Clinical trials: Brain Stroke
Myocardial Infarction, Cardiovascular Death
Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin
This study is being carried out to see if a new drug called ticagrelor given twice daily in addition to the ASA therapy decreases the frequency of cardiovascular events (e.g., death from heart disease, heart attack, or stroke).
- Conditions
- Myocardial Infarction, Cardiovascular Death, Atherothrombosis, Stroke
- Trial name
- PEGASUS (NCT01225562)
- Testing
- Ticagrelor 90 mg, Ticagrelor 60 mg
- Where
- 826 sites in United States, Argentina and 29 more
- Volunteers
- 21,379 people
- Sponsor
- AstraZeneca
Stroke
Robotic Therapy and Transcranial Direct Current Stimulation in Patients With Stroke
Stroke is the second cause of death worldwide and represented the first cause of death in Brazil between 2006 and 2010. Most patients survive, and there is a need to develop cost-effective rehabilitation strategies to decrease…
- Trial name
- ROTS (NCT02416791)
- Testing
- Robotic Therapy, Active tDCS, Physical Therapy
- Where
- Brazil
- Volunteers
- 9 people
- Sponsor
- University of Sao Paulo General Hospital
Cerebral Stroke, Hemiplegia, Spastic
Compensatory Kinematic Movements in Various Directions After Stroke
This is cross-sectional study. By comparing kinematic analysis between stroke and healthy subjects in various directions, this investigation analyzes the compensatory kinematic movement for reaching task in stroke survivors
- Trial name
- NCT05683158
- Where
- South Korea
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Transient Ischemic Attack, Stroke
Protocol-guided Rapid Evaluation of Veterans Experiencing New Transient Neurological Symptoms
This program will seek to implement a quality improvement program to improve the care of Veterans with TIA or minor stroke at 6 Veteran Health Administration Hospitals.
- Trial name
- PREVENT (NCT02769338)
- Testing
- Quality Improvement Program
- Where
- United States
- Volunteers
- 2,292 people
- Sponsor
- VA Office of Research and Development
Stroke
Robotic Pedaling Therapy for Targeted Neural Plasticity
The aim of this Pilot study is to determine whether robotically targeted lower-limb pedaling therapy can increase the extent of stroke recovery on behavioral measures and induce brain plasticity as measured by functional magnetic…
- Trial name
- NCT03300258
- Testing
- Robotic therapy, Aerobic therapy
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Stroke
Nutrition and Aerobic Exercise in Chronic Stroke
Strokes are very common in the United States and occur more in the elderly. The number of strokes is likely to double in the next 50 years.
- Trial name
- NEXIS (NCT02043574)
- Testing
- Treadmill Exercise, Stretching (control)
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- VA Office of Research and Development
Stroke
Finding an Optimal Latency for Paired Associative Stimulation in People With Chronic Stroke
After a stroke, there is an exaggerated inhibitory influence from the non-stroke hemisphere to the stroke hemisphere. Brain stimulation using repetitive transcranial magnetic stimulation (rTMS) to the non-stroke hemisphere can…
- Trial name
- NCT02188420
- Testing
- Transcranial Magnetic Stimulation will be applied to the primary motor cortex at the interstimulus interval of ("Latency" - 3ms), Transcranial Magnetic Stimulation will be applied to the primary motor cortex at the interstimulus interval of ("Latency" - 5ms), ranscranial Magnetic Stimulation will be applied to the primary motor cortex at the interstimulus interval of ("Latency" - 7ms)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Minnesota
Subarachnoid Hemorrhage, Intracranial Hemorrhage
Enteral Nutrition and Glycemic Variability Neurological Intensive Care Unit Study
Primary Objective: To determine the effects of a diabetes specific enteral formula compared to a standard formula supplemented with protein (isocaloric and isonitrogenous) on the mean blood glucose and glycemic variability in a…
- Conditions
- Subarachnoid Hemorrhage, Intracranial Hemorrhage, Ischemic Strokes, Subdural Hematoma
- Trial name
- ANUS1014 (NCT01463878)
- Testing
- Glycerna, Jevity - Control Diet
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Eastern Virginia Medical School
Stroke
New Tool to Enhance Post-stroke Upper Extremity Disability
Individuals with low socioeconomic status (SES) are more likely to have a stroke, more disabled at 3 months, and less likely to be independently ambulatory.
- Trial name
- NCT05277389
- Testing
- START - Startle Adjuvant Rehabilitation Therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Arizona State University
Stroke, Ischemic, Motor Activity
Transcranial Direct Current Stimulation for Post-stroke Motor Recovery
This research study is to find out if brain stimulation at different dosage level combined with an efficacy-proven rehabilitation therapy can improve arm function.
- Conditions
- Stroke, Ischemic, Motor Activity, Upper Extremity Paralysis
- Trial name
- TRANSPORT 2 (NCT03826030)
- Testing
- Low dose tDCS, High dose tDCS, mCIMT
- Where
- 14 sites in United States
- Volunteers
- 129 people
- Sponsor
- Duke University
Stroke
Forearm Rotation Orthosis for Stroke
The purpose of this study is to examine the efficacy of a forearm rotation orthosis combined with the occupational therapy task-oriented approach on functional performance for persons with a hemiparetic arm.
- Trial name
- NCT01987414
- Testing
- occupational therapy task-oriented approach, Forearm rotation orthosis, No treatment
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Minnesota
Acute Ischemic Stroke, Large Vessel Occlusion
THUNDER: Acute Ischemic Stroke Study With the Penumbra System® Including Thunderbolt™ Aspiration Tubing
The objective of this study is to demonstrate the safety and efficacy of the Penumbra System including Thunderbolt Aspiration Tubing (Thunderbolt) in a population presenting with acute ischemic stroke (AIS) secondary to…
- Trial name
- NCT05437055
- Testing
- Mechanical Thrombectomy (Penumbra System with Thunderbolt)
- Where
- 32 sites in United States
- Volunteers
- 216 people
- Sponsor
- Penumbra Inc.
MELAS
Phase 2a Study of IW-6463 in Adults Diagnosed With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS)
This is a single-arm study to evaluate safety and tolerability of oral IW-6463 in adults diagnosed with MELAS.
- Trial name
- NCT04475549
- Testing
- IW-6463 Tablets
- Where
- 5 sites in United States
- Volunteers
- 8 people
- Sponsor
- Tisento Therapeutics
Stroke
PROPEL Randomized Trial
It is important for people with stroke to exercise in order to improve their overall recovery and general health. However, these individuals are less physically active than people without stroke, and they often do not achieve the…
- Trial name
- NCT02951338
- Testing
- PROPEL program, Group aerobic exercise
- Where
- 5 sites in Canada
- Volunteers
- 57 people
- Sponsor
- Toronto Rehabilitation Institute
Ischemic Stroke
TNK-tPA Evaluation for Minor Ischemic Stroke With Proven Occlusion
This trial will enroll patients that have been diagnosed with a transient ischemic attack (TIA) or minor stroke that has occurred within the past 12 hours.
- Trial name
- TEMPO-1 (NCT01654445)
- Testing
- Tenecteplase
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Stroke
Effects of an Overground Propulsion Neuroprosthesis in Community-dwelling Individuals After Stroke
This interventional study evaluates the effects of an overground propulsion neuroprosthesis that delivers adaptive neurostimulation assistance to the paretic plantarflexors and dorsiflexors of people post-stroke.
- Trial name
- NCT06459401
- Testing
- Propulsion Neuroprosthesis
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Boston University Charles River Campus
Stroke, Stroke, Ischemic
Coordinated, Collaborative, Comprehensive, Family-based, Integrated, Technology-enabled Stroke Care
Stroke is the 5th leading cause of death and the leading cause of adult disability in the United States (US). Stroke is a complex disease with multiple interacting risk factors (including genetic, high blood pressure and…
- Conditions
- Stroke, Stroke, Ischemic, Stroke, Acute, Stroke Sequelae
- Trial name
- C3FIT (NCT04000971)
- Testing
- Integrated Stroke Practice Unit, Comprehensive or Primary Stroke Center
- Where
- 21 sites in United States
- Volunteers
- 1,196 people
- Sponsor
- Vanderbilt University Medical Center
Stroke
Sensory Augmentation Methods in Stroke
Many chronic stroke survivors have poor walking balance, contributing to an increased risk of falls and fear of falling. One factor contributing to these balance deficits is a reduced ability to place the feet appropriately when…
- Trial name
- SAM (NCT03988400)
- Testing
- Sensory Augmentation, Random Vibration
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- VA Office of Research and Development
Chronic Ischemic Stroke
A Study of Modified Stem Cells in Stable Ischemic Stroke
The primary purpose of the clinical study is to determine the safety of a modified stem cell SB623 when administered to chronic, stable ischemic stroke patients.
- Trial name
- NCT01287936
- Testing
- SB623
- Where
- 5 sites in United States
- Volunteers
- 18 people
- Sponsor
- SanBio, Inc.
Stroke
CLOTBUST Hands-Free: A Phase I/II Pilot Safety Trial
The purpose of CLOTBUST-HF is to determine the safety of a novel, external Hands-Free transcranial Doppler (TCD) ultrasound system in healthy volunteers and ischemic stroke patients.
- Trial name
- CLOTBUST-HF (NCT01240356)
- Testing
- 2-MHz transcranial Doppler ultrasound, 2-MHz transcranial Doppler ultrasound insonation
- Where
- 2 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston