Clinical trials: Cancer Patients and Physical Activity
Bladder Cancer, Cystectomy
A Home-based Lifestyle Intervention for Optimizing Surgical Outcomes Among Urinary Bladder Cancer Patients
The purpose of this study is to test a randomized, controlled diet and physical activity intervention designed to be simple and address barriers to participation in lifestyle intervention among 16 urinary bladder cancer patients.
- Conditions
- Bladder Cancer, Cystectomy, Chemotherapy
- Trial name
- BOOST (NCT06002269)
- Testing
- Dietary and Exercise Intervention
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Utah
Non Hodgkin Lymphoma, Heart; Functional Disturbance
Improving Exercise Capacity With a Tailored Physical Activity Intervention
The purpose of this research is to test whether participating in either a physical activity intervention or a series of educational classes will help to preserve exercise capability, heart function, brain-based activities (like…
- Conditions
- Non Hodgkin Lymphoma, Heart; Functional Disturbance, Hodgkin Lymphoma, Quality of Life
- Trial name
- PALS (NCT05595577)
- Testing
- Exercise with Trainerize application, Cardiopulmonary exercise testing, MRI scan
- Where
- 2 sites in United States
- Volunteers
- 105 people
- Sponsor
- Wake Forest University Health Sciences
Preoperative Physical Exercise Training, Aerobic Capacity
Home-based Prehabilitation in Pancreatic Resection
Rationale: The complication rate after pancreatic resection is high, especially in elderly and physically unfit patients. Aerobic capacity, as indicated by the ventilatory anaerobic threshold (VAT) assessed by a cardiopulmonary…
- Conditions
- Preoperative Physical Exercise Training, Aerobic Capacity, Aerobic Fitness, Functional Mobility
- Trial name
- NCT05496777
- Testing
- Home-based prehabilitation program
- Where
- 3 sites in Italy, Netherlands
- Volunteers
- 45 people
- Sponsor
- Nicole Hildebrand
Advanced Solid Tumors
First-In-Human Study in Participants With Advanced Solid Tumors
A Phase 1 Study of KH815 for Injection to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumor Activity in Patients with Advanced Solid Tumors
- Trial name
- NCT06885645
- Testing
- KH815 for injection
- Volunteers
- 30 people
- Sponsor
- Chengdu Kanghong Biotech Co., Ltd.
Acute Myeloid Leukemia
Safety Study Evaluating Intravenous Infusions of Tigecycline to Treat Acute Myeloid Leukemia
The purpose of this study is to determine whether tigecycline is safe and which dosage is most effective in the treatment of patients with acute myeloid leukemia.
- Trial name
- NCT01332786
- Testing
- Tigecycline
- Where
- 3 sites in United States, Canada
- Volunteers
- 27 people
- Sponsor
- University Health Network, Toronto
Ovarian Carcinoma
Evaluation of Pretreatment Sarcopenia in Patients With Inoperable High-grade Ovarian Carcinoma as Part of Optimised Management
Prospective, monocentric study evaluating the presence of sarcopenia prior to neoadjuvant chemotherapy and during chemotherapy as part of optimised management.
- Trial name
- OPTIMOVA (NCT05415527)
- Testing
- Presence of sarcopenia evaluated prior to neoadjuvant chemotherapy and during chemotherapy as part of optimised management(dietician and APA).
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Institut Bergonié
Non-small Cell Lung Cancer, Head and Neck Cancer
A First-in-Human Study of JAB-3068 (SHP2 Inhibitor) in Adult Patients With Advanced Solid Tumors in China
This is a Phase 1/2a, open-label, multi-center study of JAB-3068 in Patients with advanced solid tumors.This study has two phases: dose escalation phase and dose expansion phase.
- Conditions
- Non-small Cell Lung Cancer, Head and Neck Cancer, Esophageal Cancer, Other Metastatic Solid Tumors
- Trial name
- NCT03565003
- Testing
- JAB-3068
- Where
- 4 sites in China
- Volunteers
- 126 people
- Sponsor
- Jacobio Pharmaceuticals Co., Ltd.
NSCLC (Non-small Cell Lung Cancer), Solid Tumor
A Phase 1/2, Open-label, Multicenter, FIH Study to Evaluate Safety, Tolerability, PK and Anti-tumor Activity of YH42946
The goal of this YH42946-101 is to evaluate the safety, Tolerability, Pharmacokinetics and anti-tumor activity of YH42946 in patients with locally advanced of metastatic solid tumors with HER2 aberration and EGFR exon 20…
- Trial name
- NCT06616766
- Testing
- YH42946
- Where
- 8 sites in United States, South Korea
- Volunteers
- 201 people
- Sponsor
- Yuhan Corporation
Chemotherapy-induced Peripheral Neuropathy
Exercises for Patients Who Were Receiving Chemotherapy
To evaluate the effect of lower extremity strengthening and balance exercises on balance, quality of life and neuropathic pain of the cancer patients receiving neurotoxic chemotherapy.
- Trial name
- NCT03798379
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hitit University
Colorectal Cancer
Pedometer Intervention and Health Effects for Sedentary Colorectal Cancer Patients During Adjuvant Chemotherapy
Colorectal cancer is one of the most common cancers in Denmark, annually 4,200 men and women are diagnosed and approx. 2000 patients die of their colorectal cancer.
- Trial name
- NCT02522520
- Testing
- Pedometer intervention, Pedometer + hospital based intervention, Omron Walking Style pro. 20
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Carcinoma, Hepatocellular
A Dose-Finding and Exploratory Study of RO5323441 in Combination With Sorafenib in Patients With Hepatocellular Carcinoma
This open-label study will assess the safety, efficacy and pharmacokinetics of RO5323441 in combination with sorafenib in patients with advanced or metastatic hepatocellular carcinoma previously untreated with systemic therapy.
- Trial name
- NCT01308723
- Testing
- RO5323441, sorafenib
- Where
- 2 sites in Singapore
- Volunteers
- 6 people
- Sponsor
- Hoffmann-La Roche
Advanced Solid Tumors, Pancreatic Cancer
Phase 1/2 Study to Evaluate Safety, PK and Efficacy of the MYC-Inhibitor OMO-103 in Solid Tumours
This study is an open label, two-part, First in Human (FIH) Phase 1/2 dose-finding study designed to determine the safety, tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD) and proof-of-concept (POC) of OMO-103 in…
- Conditions
- Advanced Solid Tumors, Pancreatic Cancer, CRC
- Trial name
- MYCure (NCT04808362)
- Testing
- OMO-103
- Where
- 3 sites in Spain
- Volunteers
- 22 people
- Sponsor
- Peptomyc S.L.
Gastric Cancer, Triple Negative Breast Cancer
A Study of Niraparib Combined With MGD013 in Patients With Advanced or Metastatic Solid Tumor Who Failed Prior Treatment
This is a a Multicenter, Open-label, Single-arm, Phase Ib Dose Escalation and Multi-cohort Expansion Clinical Study to Assess the Safety and Antitumor Activity of Niraparib in Combination with MGD013 in Patients with Advanced or…
- Conditions
- Gastric Cancer, Triple Negative Breast Cancer, Biliary Tract Carcinoma, Endometrial Carcinoma
- Trial name
- NCT04178460
- Testing
- Niraparib combined with MGD013
- Where
- 19 sites in China
- Volunteers
- 60 people
- Sponsor
- Zai Lab (Shanghai) Co., Ltd.
Rheumatoid Arthritis
Exercise-induced Cardiac Adaptions in Rheumatoid Arthritis Patients During IL-6 vs. TNF Antibody Therapy
The present study will investigative the physiological effects of the cytokines interleukin-6 (IL-6) and tumor necrosis factor (TNF) on the adaptive changes to exercise in patients with rheumatoid arthritis.
- Trial name
- RABEX (NCT05215509)
- Testing
- Exercise, No exercise
- Where
- Denmark
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Newly Diagnosed Glioblastoma
Efficacy and Safety Study of GX-I7 Plus Adjuvant Temozolomide Combination in Patients With Newly Diagnosed Glioblastoma
This is a phase 1/2, randomized, placebo-controlled study to evaluate safety, tolerability, anti-tumor activity and impact on absolute lymphocyte count of GX-I7 plus adjuvant temozolomide combination regimen in patients with…
- Trial name
- NCT04065087
- Testing
- GX-I7
- Where
- South Korea
- Sponsor
- Genexine, Inc.
Solid Tumor
A First-in-human of Multiplle Doses of BB-1705 in Subjects With Locally Advanced/Metastatic Solid Tumors
The study consists of two phases: dose-escalation (Phase I) and cohort expansion (Phase II).
- Trial name
- NCT05217693
- Testing
- BB-1705
- Where
- 7 sites in China
- Volunteers
- 288 people
- Sponsor
- Bliss Biopharmaceutical (Hangzhou) Co., Ltd
Breast Cancer, Fatigue
Exercise Testing for Early Stage Breast Cancer Patients Receiving Radiation Treatment
Many patients receiving radiation therapy for breast cancer experience fatigue although doctors do not fully understand why. The purpose of this study is to test if patients who experience fatigue during radiation treatment for…
- Trial name
- NCT02836093
- Testing
- FACIT-Fatigue 52-point questionnaire
- Where
- 7 sites in United States
- Volunteers
- 45 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Non-small Cell Lung Cancer
BPI-7711 Capsule in Patients With EGFR Mutation T790M Positive Non-small Cell Lung Cancer
Lung cancer has the highest incidence rate in China and is also a very common cancer in the world. BPI-7711 is a new drug developed for patients with non-small cell lung cancer.
- Trial name
- NCT03386955
- Testing
- BPI-7711 Capsule
- Where
- 4 sites in China
- Volunteers
- 215 people
- Sponsor
- Beta Pharma Shanghai
Cardiovascular Diseases, Cardiovascular Risk Factor
Cooking for Health Optimization With Patients
Cooking for Health Optimization with Patients (CHOP) is the first known multi-site prospective cohort study with a nested Bayesian adaptive randomized trial in the preventive cardiology field of culinary medicine.
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Nutrition Disorders, Diabetes
- Trial name
- CHOP (NCT03443635)
- Testing
- Treatment
- Where
- United States
- Volunteers
- 7,192 people, healthy volunteers welcome
- Sponsor
- Tulane University
Cancer, Muscle Atrophy
Influence of Motor Proteins on Muscle Atrophy in Cancer Patients
The aim of the study is to investigate the effect of exercise in form of whole-body electromyostimulation (WB-EMS) on early tumor-induced muscular dysfunction.
- Trial name
- NCT03551990
- Testing
- whole-body electromyostimulation WB-EMS
- Where
- Germany
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
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