Clinical trials: Bronchoalveolar Lavage (BAL)
Invasive Aspergillosis
Incidence of Invasive Aspergillosis and Its Relation to Galactomannan Clinical Outcomes
The goal of this observational study is to analyze the relationship between galactomannan index values and clinical outcomes , as well as to determine the annual and seasonal incidence of invasive aspergillosis in pediatric and…
- Trial name
- NCT07621263
- Where
- Mexico
- Volunteers
- 150 people
- Sponsor
- Hospital H+ Queretaro
COVID-19 Pneumonia
Multiparametric Assessment of Peripheral Blood and Tissue Myeloid Cells. Phenotype for Precision Medicine in Patients With SARS-Cov-2 Infection
We hypothesise that patients with SARS-Cov-2 infection are characterized by progressive changes in distribution of distinct lung macrophages populations mediated by influx of circulating monocytes into the lungs .
- Trial name
- NCT05767853
- Testing
- Immune-phenotyping of tissue and peripheral blood myeloid compartment
- Where
- 2 sites in Italy, United Kingdom
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pulmonary Infection
Massively Parallel Sequencing to Identify Microbiological Organisms in Bronchoalveolar Lavage Fluid
Patients who are post hematopoietic stem cell transplantation who require a bronchoalveolar lavage (BAL) for standard clinical car will have extra fluid collected and sent for massively parallel sequencing to see if it is as…
- Trial name
- NCT03995030
- Testing
- massively paralleled sequencing
- Volunteers
- 10 people
- Sponsor
- New York Medical College
Pneumonia, Pulmonary Disease
Study of Lung Proteins in Patients With Pneumonia
This study will examine the different types of proteins present in the lungs of patients with pneumonia to explore the causes of different types of the disease.
- Conditions
- Pneumonia, Pulmonary Disease, Lung Disease
- Trial name
- NCT00077909
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Interstitial Lung Disease, Pneumonia
Predictors for Bronchoalveolar Lavage (BAL) Recovery Rate Derived From Quantified Computed Tomography (qCT)
Bronchoalveolar lavage (BAL) is an important diagnostic method. The percentage of fluid extracted after instillation (recovery rate) is crucial for following diagnostic tests.
- Conditions
- Interstitial Lung Disease, Pneumonia, Malignant Neoplasm
- Trial name
- NCT03388580
- Testing
- bronchoalveolar lavage (BAL)
- Volunteers
- 33 people
- Sponsor
- Universitätsmedizin Mannheim
Ventilator Acquired Pneumonia, Mechanical Ventilation Complication
ClusterVAP: Multicentre Proteomic Endotyping of Ventilator-associated Pneumonia
Ventilator-associated pneumonia (VAP) is a common and serious infection in patients receiving mechanical ventilation in intensive care units.
- Trial name
- ClusterVAP (NCT07245888)
- Where
- 4 sites in France, Portugal and 1 more
- Volunteers
- 400 people
- Sponsor
- Region Skane
Lung Transplant, Chronic Allograft Rejection
Mechanisms of Lung Allograft Rejection
This study will explore the ways in which lung transplants are rejected. A series of experiments will evaluate the differences in airway gene expression.
- Trial name
- NCT00340418
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Fiberoptic Bronchoscopy (FOB), Bronchoalveolar Lavage (BAL)
Fiberoptic Bronchoscopy and Bronchoalveolar Lavage in Critically Ill Ventilated Patients
Fiberoptic bronchoscopy (FOB) is widely used as a diagnostic or therapeutic procedure in intensive care units. Patients with ARDS or COVID-19 disease often undergoes to these procedures.
- Conditions
- Fiberoptic Bronchoscopy (FOB), Bronchoalveolar Lavage (BAL), Respiratory Disease
- Trial name
- NCT04502368
- Testing
- Fiberoptic Bronchoscopy (FOB), Bronchoalveolar Lavage (BAL), Electrical Impedance Tomography (EIT)
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Erasme University Hospital
COVID-19 Pneumonia
Hydroxychloroquine for the Treatment of SARS-CoV2 (COVID 19) : Pharmacokinetic Study
This study is a prospective, observational, open, monocentric multisite, pharmacokinetic study of hydroxychloroquine in critically ill patients.
- Trial name
- CHLORO-VID (NCT04625218)
- Where
- France
- Sponsor
- University Hospital, Toulouse
Tuberculosis
TB PCR in BAL and EBUS-TBNA
This prospective observational multi-centre UK study will evaluate Xpert MTB/RIF Ultra for the detection of Mycobacterium tuberculosis (MTB) in bronchoalveolar lavage (BAL) samples for pulmonary TB and endobronchial ultrasound…
- Trial name
- TRiBE (NCT04909385)
- Where
- United Kingdom
- Volunteers
- 394 people
- Sponsor
- Imperial College Healthcare NHS Trust
ARDS, Human
Study of the Effects of Bronchoalveolar Lavage Liquid in the ARDS on the Functioning of the Neutrophil Polynuclear System
Firstly, the study assesses the effect of bronchoalveolar lavage fluid (BAL) from patients in (acute respiratory distress syndrome (ARDS) on the life span of PNNs and on the phagocytosis of apoptotic cells by macrophages and…
- Trial name
- BALARDS (NCT04008225)
- Testing
- Bronchoalveolar lavage
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Rennes University Hospital
Community-acquired Infection
An Open-label, Randomized, Single Period, Parallel-Cohort Study To Evaluate Serum and Pulmonary Pharmacokinetics Following Single and Multiple Dose Administration of Intravenous GSK2251052 in Healthy Adult Subjects
GSK2251052 is a member of a novel mechanistic and structural class of antibiotics that inhibits the bacterial enzyme leucyl tRNA synthetase (LeuRS) by forming a boron adduct with tRNA and is currently in development for the…
- Trial name
- NCT01267968
- Testing
- GSK2251052
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Asthma
Study of TNFR:Fc (Enbrel) in the Treatment of Asthma
The proposed study is a phase II clinical trial of TNFR:Fc therapy in a segmental allergen bronchoprovocation model of atopic asthma.
- Trial name
- NCT00001893
- Testing
- TNFR:Fc
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Lower Respiratory Tract Infections
Study Bronchoalveolar Lavage Fluid Driven Pathogenic Diagnosis of Lower Respiratory Tract Infections
Comparison of microbiological yield from Bronchoalveolar Lavage Fluid (BALF) for the two common-used volume bronchoalveolar lavages(60ml and 120ml)in patients with different types of lower respiratory tract infection.
- Trial name
- BALFinder (NCT02852070)
- Testing
- bronchoalveolar lavage 120ml, bronchoalveolar lavage 60ml
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Ventilator-Associated Pneumonia
Impact of Using Mini-Bronchoalveolar Lavage as a Diagnostic Test for Ventilator-Associated Pneumonia
The proposed study will evaluate adult patients admitted to the medical or surgical intensive care units (ICUs) at San Francisco General Hospital (SFGH).
- Trial name
- NCT00319644
- Testing
- Bronchoalveolar lavage
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of California, San Francisco
Acute Respiratory Failure, Bronchoscopy
HFNC During Bronchoscopy for Bronchoalveolar Lavage
The execution of diagnostic-therapeutic investigations by bronchial endoscopy can expose the patient to acute respiratory failure (ARF). In particular, the risk of hypoxemia is greater during broncho-alveolar lavage (BAL).
- Conditions
- Acute Respiratory Failure, Bronchoscopy, Bronchoalveolar Lavage
- Trial name
- NCT04016480
- Testing
- High Flow Nasal Cannula, Conventional Oxygen Therapy
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- University Magna Graecia
Bronchoalveolar Lavage Fluid, Sensitivity and Specificity
Aspergillosis Detection Via EBC-GM in Ventilated Patients
Brief Research Proposal: Non-Invasive Detection of Invasive Pulmonary Aspergillosis in ICU Patients Background: Invasive Pulmonary Aspergillosis (IPA) is a critical threat to patients in ICUs, especially those undergoing…
- Conditions
- Bronchoalveolar Lavage Fluid, Sensitivity and Specificity, Critical Illness, Respiration Failure
- Trial name
- NCT06333379
- Testing
- Compare the levels of Galactomannan (GM) levels in exhaled breath condensate (EBC) and BALF
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Lin Chen
Pneumonia, Fungal Pneumonia
Derivation and Validation of the Fungal Pneumonia Assessment and Likelihood Predictor Score
The FUNGAL-P study is a single-center observational study designed to derive and validate a clinical prediction score for the early identification of fungal pneumonia in adult patients presenting with pneumonia.
- Conditions
- Pneumonia, Fungal Pneumonia, Aspergillosis Pneumonia, Pulmonary Aspergillosis
- Trial name
- FUNGAL-P (NCT07681583)
- Testing
- FUNGAL-P Score Assessment
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Bronchoscopy
Exploratory Study of Potential Pulmonary Aspiration Markers From Bronchoalveolar Lavage Fluid
The purpose of this study is to learn if chemicals from the mouth or stomach can be found in the lungs. This may suggest a process called aspiration.
- Trial name
- Pepsin (NCT00915941)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
ARDS (Acute Respiratory Distress Syndrome)
Comparative Analysis of Salivary and Bronchoalveolar Lavage IL-6 and TNF-α as Biomarkers in Pediatric Acute Respiratory Distress Syndrome
The aim of this study is to determine the degree of agreement in cytokines level measured through BAL and those measured through salivary glands excretion.
- Trial name
- NCT07380373
- Testing
- Bronchoscopy
- Where
- Egypt
- Volunteers
- 37 people
- Sponsor
- Ain Shams University