Clinical trials: COVID19 Patients
COVID-19
Intranasal Lavage With Hypochlorous Acid Safely Reduces the Symptoms in the Ambulatory Patient With COVID-19.
The goal of this observational study is to determine if intranasal lavage reduces symptoms in adults with COVID-19. The main question is can a hypochlorous acid solution reduce the symptoms of COVID-19.
- Trial name
- NCT05950295
- Testing
- Intranasal lavage with hypochlorous acid solution
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Monique Lisa Abner
COVID-19 Pneumonia
Traditional Chinese Medicine or Low-dose Dexamethasone in COVID-19 Pneumonia
The goal of this type of clinical trial is to learn about symptomatic patients with post-COVID-19 parenchymal lung abnormalities.
- Trial name
- NCT05798195
- Testing
- conventional western medicine treatment, Dexamethasone oral tablet, Traditional Chinese medicine decoction
- Where
- China
- Volunteers
- 420 people
- Sponsor
- China-Japan Friendship Hospital
Myocarditis
Incidence, Patient Characteristics and Outcome of Myocarditis After COVID-19 mRNA Vaccine
This study evaluates the incidence, patient characteristics and outcome of myocarditis after the COVID-19 mRNA vaccination in healthcare professionals.
- Trial name
- MACIS (NCT05438472)
- Testing
- data collection in healthcare professionals with COVID-19 mRNA vaccine booster
- Where
- Switzerland
- Volunteers
- 835 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Ischemic Heart Diseases
The Relationship Between Belief, Expectation, and Adherence to Therapy During COVID-19 Pandemic
The goal of this [type of study: observational study or clinical trial ] is to learn about, test, compare etc.] in [ describe participant population/health conditions ].
- Trial name
- RACAT-COVID (NCT06530472)
- Testing
- Monitoring
- Where
- Italy
- Volunteers
- 196 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Sedation Complication, Acute Respiratory Distress Syndrome Due to COVID-19
Assessment of Sedation Depth Using Processed EEG in ICU Patients With ARDS Receiving Neuromuscular Blockade: A Prospective Observational Study"
"In intensive care units, therapeutic paralysis has been a routine treatment method for many years in a select group of patients.
- Conditions
- Sedation Complication, Acute Respiratory Distress Syndrome Due to COVID-19, Anesthesia Awareness
- Trial name
- NCT06337877
- Testing
- Depth of sedation monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Tepecik Training and Research Hospital
COVID, ARDS
PROne Positioning in coVID-19 Oxygeno-dependent Patients in Spontaneous Ventilation (PROVID Study)
The COVID epidemics is responsible for a huge number of death following COVID acute respiratory failure. First instance treatment includes oxygenotherapy up to 15L/min in spontaneous ventilation.
- Trial name
- PROVID (NCT04366856)
- Testing
- 1: Prone positioning, 2: No instruction regarding positioning
- Where
- France
- Volunteers
- 446 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Covid19
A Study to Evaluate the Safety and Efficacy of GX-I7 in Elderly Patients With Asymptomatic or Mild Symptoms of COVID-19
This is a Phase 2 prospective, randomized, placebo-controlled, double-blinded, parallel group, single administration, multi-center study to assess the safety and efficacy of efineptakin alfa single treatment compared to placebo…
- Trial name
- NCT04810637
- Testing
- GX-I7
- Where
- 2 sites in Indonesia
- Volunteers
- 210 people
- Sponsor
- PT Kalbe Genexine Biologics
Covid19
Efficacy of Sofosbuvir Plus Ledipasvir in Egyptian Patients With COVID-19 Compared to Standard Treatment
Currently there is no known effective therapy or vaccine for treatment of SARS-CoV-2, highlighting urgency around identifying effective therapies.
- Trial name
- NCT04530422
- Testing
- Sofosbuvir plus Ledipasvir
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Almaza Military Fever Hospital
COVID 19, Patients Hospitalized
Evaluation of the Efficacy and Safety of Treatments for Patients Hospitalized for COVID-19 Infection Without Signs of Acute Respiratory Failure, in Tunisia
Evaluation of the efficacy and safety of Treatments for Patients Hospitalized for COVID-19 Infection without signs of acute respiratory failure, in Tunisia Multicentric Randomized Comparative Study
- Trial name
- THINC (NCT04528927)
- Testing
- HCQ, Azithromycin, Doxycycline
- Where
- Tunisia
- Sponsor
- Abderrahmane Mami Hospital
COVID-19
Longitudinal Energy Expenditure and Metabolic Effects in Patients With COVID-19 (LEEP-COVID)
This current proposal evaluates the Longitudinal Energy Expenditure and Metabolic Effects in Patients with COVID-19 (LEEP-COVID) to understand, guide and optimize our metabolic and nutritional care of these high risk patients.
- Trial name
- NCT04350073
- Testing
- Q-NRG Metobolic Cart Device, MuscleSound Ultrasound, Multifrequency Bioimpedance Spectroscopy
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Duke University
Covid19
Phase 1 Study to Assess Safety, Tolerability, PD, PK, Immunogenicity of IV NTR-441 Solution in Healthy Volunteers and COVID-19 Patients
This first-in-human clinical study is a Phase 1a/ 1b, randomized, double-blind, placebo-controlled study to assess the safety, tolerability, and PK/PD of NTR-441 in healthy subjects and patients with COVID-19 after single…
- Trial name
- NCT04941183
- Testing
- NTR-441
- Where
- 4 sites in Austria, Ukraine
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Neutrolis
COVID-19 Pneumonia, Pulmonary Embolism
External Validation of the CHOD Risk Scale
Severe COVID-19 is associated with a hypercoagulable state, with a high risk of thrombotic phenomena such as pulmonary thromboembolism (PE).
- Trial name
- CHOD-1 (NCT04889261)
- Where
- Spain
- Volunteers
- 245 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Severe Pneumonia
Reparixin in COVID-19 Pneumonia - Efficacy and Safety
Phase 2 Study Objectives: efficacy and safety of of Reparixin treatment as compared to the control arm in adult patients with severe COVID-19 pneumonia Phase 3 Study Objectives: efficacy and safety of Reparixin treatment as…
- Trial name
- NCT04794803
- Testing
- Reparixin, Standard of care
- Where
- 4 sites in Brazil, Italy
- Volunteers
- 56 people
- Sponsor
- Dompé Farmaceutici S.p.A
Covid19
Antiseptic Mouth Rinses to Reduce Salivary Viral Load in COVID-19 Patients
As no curative treatment for SARS-CoV-2 is currently available, most public health measures to contain the pandemic are based on preventing the spread of the pathogen.
- Trial name
- BUCOSARS (NCT04707742)
- Testing
- Betadine© bucal 100 mg/ml, Oximen® 3%, Clorhexidine Dental PHB©
- Where
- Spain
- Volunteers
- 160 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Covid19
Risk Stratification of COVID-19 Patients Discharged From the Emergency Department
Risk stratification of COVID-19 patients is essential to define their appropriate treatment setting. So far, available studies have focused on morbidity and mortality prediction in patients admitted to hospital.
- Trial name
- CODED (NCT04629183)
- Testing
- integrated clinical evaluation
- Where
- 7 sites in Italy
- Volunteers
- 742 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Bariatric Surgery, Obesity
Home-based Exercise Training During Covid-19 Pandemic in Post-bariatric
The aim of this study is to assess the effect of a home-based exercise training during social isolation due to covid-19 pandemic in patients who undertook bariatric surgery.
- Trial name
- NCT04425005
- Testing
- Home-based exercise
- Where
- Brazil
- Volunteers
- 55 people
- Sponsor
- University of Sao Paulo
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
mRNA Based-Covid-19 Vaccine Effects on Blood Glucose Levels
To determine if patients with a history of Diabetes Mellitus Type I or II developed a change in blood glucose levels as reported on Continuous glucose monitoring devices (CGMS) within the first week following administration of…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, Hyperglycemia, Vaccine Adverse Reaction
- Trial name
- NCT04923386
- Testing
- None (not interventional)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Levenson, David I., M.D.
CPAP Ventilation, COVID-19
Early CPAP in COVID-19 Patients With Respiratory Failure.
The study aims at clarifying whether early treatment with continuous positive airway pressure (CPAP) ventilation is able to reduce the need for intubation or death in patients visiting an emergency department (ED) with known or…
- Conditions
- CPAP Ventilation, COVID-19, Emergency Departments
- Trial name
- EC-COVID-RCT (NCT04326075)
- Testing
- CPAP treatment
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Copd, COVID-19
Physiology and Structure of the Small Airways in Patients With Chronic Airflow Obstruction or COVID-19
The purpose of this research project is to study small airways physiological function in patients with chronic obstructive lung disease or COVID-19 and explore the relationship with in-vivo microanatomical small airway structure…
- Conditions
- Copd, COVID-19, Asthma, Small Airways Disease
- Trial name
- PASSPORT (NCT04716023)
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- Imperial College London
Covid19
Selenium as a Potential Treatment for Moderately-ill, Severely-ill, and Critically-ill COVID-19 Patients.
Given its anti-viral, anti-oxidative, immune-enhancing, cytokine-modulating, and anticoagulant properties, the investigators hypothesize that Selenium infusion at supranutritional doses for moderately-ill, severely-ill, and…
- Trial name
- SeCOVID (NCT04869579)
- Testing
- Selenium (as Selenious Acid)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- CHRISTUS Health
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