Clinical trials: COPD Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease
Evaluation of Efficacy on Exercise Tolerance of Symbicort (Budesonide/Formoterol) Compared to Placebo and Oxis in Patients With Severe COPD
The purpose of this study is to investigate the effect on exercise tolerance, lung function and symptoms after treatment with Symbicort, Oxis or placebo in patients with severe chronic obstructive pulmonary disease.
- Trial name
- CODEX (NCT00489853)
- Testing
- budesonide/formoterol Turbuhaler 320/9µg, formoterol Turbuhaler 9µg
- Where
- 9 sites in Germany, Switzerland
- Volunteers
- 137 people
- Sponsor
- AstraZeneca
COPD
Pharmacokinetics and Safety Study of PT010 in Healthy Subjects
This is a single-center, Phase I, healthy adult subject study with a randomized, double blind, three period, three-treatment, cross-over design.
- Trial name
- NCT02189304
- Testing
- PT010, PT009, Symbicort Turbohaler
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Pearl Therapeutics, Inc.
COPD, Small Airway Disease
The Prevalence of Small Airways Dysfunction In COPD Patients and The Impact on COPD Control
Chronic obstructive pulmonary disease (COPD) is a worldwide prevalent disease. During recent years, increasing attention has been directed to the importance of the contribution of small airways in respiratory diseases.
- Trial name
- NCT04384133
- Testing
- Impulse oscillometry, Spirometric pulmonary function test, Fractional exhaled nitric oxide (FENO) test
- Where
- Turkey (Türkiye)
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Sibel Naycı
Chronic Obstructive Pulmonary Disease
Safety and Efficacy Study of Treatment With Single Doses of CHF 4226 pMDI in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to characterize the dose-response profile of peak and trough FEV1 after single dose administrations of carmoterol in patients with COPD.
- Trial name
- NCT00782535
- Testing
- CHF 4226 pMDI
- Where
- 5 sites in United States
- Volunteers
- 20 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Chronic Hypersecretions
Efficacy of Temporary Positive Expiratory Pressure (TPEP) in Chronic Hypersecretion
Mechanical devices to increase the individual's bronchial hygiene are commonly used in patients with chronic retention of secretions and abnormal cough reflex.
- Trial name
- UNIKO (NCT00700388)
- Testing
- TPEP device (UNIKO), MABT (Manually assisted breathing techniques)
- Where
- 6 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Villa Pineta Hospital
COPD
Effectiveness of Standardized Respiratory Physiotherapy in Primary Care (FREAP)
Chronic Obstructive Pulmonary Disease (COPD) is a very important public health problem and one of the most common lung diseases in the world, with repercussions on mortality and high economic costs.
- Trial name
- FREAP (NCT01152762)
- Testing
- Standardized Respiratory Physiotherapy
- Where
- Spain
- Volunteers
- 129 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Chronic Obstructive Pulmonary Disease
A Study on the Heat Transport Characteristics of Meridian Phenomenon for the Heart and Lung Meridians Based on Patients With Stable Angina Pectoris
Although some important progresses were made in the field of the meridian research, no breakthroughs have been achieved. Besides,there are some problems in meridian researches.
- Trial name
- NCT04046640
- Testing
- Infrared thermal imaging
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhejiang Chinese Medical University
Pulmonary Disease, Chronic Obstructive, Heart Failure
Telehealth Program in Chronic Patients
The aim of this randomized control study is to determine the feasibility and efficacy of an innovative multidisciplinary telehealth program in chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) patients.
- Trial name
- NCT02269618
- Testing
- Home-based telehealth program, Home-based rehabilitation, Usual care
- Where
- 3 sites in Italy
- Volunteers
- 113 people
- Sponsor
- Fondazione Salvatore Maugeri
Pulmonary Disease, Chronic Obstructive
Development and Validation of the GLORI-COPD Score
The objective of this study is to evaluate the diagnostic accuracy of the GLORI-COPD score in ambulatory care, to enable the screening of COPD patients at risk of complications, requiring early management
- Trial name
- GLORI-COPD (NCT04027296)
- Where
- France
- Volunteers
- 462 people
- Sponsor
- University of Paris 5 - Rene Descartes
Pulmonary Disease, Chronic Obstructive
An Investigation Of The Interaction Of GSK961081 With Inhaled Beta-Agonist And Anti-Muscarinic Drugs.
GSK961081 is a potent dual pharmacophore that demonstrates both antimuscarinic and beta-agonist pharmacology in preclinical studies, both pharmacologies being of long duration.
- Trial name
- NCT00674817
- Testing
- 400 microgrammes GSK961081, 1200 microgrammes GSK961081
- Where
- 4 sites in New Zealand, Thailand and 1 more
- Volunteers
- 45 people
- Sponsor
- Theravance Biopharma
COPD
The Copmparison of Accuracy of PtcCO2 and in PetCO2 in COPD Patients With NIV Treatment
The chronic obstructive pulmonary disease (COPD) patients with type II respiratory failure always needs PaCO2 test to monitor the changes of disease.
- Trial name
- NCT04258982
- Testing
- no intervention
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Zhenfeng He
COPD, Walking, Difficulty
Effect of Face Masks on Pulmonary Function in Patients With COPD
Given the heightened vulnerability of COPD patients to severe illness upon SARS-CoV-2 infection, precautions like mask-wearing are deemed crucial.
- Trial name
- NCT05742880
- Testing
- 6 Minute Walking Test, Blood gas analysis, Wearing a Surgical Facemask
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Chronic Obstructive Pulmonary Disease
Educational Follow-up in COPD Patients After Pulmonary Rehabilitation.
After pulmonary rehabilitation, the challenge is to maintain the benefits reached during the program and increase physical activity. As exercise training, education is the corner stone of pulmonary rehabilitation.
- Trial name
- EDURESPI (NCT04473313)
- Where
- 2 sites in France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Brest
Chronic Obstructive Pulmonary Disease
Different Inspiratory Muscle Trainings in Patients With COPD
COPD is one of the most life-threatening pulmonary diseases. According to the World Health Organization, it is expected to rise to the third leading cause of death by 2030. Smoking is the most significant contributing factor.
- Trial name
- NCT07406659
- Testing
- Basic Inspiratory Muscle Training, Functional Inspiratory Muscle Training, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- University of Yalova
Chronic Obstructive Pulmonary Disease, Exercise
Mind-Body Walking Exercise for Chronic Obstructive Pulmonary Disease
Mind-body exercise improves symptom of negative moods, dyspnea and quality of life in chronic diseases, but these improvements for chronic obstructive pulmonary disease (COPD) are unproven.
- Conditions
- Chronic Obstructive Pulmonary Disease, Exercise, Anxiety, Depression
- Trial name
- NCT03388489
- Testing
- Mind-Body Walking
- Volunteers
- 84 people
- Sponsor
- National Taiwan University Hospital
Chronic Obstructive Pulmonary Disease (COPD)
A Prospective, Cohort Study of Hyperpolarized 3He MRI in Chronic Obstructive Pulmonary Disease
The purpose of this study is to determine the MRI characteristics of Chronic Obstructive Pulmonary Disease subjects both at baseline and yearly for a period of 5 years, and to correlate these biomarkers with pulmonary function…
- Trial name
- NCT02734368
- Testing
- Hyperpolarized Helium-3
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Chronic Obstructive Pulmonary Disease
Efficacy & Safety of Dry Powder Ivy Extract (Syrup Prospan) Versus NAC Among COPD Patients
As the third global leading cause of death, Chronic Obstructive Pulmonary Disease (COPD) affects more than 300 million people worldwide. These patients suffer from 0.5-3.5 exacerbations per year on average.
- Trial name
- SyProNAC (NCT06377410)
- Testing
- Syrup Prospan, N-Acetylcysteine
- Where
- 2 sites in Malaysia
- Volunteers
- 100 people
- Sponsor
- National University of Malaysia
Chronic Obstructive Pulmonary Disease (COPD)
A Clinical Study of TQC3721 Inhalation Powder in Patients With Chronic Obstructive Pulmonary Disease
This is a randomized, double-blind, placebo-controlled, dose escalation, multicenter study design. The purpose is to evaluate the safety, tolerability, pharmacokinetics, and pharmacokinetic characteristics of TQC3721 inhalation…
- Trial name
- NCT06748079
- Testing
- TQC3721 inhalation powder, TQC3721 inhalation powder combined with glyberlam inhalation powder or a control group
- Where
- China
- Volunteers
- 113 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
COPD
Effects of Blow Bottle Verses ACBTs Technique in Patients of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease is a common disease worldwide. Pulmonary rehabilitation is an important part to decrease the complications of COPD.
- Trial name
- NCT06189196
- Testing
- BLOW BOTTLE, ACBT
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- Riphah International University
Chronic Obstructive Pulmonary Disease (COPD)
Extension Study to Evaluate the Safety and Efficacy of PT003, PT001, and PT005 in Subjects With Moderate to Very Severe COPD, With Spiriva® Handihaler® (PINNACLE 3)
This is a multi-center, randomized, double-blind, parallel group, chronic dosing, active-controlled, 28-week safety extension study of the two pivotal 24-week safety and efficacy studies (Studies PT003006 and PT003007).
- Trial name
- NCT01970878
- Testing
- GFF MDI (PT 003), GP MDI (PT001), FF MDI (PT005)
- Where
- 125 sites in United States, Australia and 1 more
- Volunteers
- 892 people
- Sponsor
- Pearl Therapeutics, Inc.