Clinical trials: Breast-conserving Surgery
Triple Negative Breast Cancer, HER2-positive Breast Cancer
A Dose Escalation Study of Proton and Carbon Ion Irradiation for HER2 Positive and Triple Negative Breast Cancer
Adjuvant radiotherapy is the standard treatment for early breast cancer after breast conserving surgery. Molecular subtypes was significantly associated with the risk of local recurrence of breast cancer.
- Trial name
- NCT05692661
- Testing
- proton plus carbon ion radiotherapy
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Shanghai Proton and Heavy Ion Center
Breast Cancer With Low to Intermediate HER2 Expression, Breast Cancer (Triple Negative Breast Cancer (TNBC))
Use of Magtrace Bracketing for Excision of Lesion and Sentinel Lymph Node Localization in Breast Conserving Surgery for Breast Cancer
Breast cancer is the commonest cancer affecting women worldwide. Early breast cancer is treated surgically with wide local excision of tumor with axillary staging operations like sentinel node biopsy.
- Conditions
- Breast Cancer With Low to Intermediate HER2 Expression, Breast Cancer (Triple Negative Breast Cancer (TNBC)), Breast Cancer (Triple Negative Type), Breast Cancer - Infiltrating Ductal Carcinoma
- Trial name
- MagBracket (NCT07844473)
- Testing
- Super paramagnetic iron oxide bracketing injection
- Where
- Saudi Arabia
- Volunteers
- 35 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Breast Cancer
IRIS: Risk-Based Imaging After Breast-Conserving Surgery
Breast cancer follow-up after curative treatment is currently based on largely uniform imaging surveillance strategies, despite substantial variation in recurrence risk across patient subgroups.
- Trial name
- IRIS (NCT07426510)
- Testing
- Risk-Stratified Imaging Surveillance, Standard Mammographic Surveillance
- Volunteers
- 2,300 people
- Sponsor
- Umeå University
Postoperative Pain
BRILMA Block in Breast-Conserving Surgery
Regional analgesia technique in addition to multimodal analgesia in breast-conserving surgery aims to reduce opioid consumption.
- Trial name
- NCT07056413
- Testing
- BRILMA block, Standard intravenous analgesia.
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Breast Ductal Carcinoma in Situ
Radiotherapy Versus Low-Dose Tamoxifen Following Breast Conserving Surgery for Low-Risk Breast Ductal Carcinoma in Situ
Although the results obtained from ECOG E5194 cohort 1 (criteria: mammographically detected low- or intermediate-grade DCIS, measuring less than 2.5 cm with margins ≥ 3 mm) and RTOG 9804 trial (the same enrolled…
- Trial name
- NCT04046159
- Testing
- Low-dose tamoxifen, Whole breast radiotherapy
- Where
- Taiwan
- Volunteers
- 810 people
- Sponsor
- National Taiwan University Hospital
Breast Cancer
Breast-Conserving Surgery Techniques in Treating Women With Breast Cancer
RATIONALE: Breast-conserving surgery is a less invasive type of surgery for breast cancer and may have fewer side effects and improve recovery.
- Trial name
- NCT00870415
- Testing
- quality-of-life assessment, therapeutic conventional surgery
- Where
- France
- Volunteers
- 263 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Breast Cancer, Ductal Carcinoma In Situ
HISMAR: Intraoperative Margin Assessment Using the Histolog® Scanner to Reduce Reoperation in Breast-Conserving Surgery
This study evaluates whether systematic intraoperative margin assessment using the Histolog® Scanner - a confocal fluorescence microscopy device - reduces the need for reoperation after breast-conserving surgery (lumpectomy) in…
- Conditions
- Breast Cancer, Ductal Carcinoma In Situ, Invasive Lobular Carcinoma, Breast Neoplasm Female
- Trial name
- HISMAR (NCT07527468)
- Testing
- Histolog® Scanner
- Where
- Switzerland
- Volunteers
- 228 people
- Sponsor
- Hôpital du Valais
Breast Cancer
Breast Cancer Detection in Breast Surgical Specimens With the Histolog Scanner, Slide-free Confocal Microscope
Study to assess the capability of physicians (breast surgeons and pathologists) to recognize breast cancer in images of fresh lumpectomies generated with the Histolog Scanner, a recent large field-of-view confocal laser scanning…
- Trial name
- Hibiscuss (NCT04976556)
- Testing
- Histolog Scanner
- Where
- France
- Volunteers
- 181 people
- Sponsor
- SamanTree Medical SA
Breast Neoplasms
Magnetic Occult Lesion Localization and Imaging (MOLLI)
The proposed trial is a non-randomized, single-arm study examining the technical feasibility and safety of magnetic occult lesion localization and imaging (MOLLI) for Breast Conserving Surgery (BCS), in patients with non-palpable…
- Trial name
- MOLLI (NCT03660137)
- Testing
- MOLLI Localization
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Sunnybrook Health Sciences Centre
Breast Cancer
A Novel Optical Spectral Imaging System for Imaging Breast Tumor Margins
The goal of this research is to further develop novel optical assay systems for intra operative assessment of tumor margins in partial mastectomy or mastectomy specimens.
