Clinical trials: CAD
Arterial Occlusive Diseases, Atherosclerosis
Potential Role of CMV in Restenosis Following Angioplasty, in Atherosclerosis, and in Endothelial Dysfunction
The purpose of this study is to investigate whether the susceptibility of subjects to atherosclerosis is influenced by prior CMV exposure, whether the susceptability to endothelial dysfunction in patients with and in patients…
- Conditions
- Arterial Occlusive Diseases, Atherosclerosis, Coronary Disease, Cytomegalovirus Infections
- Trial name
- NCT00001531
- Where
- United States
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
CCTA to Optimize Diagnostic Yield of Invasive Angiography With AI
Coronary artery disease (CAD) is a leading cause of death. The gold-standard test used to diagnose CAD is invasive coronary angiography (ICA).
- Trial name
- CarDIA-AI (NCT06648239)
- Testing
- Usual Care, Centralized triage with risk score-based screening for obstructive CAD
- Where
- 3 sites in Canada
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Coronary Restenosis
Effect of Combination of Non-sLip Element Balloon (NSE) and druG-coated bAlloon (DCB) for In-steNT Restenosis Lesions
Use of SeQuent® Please drug coated balloon (DCB) is effective to treat patients with in-stent restenosis (ISR). However, whether the type of pre-dilatation balloon prior to DCB dilatation impacts on clinical and angiographic…
- Trial name
- ELEGANT (NCT02300454)
- Testing
- Non-slip element balloon (NSE), Balloon
- Where
- 2 sites in Japan
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Mitsui Memorial Hospital
Cardiovascular Diseases, Heart Diseases
Molecular Epidemiology of Essential Hypertension
To localize individual genes, called blood pressure quantitative trait genes [BPQTGs], which influence blood pressure levels in the population-at- large, and to determine if these genes are able to predict the occurrence of…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Hypertension
- Trial name
- NCT00005377
- Volunteers
- 573 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Hypercholesterolemia, Coronary Disease
Translating ATP III Cholesterol Management Guidelines Into Primary Care Practice
This quality improvement trial aims to evaluate whether giving patients information about their coronary heart disease risk via a computer kiosk in the doctors waiting room and providing primary care doctors with a personal…
- Conditions
- Hypercholesterolemia, Coronary Disease, Primary Health Care, Management, Risk
- Trial name
- NCT01242319
- Testing
- HeartAge intervention
- Where
- United States
- Volunteers
- 5,218 people, healthy volunteers welcome
- Sponsor
- Memorial Hospital of Rhode Island
Spinal Anesthesia, Pregnancy
Ephedrine vs Phenylephrine - ECG Changes
ECG changes during caesarean section are common. Incidence of ST depression on the ECG is up to 81% in some studies. Although this may indicate inadequate oxygen supply to the heart muscle (myocardial ischaemia) many other…
- Trial name
- NCT01243970
- Testing
- Phenylephrine, Ephedrine
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Cardiovascular Diseases, Stroke
Prediction of Primary Cardiovascular Events Using the Multimarker Approach
The study of biochemical risk factors for cardiovascular diseases is important not only for analysis, but also for preventive measures, given that changes in the level of biomarkers can be detected before the first clinical…
- Conditions
- Cardiovascular Diseases, Stroke, Myocardial Infarction, Death
- Trial name
- NCT05704569
- Testing
- measurement of multiple biomarkers
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Karaganda Medical University
Primary Ovarian Insufficiency, Cardiovascular Diseases
Associations of Combinations of Single-nucleotide Polymorphisms in Women With Premature Ovarian Failure
Research objective. To study the associations between combinations of single nucleotide polymorphisms and behavioural risk factors with non-communicable diseases and adverse outcomes in women with premature ovarian failure.
- Conditions
- Primary Ovarian Insufficiency, Cardiovascular Diseases, Menopause, Premature, Coronary Disease
- Trial name
- NCT04943354
- Testing
- Taking a person's venous blood
- Where
- Russia
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Ryazan State Medical University
Cardiovascular Diseases, Adherence, Medication
Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications
The study plans to learn if sending different text messages, serving as reminders or encouragement, may help patients take their medication more often if they have had trouble keeping up with their medicines.
- Conditions
- Cardiovascular Diseases, Adherence, Medication, Medication Adherence, Diabetes Mellitus
- Trial name
- NCT03973931
- Testing
- Nudge
- Where
- 4 sites in United States
- Volunteers
- 9,501 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Coronary Disease
Impact of Pumps on Internal Thoracic Arteries (IPITA)
Cardiopulmonary bypass (CPB) induces a systemic inflammatory response and affects the organ vascular bed. Experimentally, the lack of pulsatility alters myogenic tone of resistance arteries and increases the parietal inflammatory…
- Trial name
- IPITA (NCT04168853)
- Testing
- vascular reactivity of internal thoracic arteries
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Coronary Artery Disease
2nd International Survey on Interventional Strategies
The study aims to evaluate the decision-making pathways of interventional cardiologists, when assessing patients, presented with stable coronary artery disease.
- Trial name
- NCT04001452
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Coronary Artery Disease
Influence of Coffee on the Health and on the Heart of Normal, Diabetics e Coronary Artery Disease Patients
Coffee is a worldwide drink, been part of any culture. There are some concerns about effects of coffee on the health. Recently, epidemiological studies have shown benefits of coffee drinking to diabetics and also to prevent…
- Trial name
- Coffee&Heart (NCT01003392)
- Where
- Brazil
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Cardiovascular Disease, Obesity
Heart-Healthy Lenoir Lifestyle Study
This study aims to reduce cardiovascular disease (CVD) risk and disparities in risk by improving lifestyle factors which underlie the development of CVD.
- Trial name
- NCT01433484
- Testing
- Maintenance of Weight Loss--Control, Maintenance of Weight Loss--Experimental
- Where
- United States
- Volunteers
- 339 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Bites, Human
Biting Force in Heat Cured Acrylic Resin Versus CAD/CAM Maxillary Single Denture Bases
measuring difference in biting force between (computer aided design/computer aided manufacturing) maxillary dentures and conventional ones.
- Trial name
- NCT02996123
- Testing
- cad/cam maxillary dentures
- Where
- Egypt
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Cairo University
Ischemic Heart Disease, Coronary Artery Disease
Evaluating Myocardial Ischemia in Chest Pain Using Exercise CMR
Ischemic Heart Disease (IHD) is a condition of recurring chest pain or discomfort that occurs when a part of the heart is not receiving sufficient blood flow.
- Conditions
- Ischemic Heart Disease, Coronary Artery Disease, Cardiovascular Diseases, Myocardial Ischemia
- Trial name
- EMPIRE (NCT03217227)
- Testing
- Cardiovascular Magnetic Resonance Imaging with Exercise Bike, Cardiac Catheterization, Retinal Photography (Optional)
- Where
- 2 sites in Singapore
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Cardiovascular Diseases, Cardiovascular Mortality
Korea Atherosclerosis Study-3
Multidetector-row Computed Tomography (CT) has been introduced for use in the diagnosis of coronary heart disease. The investigators aimed to characterize coronary artery disease in subjects with cardiovascular risk or not, and…
- Conditions
- Cardiovascular Diseases, Cardiovascular Mortality, All-cause Mortality
- Trial name
- KAS3 (NCT01168362)
- Where
- South Korea
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Coronary Artery Disease
A Study of 123I-CMICE-013 Radiopharmaceutical in Healthy Volunteers
The need exists for alternatives to 99mTc based perfusion radiotracers for cardiac patient management. An alternative radiotracer, I123-CMICE-013, has been developed at the Canadian Molecular Imaging Center of Excellence (C-MICE)…
- Trial name
- CMICE (NCT01558362)
- Testing
- 123I-CMICE-013
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Coronary Occlusion
Safety and Efficacy of Autologous, Intracoronary Stem Cell Injections in Total Coronary Artery Occlusions
This phase I clinical trial will evaluate the safety and efficacy of intra-coronary injection of AC133 selected autologous marrow-derived stem cells in patients with chronic coronary artery occlusion.
- Trial name
- NCT00365326
- Testing
- Catheter-based intracoronary injection
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Shade Match
Shade Match, Marginal Adaptation and Patient Satisfaction of VITA ENAMIC multiColor Versus IPS e.Max CAD Veneers
It is assumed that there will be no difference in shade match, marginal adaptation and patient satisfaction between VITA ENAMIC multiColor and IPS e.max CAD anterior laminate veneers.
- Trial name
- NCT04774614
- Testing
- anterior laminate veneers
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Cairo University
Coronary Artery Diseases, Myocardial Infarction
The Efficacy of Influenza Vaccination in Patients With Coronary Artery Diseases
This study wishes to understand: 1. whether vaccination against influenza in coronary artery disease (myocardial infarction and stable angina) patients is as effective as it is in healthy subjects; 2.
- Conditions
- Coronary Artery Diseases, Myocardial Infarction, Stable Angina
- Trial name
- NCT00607217
- Testing
- influenza vaccine
- Where
- Iran
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences