Clinical trials: Cancer Progression
Progression From Impaired Fasting Glucose to Diabetes Mellitus
Progression From Impaired Fasting Glucose to Diabetes Mellitus Among Chinese
Impaired fasting glucose (IFG), a significant risk factor for diabetes mellitus (DM), is commonly encountered in the primary care setting and represents an important target for DM prevention.
- Trial name
- NCT03617757
- Testing
- Oral Glucose Tolerance Test, HbA1c
- Where
- 3 sites in Hong Kong
- Volunteers
- 386 people
- Sponsor
- The University of Hong Kong
Chronic Pancreatitis
A Prospective Study of Natural History of Pancreatitis
To prospectively define the natural history and the clinical, laboratory and histomorphometric features of chronic pancreatitis (CP) of varying etiology.
- Trial name
- NCT00685087
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Virginia Commonwealth University
Parkinson Disease
Synaptic Density and Progression of Parkinson's Disease.
AIM: To assess synaptic density and to investigate the potential relationship of regional synaptic loss with motor and non-motor symptoms and with disease progression in the human brain in vivo in patients with PD.
- Trial name
- NCT04243304
- Testing
- 11C-UCB-J PET-CT, 18F-PE2I PET-MR
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cancer
Sutent and Radiation as Treatment for Limited Extent Metastatic Cancer
Cancer is the second leading cause of death in the United States, with approximately 90% of deaths resulting from patients with metastatic spread.
- Trial name
- NCT00463060
- Testing
- sunitinib malate (Sutent), radiotherapy
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Branch Atheromatous Disease, Cognitive
Cognitive Outcomes in BAD-related Stroke
Branch atheromatous disease (BAD) is a distinct subtype of ischemic stroke that is particularly prevalent among Chinese and other Asian populations.
- Conditions
- Branch Atheromatous Disease, Cognitive, Deterioration, Clinical
- Trial name
- NCT07761182
- Testing
- END exposure
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Glioma
Differentiation of Progression From Treatment Effects in High-Grade Gliomas: A Clinical Trial With Multimodality MR Imaging
To evaluate the efficacy of multi-modality magnetic resonance quantitative parameters in evaluating the treatment effects of high-grade gliomas, and to provide new biomarkers for the establishment of new diagnostic criteria for…
- Trial name
- NCT03102203
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Jinling Hospital, China
Myopia
Myopia Intervention in Children and Adolescents and Establishment of a Precise Intervention Model
Investigators are going to conduct a multi-centered randomized clinical trial that myopic children are randomly allocated into three groups: 0.01% atropine， 0.04% atropine and orthokeratology in order to evaluate the efficacy and…
- Trial name
- NCT05357326
- Testing
- Atropine Sulfate 0.01% Eye Drop, Orthokeratology, Atropine Sulfate 0.04% Eye Drop
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Gastric Cancer
Erbitux in Combination With Xeloda and Cisplatin in Advanced Esophago-gastric Cancer
The primary objective of this study is to demonstrate that addition of cetuximab to 1st-line treatment with capecitabine (Xeloda, X) and cisplatin (P) [XP] chemotherapy regimen has a clinically relevant benefit for subjects with…
- Trial name
- EXPAND (NCT00678535)
- Testing
- Cetuximab, Capecitabine, Cisplatin
- Where
- 130 sites in Argentina, Australia and 23 more
- Volunteers
- 904 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Oral Uremic Toxin Absorbent
Study of Oral Uremic Toxin Absorbent/Probiotics to Modulate Systemic Inflammation and Retard the Progression of Chronic Kidney Disease in Patients With Diabetes.
Diabetes mellitus (DM) is a chronic inflammatory disease characterized by insufficient insulin secretion or insulin resistance, leading to hyperglycemia.
- Trial name
- NCT07333313
- Testing
- oral uremic toxin absorbent, probiotics, oral uremic toxin absorbent + probiotics
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Cystic Fibrosis, Pseudomonas Aeruginosa Airway Infection
Aztreonam Lysine for Inhalation in Patients With Cystic Fibrosis and Pseudomonas Aeruginosa Airway Infection
The primary objective of this program is to provide expanded access to aztreonam lysine for inhalation (AZLI) 75 mg prior to its commercial availability to patients with cystic fibrosis (CF) and chronic P.
- Trial name
- NCT00499720
- Testing
- Aztreonam Lysine for Inhalation
- Where
- 65 sites in United States, Puerto Rico
- Sponsor
- Gilead Sciences
Uterine Contraction, Oxytocin
The Influence of Oxytocin on Intrapartum Fetal Well-being and Delivery Outcomes in Patients Receiving Epidural Analgesia
The aim of this study is to determine the influence of oxytocin on fetal well-being during labor in patients receiving epidural analgesia (ELA) with the use of cardiotocography (CTG) and doppler ultrasonography.