- Trial name
- NCT01372631
- Testing
- miniature spectral imaging system, Bench-top optical spectrometer, High resolution microendoscope
- Where
- 2 sites in United States
- Volunteers
- 218 people
- Sponsor
- Duke University
Breast Neoplasm
Magnetic Occult Lesion Localization Instrument (MOLLI) Guidance System for Breast Lesion Localization
The proposed trial is a non-randomized, multi-center, sequential arm registry evaluating clinical, and health economic outcomes following treatment with the Magnetic Occult Lesion Localization Instrument (MOLLI), an approved…
- Trial name
- MOLLI (NCT04893421)
- Testing
- MOLLI Localization
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- Sunnybrook Health Sciences Centre
Breast Cancer
Intraoperative Radiotherapy for Korean Patients With Breast Cancer
The purpose of this study is to evaluate acute local toxicity of IORT at the dose of 20 Gy for the replacement of boost-external beam radiotherapy in Korean women who are candidates for breast-conserving treatment.
- Trial name
- NCT02213991
- Testing
- Intraoperative radiotherapy using Intrabeam®
- Where
- South Korea
- Volunteers
- 215 people
- Sponsor
- Gangnam Severance Hospital
Breast Cancer, Quality of Life
Comparison of the Cosmetic Results, Quality of Life and Patient Satisfaction Achieved With Round-block and Retroglandular Oncoplastic Breast Conserving Surgeries
The aim of this clinical study is to analyze due long term follow-up, the clinical, oncological, aesthetic results and patients' reported quality of life and satisfaction in a responsive-adaptive (RAR) prospective, randomized…
- Conditions
- Breast Cancer, Quality of Life, Patient Satisfaction
- Trial name
- NCT04349527
- Testing
- Round-block Oncoplastic Breast Conserving Surgeries, Retroglandular Oncoplastic Breast Conserving Surgeries
- Where
- Hungary
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- National Institute of Oncology, Hungary
Breast Cancer Invasive
Long-Term Outcomes of Endoscopic-assisted vs Conventional Breast-conserving Surgery in Breast Cancer Patients After Neoadjuvant Therapy: a Randomized, Multicenter, Open Label, Non-inferiority Trial
With the title of "Long-Term Outcomes of endoscopic-assisted vs conventional breast-conserving surgery in breast cancer patients after neoadjuvant therapy: a randomized, multicenter, open label, non-inferiority trial", this study…
- Trial name
- NCT06716073
- Testing
- Surgery
- Where
- 2 sites in China
- Volunteers
- 804 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Cancer
Partial Breast Radiation Therapy in Treating Women Undergoing Breast-Conserving Therapy for Early Stage Breast Cancer
RATIONALE: Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells. Giving radiation therapy in different ways may kill more tumor cells.
- Trial name
- NCT00527293
- Testing
- adjuvant therapy, 3-dimensional conformal radiation therapy, brachytherapy
- Where
- 4 sites in United States
- Volunteers
- 29 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Conserving Surgery, Mastectomy With Reconstruction
A Study of the BREAST-Q REACT Tool for People Having Breast Surgery
The researchers are doing this study to find out whether it is practical (feasible) to conduct a larger study looking at the effects of the BREAST-Q Real-time Engagement and Communication Tool (REACT) on people's quality of life…
- Trial name
- NCT06550401
- Testing
- BREAST-Q Physical Well-Being, QuickDASH
- Where
- 6 sites in United States
- Volunteers
- 69 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer
Comparison of Axillary Sentinel Lymph Node Biopsy Versus no Axillary Surgery
Although there is no doubt that the presence of lymph node metastases worsens prognosis of a patient, unambiguous evidence to support lymph node dissection is still lacking.
- Trial name
- INSEMA (NCT02466737)
- Testing
- no axillary surgery versus SLNB, SLNB versus completion ALND
- Where
- 150 sites in Austria, Germany
- Volunteers
- 5,505 people
- Sponsor
- University of Rostock
Breast Cancer, Early-Stage Invasive Breast Carcinoma
Radiotherapy and Long-term Outcomes in Early Breast Cancer With SLNB Omission
This prospective, multicenter observational cohort study evaluates long-term outcomes in patients with early-stage invasive breast cancer who undergo breast-conserving surgery without sentinel lymph node biopsy or other axillary…
- Trial name
- APROOB Cohort (NCT07803081)
- Testing
- Adjuvant Breast Radiotherapy
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Samsung Medical Center
Breast Cancer
Adjuvant Whole Breast Radiotherapy (RT) With Intensity Modulated Radiotherapy (IMRT) and a Simultaneous Integrated Boost Versus Conventional RT and a Sequential Boost
The IMRT-MC2 study is a prospective, two armed, multicenter, randomized phase-III-trial comparing intensity modulated radiotherapy with integrated boost to conventional radiotherapy with consecutive boost in patients with breast…
- Trial name
- IMRT-MC2 (NCT01322854)
- Testing
- IMRT with an simultaneous integrated boost
- Where
- 2 sites in Germany
- Volunteers
- 502 people
- Sponsor
- Heidelberg University
Breast Cancer
Hypofractionated Whole-breast Irradiation With Simultaneously Integrated Boost For Early-Stage Breast Cancer After Breast-conserving Surgery
The study was designed to evaluate the feasibility and safety of hypofractionated whole-breast irradiation with simultaneously integrated boost for early-stage breast cancer after breast conserving surgery in Chinese population.
- Trial name
- HF-WBI-SIB (NCT02617043)
- Testing
- hypofractionated whole breast irradiation with simultaneously integrated boost
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fudan University