Clinical trials: CONTROL Condition
Postprandial Fatigue
Role of Interleukin-1 in Postprandial Fatigue - The Cheesecake Study
The aim of the study is to investigate, if postprandial fatigue symptoms after ingestion of a high-fat, high-carbohydrate meal are regulated by Interleukin (IL)-1 and can be prevented by inhibition of IL-1 using a single dose…
- Trial name
- NCT01810549
- Testing
- Anakinra
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Influenza
The Effectiveness of CD388 to Prevent Flu in an Influenza Challenge Model in Healthy Adults
The purpose of this study is to evaluate the preventative antiviral activity of CD388, as compared to saline placebo, when administered as a single dose to healthy adult participants in a human viral challenge model of influenza.
- Trial name
- NCT05523089
- Testing
- CD388
- Where
- United Kingdom
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Obesity
The Randomized Controlled Cocoa-Appetite Trial
The purpose of this study is to determine whether high-flavonoid cocoa can decrease appetite in humans. In addition the study is designed to test epicatechin, a compound found in cocoa and procyanidins, a class of compounds found…
- Trial name
- NCT02408289
- Testing
- Lo-Flav, Hi-Flav, Epicatechin
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Brooklyn College of the City University of New York
Fibromyalgia, Pain
Catastrophizing and Virtual Reality's Impact on Pain in Patients With Fibromyalgia
This study evaluates the potential association between Virtual Reality, pain catastrophizing thoughts and pain measures in fibromyalgia.
- Trial name
- NCT04294914
- Testing
- Cold Pressor Test, Cold Pressor Test + Virtual Reality
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Metabolic Syndrome, Physical Activity
The Effect of Feedback on Physical Activity Surveillance Using Wearable Device-Smartphone Application for Resolution of Metabolic Syndrome in Aged 60 or Older
The Effect of Feedback on Physical Activity Surveillance using Wearable Device-Smartphone Application for Resolution of Metabolic Syndrome in Aged 60 or older; a 12-Week Randomized Control Study
- Conditions
- Metabolic Syndrome, Physical Activity, Wearable Device
- Trial name
- NCT05830552
- Testing
- Receving feedback, No regular feedback
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Psychological Distress, Quality of Life and Menopause
The Effect of Continuous Care Model on Psychological Distress and Quality of Life Among Postmenopausal Women With Urinary Incontinence
This research aimed to evaluate the effect of continuous care model on psychological distress and quality of life among postmenopausal women with urinary incontinence.
- Trial name
- NCT07538752
- Testing
- Continuous Care Model sessions
- Where
- Palestinian Territories
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Al-Quds University
Nursing Students
The Effect of Exergames on Sleep Quality
University students are at risk of developing insufficient sleep and poor lifestyle behaviors. Sleep-related problems are frequently seen in nursing students. Regular exercise has a positive effect on sleep quality.
- Trial name
- EXSLEEPQUALITY (NCT06948643)
- Testing
- Play the Oculus Quest 2
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bartın Unıversity
Immunoglobulin A Nephropathy, IgAN - IgA Nephropathy
First in Human Study to Assess Safety of VIS649 in Healthy Subjects
This is a phase 1, randomized, placebo-controlled, double-blind, single ascending dose study of IV VIS649 in healthy subjects. VIS649 is a monoclonal immunoglobulin G2 (IgG2) antibody targeting the B-cell growth factor APRILL.
- Conditions
- Immunoglobulin A Nephropathy, IgAN - IgA Nephropathy, IgA Nephropathy
- Trial name
- NCT03719443
- Testing
- VIS649
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Sleep Quality, Anxiety Level
Hand Massage Applied To Elderly Stayıng In Nursing Homes
Hand massage; behavioral and reduce psychological symptoms, enable individuals to calm down and relax, and provide individual and care It is applied to contribute to communication between donors, to ensure reliability and ease of…
- Trial name
- NCT06872008
- Testing
- Hand Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Amasya University
Hypertension in Pregnancy, Preeclampsia Severe
Comparing Nifedipine and Enalapril in Medical Resources Used in the Postpartum Period
This study evaluates whether nifedipine or enalapril is better at decreasing the amount of medical resources used in the postpartum period by women who have high blood pressure in pregnancy and the postpartum period.
- Conditions
- Hypertension in Pregnancy, Preeclampsia Severe, Gestational Hypertension, Postpartum Preeclampsia
- Trial name
- NCT04236258
- Testing
- NIFEdipine ER, Enalapril
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Tooth Extraction, Postoperative Hemorrhage
Post-extraction Bleeding in Older Adults on Uninterrupted Antiplatelet Therapy
This prospective, assessor-blinded, controlled observational study compares bleeding after simple tooth extraction between adults aged 40 years or older who continue their antiplatelet therapy (aspirin, clopidogrel or dual…
- Conditions
- Tooth Extraction, Postoperative Hemorrhage, Platelet Aggregation Inhibitors
- Trial name
- NCT07913035
- Testing
- Antiplatelet therapy (uninterrupted), Simple tooth extraction with stepwise local haemostatic protocol
- Where
- Vietnam
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
L-PRF, Photodynamic Therapy
The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Aggressive Periodontitis
Antimicrobial photodynamic therapy (aPDT) is associated with photosensitizing agents which promote the generation of free radicals and singlet oxygen, which are cytotoxic to certain bacteria.
- Conditions
- L-PRF, Photodynamic Therapy, Aggressive Periodontitis
- Trial name
- NCT05043935
- Testing
- L-PRF with antimicrobial photodynamic therapy, antimicrobial photodynamic therapy without L-PRF
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Subthreshold Depression, Exercise
The Effect of Exercise on Cognition and Preventing Depression in Young People
It is estimated that approximately 30% of child and adolescents manifest subthreshold depression (including other specified depressive disorder and unspecified depressive disorder), which can further develop into major depression…
- Conditions
- Subthreshold Depression, Exercise, Clinically-well, Cognitive Change
- Trial name
- NCT04816617
- Testing
- Aerobic exercise intervention, Psycho-education
- Where
- China
- Volunteers
- 628 people, healthy volunteers welcome
- Sponsor
- Guangzhou Psychiatric Hospital
Child Developmental Delay, Child Malnutrition
Maternal B12 Supplementation to Improve Infant B12 Deficiency and Neurodevelopment
Vitamin B12 plays a key role in the development and normal functioning of the brain and nervous system. Unborn and new-born infants derive their vitamin B12 stores almost entirely from maternal B12 stores.
- Conditions
- Child Developmental Delay, Child Malnutrition, Maternal Exposure, Vitamin B 12 Deficiency
- Trial name
- MATCOBIND (NCT03783104)
- Testing
- B12 Supplement
- Where
- 2 sites in India, Nepal
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- University College, London
Trachoma, Chlamydia Trachomatis
Impact of Two Alternative Dosing Strategies for Trachoma Control in Niger
Trachoma is a disease of poverty, which in the hyperendemic areas affects all individuals by the time they are two years old. Active disease is concentrated in children and occurs sporadically in adults.
- Trial name
- NCT00618449
- Testing
- Azithromcyin, Azithromycin
- Where
- 2 sites in United States, Niger
- Volunteers
- 1,139 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Vasomotor Symptoms, Menopausal Symptoms
Estetrol for the Treatment of Moderate to Severe Vasomotor Symptoms in Postmenopausal Women (E4Comfort Study I)
This is a two-part study designed to evaluate the effect of Estetrol (E4) 15 or 20 mg, or placebo on the severity and frequency of vasomotor symptoms (VMS) (Efficacy Study Part) and the safety of E4 20 mg (Endometrial and General…
- Trial name
- NCT04209543
- Testing
- Estetrol, Progesterone
- Where
- 224 sites in United States, Argentina and 12 more
- Volunteers
- 1,570 people, healthy volunteers welcome
- Sponsor
- Estetra
High Blood Pressure
Salt and Gut Study
High sodium intake is a significant risk factor for hypertension. Recently, animal studies connect high sodium intake to the gut-immune axis and highlight the gut microbiome as a potential therapeutic target to counteract…
- Trial name
- NCT04958148
- Testing
- Salt pills
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Augusta University
Atopic Dermatitis, Healthy Participants
A Study of BYN-001 in Healthy Adults and in Adults With Moderate to Severe Atopic Dermatitis
This first-in-human study evaluates BYN-001, a humanized IgG1 monoclonal antibody targeting interleukin-25 (IL-25), a cytokine implicated in atopic dermatitis.
- Trial name
- BYN-001-101 (NCT07746817)
- Testing
- BYN-001
- Where
- Australia
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Bionyra Pharma
Human Papillomavirus
Evaluate the Safety of Recombinant Human Papillomavirus Bivalent (Types 16 and 18) Vaccine (Yeast) in Healthy Females
This study will evaluate the safety of a novel recombinant human papillomavirus bivalent ( types 16 and 18 ) vaccine ( Yeast ) with different dose in healthy females between 9-45 years of age at enrollment.
- Trial name
- NCT01548118
- Testing
- HPV 16/18 vaccine, 0,5ml, HPV 16/18 vaccine, 1.0ml
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Shanghai Zerun Biotechnology Co.,Ltd
Hot Flashes
Acupuncture and Hot Flashes
Methods: 103 participants, after being randomized to medical versus sham acupuncture received bi-weekly treatments for 5 weeks, after a baseline assessment week. They were then followed for an additional 7 weeks.
- Trial name
- NCT00217074
- Testing
- acupuncture
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
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