Clinical trials: Botox
Compartment Syndrome of Leg
Chronic Exertional Compartment Syndrome (CECS) Treated With Abobotulinumtoxin A
Chronic Exertional Compartment Syndrome (CECS) is a painful condition affecting runners and it is caused by a reversible increase in pressure within a closed compartment in the leg.
- Trial name
- CECS (NCT05466539)
- Testing
- AbobotulinumtoxinA
- Where
- 2 sites in United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Emory University
Lateral Canthal Lines, Crow's Feet
Efficacy and Safety Study of RT001 for the Treatment of Moderate to Severe Lateral Canthal Lines in Adults
The purpose of this study is to find out if an investigational drug, called RT001 Botulinum Toxin Type A Topical Gel, is safe and useful in minimizing the wrinkles between the eye and hairline called crow's feet, also known as…
- Conditions
- Lateral Canthal Lines, Crow's Feet, Facial Wrinkles
- Trial name
- NCT01064518
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Revance Therapeutics, Inc.
Aesthetics
Safety and Efficacy of Azzalure/Dysport, Restylane/Emervel Filler and Restylane Skinbooster Treatment
The efficacy and safety, as well as subject satisfaction will be evaluated after single treatment with Azzalure/Dysport alone or Restylane/Emervel filler alone followed by repeated combined treatment with Azzalure/Dysport…
- Trial name
- NCT02297516
- Testing
- Azzalure or Dysport, Restylane or Emervel filler, Restylane Skinbooster
- Where
- 4 sites in Brazil, France and 1 more
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Glabellar Lines
Evaluate the Efficacy and Safety of INI101 Compared to BOTOX® in Subjects With Moderate to Severe Glabellar Lines.
To evaluate the efficacy and safety of botulinum toxin type A for injection INI101 compared to BOTOX® in subjects with moderate to severe glabellar lines.
- Trial name
- NCT07622004
- Testing
- Botulinum Toxin Type A Injection [INI101], Botulinum Toxin Type A Injection [Botox]
- Where
- South Korea
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- INIBIO Co., Ltd.
Wrinkle
Impact of Near-Infrared Vein Mapping on Outcomes and Satisfaction After Botox/Filler Treatment
Researchers are studying how vein mapping impacts patient outcomes and satisfaction after facial injection procedures.
- Trial name
- NCT04240080
- Testing
- Accuvein® Veinfinder
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Parkinson's Disease, Multiple System Atrophy
Botulinum A Toxin in Patients With Parkinson's Disease
The researchers investigated the effectiveness and safety of BoNT/A injected into the detrusor muscle in patients with PD and MSA all of whom had detrusor muscle overactivity unresponsive to conventional medical therapy.
- Conditions
- Parkinson's Disease, Multiple System Atrophy, Detrusor Overactivity
- Trial name
- Botox-PD (NCT00822913)
- Testing
- Intravesical injection of Botulinum A toxin
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Of Perugia
Overactive Bladder, Botulinum Toxin
Delivery of Intravesical Botulinum Toxin A Using Low Energy Shock Waves in Treatment of Overactive Bladder: A Feasibility Study
We hypothesize that LESWs might temporarily increase urothelial permeability and facilitate delivery of intravesical botulinum toxin without the need for injection.
- Conditions
- Overactive Bladder, Botulinum Toxin, Intravesical, ESWL
- Trial name
- NCT03385460
- Testing
- ESWL BOTOX
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Overactive Bladder
Standard Injections Versus Reduced Injections for Intravesical onabotulinumtoxinA Treatment of Overactive Bladder
OnabotulinumtoxinA is an effective treatment for both idiopathic and neurogenic overactive bladder and was FDA approved for this indication in 2013.
- Trial name
- NCT04020510
- Testing
- onaBoNT-A
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Gummy Smile
Effect of Clinical Crown Lengthening Surgery and Botulinum Toxin A Injection in Gummy Smile Treatment
Background: The demand for beauty is increasing in society as everyone is looking for cosmetic improvement, including gummy smile correction.
- Trial name
- NCT05057286
- Testing
- Clinical crown lengthening surgery
- Where
- Vietnam
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Stroke, Muscle Spasticity
Upper-limb Active Function and Botulinum Toxin A
This study in an observational, prospective and longitudinal study. The aim of the study is to evaluate the effect of botulinum toxin type A (BTX) injections into the elbow flexors on the reduction of spastic co-contractions…
- Conditions
- Stroke, Muscle Spasticity, Upper Extremity Paralysis
- Trial name
- ULAFBoT-Stroke (NCT03783572)
- Testing
- Clinical evaluation, Clinical evaluation and Instrumental evaluation
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Bladder Disorder, Neurogenic
Heart Rate Variability (HRV) in Patients With Neurogenic Detrusor Overactivity (NDO) Before and After Botulinum Neurotoxin Type A (BoNT/A) Intradetrusor Injections
Heart rate variability (HRV) is an important indicator of cardiac autonomic function and predictor of cardiac mortality and of all-cause mortality.
- Trial name
- HRV/Botox (NCT01337024)
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Myalgia, Bruxism
Effectiveness of Botox, Dry Needling, Pharmacological Treatment, and Manual Therapy for Bruxism-Induced Myalgia
Eighty individuals (44 female, 36 male), which were randomly divided into 4 groups of 20 patients each, due to the treatment type: Botulinum toxin (BTX); Dry needling (DN); Pharmacological therapy (PT) and Manual therapy (MT).
- Conditions
- Myalgia, Bruxism, Quality of Life
- Trial name
- NCT06583551
- Testing
- Botulinum toxin, Dry needling, Myorel
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Overactive Bladder Syndrome
Xeomin vs Botox for Treatment of Overactive Bladder Syndrome
Purpose: Multiple formulations and brands of botulinum toxin exist on the market today. Only OnabotulinumtoxinA (BOTOX®) is currently FDA approved for treatment of overactive bladder.
- Trial name
- NCT06034288
- Testing
- Xeomin 100 UNT Injection, Botox 100 UNT Injection
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Post-Traumatic Headache
Abobotulinumtoxina Efficacy in Post-Traumatic Headache
This study will evaluate the efficacy of abobotulinumtoxina on Veterans with post-traumatic headache
- Trial name
- NCT03928496
- Testing
- AbobotulinumtoxinA, Normal saline
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- VA Greater Los Angeles Healthcare System
Lateral Canthal Lines
Safety and Efficacy Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines
The purpose of this study is to determine the safety and efficacy of 2 sequential doses of RT001 compared to vehicle control following applications at Baseline (Day 0) and Week 2.
- Trial name
- NCT00884234
- Testing
- Vehicle Control, RT001 (Botulinum Toxin Type A Topical Gel)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Revance Therapeutics, Inc.
Glabellar Lines
Evaluate the Safety and Explore the Efficacy of DWP712 With Moderate to Severe Glabellar Lines
To evaluate the safety of 12-week administration of DWP712 inj. in subjects with moderate to severe glabellar lines.
- Trial name
- NCT06212960
- Testing
- DWP712, BOTOX®
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Cold Intolerance
Botulinum Toxin Type A for Cold Intolerance Secondary to Digital Amputations and Replantations: A Pilot Study
Patients will be selected for cold intolerance after finger amputation or replantation. They will be given Botox or placebo dose as treatment and assessed over 3 months.
- Trial name
- NCT04917731
- Testing
- Botulinum toxin type A
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Glabellar Frown Lines
Efficacy and Safety of a New Dilution and Injection Volume of AbobotulinumtoxinA for the Treatment of Glabellar Lines
An interventional phase 3 study to evaluate efficacy and safety of a new dilution and injection volume of AbobotulinumtoxinA treatment for glabellar lines
- Trial name
- NCT03960957
- Testing
- AbobotulinumtoxinA
- Where
- 11 sites in United States
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Scar Keloid
Botulinum Toxin Type a Injection to Prevent Keloid Recurrence
The prospective, split-scar, double-blind, randomized controlled study will enroll the patients who are older than 20 years with progressive keloid lesion which is symmetric.
- Trial name
- NCT05072821
- Testing
- Botulinum Toxin Type A Injection [Botox], 0.9% Sodium Chloride Injection
- Where
- Taiwan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Excessive Gingival Display
The Effect of Botulinum Toxin A In Patients With Excessive Gingival Display With And Without Zinc Supplementation
It has been noted since the start of using botulinum toxin for both medical and cosmetic indications that some patients simply don't achieve the responses to the drug that others do, leading to increased dose requirements and…
- Trial name
- NCT03717987
- Testing
- Botulinum toxin type A, Zinc supplementation
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University