Clinical trials: CAD
Coronary Artery Disease, Cardiovascular Mortality
the Change of Cholesterol Efflux Capacity and Coronary Artery Disease in Real Clinical Practice
The purpose of this study is to investigate the change of cholesterol efflux capacity in patients with coronary artery disease treated with secondary prevention drugs, and the correlation with the prognosis.
- Conditions
- Coronary Artery Disease, Cardiovascular Mortality, Myocardial Infarction, Stroke
- Trial name
- NCT03389529
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Lu'an Municipal Hospital
Coronary Artery Disease, Behavioral
Typical Daily Experiences, Ischemia and Repolarization in Coronary Artery Disease
The purpose of this study is to examine the role of every day experiences as they relate to coronary artery disease (CAD).
- Trial name
- NCT01531231
- Where
- United States
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Richard Lane
Heart Diseases
Developing and Testing a Personalized Evidence-based Shared Decision-making Tool for Stent Selection
The goal of this study is to gather input from patients who have undergone PCI, their family and/or caregivers, and clinicians to develop a patient decision aid.
- Trial name
- DECIDE-PCI (NCT02046902)
- Where
- 2 sites in United States
- Volunteers
- 586 people, healthy volunteers welcome
- Sponsor
- University of Missouri, Kansas City
Coronary Artery Disease, Heart Infarction
Effects of Personalized Training Program on Coronary Flow Reserve in Healthy Volunteers
This study investigates whether an individualized exercise program, including a personal trainer, can improve cardiovascular status quantified with ultrasound to assess coronary flow reserve and other non-invasive techniques.
- Trial name
- NCT02713724
- Testing
- physical exercise, limited physical exercise
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Göteborg University
CORONARY ARTERY DISEASE
"Potential Effect of Acute and Chronic Caffeine Administration on Platelet Reactivity in Patient With Coronary Artery Disease on Dual Antiplatelet Therapy"
Prasugrel is a potent thienopyridine antiplatelet agent that selectively and irreversibly inhibits ADP-induced platelet aggregation mediated by the P2Y12 receptor.
- Trial name
- CyCLOPS (NCT02054988)
- Testing
- caffeine, not caffeine
- Where
- Italy
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
CAD-CAM, Patients Specific Manufacturing
Analysis of Mandibular Proximal Segment Position Using Virtual Orthognathic Surgical Planning, Individualized Guides, and Osteosynthesis Plates
Orthognathic surgery is a surgical procedure performed to correct dentofacial deformities. In recent years, with the use of virtual surgical planning, cutting guides, and patient-specific osteosynthesis plates, highly predictable…
- Conditions
- CAD-CAM, Patients Specific Manufacturing, Osteotomy, Sagittal Split Ramus
- Trial name
- NCT06442787
- Testing
- conventional splints, cutting guides and positioning guides, cutting guides and fixation plates
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Hypercholesterolemia, Coronary Disease
Translating ATP III Cholesterol Management Guidelines Into Primary Care Practice
This quality improvement trial aims to evaluate whether giving patients information about their coronary heart disease risk via a computer kiosk in the doctors waiting room and providing primary care doctors with a personal…
- Conditions
- Hypercholesterolemia, Coronary Disease, Primary Health Care, Management, Risk
- Trial name
- NCT01242319
- Testing
- HeartAge intervention
- Where
- United States
- Volunteers
- 5,218 people, healthy volunteers welcome
- Sponsor
- Memorial Hospital of Rhode Island
Atherosclerosis, Coronary Heart Disease
Alirocumab and Reverse Cholesterol Transport
Alirocumab is an injectable treatment for elevated blood cholesterol. The hypothesis of this study is that it also increases cholesterol excretion from the body into the stool, a process sometimes called reverse cholesterol…
- Trial name
- NCT03014830
- Testing
- Alirocumab
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Obstructive Coronary Artery Disease, Coronary Arteriosclerosis
Gadofosveset Trisodium for Heart Imaging Studies
Background: Magnetic resonance imaging (MRI) is type of imaging study that uses magnetic fields and radio waves to take pictures of the body. To help the images show up more clearly, a contrast agent is injected into a vein.
- Conditions
- Obstructive Coronary Artery Disease, Coronary Arteriosclerosis, Coronary Artery Disease (CAD)
- Trial name
- NCT01853592
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Coronary Artery Disease, In-stent Restenosis
The Effect of Sleep Quality on Coronary Artery Disease and In Stent Restenosis
This is a cross-sectional and follow-up study. We analysis the relationship of sleep quality on coronary artery disease(CAD) and in stent restenosis(ISR).
- Trial name
- NCT03874481
- Testing
- Observation
- Where
- China
- Volunteers
- 958 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Disease, Peripheral Arterial Disease
VasoStat vs. TR Band for Radial Hemostasis
VasoStat vs. TR Band compression for Radial Artery Hemostasis Following Transradial Catheterization Without Prior Radial Artery Access
- Trial name
- NCT04163471
- Testing
- Radial artery mechanical compression for hemostasis
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Forge Medical
Coronary Artery Disease
A Study to Assess the Drug Absorption Into the Blood After Administration of 3 Doses of AZD5718
This study will be conducted to evaluate the AZD5718 pharmacokinetic (PK) doses in order to determine exposure in a new dose range and compare with previous results.
- Trial name
- NCT04087187
- Testing
- Treatment A, Treatment B, Treatment C
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Coronary Artery Disease, Diabetes Mellitus Type 2
Effects of Hyperglycemia on Myocardial Perfusion in Humans With and Without Type 2 Diabetes
The overall goal of this proposal is to determine the effects of acute hyperglycemia and its modulation by Glucagon-like Peptide-1 (GLP-1) on myocardial perfusion in type 2 diabetes (DM).
- Trial name
- GLP-1 (NCT01021865)
- Testing
- Glucagon-Like-Peptide-1/Regadenoson/Perflutren Lipid Microsphere
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Dentofacial Deformities
The Use of Bone-borne Guides in Orthognathic Surgery Cases
The present study was conducted to evaluate a new design of the intermediate stent that is used in orthognathic surgery cases requiring Le Fort I osteotomy.
- Trial name
- NCT04224805
- Testing
- Bone-borne CAD/CAM splint, 3D interocclusal conventional splint
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Coronary Artery Disease
Topical Nitro or Placebo Pre-Cath
Phase 2, single-center, randomized, blinded clinical study to assess the safety and efficacy of topical nitroglycerin on ease of TRA during scheduled PCI.
- Trial name
- NCT06289946
- Testing
- NitroBid
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Beta-Thalassemia Trait, Coronary Artery Disease
B-Thalasaemia Trait and Its Possible Cardioprotective Role
Our purpose is to investigate whether thallasaemia trait offers protection against cardiovascular events and whether this can be applied to specific characteristics of these people ( better lipid profile , better blood pressure…
- Trial name
- NCT02428023
- Where
- Greece
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- 404 General Military Hospital, Larissa
Atherosclerosis
Progression of Early Subclinical Atherosclerosis
The overall objective of this study is to characterize the prevalence and progression rate of subclinical atherosclerotic lesions and to study their association to the imaging characteristics of atheroma plaques and to the…
- Trial name
- PESA (NCT01410318)
- Where
- Spain
- Volunteers
- 4,184 people, healthy volunteers welcome
- Sponsor
- Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
Microvascular Angina, Microvascular Coronary Artery Disease
EUROpean Coronary microCirculatory Resistance and Absolute Flow Trial
Rationale: coronary microvascular disease is a relatively 'new' entity within the field of cardiology. The investigators are able to investigate the microcirculation by measurements performed in the catheterization laboratory.
- Conditions
- Microvascular Angina, Microvascular Coronary Artery Disease, Coronary Vasospasm, Microvascular Resistance
- Trial name
- EURO-ccraft (NCT04598308)
- Testing
- absolute flow and resistance measurements
- Where
- Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Coronary Artery Disease
The Predictive Value of the Heart Rate Response to Breathing Maneuvers for Inducible Myocardial Perfusion Deficits
Breathing maneuvers, i.e. hyperventilation followed by breath-holding, have been shown to change coronary dynamics; hyperventilating narrows the coronary arteries, puts "stress" on the heart, and increases the heart rate, whereas…
- Trial name
- SCREEN-MORE (NCT05516615)
- Testing
- 4 minute breathing maneuver
- Where
- Canada
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Hyperlipidemia, Familial Combined, Coronary Disease
Understanding the Genetic Basis of Familial Combined Hyperlipidemia in Mexican Individuals
Familial combined hyperlipidemia (FCHL) is an inherited disorder characterized by elevated levels of cholesterol and triglycerides; it often occurs in Mexican individuals with coronary heart disease (CHD).
- Trial name
- NCT00365235
- Where
- Mexico
- Volunteers
- 998 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles