Clinical trials: Caffeine
Healthy Adult Male
Acute Effects of Caffeine on Repeated Sprint Performance and Energy Distribution
The goal of this study is to learn if low-dose caffeinated coffee improves repeated sprint performance and affects energy system contributions in combat sports athletes.
- Trial name
- NCT07596511
- Testing
- Cycling Repeated Sprint Test (6 × 10 s), Breath-by-Breath VO₂ Monitoring - COSMED K5, Capillary Blood Lactate Sampling (non-invasive)
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Trabzon University
Healthy Volunteers
The Brain Alerting Mechanism Study
This is a study designed to look at how arousal levels in the brain change with age and how these changes influence thinking, vision, hearing and physical function in people of advanced age.
- Trial name
- NCT02050386
- Testing
- Cold pressor stimulation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Caffeine
Genetic Determinants of Cardiovascular Response to Coffee Drinking
Cardiovascular and neuropsychologic effects of coffee are still debated. The precise mechanism underlying the actions of caffeine on the cardiovascular and neuropsychologic systems is incompletely understood and a considerable…
- Trial name
- NCT01330680
- Testing
- Coffee, Decaffeinated coffee
- Where
- Italy
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Healthy
To Determine Blood Concentrations of Ibuprofen and Caffeine in a Tablet Against Ibuprofen Alone From Another Tablet
The objective of the trial is to compare to combination of 400 mg ibuprofen and 100 mg caffeine against 400 mg ibuprofen alone under fed conditions
- Trial name
- NCT02629354
- Testing
- Ibuprofen, Caffeine
- Where
- South Africa
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Caffeine
The Effects of Caffeine on Heart Rate and Heart Rate Variability
In previous research we have shown that an acute caffeine dose of 5 mg/kg body mass reduces heart rate at rest and during low intensity exercise, with the effect dissipating as exercise intensity increases.
- Trial name
- NCT05521386
- Testing
- Caffeine
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- St Mary's University College
Panic Disorder, Healthy
Effects of Caffeine on Anxiety, Emotional Processing, Approach-avoidance Behavior, and Interoception in Panic Disorder
The current study is a placebo-controlled, double-blind, randomized controlled study using a cross-over design, including participants with Panic disorder and healthy controls.
- Trial name
- NCT05261594
- Testing
- Caffeine
- Where
- Sweden
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Caffeine
Caffeine Supplementation, Resistance Training and Blood Antioxidant Status
The purpose of this study is to verify the effect of acute caffeine intake on resistance training volume and blood antioxidant status, in a randomised, double-blind, placebo-controlled crossover trial.
- Trial name
- NCT05230303
- Testing
- Caffeine supplementation
- Where
- Poland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Pediatric Obesity, Diet, Food, and Nutrition
Reducing Sugar-sweetened Beverage Consumption Among Children
Lowering sugar-sweetened beverage (SSB) consumption is a central component of lifestyle behavior change aimed at preventing and managing obesity, yet effective reduction of SSB intakes has been met with many challenges.
- Trial name
- NCT04025060
- Testing
- Commercially-available caffeine-free soda, Carbonated water, Regular soda
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- George Washington University
CYP1A2 Polymorphism, Caffeine and Resistance Training
Caffeine, CYPA12 and Resistance Training
Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance.
- Trial name
- NCT06610123
- Testing
- Caffeine and Resistance training
- Where
- Spain
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Caffeine, Athletic Performance
Caffeine Dose and Duration in Habitual Female Users
This study compares the effects of acute (single-session) and short-term (7-day) consumption of different doses of caffeine (3 and 6 mg/kg) on maximal strength, strength endurance, vertical jump, and medicine ball throw…
- Conditions
- Caffeine, Athletic Performance, Resistance Traaining
- Trial name
- NCT07830459
- Testing
- Caffeine 3 mg/kg, Caffeine 6 mg/kg
- Where
- Iran
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Birjand University of Medical Sciences
Chemotherapy-induced Nausea and Vomiting
An Open Label, Single Dose, Three Part Study to Assess the Effects of Rolapitant (2 mg/mL IV Solution) on the Pharmacokinetics of Digoxin; Sulfasalazine; and the Cooperstown Cocktail (Midazolam, Omeprazole, Warfarin, Caffeine, and Dextromethorphan in Healthy Subjects
The objective of this Open Label Study is to evaluate effects of Rolapitant IV solution, and its metabolite, on the pharmacokinetics (PK) of the P-gp substrate (digoxin), the BCRP substrate (sulfasalazine), and multiple…
- Trial name
- NCT02434861
- Testing
- Rolapitant, Digoxin, Sulfasalazine
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Tesaro, Inc.
Energy Expenditure
Efficacy of ONE A DAY Weightsmart Advanced Versus Caffeine and Placebo on Energy Expenditure, Thermogenesis and Perceived Energy Levels in Women.
The study is considered research because efficacy (how well a drug works) information is needed in healthy, 25-45 year-old, female subjects with moderate caffeine intake.
- Trial name
- NCT00781586
- Testing
- One-A-Day Weight S.A. (Multi-Vitamins, BAY94-9350), Caffeine
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Bayer
CORONARY ARTERY DISEASE
"Potential Effect of Acute and Chronic Caffeine Administration on Platelet Reactivity in Patient With Coronary Artery Disease on Dual Antiplatelet Therapy"
Prasugrel is a potent thienopyridine antiplatelet agent that selectively and irreversibly inhibits ADP-induced platelet aggregation mediated by the P2Y12 receptor.
- Trial name
- CyCLOPS (NCT02054988)
- Testing
- caffeine, not caffeine
- Where
- Italy
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Caffeine and Endurance Performance
The Effect of a Peat and Apple Extract on Muscle ATP and Exercise Performance
A study to test the hypothesis that a combined peat and apple extract will increase blood and muscle ATP, which will increase cycling performance
- Trial name
- APEX (NCT05641454)
- Testing
- ElevATP supplement
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Caffeine
The Repeatability of the Effect of Caffeine Supplementation on Submaximal Physiological Responses and Cycling Time Trial Performance
Recently, Grgic (2018) discussed the concept of responders and non-responders to caffeine supplementation highlighting the importance of the repeatability of results.
- Trial name
- NCT06935214
- Testing
- Caffeine
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- St. Mary's University, Twickenham
Emergence From Anesthesia
Turning Dexmedetomidine Into a Powerful Anesthetic That Can be Rapidly and Completely Reversed
In this study, the investigators will explore Atipamezole \& caffeine's ability to facilitate the emergence from anesthesia. Each subject will visit UChicago 4 times. The first time for informed consent.
- Trial name
- NCT04942340
- Testing
- Atipamezole & Caffeine, Dexmedetomidine Hydrochloride & Saline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Chicago
Caffeine
Caffeine, Resistance Exercise and EMG
Introduction: Several studies have evaluated and confirmed the ergogenic effects of acute caffeine intake on sports performance.
- Trial name
- NCT06606652
- Testing
- Caffeine
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Caffeine, Placebo
Caffeine Supplementation Improves the Cognitive Abilities and Shooting Performance of Trained E-sports Players
Purpose: investigators explored the effect of 3 mg/kg of caffeine supplementation on the cognitive ability and shooting performance of trained e-sports players.
- Trial name
- NCT05521347
- Testing
- caffeine
- Where
- Taiwan
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- National Taiwan Sport University
Cognitive Function 1, Social
Caffeine, DNA and Cognition
A study investigating the effects of acute caffeine intake on cognition based on genes associated with caffeine metabolism and physiological effect.
- Trial name
- NCT05806476
- Testing
- caffeine
- Where
- 2 sites in United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- St. Mary's University, Twickenham
Autonomic Nervous System, Cardiorespiratory Parameters
Acute Caffeine Effects on Cardiac Autonomic and Cardiorespiratory Parameters Responses After Aerobic Exercise
Check the acute influence of caffeine on the autonomic modulation and cardiorespiratory parameters after aerobic exercise. Hypothesized that caffeine can promote a slower recovery of the cardiorespiratory parameters and the SNA…
- Trial name
- NCT02917889
- Testing
- Caffeine, Cardiopulmonary test, Treadmill aerobic exercise
- Where
- Brazil
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho