Clinical trials: CPA
Cardiac Arrest (CA)
Self-training and Resuscitation Techniques: Evaluation of the Performance and Impact on the Quality of Cardiopulmonary Resuscitation (CPR)
Cardiac arrest (CA) remains one of the leading causes of death worldwide, and its incidence continues to increase. The median survival rate following in-hospital cardiac arrest in France is 19%.
- Trial name
- ATIPIQ (NCT07820605)
- Where
- France
- Volunteers
- 265 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Pulmonary Aspergillosis
Six Months Versus 12 Months of Oral Itraconazole Therapy for Management of Treatment naïve Subjects With CPA
The treatment options majorly consist of medical management with at least 6-month long treatment with antifungal drugs - most significantly the azole groups. Itraconazole is the preferred azole for the treatment of CPA.
- Trial name
- NCT03920527
- Testing
- Itraconazole 400 mg
- Where
- India
- Volunteers
- 164 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Cerebellopontine Angle Tumor
Compare the Operating Condition of Two Levels of Muscle Relaxation on Facial Nerve MEP Monitoring in CPA Surgery
compare the operating condition of two different levels of muscle relaxation on facial nerve monitoring using transcranial motor evocked potential in CPA surgery .
- Trial name
- NCT04148534
- Testing
- Rocroniom, Non Depolarizing Muscle Relaxant
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Muhammad Magdy Gaber
Chronic Pulmonary Aspergillosis
Impact of Chronic Pulmonary Aspergillosis (CPA) on Health Status and Well-being
To develop and validate a novel disease-specific questionnaire for measuring HRQoL in patients with Chronic Pulmonary Aspergillosis (CPA-HAQ) for use in clinical research, including clinical trials.
- Trial name
- CAPSULE (NCT06885905)
- Where
- 3 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- Imperial College London
Chronic Pulmonary Aspergillosis, CPA
A Trial to Compare Nebulized Amphotericin B and Nebulized Normal Saline as Maintenance in Patients With Chronic Pulmonary Aspergillosis
The treatment of CPA is with oral itraconazole for 6-12 months. Oral itraconazole results in better clinical outcomes in CPA compared to supportive care.
- Conditions
- Chronic Pulmonary Aspergillosis, CPA, Aspergilloma
- Trial name
- NAB-CPA (NCT06447402)
- Testing
- Normal saline, Amphotericin B deoxycholate
- Where
- India
- Volunteers
- 196 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Hirsutism, Androgenetic Alopecia
DUS on the Prescribing Indications for CPA/EE in 5 European Countries
This study was designed to compile the reasons and specific indications for the prescription of Cyproterone Acetate combined with Ethinyl Estradiol by Health Care Providers.
- Conditions
- Hirsutism, Androgenetic Alopecia, Severe Anemia, Seborrhea
- Trial name
- NCT02494297
- Where
- Germany
- Volunteers
- 1,597 people, healthy volunteers welcome
- Sponsor
- Center for Epidemiology and Health Research, Germany
Chronic Pulmonary Aspergillosis, Allergic Bronchopulmonary Aspergillosis
Oral Itraconazole Versus Combination of Systemic Glucorticoids and Oral Itraconazole in CPA-ABPA Overlap Syndrome
While ABPA and CPA represent two distinct manifestations of Aspergillus-related lung disease, there is an overlap of investigations that are currently used for the diagnosis of these entities.
- Trial name
- GLITZ (NCT05444946)
- Testing
- Prednisone tablet and Itraconazole, Oral itraconazole
- Where
- 2 sites in India
- Volunteers
- 104 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
PCOS (Polycystic Ovary Syndrome)
Effect of Combined Hormonal Contraceptiveson Free Androgen Index (FAI) in Polycystic Ovary Syndrome:Drospirenone-Ethinyl Estradiol (DRSP-EE) Versus Cyproterone Acetate-Ethinyl Estradiol (CPA-EE)
The goal of this clinical trial is to learn if drug Drospirenone ethinyl estradiol works better than drug Cyproterone acetate ethinyl estradiol to treat PCOS.
- Trial name
- PCOS FAI CHC (NCT07911709)
- Testing
- DRSP-EE (Experimental) group received DRSP-EE 1 tab daily (one active pill daily for 21 days and 7 inactive pills) for three cycles, .CPA-EE (Comparator) groupreceivedCPA-EE 1 tab daily (one active pill daily for 21 days and 7 pill free days) for three cycles
- Where
- Bangladesh
- Volunteers
- 60 people
- Sponsor
- Mst.Sumyara Khatun
Gender Dysphoria, Adult, Blood Coagulation
Comparing the Effects of Sublingual Estradiol Treatment Versus Oral Estradiol With Cyproterone Acetate (CPA) Treatment on The Coagulation System in Transgender Women: A Prospective, Controlled Cohort Study
The goal of this clinical trial is to learn about the effects of different routes of estradiol administration on blood clotting in transgender women starting gender-affirming hormone therapy.