- Conditions
- Uterine Contraction, Oxytocin, Labor Progress, Fetal Doppler
- Trial name
- NCT06403982
- Testing
- Continuation of oxytocin after ELA, Discontinuation of oxytocin after ELA
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland
Castration Levels of Testosterone, Castration-Resistant Prostate Carcinoma
Abiraterone Acetate, Prednisone, and Apalutamide With or Without Ipilimumab or Cabazitaxel and Carboplatin in Treating Patients With Metastatic Castration-Resistant Prostate Cancer
This randomized phase II trial studies the side effects and how well abiraterone acetate, prednisone, and apalutamide work with or without ipilimumab or cabazitaxel and carboplatin in treating patients with castration-resistant…
- Conditions
- Castration Levels of Testosterone, Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma, PSA Progression
- Trial name
- NCT02703623
- Testing
- Abiraterone Acetate, Apalutamide, Cabazitaxel
- Where
- 3 sites in United States
- Volunteers
- 196 people
- Sponsor
- M.D. Anderson Cancer Center
Multiple Sclerosis
Analysis of a Biomarker Signature in Patients With Multiple Sclerosis (MS) Treated With Gilenya (FTY720)
This study investigates whether there is a link between disease activity/progression in patients receiving Gilenya and expression of a putative biomarker signature in patients with multiple sclerosis.
- Trial name
- MS (NCT02408380)
- Where
- Canada
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- McGill University
Endocrine Tumors
Study of Lanreotide Autogel in Non-functioning Entero-pancreatic Endocrine Tumours
The study will compare the difference between lanreotide Autogel and placebo on progression free survival in patients who have an endocrine tumour in the pancreas or intestines.
- Trial name
- CLARINET (NCT00353496)
- Testing
- lanreotide (Autogel formulation)
- Where
- 71 sites in United States, Austria and 13 more
- Volunteers
- 264 people
- Sponsor
- Ipsen
Aortic Valve Stenosis
PCSK9 Inhibitors in the Progression of Aortic Stenosis
Investigators plan evaluate whether PCSK9 inhibitors, a medication that can lower lipoprotein(a) and control dyslipidemia, can inhibit the progression of aortic stenosis, through a randomized controlled trial.
- Trial name
- NCT03051360
- Testing
- PCSK9 Inhibitor [EPC]
- Where
- South Korea
- Volunteers
- 140 people
- Sponsor
- Seoul National University Hospital
Cerebral Infarction, Subcortical Infarction
Early Neurological Deterioration in Recent Small Subcortical Infarction
Recent small subcortical infarction (RSSI) is defined as a small deep infarction in the territory of a perforating artery with maximum axial diameters (MAD) of less than 20 mm.
- Conditions
- Cerebral Infarction, Subcortical Infarction, Deterioration, Clinical, Progression
- Trial name
- NCT05679986
- Testing
- no intervention
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Yuan Gao
Chronic Kidney Disease stage4
Factors Influencing Risk of Progression of Chronic Kidney Disease
The aim of this study is to identify typical patterns of renal function evolution in patients with stage 4 chronic kidney disease, regularly followed in nephrology consultation and included in a French cohort.
- Trial name
- FAIR-PROGRESS (NCT03954470)
- Where
- France
- Volunteers
- 1,300 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Asthma
Progression of Airway Obstruction in Childhood Asthma
Distinct patterns of loss in pulmonary function were identified in children with mild to moderate asthma participating in a 10-year observation period during the NHLBI Childhood Asthma Management Program.
- Trial name
- NCT00873873
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- National Jewish Health
Parkinson Disease
Effect of Fecal Microbiota Transfer on Progression of Parkinson Disease
The aim of the study is to assess impact of Fecal Microbiota Transfer (FMT) on clinical symptoms of Parkinson's disease. Assesment of tremor, slowness of movements and balance problems before and after FMT will be performed.
- Trial name
- EFFACE-PD (NCT05204641)
- Testing
- Fecal Microbiota Transfer provided by Human Biome Institute
- Where
- Poland
- Volunteers
- 59 people
- Sponsor
- Medical University of Warsaw
Pulmonary Fibrosis, Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis
Senicapoc in Patients With Worsening Fibrotic Interstitial Lung Disease
This study will investigate whether the senicapoc drug can prevent the scarring from worsening in interstitial lung disease. Researchers will compare Senicapoc to a placebo (a look-alike substance that contains no drug) to see if…
- Trial name
- FIBROPOC (NCT06714123)
- Testing
- Senicapoc
- Where
- 5 sites in Denmark, Estonia and 1 more
- Volunteers
- 140 people
- Sponsor
- Vejle Hospital
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