Clinical trials: Bone Regeneration, open to volunteers
Alveolar Bone Regeneration, Advanced Platelet-Rich Fibrin
Alveolar Bone Regeneration Using Advanced Platelet-Rich Fibrin Combined With Strontium-Doped Hydroxyapatite
This study aims to evaluate the effectiveness of advanced platelet-rich fibrin (A-PRF) combined with strontium-doped hydroxyapatite (Sr-HA) in enhancing alveolar bone regeneration following tooth extraction compared with…
- Conditions
- Alveolar Bone Regeneration, Advanced Platelet-Rich Fibrin, Strontium-Doped Hydroxyapatite
- Trial name
- NCT07918014
- Testing
- Advanced Platelet-Rich Fibrin, Advanced Platelet-Rich Fibrin combined with Strontium-Doped Hydroxyapatite, Heal spontaneously without placement of any grafting material
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Kafrelsheikh University
Guided Bone Regeneration
Impact of Gingival Phenotype on Guided Bone Regeneration in the Maxillary Anterior Region
Research background: Guided bone regeneration (GBR), as a bone augmentation technique, is widely used for reconstructing hard tissue defects in implant placement in the anterior esthetic zone.
- Trial name
- NCT07918118
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fuming He
Guided Bone Regeneration
Clinical Efficacy Assessment of Digitally Fabricated PEEK Barrier Membranes for Guided Bone Regeneration in Severe Bone Defects
1. Research background: Guided bone regeneration (GBR), as a bone augmentation technique, is widely used for the reconstruction of hard-tissue defects in implant dentistry.
- Trial name
- NCT07918131
- Testing
- PEEK barrier membrane
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Fuming He
Alveolar Ridge Preservation Post-Extraction Bone Healing Dental Implant Site Development Tooth Loss, Alveolar Bone Regeneration Following Odontectomy
Effect of Ascorbic Acid-Loaded I-PRF With Partially Demineralized Dentin Graft on Alveolar Ridge Preservation
The goal of this clinical trial is to find out which treatment best preserves the jawbone after tooth extraction in adults planning to receive a dental implant later.
- Conditions
- Alveolar Ridge Preservation Post-Extraction Bone Healing Dental Implant Site Development Tooth Loss, Alveolar Bone Regeneration Following Odontectomy, Assisted Alveolar Bone Healing After Dental Extraction, Alveolar Bone Preservation
- Trial name
- AA-IPRF-PDDG (NCT07916545)
- Testing
- Alveolar Ridge Preservation Using Partially Demineralized Dentin Graft alone, Alveolar Ridge Preservation Using PDDG Combined with I-PRF, Alveolar Ridge Preservation Using PDDG Combined with Ascorbic Acid-Loaded I-PRF
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Nahda University
Alveolar Ridge Augmentation, Bone Substitutes
Alveolar Ridge Preservation (ARP) Study Using Alloplastic Biomaterial and a Resorbable Synthetic Membrane. A Digital Workflow (CBCT/Scanner) Evaluates Hard and Soft Tissue Volumetric Changes at 4 Months, Validating Support for the Gingival Phenotype and Buccal Bone Plate.
The dimensional collapse of the alveolar ridge following tooth extraction represents a critical challenge for implant rehabilitation.
- Conditions
- Alveolar Ridge Augmentation, Bone Substitutes, Guided Tissue Regeneration, Periodontal, Cone-Beam Computed Tomography
- Trial name
- NCT07879495
- Testing
- Alveolar Ridge Preservation using a synthetic alloplastic bone substitute and a resorbable polymer membrane, Minimally invasive flapless tooth extraction followed by unassisted spontaneous healing
- Volunteers
- 28 people
- Sponsor
- Universidad Católica San Antonio de Murcia
Guided Bone Regeneration, Bone Resorption
The Effect of IPD on Lateral Bone Augmentation
Guided Bone Regeneration (GBR) is a widely used technique during dental implant surgery to help rebuild bone around the implant and improve its long-term appearance and stability.
- Conditions
- Guided Bone Regeneration, Bone Resorption, Diagnostic Imaging
- Trial name
- NCT06999915
- Testing
- Group 1 (Test Group): IP and GBR as an over-contour augmentation beyond IPD, Group 2 (Control Group): IP and GBR as a contour augmentation up to IPD
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Queen Mary University of London
Guided Tissue Regeneration, Periodontal / Methods, Dental Enamel Proteins* / Therapeutic Use
Flapless Periodontal Regeneration Using Hyaluronic Acid Versus Enamel Matrix Derivative
The goal of this clinical trial is to radiographically assess the effectiveness of minimally invasive non-surgical technique (MINST) combined with local administration of sodium hypochlorite gel (Perisolv®) and 1.6% cross-linked…
- Conditions
- Guided Tissue Regeneration, Periodontal / Methods, Dental Enamel Proteins* / Therapeutic Use, Alveolar Bone Loss* / Therapy, Hyaluronic Acid* / Therapeutic Use
- Trial name
- NCT07339605
- Testing
- Flapless instrumentation of the defect following MINST in conjuction with NaOCl and hyaluronic acid application, Flapless instrumentation of the defect following MINST, root conditioning with EDTA and EMD application, Flapless instrumentation of the defect and product application simulation
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Valencia
Bone Regeneration
Performance and Safety of Lyoplant® in Guided Bone Regeneration (GBR) in Oral Surgery
Guided Bone Regeneration (GBR) is a well-established surgical technique that employs barrier membranes to ensure the stability of bone augmentation material while preventing the infiltration of soft tissue, thereby facilitating…
- Trial name
- LyOral (NCT06732167)
- Testing
- GBR Lyoplant, GBR Bio-Gide
- Where
- 2 sites in Spain
- Volunteers
- 68 people
- Sponsor
- Aesculap AG
Guided Bone Regeneration
Assessment Of Guided Bone Regeneration Using Xenograft Mixed With Allogenic Bone Graft Versus Xenograft Mixed With Autogenous Graft For Augmentation Of Maxillary Alveolar Ridges
This study aims to evaluate the effect of Allogenic bone graft mixed with Xenograft in ratio 1:1, on the radiographic and histomorphometric assessment versus Autologous bone graft mixed with Xenograft in ratio 1:1 in maxillary…
- Trial name
- NCT07367464
- Testing
- Allogenic bone graft mixed with Xenograft in ratio 1:1, Autologous bone graft mixed with Xenograft in ratio 1:1
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Alveolar Bone Atrophy, Alveolar Bone Grafting
Digital Planning and Clinical Assessment of the Treated Atrophic Posterior Maxilla With a Sinus Lift Procedure: a Cross-sectional Study.
Maxillary posterior area is the most challenging site for dental implant placement. Indeed, complex remodeling processes, resulting in changes of the maxillary sinus and shape of the alveolar ridge will cause difficulties in…
- Conditions
- Alveolar Bone Atrophy, Alveolar Bone Grafting, Peri-Implant Health, Sinus Floor Augmentation
- Trial name
- NCT07526337
- Where
- Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Impacted Lower Third Molar, Alveolar Bone Regeneration Following Odontectomy
Evaluating The Use of CGF Made Gel in Mandibular Extraction Sites of Lower Impacted 3rd Molars.
The goal of this clinical trial is to learn if Concentrated Growth Factor (CGF) Gel help improve bone healing and reduce pain after the surgical removal of impacted lower third molars.
- Conditions
- Impacted Lower Third Molar, Alveolar Bone Regeneration Following Odontectomy, Postoperative Pain Management in Oral Surgery, Concentrated Growth Factor for Extraction Socket Healing
- Trial name
- CGF (NCT07520097)
- Testing
- Concentrated Growth Factor (CGF) Gel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Impacted Lower Third Molar, Alveolar Bone Regeneration Following Odontectomy
Evaluating The Use of CGF Made Plugs in Mandibular Extraction Sites of Lower Impacted 3rd Molars.
The goal of this clinical trial is to learn if Concentrated Growth Factor (CGF) plugs help improve bone healing and reduce pain after the surgical removal of impacted lower third molars.
- Conditions
- Impacted Lower Third Molar, Alveolar Bone Regeneration Following Odontectomy, Postoperative Pain Management in Oral Surgery, Concentrated Growth Factor for Extraction Socket Healing
- Trial name
- CGF (NCT07484997)
- Testing
- Concentrated Growth Factor (CGF) Plug
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Impacted Lower Third Molar, Alveolar Bone Regeneration Following Odontectomy
Evaluation of the Use of CGF Based Sticky Bone Packed in Fresh Odontectomy Site of Impacted Lower 3rd Molars
This clinical study aims to evaluate the effectiveness of Concentrated Growth Factor (CGF)-based sticky bone in enhancing bone healing after surgical removal of impacted mandibular third molars.
- Conditions
- Impacted Lower Third Molar, Alveolar Bone Regeneration Following Odontectomy, Postoperative Pain Management in Oral Surgery, Concentrated Growth Factor for Extraction Socket Healing
- Trial name
- CGF (NCT07517835)
- Testing
- Concentrated growth factors
- Volunteers
- 10 people
- Sponsor
- Cairo University
Alveolar Ridge Resorption, Bone Loss in the Esthetic Zone
Clinical and Radiographic Evaluation of CGF and Alloplastic Grafting in Participants Undergoing the Socket Shield Technique for Immediate Anterior Maxillary Implant Placement. This Study Assesses Bone Healing and Stability When Managing the Crestal Gap in the Esthetic Zone.
The goal of this clinical trial is to evaluate the clinical and radiographic effectiveness of the socket shield technique combined with concentrated growth factor (CGF) and alloplastic graft in promoting bone healing and…
- Conditions
- Alveolar Ridge Resorption, Bone Loss in the Esthetic Zone, Socket Shield Technique, Partial Extraction Therapy
- Trial name
- CGF (NCT07514871)
- Testing
- Socket Shield Technique with CGF and Alloplastic Graft.
- Where
- Egypt
- Volunteers
- 7 people
- Sponsor
- Cairo University
Alveolar Bone Loss, Tooth Extraction
Evaluation of Stem Cell Exosomes Versus Platelet-Rich Fibrin in Tooth Extraction Socket Healing
This study evaluates two different treatments used to help the jawbone heal after a tooth is removed. When a tooth is extracted, the surrounding bone often shrinks, which can make it difficult to place dental implants later.
- Conditions
- Alveolar Bone Loss, Tooth Extraction, Bone Regeneration
- Trial name
- MSC-EXO vs PRF (NCT07508033)
- Testing
- MSC-Derived Exosomes, Platelet-rich fibrin (PRF)
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Al Salam University
Horizontal Alveolar Bone Defect, Guided Bone Regeneration
Guided Bone Regeneration in Lower Posterior Edentulous Arch Using Resorbable or Non Resorbable Membrane.
the purpose of this study is to compare the efficiency of non-resorbable membrane versus resorbable membrane in guided bone regeneration in atrophic posterior mandible.
- Trial name
- NCT07254494
- Testing
- guided bone regeneration using Resorbable membrane pericardium, guided bone regeneration using non resorbable ptfe membrane
- Where
- Lebanon
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beirut Arab University
Bone Regeneration, Dental Implants
Creos Xenoprotect PMCF
The goal of this retrospective PMCF study is to assess safety and performance of creos xenoprotect in all indications functioning as dental barrier membrane.
- Conditions
- Bone Regeneration, Dental Implants, Bone Grafting
- Trial name
- NCT07153185
- Testing
- Dental Barrier Membrane
- Volunteers
- 200 people
- Sponsor
- Nobel Biocare
Dental Implants, Single-tooth, Alveolar Ridge Preservation
Alveolar Ridge Preservation Versus Spontaneous Healing
Rationale: To determine the effect of alveolar ridge preservation (ARP) versus spontaneous healing (SH) in large buccal bone defects in the posterior mandible.
- Conditions
- Dental Implants, Single-tooth, Alveolar Ridge Preservation, Guided Bone Regeneration
- Trial name
- ARP versus SH (NCT07001345)
- Testing
- Alveolar Ridge Reconstruction
- Where
- Netherlands
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Bone Regeneration, Periodontal Bone Loss
Effect of Nitroglycerin Hydrogel on Repairing Critical Bone Defects
Due to their osteoconductive, osteoinductive, and osteogenic qualities, autologous bone grafts are the gold standard for augmenting bone, (1).
- Conditions
- Bone Regeneration, Periodontal Bone Loss, Healing Fracture of Bone
- Trial name
- Nitro- Bone (NCT06925763)
- Testing
- Nitroglycerin
- Where
- Egypt
- Volunteers
- 33 people
- Sponsor
- Minia University
Alveolar Bone Atrophy, Guided Bone Regeneration
Efficacy and Safety of Additive Manufacturing Personalized Titanium Mesh in Guided Bone Regeneration
This goal of this single-blind, simple randomized, positive-controlled prospective study is to evaluate the effects of additive-manufactured personalized titanium mesh and traditional titanium mesh in guided bone regeneration for…
- Trial name
- NCT06692244
- Testing
- Guided Bone Regeneration Surgery Using Additive-Manufactured Personalized Titanium Mesh, Guided Bone Regeneration Surgery Using Prefabricated Titanium Mesh
- Where
- China
- Volunteers
- 142 people
- Sponsor
- Hospital of Stomatology, Sun Yat-Sen University