Clinical trials: Breathing Rate
COVID-19
Non-comparative Trial of the Combination of HCQ and AZI in the Treatment of ICU Patients
This research is designed as an open-label,non-comparative prospective trial.
- Trial name
- NCT04458948
- Testing
- Hydroxychloroquine, Azithromycin
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of New Mexico
Lung Cancer
Trial of RAD001 in Patients With Operable Non-Small Cell Lung Cancer (NSCLC)
This is a Phase 1b pre-operative lung cancer trial wherein patients with operable lung cancer will be treated with RAD001 to evaluate the target effects of this compounds on relevant molecular pathways and on the…
- Trial name
- NCT00401778
- Testing
- RAD001
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Emory University
Asthma
Phase4/Symbicort® Versus Pulmicort Flexhaler® in African Americans
To compare the efficacy of SYMBICORT® pMDI 160/4.5 μg x 2 actuations twice daily (bid) to that of budesonide inhalation powder DPI 180 μg x 2 inhalations bid, in African American(self-reported) subjects with inhaled…
- Trial name
- Titan (NCT00702325)
- Testing
- Budesonide / formoterol fumarate (SYMBICORT), Budesonide
- Where
- 57 sites in United States
- Volunteers
- 311 people
- Sponsor
- AstraZeneca
COPD, LUNG DISEASES, OBSTRUCTIVE
Airway Effects of Tiotropium in Patients With COPD
The aim of the study is to investigate the effect of tiotropium from different devices on a panel of small (IOS, MBNW, DLCO, FVC) and large airway (FEV1, PEF) responses in patients with mild-moderate COPD.
- Trial name
- NCT02683668
- Testing
- Handihaler-Tiotropium 18 mcg untrained, Handihaler-Tiotropium 18 mcg trained, Respimat-Tiotropium 5 mcg trained
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- Imperial College London
COVID-19
LY3819253 (LY-CoV555) for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)
This study looks at the safety and effectiveness of LY3819253 in treating COVID-19 in people who have been hospitalized with the infection.
- Trial name
- NCT05780268
- Testing
- LY3819253, Remdesivir
- Where
- 57 sites in United States, Denmark and 2 more
- Volunteers
- 314 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Non-small Cell Lung Carcinoma
A Study of Pembrolizumab (MK-3475) in Combination With Chemotherapy or Immunotherapy in Participants With Non-small Cell Lung Cancer (MK-3475-021/KEYNOTE-021)
The purpose of this study is to determine the safety, tolerability, and efficacy of pembrolizumab (MK-3475) in combination with chemotherapy or immunotherapy in participants with unresectable or metastatic non-small cell lung…
- Trial name
- NCT02039674
- Testing
- Pembrolizumab, Paclitaxel, Carboplatin
- Volunteers
- 267 people
- Sponsor
- Merck Sharp & Dohme LLC
Pulmonary Arterial Hypertension
A Long-Term, Open-Label Study to Evaluate the Safety of Sitaxsentan Sodium Treatment in Patients With Pulmonary Arterial Hypertension
This is a multi-center, open-label study of sitaxsentan sodium 100 mg taken orally once daily by subjects with PAH until sitaxsentan, in a particular country or region, is commercially available for the treatment of PAH or the…
- Trial name
- STRIDE-3 (NCT00811018)
- Testing
- Sitaxsentan
- Where
- 91 sites in United States, Argentina and 14 more
- Volunteers
- 1,192 people
- Sponsor
- Pfizer
Traumatic Brain Injury
A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy for the Treatment of Traumatic Brain Injury and Hypoxic-Ischemic Encephalopathy
This study aims to determine the safety of HB-adMSC infusion and treatment effects of HB-adMSC infusion on brain structure, neurocognitive/functional outcomes, and neuroinflammation after subacute and chronic neurological injury…
- Trial name
- NCT04063215
- Testing
- HB-adMSCs
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Hope Biosciences LLC
Chronic Obstructive Pulmonary Disease
Tiotropium Respimat Versus HandiHaler on SaO2 and Sleep in COPD Patients
The aim of this study was to compare the tiotropium Respimat Soft Mist Inhaler and the HandiHaler in terms of their effects on sleeping oxygen saturation (SaO2) and sleep quality in patients with COPD.
- Trial name
- NCT02331940
- Testing
- tiotropium, Handihaler, Respimat
- Volunteers
- 200 people
- Sponsor
- University of Crete
Lung Neoplasm
Prophylactic Risedronate for Patients With Peripheral Lung Tumors Treated With SBRT
This is a double blind randomized controlled study investigating the efficacy of a single dose of 150 mg risedronate (a bone anti-resorptive) vs a single dose of placebo given prior to SBRT for peripheral lung tumors that are…
- Trial name
- NCT03861091
- Testing
- risedronate
- Where
- 2 sites in United States
- Volunteers
- 84 people
- Sponsor
- Wake Forest University Health Sciences
Covid19, Vaccination
COVID-19 Vaccination Take-Up
In this work, the investigators are partnering with Contra Costa Health Services (CCHS), the department of health in Contra Costa County, CA, to measure COVID-19 vaccinations and other COVID-19 related preventive health behaviors…
- Trial name
- NCT04867174
- Testing
- Financial incentives, Convenient scheduling link, Race concordant
- Where
- United States
- Volunteers
- 2,701 people
- Sponsor
- National Bureau of Economic Research, Inc.
Asthma
Evaluation of Safety and Efficacy of Symbicort® pMDI, With or Without Spacer, in Children (6-11 Years) With Asthma
The purpose of the study is to compare Symbicort pMDI with and without spacer in terms of steroid potency, improvement of lung function and asthma symptoms in children with asthma (6-11 years).
- Trial name
- Spacer (NCT00536913)
- Testing
- Budesonide/formoterol pMDI 40/2.25ug + spacer, Budesonide/formoterol pMDI 40/2.25 ug
- Where
- 11 sites in Hungary, Poland and 1 more
- Volunteers
- 107 people
- Sponsor
- AstraZeneca
Asthma
A Long-term Safety Study of QVM149 in Japanese Patients With Asthma
The purpose of this study is to provide long term safety data of QVM149 in Japanese patients with asthma for the registration of QVM149 in Japan.
- Trial name
- NCT03100825
- Testing
- QVM149
- Where
- 25 sites in Japan
- Volunteers
- 96 people
- Sponsor
- Novartis Pharmaceuticals
Pharmacokinetics, Epinephrine
Study of Drug Exposure in Systemic Circulation of Primatene Mist by Oral Inhalation, Versus Epinephrine Injection by Intramuscular Injection and ProAir by Oral Inhalation in Healthy Individuals
To assess the drug exposure profile in systemic circulation of Primatene Mist by inhalation, versus Epinephrine by intramuscular injection, and ProAir HFA by inhalation in healthy adults.
- Conditions
- Pharmacokinetics, Epinephrine, Albuterol, Asthma
- Trial name
- NCT04207840
- Testing
- Epinephrine (0.125 mg/inhalation), Epinephrine Injection Auto-Injector (0.3mg/0.3mL), Albuterol Sulfate (0.09 mg/inhalation)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Amphastar Pharmaceuticals, Inc.
Sleep Apnea, Obstructive
Safety and Efficacy Study of Dronabinol to Treat Obstructive Sleep Apnea
This is a proof of concept study to determine the safety and efficacy of dronabinol for the treatment of obstructive sleep apnea syndrome (OSA).
- Trial name
- PACE (NCT01755091)
- Testing
- Dronabinol
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- University of Illinois Chicago
Allergic Rhinitis
Effect of Nasaleze on Nasal Challenge With Allergen
The objectives of this protocol are: 1. to confirm the inhibitory effect of Nasaleze on the immediate response to nasal challenge with antigen, and 2.
- Trial name
- NCT01723397
- Testing
- Nasaleze Spray, Allergen
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Obstructive Sleep Apnea, OSA
Predictability of OSA With a Subjective Screening Scale (OSASSS1)
the study aims to evaluate the accuracy correlation between subjective perception of the air flow through airways from patients and survey and/or polysomnography they spent, using a brief clinical protocol they answered with a…
- Trial name
- OSASSS1 (NCT06092710)
- Testing
- neuro-sensorial subjective evaluation of the airways collapsibility
- Where
- Belgium
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Center for Sleep Medicine - Clinique André Renard
Delivery Room Resuscitation
Quantitative End Tidal CO2 Monitoring in the Delivery Room (DR)
This is a trial evaluating the use of an end tidal CO2 monitor during ventilation in the delivery room. The use of the monitor is compared with clinical assessment of ventilation.
- Trial name
- NCT01381068
- Testing
- End tidal CO2 monitor
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Neil Finer
Non-small Cell Lung Cancer
Trial of Consolidation Pembrolizumab After Concurrent Chemotherapy and Proton Reirradiation for Thoracic Recurrences of Non-Small Cell Lung Cancer
The main purpose of this study is to assess the safety, tolerability and anti-tumor activity of the experimental study drug pembrolizumab (also known as Keytruda or MK-3475) in people with non-small cell lung cancer (NSCLC) that…
- Trial name
- NCT03087760
- Testing
- Pembrolizumab
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Pneumonia
Reducing Length of Stay for Veterans Hospitalized With Pneumonia
This is a pilot study to implement a computer based intervention to safely reduce length of hospital stay and time to conversion to oral antibiotics for patients with pneumonia.
- Trial name
- NCT01068548
- Testing
- reminder
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- VA Office of Research and Development
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