Home Training in Individuals With Spinocerebellar Ataxia
Spinocerebellar ataxias are a group of disorders that cause severe disability and can be fatal. There are currently no known disease-modifying treatments available for use, and there is a critical need to find treatments that…
- Trial name
- NCT06177626
- Testing
- Aerobic Training, Balance Training
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
Healthy Humans
Processing of Salient Emotional Stimuli as a Function of Tetrahydrocannabinol (THC) and Cannabidiol (CBD)
Attentional blink refers to a phenomenon where the detection of the second of two target stimuli that are presented in Short succession within a stream of stimuli is impaired.
- Trial name
- AB_THC_CBD (NCT02291536)
- Testing
- tetrahydrocannabinol, cannabidiol
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Colorectal Neoplasms, Colorectal Polyps
Effect of Blink-Based Training on Cancer Detection in Colorectal Polyp Images by Medical Students/Non GI-trainees
This study investigates whether a brief educational intervention using Blink features can improve medical students' and non-GI trainees' ability to detect colorectal cancer in static polyp images.
- Trial name
- Blink (NCT07401004)
- Testing
- Blink Features Training Video
- Where
- Belgium
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Electromyography, Auditory Event-related Potential (AERP)
Compare the Accuracy of MindTension Blink Eye Reflex Measuring Device to DANTAC Keypoint Electromyography (EMG) System.
A clinical study aimed to compare the accuracy and precision of the MindTension MT1 auditory evoked response parallel to an FDA cleared device (Natus DANTEC Keypoint).
- Trial name
- NCT06707415
- Testing
- Auditory evoked potentials
- Where
- Israel
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- MindTension