Clinical trials: Blood Disorder
Stroke, Ischemic, Transient Ischemic Attack
Extracellular Vesicles and Dysregulated Coagulation in the Prediction of Stroke
Annually 100,000 strokes occur, placing stroke as the largest cause of disability in the UK. 90% of strokes are preventable, leading to national focus on programmes including "The National Stroke Programme" to act on preventing…
- Conditions
- Stroke, Ischemic, Transient Ischemic Attack, Coagulation Disorder
- Trial name
- PREDICT-EV (NCT05645081)
- Where
- United Kingdom
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Cwm Taf University Health Board (NHS)
Malaria
Immunization of Human Volunteers With P. Vivax Irradiated Sporozoites
It is possible to safely protect human volunteers immunized with P. vivax irradiated sporozoites from P. vivax challenge with live sporozoites.
- Trial name
- SPZ-Irrad (NCT01082341)
- Testing
- Immunization with P. vivax irradiated sporozoites
- Where
- Colombia
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Malaria Vaccine and Drug Development Center
Alcohol Drinking, Chronic Inflammation
30-to-90 Day Challenge: Effects of Alcohol Cessation on Health Outcomes
The objective for this project is to determine whether how certain behavioral and health functions change in persons with heavy drinking when they stop (or reduce) drinking for 30 days, and whether changes continue for up to 90…
- Conditions
- Alcohol Drinking, Chronic Inflammation, Neurocognitive Dysfunction, Liver Diseases
- Trial name
- NCT03353701
- Testing
- Contingency Management (CM)
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Florida
Hiv, Sexually Transmitted Diseases
Prevention of HIV/AIDS and STDs in Women Over Fifty
In response to the increasing rates of HIV/STD infections among women over the age of 50, especially minority women, and in the attempt to reduce HIV/STD risks for over ten million older adult American women who are impacted by…
- Conditions
- Hiv, Sexually Transmitted Diseases, Aging
- Trial name
- NCT03810170
- Testing
- safe sex and HIV/STD prevention education via a website, written materials on safe sex
- Where
- United States
- Volunteers
- 331 people, healthy volunteers welcome
- Sponsor
- Environment and Health Group, Inc.
Chronic Hepatitis C
Prospective Anti-Hepatitis C Virus (Anti-HCV) Trial of Peg-Interferon and Ribavirin in Subjects of First Nations, Metis and Caucasian Ethnicity
Background: According to recent estimates, the prevalence of Chronic Hepatitis C (CHC) in Canada is three times more common in First Nations (FN)and Metis compared to non-FN populations.
- Trial name
- Praire (NCT00957866)
- Testing
- Pegylated Interferons (Peg-IFN) and Ribavirin
- Where
- 3 sites in Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Pre-diabetes
The Role of Cholinergic Signaling for Mediating the Effects of GIP and/or Xenin-25 on Insulin Secretion
Glucose-dependent insulinotropic polypeptide (GIP) is a hormone produced in the intestine. It is released immediately after meal ingestion and increases insulin release. This, in turn, helps reduce blood glucose levels.
- Trial name
- NCT01951729
- Testing
- Control, Xenin-25 without atropine, GIP without atropine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
HIV Infections
Examination of B Cell Responses in Human Blood
The aim of this study is the assessment B-cell immune responses in HIV-infected individuals.
- Trial name
- NCT00806845
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Regenerative Medicine Network
Demyelinating Autoimmune Diseases, CNS
Epigenetic Evaluation of HAT/HDAC Activity in PBMC From Patients With Clinically Isolated Syndrome
The aim of the study is to compare the enzymatic activity of HATs and HDACs in peripheral blood mononuclear cell (PBMC) of patients with a clinically isolated syndrome (CIS group) and healthy controls (control group).
- Trial name
- EPIC (NCT02862301)
- Testing
- blood sample
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Neutropenia
AMS Intervention for Early Adaptation of Empirical Antibiotic Therapy in High-risk Neutropenic Patients
Febrile neutropenia (FN) is a frequent and serious complication in patients with hematological malignancies undergoing intensive chemotherapy.
- Trial name
- NCT05793073
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Puerperal Infection, Fever
Diet and Lifestyle Intervention Study in Postpartum Women in China
Previous studies have shown "Doing the month", a traditional practice for postpartum women in China and other Asian countries, may be associated with higher prevalence of postpartum problems.
- Conditions
- Puerperal Infection, Fever, Constipation, Hemorrhoids
- Trial name
- NCT01039051
- Testing
- Diet and Lifestyle Intervention in Chinese Postpartum Women
- Where
- 3 sites in China
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Anemia
Single Dose Group Stratified Study in Renal Impaired and Healthy Aged and Gender Matched Subjects
Safety, tolerability, pharmacokinetics and pharmacodynamics will be investigated in a single dose group stratified study in renal impaired and healthy subjects.
- Trial name
- NCT01318551
- Testing
- BAY85-3934
- Where
- Germany
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Bayer
Malaria
A Challenge Study to Assess the Safety, Immunogenicity and Efficacy of a Malaria Vaccine Candidate
This is an open-label, multi-centre Phase I/IIa dose escalation blood-stage malaria CHMI trial to assess the safety, immunogenicity and efficacy of the candidate malaria vaccine RH5.1/AS01.
- Trial name
- NCT02927145
- Testing
- RH5.1/ ASO1
- Where
- 2 sites in United Kingdom
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Nephrotic Syndrome, Hypoalbuminemia
Edoxaban Steady-State PK/PD in Adults With Nephrotic Syndrome
A study to evaluate the impact of nephrotic syndrome on the steady state pharmacokinetics and pharmacodynamics of edoxaban compared to health volunteers, and whether edoxaban can provide an equivalent anticoagulant effect to…
- Trial name
- NCT07116239
- Testing
- Edoxaban 60 mg, Enoxaparin 40 mg
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Sickle Cell Trait
Sickle Cell Trait in Football Players
This study will look at the five different types of sickle cell and their relation to self-reported ill health to determine whether or not one or two of the sickle cell haplotypes are correlated with worse health outcomes.
- Trial name
- NCT01891877
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Depression, HIV Infections
PET Imaging of the Dopaminergic and Serotonergic Systems in Treated HIV Positive Subjects
Background: Human immunodeficiency virus (HIV) infection is a serious disease with no cure. Some people with HIV have depression and other mood problems. They can have problems with thinking and memory.
- Conditions
- Depression, HIV Infections, HIV-Associated Cognitive Motor Complex
- Trial name
- NCT03581305
- Testing
- 18F-FDOPA, 11C-DASB
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
HIV Infections, Chlamydia Trachomatis
Safety and Acceptability of Carraguard™ Among HIV-negative Couples in Thailand
The primary aims of the study were to assess the safety and acceptability of Carraguard applied vaginally prior to sexual intercourse for six months in both women and men; and to examine several dimensions of acceptability.
- Conditions
- HIV Infections, Chlamydia Trachomatis, Nesseria Gonorrhea, Trichomonas Vaginitis
- Trial name
- NCT00213057
- Testing
- Carraguard (PC-515)
- Where
- Thailand
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Population Council
Prematurity
Evaluating Wearable Smart Sensors for Continuous Measurement of Vital Signs in ICU Patients
The purpose of this study is to develop biocompatible wireless electronic devices that will allow continuous, non-invasive hemodynamic and physiology measurements in the ICU.
- Trial name
- NCT04723654
- Testing
- Wireless Wearable Vital Sign Monitor
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Mild Traumatic Brain Injury
BRAINI-2 Elderly Mild TBI European Study
Mild traumatic brain injury (mTBI) is one of the most frequent emergencies in the elderly population. Despite most mTBI are managed with cranial computed tomography (CT), only 10% of CTs show lesions, determining CT overuse.
- Trial name
- BRAINI2ELDER (NCT05425251)
- Testing
- GFAP and UCH-L1
- Where
- 7 sites in France, Germany and 1 more
- Volunteers
- 2,297 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario 12 de Octubre
Blood Platelet Disorder, BRAF V600E
Preoperative Hemogram Parameters and BRAF Molecular Test Detected by Bethesda 3 Cytology.
The main hypothesis of this study is that preoperative hemogram parameters can be used as biomarkers for malignancy in patients with thyroid nodule Bethesda 3 cytology.
- Conditions
- Blood Platelet Disorder, BRAF V600E, Thyroid Nodule, Cytologic Atypia
- Trial name
- Bethesda3 (NCT06539702)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Homosexuality, Male, HIV
HIV Prevention Among Vulnerable Male Youth
This exploratory study aims to design and test an HIV prevention intervention for young men who have sex with men (MSM) between the ages of 16-20 as this group comprises the US adolescent population most at-risk for HIV infection…
- Conditions
- Homosexuality, Male, HIV, Substance-related Disorders, Sexual Dysfunctions, Psychological
- Trial name
- NCT01771237
- Testing
- MyPeeps Manualized Group Intervention, Standard Sexual Health Education
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
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