Clinical trials: Calprotectin
Crohn Disease
Evaluation of Immunological Markers, Inflammatory and Clinical Relapse Psychological Predictive During Crohn's Disease
Crohn disease (CD) usually evolves by surges interspersed by periods of unpredictable remission. the probability of recurrence of CD in a patient in remission is even stronger if it pre-exists endoscopic lesions of the intestinal…
- Trial name
- NCT02504255
- Testing
- Biological samplings, Questionnaires
- Where
- 3 sites in France
- Volunteers
- 144 people
- Sponsor
- Hospices Civils de Lyon
Crohn's Disease
Capsule Colonoscopy in Crohn's Disease and Its Correlation With Conventional Colonoscopy and Faecal Calprotectin
Aims: To study the feasibility of capsule colonoscopy in patients with Crohn's Disease (CD). To compare the results of capsule colonoscopy with conventional colonoscopy in assessing mucosal healing.
- Trial name
- NCT02624414
- Testing
- PillCam® COLON 2 Capsule Endoscopy
- Where
- Australia
- Volunteers
- 47 people
- Sponsor
- Melbourne Health
Cystic Fibrosis
Polyethylene Glycol and Intestinal Inflammation in Cystic Fibrosis
The main objective of the study is to evaluate the effectiveness of polyethylene glycol treatment on intestinal inflammation in children with cystic fibrosis.
- Trial name
- MUCOLAX (NCT04458129)
- Testing
- Treatment with polyethylene glycol (Macrogol 4000)
- Where
- France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Bordeaux
Inflammatory Bowel Diseases, Crohn Disease
Remote Monitoring of IBD
Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBD) with a heterogeneous disease course.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT05886322
- Testing
- patient reported outcome measures, fecal calprotectin, colonoscopy
- Where
- 5 sites in Netherlands
- Volunteers
- 400 people
- Sponsor
- Maastricht University Medical Center
Diarrhea Chronic, UC - Ulcerative Colitis
ND-12 Combined With H-6 for Adult Chronic Inflammatory Diarrhea
This is a randomized controlled trial to explore the efficacy and safety of ND-12 combined with H-6 for patients with chronic inflammatory diarrhea
- Trial name
- NCT07767370
- Testing
- mesalazine, ND-12, ND-12/H-6
- Where
- China
- Volunteers
- 36 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Preterms With Gestational Age Ranging From 30 to 35 Weeks
Evaluation of Safety, Tolerance and Effects on the Intestinal Flora of a New Fermented Milk for Preterm Infants
The intestinal flora is a complex ecosystem which is known to play various important functions in the gut. Recent data have reported a delay in intestinal colonization in preterm.
- Trial name
- NCT00711633
- Testing
- Milk with probiotic and prebiotic activities, Milk without probiotic and prebiotic activities
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity, Childhood, NAFLD
Can Fecal Calprotectin Be Used as a Biomarker of Non-alcoholic Fatty Liver Disease In Obese Adolescents?
The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing with obesity, and it is believed that ongoing inflammation in obesity and alterations in the enterohepatic axis contribute to this process.
- Trial name
- NCT06229184
- Testing
- Fecal Calprotectin Test
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Inflammatory Bowel Disease, Crohn Disease
Deep Endoscopic Remission Assessed by a Surrogate Biomarker in Patients With Inflammatory Bowel Disease
We hypothesize that the number of needed endoscopic procedure performed at IBD patients (adult and children), can be reduced by using an individualized algorithm of symptoms, blood and faecal biomarkers.
- Conditions
- Inflammatory Bowel Disease, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT01861288
- Where
- Denmark
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Inflammatory Bowel Diseases, Crohn Disease
IBD Self-management Website and Home Faecal Calprotectin Monitoring
6 month exploratory feasibility study to assess if a combination of MyMedicalRecord supported self-management website and a home faecal calprotectin smartphone testing kit is a feasible and acceptable means for patients to…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Self-care
- Trial name
- NCT03671980
- Testing
- My Medical record website
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Inflammatory Bowel Diseases, Calprotectin
Effect of Semi-vegetarian Diet in Inflammatory Bowel Disease Patients With Clinical Remission
In the 21st century, the incidence of inflammatory bowel disease (IBD) globally increases. Higher incidence of IBD development may implicate that environmental factors played essential roles in IBD pathogenesis.
- Conditions
- Inflammatory Bowel Diseases, Calprotectin, Fecal Microbiota, Vegetarian Diet
- Trial name
- NCT04835727
- Testing
- Semi-vegetarian diet and increase fiber consumption
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Inflammatory Bowel Diseases
EURECA (EUropeanRElapseCAlprotectin) Study
This study will investigate the correlation of fecal calprotectin (FC) values to quiescent ulcerative colitis and to disease activity (relapse) as assessed by clinical data and endoscopy.
- Trial name
- NCT05168917
- Testing
- LIAISON Calprotectin
- Where
- 3 sites in France, Italy and 1 more
- Volunteers
- 225 people
- Sponsor
- DiaSorin Inc.
Inflammatory Bowel Diseases, Irritable Bowel Syndrome
ALPCO Calprotectin ELISA - Measurement of Calprotectin Levels in Human Stool
The ALPCO Calprotectin ELISA is an in vitro diagnostic test intended to quantitatively measure concentrations of fecal calprotectin in human stool samples. Calprotectin is a protein biomarker of mucosal inflammation.
- Trial name
- NCT03082287
- Testing
- Fecal Calprotectin Level
- Where
- United States
- Volunteers
- 424 people, healthy volunteers welcome
- Sponsor
- American Laboratory Products Company
Hirschprung's Disease, Hirschsprung Disease
Babies With Enterocolitis - A Study of Faecal Calprotectin in Hirschsprung Disease (The BEACH Study)
Babies with Hirschsprung's Disease are born without normal nerves to the end of their bowel which means they cannot poo properly, and are at high risk of infection of the bowel, called enterocolitis.
- Conditions
- Hirschprung's Disease, Hirschsprung Disease, Hirschsprung's Disease Associated Enterocolitis
- Trial name
- BEACH (NCT06592534)
- Volunteers
- 50 people
- Sponsor
- Alder Hey Children's NHS Foundation Trust
Irritable Bowel
Effect of 6 Weeks Daily Consumption of a Cereal-based Juice Beverage on Gastrointestinal Health
The project is a randomized, 2-way, blinded parallel trial in which 56 healthy adults of both genders with frequent occurrence of stomach trouble.This intervention trial with 6 weeks of daily intake β-glucans will be carried out…
- Trial name
- NEWDRINK (NCT03046667)
- Testing
- Barley β-glucan, Control
- Where
- Denmark
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Crohn Disease
The Intensive Post Exclusive Enteral Nutrition Study
Crohn's disease (CD) is a chronic inflammatory condition with phases where the disease is active and other, where there are no symptoms.
- Trial name
- iPENS (NCT04225689)
- Testing
- CD-TREAT diet
- Where
- 5 sites in United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Necrotising Enterocolitis Neonatal
Calprotectin Levels in Necrotizing Enterocolitis
Necrotizing enterocolitis (NEC) is a serious condition that can affect premature babies, leading to complications like intestinal damage and infection.
- Trial name
- NCT06693154
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people
- Sponsor
- Ankara Yildirim Beyazıt University
Inflammatory Bowel Diseases, Crohn's Disease
Home Versus Postal Testing for Faecal Calprotectin: a Feasibility Study
This trial will test, in a representative group of IBD patients, the acceptability of - and adherence to - the IBDoc test (a new home test for faecal calprotectin in the monitoring of inflammatory bowel disease (IBD)).
- Conditions
- Inflammatory Bowel Diseases, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT02542917
- Testing
- IBDoc home test for faecal calprotectin
- Volunteers
- 54 people
- Sponsor
- King's College Hospital NHS Trust
FPIES
Longitudinal Study of the Intestinal, Cutaneous and Salivary Microbiota in Children With Food-induced Enterocolitis Syndrome (SEIPA)
Food Protein-Induced Enterocolitis Syndrome (FPIES) is a non IgE-mediated allergy, presenting with vomiting, and may be complicated by hypovolemic shock.
- Trial name
- SEIBIOTE (NCT04081415)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Crohn's Disease
An Observational Study of Fecal Calprotectin as Clinical Tool in Monitoring Moderate-to-severe Crohn's Disease on Adalimumab Induction Therapy: a KoRean Experience (FAIR)
The objective of this observational study was to assess changes in fecal calprotectin levels and its suitability as a monitoring tool in participants with moderate-to-severe Crohn's Disease who were treated with adalimumab.
- Trial name
- FAIR (NCT01759264)
- Volunteers
- 101 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Ulcerative Colitis
A Study to Determine Whether Urinary PGE-M Levels Correlate With Ulcerative Colitis Disease
The purpose of this study is to determine whether urinary PGE-M levels correlate with Ulcerative Colitis Disease activity and to compare how well urinary PGEm correlates with other noninvasive biomarkers of disease activity such…
- Trial name
- NCT00409396
- Testing
- Urinary PGEm level, fecal calprotectin
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Vanderbilt University