- Conditions
- Gender Dysphoria, Adult, Blood Coagulation, Coagulation Factors, Transgender Persons, M01.777.500
- Trial name
- NCT07145281
- Testing
- Estradiol (E2), Cyproterone Acetate (Androcur, BAY94-8367)
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Chronic Pulmonary Aspergillosis
Aspergillus-specific IgG Assays for the Diagnosis of Chronic Pulmonary Aspergillosis (CPA)-Multicenter Study
Aspergillus-specific IgG assays for the diagnosis of chronic pulmonary aspergillosis (CPA)
- Trial name
- NCT03027089
- Where
- China
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Periodontitis, Polycystic Ovary Syndrome
Evaluation of Periodontal Status and hsCRP Levels in Females With PCOS on CPA/EE Combination Drug Regimen
PCOS is a widely reported condition among young female population and anti-androgen agents are increasingly being used as part of the medical management of such cases.
- Conditions
- Periodontitis, Polycystic Ovary Syndrome, Gingivitis
- Trial name
- NCT05021861
- Testing
- Cyproterone Acetate, Ethinyl Estradiol Drug Combination, FEMALE PATIENTS WITH PCOS, Control group
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Rectal Cancer
Tecemotide (L-BLP25) in Rectal Cancer
The objective of this mechanistic study is to determine the impact of tecemotide (L-BLP25) administration on the mucinous glycoprotein 1 - (MUC1) specific immune response in subjects with newly diagnosed rectal cancer who are…
- Trial name
- SPRINT (NCT01507103)
- Testing
- Tecemotide (L-BLP25), cyclophosphamide (CPA), Chemoradiotherapy
- Where
- Netherlands
- Volunteers
- 124 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Platinum-resistant Epithelial Ovarian Cancer
Maveropepimut-S (MVP-S) and Low-Dose CPA in Patients With Platinum-Resistant Ovarian Cancer
Phase 2, single arm, study to assess the efficacy and safety of maveropepimut-S (MVP-S) and low-dose cyclophosphamide (CPA) in subjects with recurrent, platinum resistant ovarian cancer.
- Trial name
- AVALON (NCT05243524)
- Testing
- Maveropepimut-S, Cyclophosphamide 50mg
- Where
- 6 sites in United States, Canada and 1 more
- Volunteers
- 16 people
- Sponsor
- ImmunoVaccine Technologies, Inc. (IMV Inc.)
Chronic Pulmonary Aspergillosis
A Randomized Controlled Trial to Compare the Clinical Outcomes With Six Months of Therapy With Oral Itraconazole Versus Oral Voriconazole for Management of Treatment naïve Subjects With Chronic Pulmonary Aspergillosis
The current initial therapy for CPA is with six months of oral itraconazole. However, the response with six months of therapy has a response rate of 65-70% and has a relapse rate after stopping treatment of up to 50%.
- Trial name
- NCT04824417
- Testing
- Itraconazole 200 mg, Voriconazole 200mg
- Where
- 2 sites in India
- Volunteers
- 116 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
CAD - Coronary Artery Disease
REFINE-CAC Protocol: Risk Evaluation With AI-CPA + HCS For Patients IN Whom Calcium is confirmEd to Improve Coronary Artery Disease Care
REFINE-CAC is a prospective, multi-center trial assessing the management of asymptomatic participants with CAC scores 1-299 Agatston units or incidental CAC findings on chest computed tomography (CT), all of whom will undergo…
- Trial name
- REFINE-CAC (NCT07853716)
- Testing
- Heartflow Analysis
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- HeartFlow, Inc.
Open Colorectal Surgery, Early Rehabilitation After Surgery
Continuous Preperitoneal Infusion of Local Anesthetic (CPA) Versus Epidural Infusion of Local Anesthetic (EA) in Fast-Track Open Colorectal Surgery
The purpose of this study is to compare the continuous preperitoneal infusion of local anesthetic and continuous epidural analgesia for postoperative pain management in fast-track open colorectal surgery.
- Trial name
- NCT00915265
- Testing
- Multilobed catheter (group CPA), Multilobed catheter (group EA)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Malignant Melanoma Stage IV
Combined Modality Treatment for Patients With Stage IV Melanoma
The purpose of this study is to test a combined treatment using cyclophosphamide and a novel dendritic cell vaccine in patients with Stage IV melanoma.
- Trial name
- NCT00313235
- Testing
- DC Vaccine and Cyclophosphamide
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Baylor Research Institute
PCOS
Pretreatment With CPA-EE, Metformin and Myoinositol in PCOS With High AMH
Women with PCOS with high AMH randomly allocated into group A \& B.Cyproterone acetate plus ethinyl estradiol,metformin \& myoinositol in group A and Cyproterone acetate plus ethinyl estradiol \& metformin are given in group…
- Trial name
- NCT07513480
- Testing
- Cyproterone Acetate, Ethinyl Estradiol Drug Combination, Metformin 500 mg, Myoinositol 750mg
- Where
- Bangladesh
- Volunteers
- 68 people
- Sponsor
- Mst.Sumyara Khatun
Periodontal Diseases
"Effect of CPA/EE Drug on Periodontal Tissue and hsCRP Levels in PCOS Patients With Gingivitis
PCOS is a widely reported condition among young female population and anti-androgen agents are increasingly being used as part of the medical management of such cases.
- Trial name
- NCT05657171
- Testing
- cyproterone Acetate/Ethinyl Estradiol Combination
- Where
- India
- Volunteers
- 47 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Hypercholesterolemia
Statin Interchange by Pharmacist Collaborative Practice Agreement (CPA)
A group of ~ 225 patients were switched from atorvastatin to an equivalent statin either by their physicians usual management or by an collaborative pharmacist coordinated process.
- Trial name
- NCT01222182
- Testing
- atorvastatin
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic