Clinical trials: Brain Activity
Irritable Bowel Syndrome
The Role of FODMAPs in Upper GI Effects, Colonic Motor Activity and Gut-brain Signaling at the Behavioral Level
In this study, the investigators aim to assess the effect of acute FODMAP infusion on gastric motility and on gastrointestinal and psychological symptoms.
- Trial name
- NCT02980406
- Testing
- FODMAP, Glucose (control)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Stroke
Physical Fitness Training in Subacute Stroke (PHYS-Stroke)
The aim of this study is to investigate whether a 4-week physical fitness training (target intervention) in stroke patients (subacute stage) increase the walking speed and activities of daily living compared with a control…
- Trial name
- NCT01953549
- Testing
- physical fitness training, relaxation
- Where
- 7 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Charite University, Berlin, Germany
Dynapenia, Abdominal Obesity
Effectiveness of Whole Body Vibration on Health Outcomes in Older Adults With Dynapenic Abdominal Obesity
This study focuses on whole body vibration training (WBVT), a form of neuromuscular training that uses mechanical vibrations. WBVT has been shown to improve muscle function, bone mineral density, and quality of life.
- Trial name
- NCT07180485
- Testing
- whole body vibration training, control group
- Volunteers
- 120 people
- Sponsor
- Dalin Tzu Chi General Hospital
Parkinson Disease
Transcranial Photobiomodulation With Patients With Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. It is a progressive and disabling disease with significative impact on quality of life.
- Trial name
- NCT06729125
- Testing
- transcranial photobiomodulation, exercises training
- Where
- Jordan
- Volunteers
- 38 people
- Sponsor
- Al-Zaytoonah University of Jordan
Breast Cancer, Breast Neoplasms
Breast Cancer, Reasoning, and Activity Intervention
This phase II trial tests whether an exercise intervention works to improve cognitive function in breast cancer survivors. Many breast cancer survivors report cancer-related cognitive impairment, which this has recently become a…
- Conditions
- Breast Cancer, Breast Neoplasms, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- BRAIN (NCT04816006)
- Testing
- Aerobic Exercise Training, Health Education (Active comparator)
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Mayo Clinic
Healthy Aging
The Effect of Training on Brain Activity During Postural Tasks in Older Adults
Older people show deficits in dynamic weight-shifting, as the investigators found that more time is needed to perform weight-shifts and the movements became less fluent and accurate in older versus younger adults.
- Trial name
- NCT04594148
- Testing
- Weight-shift training
- Where
- Belgium
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Depression
Effects of Antidepressant Therapy on Brain Dopamine Transporter Activity in People With Major Depression
This study will examine changes in brain dopamine transporter activity before and after antidepressant therapy.
- Trial name
- NCT00655057
- Testing
- S-citalopram, Cognitive behavioral therapy (CBT), TRODAT-1 single photon emission computed tomographic (SPECT) imaging
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Parkinson Disease, Idiopathic, Freezing of Gait
AID-FOG: Artificial Intelligence-Driven Freezing of Gait Detection in the Home
Freezing of gait (FOG) is a debilitating symptom of Parkinson's disease increases the risk of falling. Despite being a common symptom, it is still difficult to evaluate freezing of gait quickly and accurately.
- Conditions
- Parkinson Disease, Idiopathic, Freezing of Gait, Validation, Wearable Sensors
- Trial name
- AID-FOG (NCT07580612)
- Where
- 3 sites in Belgium, Germany and 1 more
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Agitation in Patients With Dementia of the Alzheimer's Type
Efficacy, Safety and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type
Participants with agitation secondary to dementia of the Alzheimer's type. The diagnosis of probable Alzheimer's disease (AD) was to be based on the "2011 Diagnostic Guidelines for Alzheimer's Disease" issued by the National…
- Trial name
- NCT02442765
- Testing
- AVP-786
- Where
- 126 sites in United States, Estonia and 4 more
- Volunteers
- 387 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Parkinson Disease
Pulmonary and Musculoskeletal Impairments in Parkinson's Patients
In this study, the relationships between pain severity, chest mobility, cough strength, muscle strength, physical activity levels, and quality of life in Parkinson's disease patients will be investigated.
- Trial name
- NCT07843667
- Testing
- Physical Evaluations of Individuals with Parkinson's Disease
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Izmir Democracy University
Stroke, Cerebral Palsy
Multimodal Tracking of Therapy Activity and Effort During Rehabilitation
This study looks at whether everyday rehabilitation therapy sessions can be recorded and measured in a more complete, objective way.
- Conditions
- Stroke, Cerebral Palsy, Spinal Cord Injury, Parkinsons
- Trial name
- NCT07739134
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- ETH Zurich
Craniocerebral Trauma, Head Injury, Minor
Exercise in Patients With Post-Concussion Symptoms
Physical activity and exercise have traditionally not been much of a focus in treatment of postconcussion symptoms and posttraumatic headache.
- Conditions
- Craniocerebral Trauma, Head Injury, Minor, Postconcussion Syndrome, Posttraumatic Headache
- Trial name
- NCT04001192
- Testing
- aerobic exercise program
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- St. Olavs Hospital
Cerebral Palsy
Feasibility of a Robot-Guided Active Play Intervention for Children With Cerebral Palsy
Cerebral palsy can make it difficult for children and adolescents to participate consistently in enjoyable physical activity. This study will examine whether a small humanoid robot called NAO can deliver a short, story-based…
- Trial name
- REACT (NCT07842328)
- Testing
- Humanoid Robot-Guided Active Play Intervention
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Healthy
Functional Neuroanatomy of Emotion Perception, Recognition, Learning, and Memory
This study uses magnetic resonance imaging (MRI) to explore the areas of the brain involved in different types of mental processes, in particular, the brain regions involved in perception, recognition, learning, and memory.
- Trial name
- NCT00458432
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Renal Replacement Therapy, Renal Dialysis
A Clinical Trial of IntensiVE Dialysis
This study will assess clinical outcomes of extended weekly hours of haemodialysis (>= 24 hours per week) compared with standard hours of haemodialysis (<=18 hours/week) in people with ESKD.
- Conditions
- Renal Replacement Therapy, Renal Dialysis, End Stage Kidney Disease, End Stage Renal Disease
- Trial name
- ACTIVE (NCT00649298)
- Testing
- haemodialysis
- Where
- 40 sites in Australia, Canada and 2 more
- Volunteers
- 200 people
- Sponsor
- The George Institute
Obesity & Overweight, Headache
Investigation of the Relationship Between Gray and White Matter Volumes, Walking Exercise, and Body Fat Percentage in Adults With a Body Mass Index Above 25
This study examines the relationship between walking exercise, body fat percentage changes, and brain gray and white matter volumes in overweight and obese adults with headache complaints.
- Conditions
- Obesity & Overweight, Headache, Sedentary Lifestyle, Body Fat Percentage
- Trial name
- NCT07425093
- Testing
- Walking Exercise Program, Dietary Intervention, Brain MRI Morphometry
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Amasya University
Alzheimer's Disease
An Evaluation of the Safety and Efficacy of Memantine in Agitated Patients With Moderate to Severe Alzheimer's Disease
About 65% of patients with severe Alzheimer's Disease (AD) will have symptoms of agitation. There are drawbacks associated with the currently available therapeutic interventions for agitation associated with Alzheimer's Disease.
- Trial name
- NCT00097916
- Testing
- memantine HCl
- Where
- 9 sites in United States
- Volunteers
- 34 people
- Sponsor
- Forest Laboratories
Stroke
Stroke Inpatients Rehabilitation Reinforcement of Activity
The amount of active therapy provided to patients on an inpatient stroke rehabilitation unit has been reported as often insufficient.
- Trial name
- NCT01891565
- Testing
- Feedback
- Where
- Nigeria
- Volunteers
- 100 people
- Sponsor
- University of Ibadan
Stroke
Comparison Between Custom and Non-custom Serious Games Poststroke
Serious games for rehabilitation are delivered through systems that are either customised or non-customised. Custom serious games allow for control of feedback, setting of game speed and difficulty, while non-custom games are…
- Trial name
- SeriousGames (NCT06463730)
- Testing
- Serious games
- Where
- Slovenia
- Volunteers
- 27 people
- Sponsor
- University Rehabilitation Institute, Republic of Slovenia
Migraine
Study of Oral Ubrogepant to Assess Adverse Events and Change in Disease Activity in Adult Participants With Menstrual Migraine
A migraine is a moderate to severe headache typically on one side of the head. A migraine attack is a headache that may be accompanied by throbbing, nausea, vomiting, sensitivity to light and sound, or other symptoms.
- Trial name
- UBRO MM (NCT06417775)
- Testing
- Ubrogepant
- Where
- 106 sites in United States, Puerto Rico
- Volunteers
- 496 people
- Sponsor
- AbbVie
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