Clinical trials: Bone
Arthralgia, Trouble Balancing
Even-Up to Minimize Secondary Site Pain For Ankle Fracture
Evaluating impact of use of Even-Up shoe wear device for patients treated in CAM boot walker for an ankle fracture. Randomized controlled trial, randomizing patients into control group with boot treatment only versus boot…
- Trial name
- NCT04164563
- Testing
- Even-Up
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sickle Cell Disease, Sickle Cell Trait
Sickle Cell Hemoglobinopathies and Bone Health
This research study has two purposes. The first purpose is to determine whether having sickle cell trait (SCT) is a risk factor for the development of bone thinning at an earlier age than expected.
- Trial name
- NCT02306993
- Testing
- Healthy volunteers without SCT, Healthy volunteers with SCT, Volunteers with SCD
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- UConn Health
Bone Metabolism, Electrolyte Metabolism
Salty Life 7 Study: Effect of High Salt Intake on Several Physiological Systems in Immobilisation
The Salty Life 7 study aimed to examine the effect of a high salt (sodium chloride, NaCl) intake on different forms of sodium retention, acid-base balance and bone metabolism and other influenced physiological systems.
- Conditions
- Bone Metabolism, Electrolyte Metabolism, Acid-Base Metabolism, Energy Metabolism
- Trial name
- SL7 (NCT01183299)
- Testing
- Dietary salt intake
- Where
- Germany
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- DLR German Aerospace Center
Ridge Deficiency
Comparison of Dehydrated Human Amnion-Chorion and Type 1 Bovine Collagen Membranes for Guided Bone Regeneration
The objective of this randomized clinical study was to evaluate the use of dehydrated human amnion-chorion membrane as an exposed barrier for guided bone regeneration (GBR) after tooth extraction and to determine whether…
- Trial name
- GBR (NCT03290638)
- Testing
- Guided Bone Regeneration (GBR)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Samer Faraj
Multiple Myeloma, Disease of the Marrow
Evaluation of PET/MR and PET/CT Imaging for Bone Marrow Lesions
Developing an MRI protocol at 1.5 T allowing quantification of the hematopoietic, fatty and trabecular moieties of marrow. An ideal protocol would differentiate red marrow from neoplastic cellular infiltration, and detect loss of…
- Conditions
- Multiple Myeloma, Disease of the Marrow, Osteoporosis
- Trial name
- NCT01880762
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Parathyroid Adenoma, Thyroid Adenoma
Evaluation of a New CZT System
The purpose of the study is to check if the new CZT system has an advantage in detection of small osseous processes, thyroid adenomas, parathyroid adenomas and detection of sentinel node, in comparison with the techniques in use.
- Trial name
- NCT01084356
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Peri-implant Bone Loss, Peri-implant Marginal Bone Loss
Evaluation of Fluid Biomarkers Around Implants Exhibiting Early Stage Periimplant Bone Loss
This study aimed to compare biological mediators known to be important in peri-implant diseases in implants with and without early stage marginal bone loss.
- Conditions
- Peri-implant Bone Loss, Peri-implant Marginal Bone Loss, Marginal Bone Loss, Peri-Implant Health
- Trial name
- NCT07584759
- Testing
- Collecting of peri-implant sulcus fluid, Periapical radiography
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Cardiovascular Diseases, Osteoporosis
Macrobiotic Diet and Flax Seed: Effects on Estrogens, Phytoestrogens, & Fibrinolytic Factors
This study will assess whether alternative, high phytoestrogen dietary interventions result in favorable effects on biological parameters that have been associated with hormone-dependent cancers, cardiovascular disease, and…
- Conditions
- Cardiovascular Diseases, Osteoporosis, Breast Cancer, Endometrial Cancer
- Trial name
- NCT00010829
- Testing
- American Heart Association Step 1 diet, American Heart Association Step 2 diet + 10 g/day flax seed, Macrobiotic dietary intervention
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Paresis, Lumbar Disc Herniation
Validation of a Methodology Using Isometric Dynamometer for Ankle STrength Assessment to Quantify LDH-induced Paresis
Lumbar disc herniation (LDH) is a common condition that may cause lower limb motor weakness (paresis), particularly affecting ankle dorsiflexion and plantarflexion.
- Trial name
- VAST-LDH (NCT07763522)
- Testing
- Strength test validity and reliability
- Where
- Finland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Kyphosis
Yoga for Kyphosis Trial
This study seeks to determine whether a specially designed Hatha Yoga program can reduce hyperkyphosis in men and women who are at least 60 years of age and who have excessive thoracic kyphosis.
- Trial name
- NCT00781729
- Testing
- Yoga, one hour class, 3 times per week, for 24 weeks, Luncheon Seminar Series, once per month, for 24 weeks
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Osteoporosis, Sarcopenia
Effectiveness of Creatine Supplementation and Exercise on Muscle and Bone
As we age, we experience a reduction in muscle and bone which inevitably decreases strength and the ability to perform tasks of daily living such as gardening, carrying groceries, and climbing stairs.
- Trial name
- NCT01057680
- Testing
- creatine monohydrate
- Where
- 2 sites in Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Scoliosis
Functional Intimate Apparel for Adolescents With Early Scoliosis
Adolescent idiopathic scoliosis (AIS) is a prevalent chronic condition that gradually leads to the three dimensional deformity of the spine. Spinal curvature increases in youths as puberty progresses.
- Trial name
- NCT02271256
- Testing
- Functional Intimate Apparel
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Depression
The Effect of a Selective Serotonin Reuptake Inhibitor on Gait, Balance, and Bone Metabolism in Older Adults
The purpose of this study is to examine the effects of sertraline treatment of depression in older adults on gait stability, balance recovery reactions, and markers of bone metabolism.
- Trial name
- NCT02228005
- Testing
- Sertraline
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Osteoporosis
Assessment of Anti-RANKL Antibody in Post-menopausal Women
This is a single-center, open-label, dose-escalating study to evaluate the safety, pharmacokinetics, immunogenicity, and preliminary efficacy of single dose subcutaneous injection of a fully human monoclonal antibody of receptor…
- Trial name
- NCT03242512
- Testing
- TK006
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Jiangsu T-Mab Biopharma Co.,Ltd
Atrophic Maxilla, Ridge Preservation
Effect of L-PRF and A-PRF in Ridge Preservation
A split-mouth design study will be performed regarding the use of platelet concentrates on ridge preservation: L-PRF vs A-PRF vs control.
- Trial name
- NCT03268512
- Testing
- L-PRF, A-PRF
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy Adults With Subjective Memory Complaints
Effects of Deer Bone Extract NS on Improvement in Cognitive-Bio-Markers of Cognitive Functions
This study aims to elucidate the effects of deer bone extract NS on cognitive function improvement and its safety in healthy adults aged 40 to 65 years who report decline in subjective cognitive functions using multimodal…
- Trial name
- NCT02379481
- Testing
- NS 550mg, NS 1100mg
- Where
- South Korea
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University
Dental Implant
Autogenous Tooth Graft for Ridge Augmentation
This study is designed to evaluate the clinical and radiographical outcome of tooth shell for alveolar ridge reconstruction in maxilla as an alternative to traditional autologous bone shell graft.
- Trial name
- NCT06416605
- Testing
- Maxillary Alveolar Ridge Augmentation
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Treatment Complication
Autologous Bone Marrow Aspirate Concentrate Injection for the Treatment of Early Osteoarthritis:Baghdad 2022
We present a randomized controlled trial (RCT) to assess the efficacy of autologous bone marrow aspirate concentrate BMAC of 1.8x 10 9 median cellular content in the treatment of early symptomatic knee OA.
- Trial name
- NCT05193877
- Testing
- autologous bone marrow aspirate concentrate by centrifugation
- Where
- Iraq
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Global Stem Cell Center, Baghdad
Fracture, Fractures, Hip
The PREVENT Trial: a Pragmatic Cluster Randomized Controlled Trial of a Multifaceted Fracture Prevention Model for Long-term Care
Hip fractures occur nearly twice as often for older adults residing in long-term care as they do in older adults of a similar age still living in other settings.
- Conditions
- Fracture, Fractures, Hip, Osteoporosis
- Trial name
- PREVENT (NCT04947722)
- Testing
- PREVENT Program
- Where
- Canada
- Volunteers
- 3,060 people, healthy volunteers welcome
- Sponsor
- McMaster University
Type 2 Diabetes, Neuropathy, Painful
Methylglyoxal Evaluation in Humans
The investigators will test the hypothesis that patients with low back pain associated with lumbar disc aberrancy will have elevated MGO-protein levels circulating in the blood that are comparable to patients with painful…
- Conditions
- Type 2 Diabetes, Neuropathy, Painful, Chronic Low-back Pain, Lumbar Disc Herniation
- Trial name
- MEH (NCT05350553)
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
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