Clinical trials: CAD
Heart Diseases, Cardiovascular Diseases
Risk Factors in the Initial Presentation of Specific Cardiovascular Disease Syndromes
Cardiovascular disease (CVD) is an important public health problem that affects millions of people worldwide. Associations between risk factors, such as smoking, dyslipidaemia or hypertension, and prevalent CVD are well…
- Conditions
- Heart Diseases, Cardiovascular Diseases, Acute Myocardial Infarction, Unstable Angina
- Trial name
- NCT01804439
- Volunteers
- 2,240,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Atherosclerosis, Stroke
Evaluation of Vascular Structure in Elderly Using High-frequency Ultrasound and Construction of a Multimodal Risk Assessment System for Cardiovascular Diseases: a Multicenter Study
Coronary heart disease(CHD), stroke, and hypertension are major diseases that seriously affect human health.Pathologic changes in the arteries involved in the above diseases mainly occur in the intimal or medial layer of the…
- Conditions
- Atherosclerosis, Stroke, Coronary Disease
- Trial name
- NCT06221618
- Testing
- High-frequency carotid arteries ultrasound, CCTA, Cranial MRA
- Where
- China
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Evaluate the Relationship Between HIV Medications and Coronary Atherosclerosis
Utilizing Computed Tomographic Angiography to Evaluate Coronary Artery Disease in Patients on Long-Term Antiretroviral Therapy
Utilizing Computed Tomographic Angiography to Evaluate Coronary Artery Disease in Patients on Long-Term Antiretroviral Therapy Intro: It is well known that HIV treated with antiretroviral drugs increases the risk for coronary…
- Trial name
- NCT02191306
- Where
- 2 sites in United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Florida State University
HIV Infections, Coronary Artery Disease
Coronary Artery Disease and Its Association With Liver Steatosis Among HIV-Infected Persons
The primary purpose of this study is to evaluate the association between nonalcoholic fatty liver disease (NAFLD) by computed tomography (CT) scan and coronary artery disease (CAD) measured by the calcium (CAC) score among…
- Conditions
- HIV Infections, Coronary Artery Disease, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT00889577
- Where
- United States
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Coronary Artery Disease
A Study to Assess the Drug Absorption Into the Blood After Administration of 3 Doses of AZD5718
This study will be conducted to evaluate the AZD5718 pharmacokinetic (PK) doses in order to determine exposure in a new dose range and compare with previous results.
- Trial name
- NCT04087187
- Testing
- Treatment A, Treatment B, Treatment C
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Cardiovascular Diseases
Molecular Investigation of GENetic Factors in Cardiovascular and Immune-related Traits and Diseases Using a BIOresource of Healthy Volunteers (GENBIO)
The risk of cardiovascular disease is determined by the complex interplay between an individual's genetic make-up, lifestyle, and the environment.
- Trial name
- GENBIO (NCT04931498)
- Testing
- Questionnaire, Anthropometric measurements: height, weight, and body fat, Blood pressure and heart rate
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Cardiovascular Diseases, Coronary Heart Disease
Meta-analysis of Oat Fiber and Cardiovascular Risk Reduction
Oat fibre has been shown to lower cholesterol and may have cardioprotective effects. However, whether this translates to actual cardiovascular risk reduction is unclear, as there is a lack of controlled human trials.
- Trial name
- NCT05171283
- Testing
- Oats or Oat Fibre
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Coronary Artery Disease, Cardiometabolic Risk Factors
Impact of New Anthropometric Indices on Outcomes After Cardiac Surgery
Obesity is associated with a number of risk factors for cardiovascular disease. Body mass index (BMI) is the most commonly recommended and used anthropometric measure to classify general obesity in clinical and epidemiological…
- Conditions
- Coronary Artery Disease, Cardiometabolic Risk Factors, Cardiac Anesthesia, Cardiac Surgery
- Trial name
- NCT05403294
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Partial Coverage Restoration
Clinical Outcomes of Zirconia-reinforced Lithium Silicate Partial Coverage Crowns Compared to Lithium Disilicate Partial Coverage Crowns
The purpose of this randomized controlled clinical trial is to evaluate the clinical outcomes of Partial Coverage Restorations fabricated with zirconia-reinforced lithium silicate ceramic system compared to partial coverage…
- Trial name
- NCT02861729
- Testing
- Vita Suprinity, IPS e.max
- Where
- Egypt
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Cairo University
Coronary Artery Disease
Breathing-Induced Myocardial Oxygenation Reserve
This is a clinical trial to test the clinical feasibility and safety of a novel CMR protocol, combined with a specific breathing maneuver to identify myocardial regions exposed to severe coronary artery stenosis.
- Trial name
- B-MORE-Pilot (NCT03050346)
- Where
- 6 sites in United States, Canada and 3 more
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Coronary Artery Disease
PrOgnostic Implications of PRe-stent Pullback Pressure GradIent and Post-stent Quantitative Flow Ratio in Patients UnderGoing Percutaneous Coronary INtervention
The purpose of this study is to investigate the prognostic implication of pre-percutaneous coronary intervention (PCI) focal or diffuse disease patterns combined with post-PCI quantitative flow ratio (QFR).
- Trial name
- CHART-ORIGIN (NCT05104580)
- Testing
- Quantitative Flow Ratio derived PPG
- Volunteers
- 1,395 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Bone Resorption
Guided Bone Regeneration With Customized Titanium Meshes
The aims of this prospective clinical study are to evaluate: a) the effectiveness of digitally customized titanium meshes in association with autologous bone particles and bovine bone mineral and covered with collagen membranes…
- Trial name
- NCT04480073
- Testing
- Customized CAD-CAM Titanium Mesh (Y-xoss CBR® by Reoss -Filderstadt - Germany) for Guided Bone Regeneration of atrophic alveolar ridges
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Milan
Coronary Artery Disease
Plasma Myeloperoxidase Levels in Patients With Coronary Artery Disease
The investigators sought to assess whether plasma myeloperoxidase (MPO) levels differ among patients with stable and unstable CAD patients and control subjects, and correlate with inflammatory and clinical risk factors such as…
- Trial name
- NCT01239979
- Where
- Iran
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Coronary Disease
Plasma TMAO (Trimethylamine N-oxide) as a Predictive Marker in Coronary Disease Patients
The primary aim of the current research project is to determine whether the TMAO concentration in the blood can serve as a prognostic indicator of myocardial infarction.
- Trial name
- NCT03899389
- Testing
- plasma samples collection
- Where
- Poland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Coronary Heart Disease
Rapid Engagement for Solutions to Population and Outcomes Through Networked Dialogue for Coronary Heart Disease
Cardiometabolic diseases are major causes of morbidity and mortality in the state of Wisconsin and are expected to pose an increasing burden over the next few decades.
- Trial name
- RESPOND (NCT07260552)
- Testing
- Polygenic risk score
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Endodontically Treated Teeth, Nonvital Teeth
Clinical Comparison of Lithium Disilicate and 3D-Printed Resin Endocrowns
This randomized controlled clinical trial aims to compare the clinical performance of CAD/CAM lithium disilicate (IPS e.max CAD) and 3D-printed resin (BEGO VarseoSmile TriniQ) endocrown restorations in endodontically treated…
- Conditions
- Endodontically Treated Teeth, Nonvital Teeth, Restoration of Endodontically Treated Posterior Teeth
- Trial name
- NCT07874906
- Testing
- IPS e.max CAD Lithium Disilicate Endocrown, BEGO VarseoSmile TriniQ Resin Endocrown
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medipol University
Coronary Artery Disease, Adherence
Using Feedback Reports to Improve Medication Adherence
The purpose of this research study is to improve statin medication adherence among Veterans with coronary artery disease with poor adherence to medications.
- Trial name
- NCT02480530
- Testing
- Individual Feedback, Feedback Friend
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Corporal Michael J. Crescenz VA Medical Center
Hyperlipidemia, Hypercholesterolemia
Cholesterol and Pharmacogenetic Study
The overall objective of the CAP study was to determine genetic influences on efficacy of simvastatin treatment with regard to LDL cholesterol reduction and changes in other markers of cardiovascular disease risk.
- Conditions
- Hyperlipidemia, Hypercholesterolemia, Coronary Heart Disease, Cardiovascular Disease
- Trial name
- CAP (NCT00451828)
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Coronary Artery Disease
The Correlation of Heart Hemodynamic Status Between 320 Multidetector Computed Tomography, Echocardiography and Cardiac Catheterization in Patients With Coronary Artery Disease
With the advances in multidetector computed tomography (MDCT) technology, CT angiography (CTA) of the coronary arteries using 64-slice or dual-source CT systems has evolved into a robust, alternative, noninvasive imaging…
- Trial name
- NCT01083134
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Atopic Dermatitis, Vascular Inflammation
Trial on Vascular Inflammation in Atopic Dermatitis
A total of 30 subjects with moderate to severe atopic dermatitis. Thirty subjects without AD matched for sex, age and coronary artery disease risk factor with the AD subjects will also be included.
- Conditions
- Atopic Dermatitis, Vascular Inflammation, Coronary Atherosclerosis
- Trial name
- NCT02926807
- Testing
- FDG-PET Scan, MDCT, biopsy and blood collection
- Where
- Canada
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Innovaderm Research Inc.