Clinical trials: Bone Marrow Transplant (BMT)
Social Adaptation
Social Adaptation in Long Term Survivors of Blood and Marrow Transplantation
1. To explore specific aspects of social adaptation such as social connectedness, occupational outcomes and family relationships in lymphoma patients after autologous blood or marrow transplantation (BMT). 2.
- Trial name
- NCT01165788
- Testing
- Semi structured personal interview
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
HIV
Optimized Antiretroviral Therapy During Allogeneic Hematopoietic Stem Cell Transplantation in HIV-1 Individuals
To find out if it is possible for HIV-1 patients to maintain antiretroviral medications during allogeneic bone marrow transplant
- Trial name
- NCT01836068
- Testing
- Enfuvirtide
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Severe Aplastic Anemia
A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Aplastic Anemia (TransIT, BMT CTN 2202)
Severe Aplastic Anemia (SAA) is a rare condition in which the body stops producing enough new blood cells. SAA can be cured with immune suppressive therapy or a bone marrow transplant.
- Trial name
- TransIT (NCT05600426)
- Testing
- cyclosporine, Matched Unrelated Donor Hematopoetic Stem Cell Transplant, horse anti-thymocyte globulin (ATG)
- Where
- 52 sites in United States, Canada
- Volunteers
- 53 people
- Sponsor
- Boston Children's Hospital
Cancer
Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation
RATIONALE: Antivirals such as ribavirin are used to treat infections caused by viruses. It is not yet known if ribavirin is more effective with or without monoclonal antibody therapy in treating patients who develop RSV pneumonia…
- Trial name
- NCT00014391
- Testing
- palivizumab, ribavirin
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Fungus Disease
Surveillance of Fungal Infections in Bone Marrow/Stem Cell and Organ Transplant Recipients
This study will collect data on the incidence (rate of occurrence) of fungal infections in recipients of bone marrow, stem cell or organ transplants.
- Trial name
- NCT00026767
- Where
- United States
- Volunteers
- 217 people
- Sponsor
- National Cancer Institute (NCI)
Transplant-Related Cancer
Patient-donor Vaccination in the Context of Allogeneic Bone Marrow Transplant With Post-transplant Cyclophosphamide
This research is being done to understand the effects of certain types of bone marrow transplant (BMT) on the immune system. Your doctors are planning a BMT, using one of your family members as the bone marrow donor, for your…
- Trial name
- NCT01282216
- Testing
- Havrix, PCV13
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Hyperglycemia, Malignant Neoplasm
Computer-Guided Glucose Management Systems in Treating Patients With Hyperglycemia Who Have Undergone Blood and Bone Marrow Transplant
This clinical trial studies computer-guided glucose management systems in treating patients with hyperglycemia who have undergone blood and bone marrow transplant.
- Trial name
- NCT01236885
- Testing
- computer-assisted intervention
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Fred Hutchinson Cancer Center
Severe Aplastic Anemia
Clinical Trial of Upfront Haploidentical or Unrelated Donor BMT to Restore Normal Hematopoiesis in Aplastic Anemia
BMT CTN 2207 will investigate the use of marrow transplantation for treatment of severe aplastic anemia that has not previously been treated.
- Trial name
- BMT CTN CureAA (NCT06517641)
- Testing
- Haploidentical donor bone marrow transplant, Unrelated donor bone marrow transplant
- Where
- 25 sites in United States
- Volunteers
- 60 people
- Sponsor
- Medical College of Wisconsin
Breast Neoplasms
High Dose Chemo With Autologous BMT for Treatment of Metastatic Breast Cancer
To evaluate the response rate and the response duration of high dose chemotherapy with autologous bone marrow transplantation as intensification following induction chemotherapy in metastatic breast cancer and to evaluate…
- Trial name
- NCT00584428
- Testing
- High-Dose Chemo with Autologous BMT
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Oklahoma
Multiple Myeloma, End Stage Renal Disease
Combined Bone Marrow Transplantation (BMT) and Renal Transplant for Multiple Myeloma (MM) With End Stage Renal Disease (ESRD)
The primary objective is to cure multiple myeloma with less toxic allogeneic bone marrow transplantation while inducing renal allograft tolerance through mixed chimerism in patients with end stage renal failure and multiple…
- Trial name
- NCT00854139
- Testing
- Cyclophosphamide, anti-thymocyte globulin, Kidney transplant, Thymic irradiation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Bone Marrow Transplant Complications, Hematologic Malignancy
BMT-CARE: Psychosocial Intervention for Transplant Caregivers
The goal of this study is to evaluate whether a psychological intervention (BMT-CARE) is effective at improving the quality of life in caregivers and patients treated with hematopoietic cell transplant compared to usual care, and…
- Trial name
- BMT-CARE (NCT06472089)
- Testing
- BMT-CARE, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 800 people
- Sponsor
- Massachusetts General Hospital
Beta-Thalassemia, Bone Marrow Transplantation
Zoledronic Acid for the Prevention of Bone Loss Post-bone Marrow Transplantation for Thalassemia Major Patients
This is prospective randomized, double blind study designed to evaluate the use of zoledronic acid in the prevention prevention of bone loss post allogenic BMT done for beta-thalassemia major patients.
- Trial name
- NCT01016093
- Testing
- Zoledronic acid
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Tehran University of Medical Sciences
Bone Marrow Transplantation, Bone Marrow Disease
Impact of Physical and Occupational Therapy in New BMT Patients
This is a single-site, non-randomized, observational study designed to evaluate the impact of adding physical and occupational therapy consultation upon inpatient admission for a bone marrow transplantation (BMT).
- Trial name
- NCT05978583
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Leukemia, Myelocytic, Acute, Leukemia
Autologous Bone Marrow Transplantation in Acute Non-Lymphoblastic Leukemia During First or Subsequent Remission
Evaluate the role of high dose chemotherapy with autologous hematopoietic cell transplantation for AML.
- Conditions
- Leukemia, Myelocytic, Acute, Leukemia, Blood and Marrow Transplant (BMT)
- Trial name
- NCT00186381
- Testing
- high dose chemotherapy then autologous hematopoietic cell transplant
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Stanford University
Primary Immunodeficiency, PID
Bilateral Orthotopic Lung Transplant - Bone Marrow Transplant
The purpose of this study is to determine whether bilateral orthotopic lung transplantation (BOLT) followed by cadaveric partially-matched CD3+/CD19+ depleted bone marrow transplant (BMT) is safe and effective for individuals…
- Trial name
- BOLT-BMT (NCT03330795)
- Testing
- CD3/CD19 neg allogeneic BMT
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Blood Cancer, Bone Marrow Transplant (BMT)
Understanding the Implementation of Cued Exercise Using Wearable Devices and a Custom Smartphone Application Following Bone Marrow Transplant.
The purpose of this study is to pilot test the feasibility of providing patients diagnosed with a hematologic malignancy, undergoing an allogeneic bone marrow transplant, a wearable device and smartphone app (similar to a…
- Trial name
- NCT06645132
- Testing
- exercise intervention
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Medical College of Wisconsin
Acute Leukemia, Chronic Myelogenous Leukemia
Peripheral Blood (PB) Versus Bone Marrow (BM) in Allogeneic Stem Cell Transplantation
350 patients with early leukemias were assigned to receive peripheral blood or bone marrow transplantation; the occurrence of acute and chronic graft versus host disease, survival, transplantation-related mortality, and relapse…
- Conditions
- Acute Leukemia, Chronic Myelogenous Leukemia, Myelodysplastic Syndrome
- Trial name
- NCT01020175
- Testing
- Bone marrow transplantation, Peripheral blood stem cell transplantation
- Where
- Germany
- Volunteers
- 350 people
- Sponsor
- European Society for Blood and Marrow Transplantation
Myelodysplastic Syndrome, Acute Myeloid Leukemia
Dose Finding Study of Post-BMT Decitabine Maintenance Treatment in Higher-risk MDS and MDS/AML
Brief Scientific Rationale: Decitabine has been shown to be effective for treatment of MDS and associated with very limited extramedullary toxicity at the lower doses.
- Trial name
- PODAC (NCT01277484)
- Testing
- Decitabine
- Where
- South Korea
- Volunteers
- 19 people
- Sponsor
- Seoul St. Mary's Hospital
Bone Marrow Transplantation, Graft Versus Host Disease
A Study to Assess Efficacy, Safety and Pharmacokinetics of a Tacrolimus New Oral Formulation (MR4) in BMT Recipients
A study to assess efficacy, safety and pharmacokinetics of a tacrolimus new oral formulation (MR4) in de novo bone marrow transplant recipients
- Conditions
- Bone Marrow Transplantation, Graft Versus Host Disease, Graft-Vs-Host Disease, Graft-Versus-Host Disease
- Trial name
- NCT00189761
- Testing
- Tacrolimus
- Where
- 4 sites in Japan
- Sponsor
- Astellas Pharma Inc
Candidemia, Mycoses
Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantation
The purpose of this pivotal study is to determine if intravenous Rezafungin is efficacious and safe in the prevention of invasive fungal diseases when compared to the standard antimicrobial regimen.
- Conditions
- Candidemia, Mycoses, Fungal Infection, Fungemia
- Trial name
- ReSPECT (NCT04368559)
- Testing
- Rezafungin for Injection, Posaconazole, Fluconazole
- Where
- 53 sites in United States, Belgium and 7 more
- Volunteers
- 602 people
- Sponsor
- Mundipharma Research Limited