Clinical trials: Brain Injured Patients
Traumatic Brain Injury, Intracranial Hypertension
Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents
Severely brain injured patients are at high risk of intracranial hypertension. Among medical treatments (sedatives), neuromuscular blocking agents (NMBA) are recommended by french but not english speaking societies.
- Trial name
- THIC Cu (NCT02404779)
- Testing
- cisatracurium besilate
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Clermont-Ferrand
Mild Traumatic Brain Injury
Functional MRI Study of Attention in Normal Controls and Traumatic Brain Injured Patients
The purpose of this study will be to assess the attentional ability of patients with mild to moderate traumatic brain injury (TBI) using the functional Magnetic Resonance Imaging (fMRI) technique.
- Trial name
- NCT00580918
- Testing
- functional magnetic resonance imaging fMRI
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Irvine
Intra Cerebral Hypertension, Lactate Sodium Solution
Sodium Lactate Versus Hypertonic Saline Solution in the Treatment of Intracranial Hypertensive Episodes in Severe Brain Injured Patients
Brain oedema is a major complication of brain injury (TBI). It increases the risk of intracranial hypertension (ICH) and brain hypoxia, leading to an increase in mortality and poor neurologic outcome.
- Trial name
- SLHYSS (NCT06110429)
- Testing
- Lactate, Sodium, Hypertonic saline
- Volunteers
- 52 people
- Sponsor
- University Hospital, Geneva
Severe Trauma Brain Injury, Intracranial Hypertension
Sodium-Lactate and Traumatic Brain Injury
The purpose of this study is to compare the effect of bolus of either sodium-lactate or mannitol on the evolution of intracranial pressure (ICP) during intracranial hypertensive episodes (IHE)
- Trial name
- NCT00319345
- Testing
- Mannitol, Sodium-Lactate
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Institut d'Anesthesiologie des Alpes Maritimes
Acute Brain Injury, Blood Transfusion
TRansfusion Strategies in Acute Brain INjured Patients
To compare a "liberal" and a "restrictive" strategy to administer blood transfusions in critically ill patients with a primary brain injury.
- Trial name
- TRAIN (NCT02968654)
- Testing
- Restrictive Transfusion Strategy, Liberal Transfusion Strategy
- Where
- Belgium
- Volunteers
- 850 people
- Sponsor
- Erasme University Hospital
Early Ventilation Acquired Pneumonia in Brain Injured Patients
PROPHY-VAP: Prevention of Early Ventilation Acquired Pneumonia (VAP) in Brain Injured Patients by a Single Dose of Ceftriaxone
Ventilation-associated pneumonia (VAP) is the main site of healthcare-associated infections in the brain injured patients, with an incidence rate of 22% to 58%.
- Trial name
- PROPHY-VAP (NCT02265406)
- Testing
- Anti-Infective Agents
- Where
- 8 sites in France
- Volunteers
- 354 people
- Sponsor
- Poitiers University Hospital
Disorder of Consciousness, Minimally Conscious State
Two Intensities of Transcranial Direct Current Stimulation to Improve Consciousness in Severely Brain Injured Patients
Limited treatments are available to improve consciousness in severely brain injured patients. Transcranial Direct Current stimulation (tDCS) is one of the few therapeutics that showed evidence of efficacy to increase level of…
- Conditions
- Disorder of Consciousness, Minimally Conscious State, Vegetative State, Cognitive Impairment
- Trial name
- STIMCOM (NCT03007784)
- Testing
- transcranial direct current stimulation (tDCS) / Comparison of current intensities
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Coma
Longitudinal Study of the Default-mode Network Connectivity in Brain Injured Patients Recovering From Coma
Several studies in healthy volunteers have suggested that the synchronized functional connectivity in the DMN (Deafult-Mode Network) would sustain the mental content at rest, and when required, a switch in the activity between…
- Trial name
- ACI-Coma (NCT01620957)
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Brain Injuries
Influence of Respiratory Mechanics on Brain-specific Monitoring in Brain-injured Patients
Increase in intracranial pressure (ICP) could be associated with increase in positive end-expiratory pressure (PEEP) level. Data are however disparate and interactions between ventilation with high PEEP and intracranial…
- Trial name
- ABIVENT (NCT04013698)
- Testing
- PEEP level 5 cmH2O, PEEP level 15 cmH2O
- Where
- Switzerland
- Sponsor
- Piquilloud Imboden Lise
Disorders of Consciousness, Minimally Conscious State
Aiming for a Better Understanding and Improvement of the Diagnosis and Prognosis of Patients With Disorders of Consciousness Through Multimodal Observations
Improved treatment of severe brain injuries has resulted in increased survival rates. While some of these patients regain consciousness after a transient state of coma, others may develop a disorder of consciousness (DoC).
- Conditions
- Disorders of Consciousness, Minimally Conscious State, Unresponsive Wakefulness Syndrome, Caregivers
- Trial name
- PerBrain (NCT04798456)
- Testing
- Coma scales, Imaging, electrophysiology, body signals, and brain stimulation, Questionnaires
- Where
- 4 sites in France, Germany and 2 more
- Volunteers
- 150 people
- Sponsor
- Paris Brain Institute (ICM)
Acute Brain Injury
Frontal Bone Window in ICUF (FBW-ICU)
Transcranial doppler (TCD) is an established tool for monitoring flows in intracranial cerebral arteries. Its use is recommanded in the last guidelines on traumatic brain injury.
- Trial name
- FBW-ICU (NCT02832895)
- Testing
- Transcranial doppler examination
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Montpellier
Brain Injury, Acute Lung Injury
Respiratory Mechanics in Brain Injured Patients
The hypothesis is that brain injury patients have alterations of the respiratory system related to intraabdominal pressure. Furthermore application of moderate levels of PEEP may improve respiratory function in these patients.
- Trial name
- NCT00639990
- Testing
- PEEP
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Università degli Studi dell'Insubria
Brain Injuries, Mechanical Ventilation
Patient-ventilator Asynchrony in Patients With Brain Injury
Mechanical ventilation is an important support strategy for critically ill patients. It could improve gas exchange, reduce the work of breathing, and improve patient comfort.
- Trial name
- NCT03212482
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jian-Xin Zhou
Early Ventilator Associated Pneumonia, Acute Brain Injuries
PK/PD Target Attainment of Ceftriaxone for the Prevention of Early Ventilator-associated Pneumonia in Neurologically Injured Patients
Critically ill patients admitted for acute brain injury are exposed to many heath-care associated infections such as ventilator associated pneumoniae (VAP).
- Trial name
- NeuroPKVAP (NCT07450404)
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Traumatic Brain Injury, Hemorrhagic Shock
The Use of Tissue Oxygen Monitoring in Critically Injured Patients
It is anticipated that the use of tissue oxygen monitoring to measure brain tissue oxygen and deltoid muscle oxygen will provide more precise information about focal brain ischemia and systemic hypoperfusion than current…
- Conditions
- Traumatic Brain Injury, Hemorrhagic Shock, Trauma
- Trial name
- NCT00328341
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- University of California, San Francisco
Traumatic Brain Injury
Vasopressin Versus Catecholamines for Cerebral Perfusion Pressure Control in Brain Injured Trauma Patients
Traumatic brain injury (TBI) is among the leading causes of trauma death and disability in both civilian and military populations.
- Trial name
- AVP (NCT00795366)
- Testing
- arginine vasopressin, Standard catecholamine
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Miami
Traumatic Brain Injury, Intracranial Hypertension
Cerebral Hemodynamic Effects of Hypertonic Solutions in Severely Head-Injured Patients
This is a clinical study comparing the physiologic effects of two hypertonic solutions (mannitol, hypertonic saline) with a particular emphasis on changes in cerebral blood flow in patients with intracranial hypertension…
- Trial name
- NCT00125229
- Testing
- Mannitol, Hypertonic Saline
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Spinal Cord Injured, Post-stroke
Effects of an Eccentric Muscle Strengthening Protocol on Force Moment, Muscle Activation and Plantar Flexor Structure of Patients With Central Nervous System Injuries.
Neurological disorders [such as Cerebral Vascular Accident (CVA) or Spinal Cord Injury (SCI)] are among the most costly health problems to society in industrialized countries.
- Trial name
- RenfExc (NCT06099340)
- Testing
- muscle-strengthening program
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Nantes University Hospital
Brain Injuries
Validation Of TBI Detection System For Head Injured Patients
A prospective, non-randomized trial to validate the database of brain electrical activity recordings and clinical information collected from patients who present to the ED following closed head injury.
- Trial name
- B-AHEAD III (NCT02367300)
- Testing
- BrainScope Ahead 200
- Where
- 11 sites in United States
- Volunteers
- 981 people
- Sponsor
- BrainScope Company, Inc.
Cerebral Blood Flow
Prone Positioning for Brain-injured Patients With Severe ARDS (ProBrain)
Prone position (PP) is a key component to treat hypoxemia in patients with severe acute respiratory distress syndrome (ARDS). However, most studies evaluating PP effects in patients with ARDS exclude those with brain-injuries…
- Trial name
- ProBrain (NCT05050838)
- Testing
- Transcranial Doppler (TCD)
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild