Clinical trials: Breathlessness, open to volunteers
Healthy Adults
Effects of Isocapnic Respiratory Muscle Endurance Training in Healthy Adults
Respiratory muscle training (RMT) strengthens breathing muscles and may improve exercise performance and reduce breathlessness. However, different training methods and devices create controversy in the field.
- Trial name
- NCT07103291
- Testing
- Respiratory muscle endurance training
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Chronic Obstructive Pulmonary Disease (COPD), Pulmonary Hyperinflation
Effect of Simeox® on Residual Volume in COPD Patients With Pulmonary Hyperinflation
Brief Summary People with severe chronic obstructive pulmonary disease (COPD) often have too much air trapped in their lungs (pulmonary hyperinflation). This makes it hard to breathe and reduces quality of life.
- Trial name
- SIMEO-RV COPD (NCT07665931)
- Testing
- Simeox
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- Azienda Socio Sanitaria Territoriale di Lodi
Lung Neoplasms, Thoracic Surgery Lung
Telerehabilitation Exercise Program for Postoperative Recovery in Lung Cancer.
Lung cancer is one of the leading causes of cancer-related morbidity and mortality worldwide. Thoracic surgery remains the treatment of choice for patients with early-stage disease; however, postoperative recovery is frequently…
- Trial name
- TEPUL (NCT07861282)
- Testing
- Therapeutic Exercise-Based Telerehabilitation, Usual Postoperative Care
- Where
- Spain
- Volunteers
- 56 people
- Sponsor
- University of Seville
Respiratory Distress Neonatal, Noninvasive Ventilation
Comparison of the Silverman-Andersen Score and the Downes Score
This study aimed to compare the Silverman-Andersen score and the Downes score in predicting noninvasive ventilation (NIPPV) failure in preterm and term infants who received NIPPV support due to postnatal respiratory distress, as…
- Conditions
- Respiratory Distress Neonatal, Noninvasive Ventilation, Intubation, Scoring Systems
- Trial name
- CSASDS (NCT07183956)
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 220 people
- Sponsor
- Muğla Sıtkı Koçman University
Early Stage Breast Carcinoma, Dyspnea
Inspiratory Muscle Training for Breast Cancer Patients on Chemotherapy
This clinical trial studies whether breathing exercises for the muscles that help with breathing air in, inspiratory muscle training (IMT), works to improve breathing muscle strength, shortness of breath, and physical activity…
- Trial name
- IMACT (NCT07386444)
- Testing
- Inspiratory muscle training
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Acute Disease, Sepsis
Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine
Research in acute care faces many challenges, including enrollment challenges, legal limitations in data sharing, limited funding, and lack of singular ownership of the domain of acute care.
- Conditions
- Acute Disease, Sepsis, Pneumonia, Frailty
- Trial name
- Acutelines (NCT04615065)
- Where
- Netherlands
- Volunteers
- 35,000 people
- Sponsor
- University Medical Center Groningen
Shortness of Breath
A Validation Study to Evaluate the Performance of Caption Health Lung Guidance and Interpretation
The purpose of this study is to assess the efficacy of Caption LungAI.
- Trial name
- NCT05992324
- Testing
- Caption LungAI
- Where
- 4 sites in United States
- Volunteers
- 220 people
- Sponsor
- Caption Health, Inc.
Dyspnea, Chest Pain
Contactless Ultrasound Data Acquisition in Emergency Departments to Discriminate the Origin of Dyspnea and Chest Pain
PAnDA-One is a prospective, multicenter, interventional study (10 centers, France) aimed at developing and validating a diagnostic support algorithm based on the ADx-One medical device, which non-invasively acquires thoracic…
- Trial name
- PAnDA-One (NCT07653204)
- Testing
- All patients from both groups will be imaged with airborne ultrasound device
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Austral Diagnostics
Chronic Obstructive Pulmonary Disease (COPD), Dyspnea
Evaluation of the Benefits of Hypnosis in Improving the Quality of Life of Patients With Chronic Obstructive Pulmonary Disease (COPD) Suffering From Persistent Dyspnea
Chronic Obstructive pulmonary Disease (COPD) is a common progressive disorder characterized by persistent airflow limitation. It is usually caused by exposure to tobacco smoke, toxic particles, or toxic gases.
- Trial name
- HYPNODYS (NCT07637604)
- Testing
- Hypnosis, standardized telephone calls
- Where
- France
- Volunteers
- 154 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breathlessness, Cardiovascular
"Breathlessness Diagnostics in a Box" (BiaB) for Primary Care. A Multi-country Quality Improvement Project Using a Randomized Stepped-wedge Design
This prospective stepped-wedge study evaluates whether use of the Breathlessness diagnostics in a Box (BiaB) tool shortens the time to diagnosis in patients presenting with breathlessness, compared with usual care.
- Conditions
- Breathlessness, Cardiovascular, Pulmonary, Mental Disease
- Trial name
- BiaB (NCT07320703)
- Testing
- Breathlessness diagnostics in a Box (BiaB)
- Where
- 3 sites in Netherlands, Portugal and 1 more
- Volunteers
- 900 people
- Sponsor
- General Practitioners Research Institute
Heart Failure With Preserved Ejection Fraction, Chronic Kidney Diseases
Enhancing the Natriuretic Peptide System in HFpEF
The purpose of this study is to look at the differences in how individuals with heart failure with preserved ejection fraction in the presence of chronic kidney disease (HFpEF-CKD) and exercise induced dyspnea without objective…
- Trial name
- NCT05279742
- Testing
- MANP, Sacubitril/Valsartan
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Horng Chen
Pediatric Acute Respiratory Distress Syndrome (PARDS)
Role of Dyspnea in the Progression of Pediatric Acute Respiratory Distress Syndrome
Pediatric acute respiratory distress syndrome (ARDS) is a life-threatening clinical syndrome, and dyspnea is its key symptom. Strenuous respiratory effort is a "second hit" for ARDS lungs, inducing changes in regional lung…
- Trial name
- NCT07750288
- Testing
- Noninvasive respiratory support, Transition from controlled to assisted mechanical ventilation, Weaning from mechanical ventilation
- Where
- Chile
- Volunteers
- 68 people
- Sponsor
- Universidad Nacional Andres Bello
Respiratory Decompensation, Multiple Disabilities
Long-term Use of Intrapulmonary Percussive Ventilation for Preventing Hospitalizations Due to Respiratory Decompensation in Children With Multiple Disabilities
Chronic respiratory failure is the leading cause of morbidity and mortality in children with multiple disabilities. Musculoskeletal disorders, swallowing disorders and ventilatory control abnormalities lead to progressive…
- Trial name
- PERKINE (NCT07473856)
- Testing
- Intrapulmonary Percussive Ventilation IPV
- Where
- France
- Volunteers
- 146 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COPD (Chronic Obstructive Pulmonary Disease)
RESP-FIT: A Respiratory Muscle Strength Training Intervention for COPD
Individuals with chronic obstructive pulmonary disease (COPD) often experience dyspnea, low physical activity, and reduced quality of life.
- Trial name
- NCT07811219
- Testing
- RESPFIT Intervention
- Volunteers
- 288 people
- Sponsor
- Medical University of South Carolina
Respiratory Distress of Newborn
Feasibility of Using the Neovent in Low-Resource Settings
Breathing problems are a leading cause of newborn death/sickness worldwide but most of deaths are in low resources areas. Over 99% of newborn death is in countries with limited healthcare resources like Nigeria and Nepal.
- Trial name
- Neovent (NCT06697951)
- Testing
- bilevel ventilation with the Neovent
- Where
- 2 sites in Nepal, Nigeria
- Volunteers
- 70 people
- Sponsor
- Tina Slusher
Breathing Pattern Disorder, Breathlessness
The Physiotherapy Assessment of Breathing Pattern Disorder
This study aims to evaluate a clinical tool called the Breathing Pattern Assessment Tool (BPAT), which is used by physiotherapists to assess breathing pattern disorder (BPD).
- Trial name
- PHAB (NCT07543588)
- Testing
- Assessment of Breathing Pattern- Breathing Pattern Assessment Tool
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Acute Decompensated Heart Failure
Low Level Tragus Stimulation in Acute Decompensated Heart Failure
Acute Decompensated Heart Failure (ADHF) is a major cause of morbidity and mortality. It is associated with increased systemic inflammation.
- Trial name
- TREAT-HF (NCT02898181)
- Testing
- Neuromodulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Oklahoma
Dyspnea
Feasibility and Accuracy of an Ultrasound Algorithm for Acute Dyspnea Diagnosis in the Emergency Department
The management of chest pain has revolutionized its prognosis, primarily by improving urgent diagnosis of myocardial infarction.
- Trial name
- EMERALD-US (NCT03691857)
- Testing
- Ultrasound algorithm (EMERALD-US)
- Where
- 7 sites in France
- Volunteers
- 225 people
- Sponsor
- CHOUIHED Tahar
Difficult Mechanical Ventilation Weaning, Spontaneous Breathing Trial
Non-medicinal Technique and Dyspnea in Weaning Patients
This is a randomized, controlled, multicenter, open-label, category 2, parallel-arm study of efficacy and superiority. The target population are patients hospitalized in the intensive care unit (ICU), ventilated with invasive…
- Conditions
- Difficult Mechanical Ventilation Weaning, Spontaneous Breathing Trial, Dyspnea
- Trial name
- Easy Wean (NCT06926231)
- Testing
- Protocolized medical hypnosis, Protocolized standard of care
- Where
- 5 sites in France
- Volunteers
- 82 people
- Sponsor
- Hospices Civils de Lyon
COPD (Chronic Obstructive Pulmonary Disease), Quality of Life
Chronic Obstructive Pulmonary Disease, Quality of Life, COPD Assessment Test, Nepal, Dyspnea, Spirometry
Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is not fully reversible. The study "Quality of life among people living with Chronic Obstructive Pulmonary Disease- visiting spirometry…
- Trial name
- NCT07261813
- Testing
- Evaluation of Quality of life in COPD patients
- Volunteers
- 71 people
- Sponsor
- Institute of medicine, Maharagjung medical campus