Clinical trials: CUP
Arthroplasty, Replacement, Hip
Pelvic Alignment Level (PAL) Instrument Evaluation
The study is conducted to evaluate the performance of the Pelvic Alignment Level (PAL) instrument in achieving desired acetabular position, desired leg length and offset after Total Hip Replacement (THR) reconstruction.
- Trial name
- PAL (NCT01312428)
- Testing
- Pelvic Alignment Level (PAL) Instrument, No Pelvic Alignment Level (PAL) Instrument
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Stryker Orthopaedics
End of Life, Advanced Cancer
Engagement of Patients With Advanced Cancer
The Engagement of Patients with Advanced Cancer is an intervention that utilizes well-trained lay health coaches to engage patients and their families in goals of care and shared decision-making after a diagnosis of advanced…
- Conditions
- End of Life, Advanced Cancer, Lung Neoplasm, Gastric Cancer
- Trial name
- EPAC (NCT02966509)
- Testing
- EPAC
- Volunteers
- 213 people
- Sponsor
- Stanford University
Plagiocephaly, Scaphocephaly
Cranial Cup Use for the Prevention of Positional Head Shape Deformity in the NICU
Many hospitalized infants can develop a flattening of the back or sides of their head. This condition develops gradually when an infant's head rests on a firm or semi-firm surface for a prolonged period of time.
- Conditions
- Plagiocephaly, Scaphocephaly, Brachycephaly
- Trial name
- NCT01218087
- Testing
- Cranial cup device and Moldable positioner, Moldable positioner device
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Boston Children's Hospital
Pregnant
Compare the Q-Cup With Other Umbilical Cord Blood Collection Techniques
Currently there is no standardized method of collecting and transferring umbilical cord blood to laboratory vacuum tubes. Current methods are messy and may require needles to draw the blood presenting risk of blood exposure and…
- Trial name
- qcup (NCT03144180)
- Testing
- Q-cup
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Cancer of Unknown Primary Site
Sintilimab in Cancer of Unknown Primary
This is a Phase 2 clinical trial evaluating the efficacy and safety of sintilimab in subjects with CUP. Up to 45 subjects with CUP will be enrolled.
- Trial name
- NCT05024968
- Testing
- Sintilimab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- M.D. Anderson Cancer Center
Healthy
What Makes a Cup, a Cup? Generalizing Novel Words
The goal of this work is to address increasing concerns about young children's digital media exposure and language outcomes by testing how the times course of word learning unfolds in digital environments and the cascading impact…
- Trial name
- NCT05443399
- Testing
- Modality - 3D-2D, Modality - 2D-3D, Modality - 2D-2D
- Where
- United States
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
Healthy
Reliability of Sacral Slope, Pelvic Femoral Motion and Cup Ante-inclination on AP Pelvic Radiographs in Healthy Pts
Currently, there are no validated anatomical landmarks that can be used to predict risk of and diagnose abnormal patterns of pelvic motion.This proposed study will measure sacral slope, pelvic femoral angle and cup…
- Trial name
- NCT04687306
- Testing
- X-rays- total of 4
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Non-inflammatory Degenerative Joint Disease
Multi-Center Comparative Trial of the ASR™-XL Acetabular Cup System vs. the Pinnacle™ Metal- on- Metal Total Hip System
The primary objective of this investigation is to evaluate the clinical and radiographic outcomes of the ASR™-XL Acetabular Cup System compared to the Pinnacle™ Acetabular Cup with a 28mm or 36mm ULTAMET™ metal insert.
- Trial name
- ASR (NCT00561600)
- Testing
- ASR™-XL Modular Acetabular Cup System, Pinnacle™ acetabular shell
- Where
- 8 sites in United States
- Volunteers
- 265 people
- Sponsor
- DePuy Orthopaedics
Carcinoma of Unknown Primary
Pembrolizumab in Patients With Poor-Prognosis Carcinoma of Unknown Primary Site (CUP)
Abbreviated Title: Pembrolizumab in Patients with Poor-Prognosis Carcinoma of Unknown Primary Site (CUP) Trial Phase: 2 Clinical Indication: Treatment naïve patients with poor prognosis carcinoma of unknown primary site Trial…
- Trial name
- CUP (NCT03391973)
- Testing
- Pembrolizumab Injection
- Where
- 3 sites in Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- AHS Cancer Control Alberta
Primary Osteoarthritis, Post-traumatic Osteoarthritis of Hip Nos
Observational Study Evaluating Outcomes of Hip Arthroplasty Using Tornier Dual Mobility Acetabular Cup
The purpose of this study is to demonstrate the performance and reliability of Tornier "Dual Mobility Cup" used during primary total hip replacement or hip replacement revision surgery at least 24 months post-insertion.
- Conditions
- Primary Osteoarthritis, Post-traumatic Osteoarthritis of Hip Nos, Femur Head Necrosis, Femur Neck Fracture
- Trial name
- NCT02062450
- Testing
- Primary surgery with Dual Mobility Cup, Revision surgery with Dual Mobility Cup
- Volunteers
- 379 people
- Sponsor
- Stryker Trauma and Extremities
Non-inflammatory Degenerative Joint Disease
36 mm Ceramic-on-Ceramic Acetabular Cup Total Hip Replacement
This study is a supplement to the 28 mm Ceramic-on-Ceramic study which was designed to evaluate artificial hips with a 28 mm ceramic head and liner to determine whether they perform as well as artificial hips with a 28 mm ceramic…
- Trial name
- NCT00953719
- Testing
- 36 mm ceramic head on a ceramic acetabular liner, 28 mm ceramic head on a polyethylene acetabular liner
- Where
- 5 sites in United States
- Volunteers
- 243 people
- Sponsor
- DePuy Orthopaedics
Arthropathy of Hip
Study Comparing BoneMaster Hydroxyapatite Coating With Plasma-sprayed Hydroxyapatite Coating on Acetabular Cups
The randomised controlled trial will be carried out on patients that require a total hip replacement (THR) to reduce pain and restore their function.
- Trial name
- NCT00859976
- Testing
- BoneMaster coated acetabular shell., Plasma Coated Acetabular Shell
- Where
- United Kingdom
- Volunteers
- 167 people
- Sponsor
- Zimmer Biomet
Revision, Joint
Evaluation of the Trabecular Metal™ Revision Hip Cup Using Bone Mineral Density (DEXA)
In 1997, the FDA approved the use of Trabecular Metal™ (Zimmer, Trabecular Metal Technology, Inc., Parsippany, NJ) for acetabular cups, a porous tantalum structural biomaterial that was developed to address the limitations of…
- Trial name
- NCT01183260
- Testing
- Trabecular Metal Revision Cup, Trabecular Metal Modular Cup
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The Cleveland Clinic
Carcinoma, Unspecified Site
Study of Pembrolizumab and Concurrent Radiation in Patients With Previously Treated Carcinoma of Unknown Primary
Single-arm phase 2 study to examine pembrolizumab and concurrent radiation to induce an abscopal effect in patients with previously treated carcinoma of unknown primary (CUP16-268)
- Trial name
- NCT03396471
- Testing
- Pembrolizumab, External Beam Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Hoosier Cancer Research Network
Carcinoma of Unknown Primary
Belinostat, Carboplatin and Paclitaxel (BelCaP) Compared to Carboplatin and Paclitaxel in Patients With Cancer of Unknown Primary
The purpose of this study is to assess efficacy and safety of belinostat in combination with carboplatin and paclitaxel in patients with previously untreated carcinoma of unknown primary.
- Trial name
- NCT00873119
- Testing
- belinostat, carboplatin, paclitaxel, carboplatin, paclitaxel
- Where
- 23 sites in United States, Denmark and 2 more
- Volunteers
- 89 people
- Sponsor
- Valerio Therapeutics
Avascular Necrosis, Osteoarthritis
PMCF Study on the Safety and Performance of the Alloclassic Variall Cup Ceramic Bearing System in Total Hip Arthroplasty
The study is a multicenter, prospective, non-randomized, non-controlled consecutive cohort post-market clinical follow-up study.
- Conditions
- Avascular Necrosis, Osteoarthritis, Inflammatory Arthritis, Posttraumatic Arthritis
- Trial name
- NCT03672370
- Where
- 2 sites in Austria
- Volunteers
- 100 people
- Sponsor
- Zimmer Biomet
Dolichocephaly
Cranial Cup Use for Correction of Head Shape Deformities
The purpose of this descriptive study is to provide information on the feasibility of using the cranial cup, a new positioning device, in a small sample of prematurely born infants with elongated head shapes as a result of laying…
- Trial name
- NCT01683812
- Testing
- Cranial Cup
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Boston Children's Hospital
Neck Squamous Cell Carcinoma of Unknown Primary, Recurrent Hypopharyngeal Squamous Cell Carcinoma
Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
This randomized phase III trial studies chemotherapy to see how well it works with or without bevacizumab in treating patients with head and neck squamous cell carcinoma that has come back (recurrent) or that has spread to other…
- Conditions
- Neck Squamous Cell Carcinoma of Unknown Primary, Recurrent Hypopharyngeal Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma, Recurrent Laryngeal Verrucous Carcinoma
- Trial name
- NCT00588770
- Testing
- Bevacizumab, Carboplatin, Cisplatin
- Where
- 779 sites in United States, Puerto Rico and 1 more
- Volunteers
- 403 people
- Sponsor
- National Cancer Institute (NCI)
Hip Impingement Syndrome, Prosthetic Complication
Retrospective Study on Radiological Factors Predictive of Psoas Impingement
The purpose of this study is to identify radiological factors on TC of the hip that could lead to prediction of development of symptomatic psoas impingement in patients with protruding acetabular cup after primary total hip…
- Trial name
- NCT05893823
- Testing
- Pelvis CT scan
- Where
- 2 sites in Italy
- Volunteers
- 52 people
- Sponsor
- Istituto Ortopedico Rizzoli
Noninflammatory Degenerative Joint Disease, Avascular Necrosis
Signature Acetabular Posterior/Lateral Data Collection
The primary purpose of this pilot study is to evaluate the accuracy of cup placement between two instrumentation technologies: Cutting Guide and Conventional Instrumentation.
- Conditions
- Noninflammatory Degenerative Joint Disease, Avascular Necrosis, Rheumatoid Arthritis
- Trial name
- NCT02220478
- Testing
- Posterior Lateral Approach Total Hip Arthroplasty
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet