Clinical trials: Bronchial Hyperreactivity
Allergic Asthma
Bronchial Allergen Provocation Tests in Asthmatics in Guangzhou
The purpose of this study is to establish the methodology of bronchial provocation tests with house dust mites in China, and to evaluate its safety and effects on upper and lower airways inflammation.
- Trial name
- NCT02504528
- Testing
- house dust mites
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Bronchial Hyperreactivity, Bronchial Asthma
Comparison of Two Methods of Bronchial Methacholine Provocation
This study is meant to compare two routine diagnostic approaches in patients with bronchial asthma. Patients are challenged with methacholine in order to measure their bronchial response.
- Trial name
- NCT00503659
- Testing
- Bronchial methacholine provocation
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Bronchial Hyperreactivity, Inhalant Use
Contrasting Dosivent With Plus Flow Vu Spacer in Bronchial Hyperreactivity Participants
This study aims to compare the efficacy, as measured by changes in forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC), of salbutamol inhaled with the Dosivent® chamber versus the widely used…
- Trial name
- NCT05821868
- Testing
- Dosivent, Aerochamber Plus Flow Vu
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital General Universitario Gregorio Marañon
Asthma, COPD
Sputum and Plasma Levels of Nociceptin and Substance P in Patients With Asthma, COPD and Chronic Cough
The aims of this study are to investigate the association between sputum and plasma levels of nociceptin and substance P with cough severity and airway hyperreactivity in patients with asthma, COPD and chronic cough.
- Conditions
- Asthma, COPD, Cough
- Trial name
- NCT00173225
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Bronchial Hyperreactivity, Hypersensitivity
Influence of Nutrition on Nasal and Bronchial Affliction in Patients With Allergy on Grass-Pollen
The study is meant to observe the influence of nutrition on nasal and bronchial discomfort in patients with allergy on grass pollen after specific bronchial provocation.
- Conditions
- Bronchial Hyperreactivity, Hypersensitivity, Allergy, Bronchial Asthma
- Trial name
- NCT00519740
- Testing
- inhalative specific bronchial provocation with grass-pollen
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Asthma, Chronic Obstructive Pulmonary Disease
Towards Restoring the Physiological Inhibition of Airway Narrowing in Asthma
Asthma and COPD are characterized by airway narrowing. The most potent, physiological mechanism leading to bronchodilation is taking a deep inspiration.
- Trial name
- NCT00279136
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Primary Ciliary Dyskinesia, Healthy
Examining Bronchial Hyperresponsiveness in Primary Ciliary Dyskinesia
The purpose of this study is to look at children with PCD and see if they have another condition called "bronchial hyperresponsiveness".
- Trial name
- BHR (NCT07288827)
- Testing
- Lung Function Testing, Phlebotomy, Allergy skin prick testing
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indiana University
Hyperreactive Airway Disease
Methacholine Challenge Test (MCT) in Healthy Adults
Knowledge of Methacholine Challenge Test (MCT) and impedance Oscillometry (IOS) is limited. Only three studies have included adult patients, and none of these with healthy controls.
- Trial name
- NCT06509659
- Testing
- Methacholine Challenge Test
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Allergi- og Lungeklinikken, Elsinore
Asthma, Vitamin D Resistant Rickets
Assessment Of Vitamin D Role In The Pathogenesis Of Asthma In Vitamin D Resistent Patients
Research Title: Evaluation of airway reactivity, allergy and inflammatory mediators in exhaled breath condensate in vitamin D resistant rickets.
- Trial name
- NCT01578824
- Testing
- Methacholine Challenge Test
- Where
- Israel
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Allergic Rhinitis, Asthma
Leukotriene D4 Nasal Provocation Test in Allergic Rhinitis
Leukotrienes play critical roles in the inflammatory process in allergic rhinitis and bronchial asthma, therefore, anti-leukotriene therapy is part of treatment for asthma.
- Trial name
- NCT01963741
- Testing
- leukotriene D4, histamine
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Asthma
A Comparative Bronchial Provocation Study With Mannitol and Methacolinie in a Korean Population
Asthmatic patients and non-asthmatic controls were recruited prospectively from four referral hospitals in Korea. Participants were challenged with each of methacholine and mannitol inhalation on different days.
- Trial name
- NCT02104284
- Testing
- methacholine and mannitol bronchial challenge tests
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- BL&H Co., Ltd
Hyperreactive Airway
Evaluating the Capacity of High-sensitivity Serum CRP Levels to Predict Bronchial Hyper Responsiveness in School Age Children
Background: Bronchial hyper responsiveness (BHR) assessed by methacholine challenge test (MCT) may aid in the diagnosis of asthma, while negative MCT can help to exclude the diagnosis.
- Trial name
- NCT01963585
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Asthma, Dermatitis, Atopic
A Long-Term Examination of Asthma From Childhood Through Adolescence
Asthma is a common disease that is often diagnosed in childhood. In some teenagers, asthma symptoms disappear and treatment can be stopped; however, for some of these people, asthma symptoms return in adulthood.
- Conditions
- Asthma, Dermatitis, Atopic, Rhinitis, Urticaria
- Trial name
- NCT00541255
- Where
- United Kingdom
- Volunteers
- 1,313 people, healthy volunteers welcome
- Sponsor
- Isle of Wight NHS Trust
Gastroesophageal Reflux Disease, Chronic Cough
Cough Reflex Sensitivity and Bronchial Hyper-responsiveness
The aim of this study is to provide pilot data on the possible gastrointestinal predictors of respiratory hyper-responsiveness and how these relate to the clinical sub-types of gastroesophageal reflux disease (GERD) and visceral…
- Conditions
- Gastroesophageal Reflux Disease, Chronic Cough, Broncho-hyperreactivity
- Trial name
- NCT01777867
- Testing
- Cough Reflex Sensitivity, Methacholine Challenge
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Asthma
The Use of Rosiglitazone to Treat Asthma
Asthma is a common chronic disease characterized by airway inflammation and bronchoconstriction. This study utilizes the drug rosiglitazone (Avandia)to treat the effects of airway inflammation in patients with asthma.
- Trial name
- NCT00614874
- Testing
- rosiglitazone
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Creighton University
Asthma Bronchiale, Lung Function Tests
Methacholine Challenge Test in School Children With/Without Asthma RISKA
The study includes a pre-study telephone interview with healthy controls to assess their eligibility for participation. During the study visit, a background information form and an asthma questionnaire are completed.
- Conditions
- Asthma Bronchiale, Lung Function Tests, Bronchial Hyperresponsiveness
- Trial name
- RISKA (NCT07031102)
- Where
- Finland
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Rhinitis, Asthma
Airway Inflammation and Bronchial Hyperresponsiveness in Rhinitic Children With or Without Asthma
This is a prospective observational study , to clarity the characteristics of airway inflammation, airway reactivity and airway resistance in rhinitic children with or without asthma and to explore the possible predictors in the…
- Conditions
- Rhinitis, Asthma, Inflammation, Hypersensitivity
- Trial name
- NCT02360072
- Where
- China
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Health, Subjective, Hyperreactivity, Bronchial
Methacholine, Long-acting M-cholinolytic and beta2-agonist on the Activity of Beta-receptors in Healthy Volunteers
Interventional open-labeled study in parallel groups is aimed to evaluate changes of beta receptors in healthy volunteers under the influence of inhaled metacholine, long-acting anticholinergics and beta-agonists using modified…
- Trial name
- NCT04137029
- Testing
- Formoterol, Tiotropium Bromide, metacholine test
- Where
- Russia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Institution, Pulmonology Scientific Research Institute
Crohn's Disease
Bronchial Hyperreactivity in Children With Crohn Disease
Background: Latent pulmonary involvement is described in Crohn Disease(CD). Bronchial hyperreactivity measured by the Methacholine Challenge Test (MCT) has been evaluated in two studies involving mainly adults.Our aim was to…
- Trial name
- NCT01297907
- Testing
- Methacholine Challenge Test, Fractional Exhaled NO (FENO), Blood Test
- Where
- Israel
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Bronchial Hyperreactivity, Abnormal Respiratory Airway Resistance
Diagnostic Utility of Different Airway Resistance Assessment Techniques in the Methacholine Challenge Test
The aim of the study is to compare standard spirometric evaluation of methacholine challenge test with plethysmographic, interrupter technique and forced oscillation technique (FOT) evaluation of the airways resistance.
- Trial name
- NCT02343419
- Testing
- Methacholine Challenge Test
- Where
- Poland
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw