Clinical trials: Cardiac Conditions
Chronic Obstructive Pulmonary Disease
USCOM For Assessing Patients With COPD
Objective The Ultrasonic Cardiac Output Monitor (USCOM) is a non-invasive, quantitative method for measuring and monitoring cardiovascular haemodynamic parameters in patients. The aims of this study are: 1.
- Trial name
- NCT02329522
- Testing
- Ultrasonic Cardiac Output Monitor, Spirometry
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Paroxysmal Atrial Fibrillation, Catheter Ablation Strategies
Unexcitability Along the Ablation as an Endpoint for Atrial Fibrillation Ablation
to assess the near-term (12 months) efficacy of pulmonary vein isolation.
- Trial name
- NCT01724437
- Testing
- catheter based pulmonary vein isolation
- Where
- Germany
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Pain, Anxiety
The Effect of Cold Spray Applied Before Local Anaesthesia
Coronary angiography is a reliable and valid method used in the diagnosis of Coronary Artery Disease (CAD). Coronary angiography is defined as the process of obtaining cineangiographic images by administering radio-opaque…
- Conditions
- Pain, Anxiety, Coronary Artery Disease
- Trial name
- EffectofCold (NCT06035237)
- Testing
- Cold Spray
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ozkan Sir
Atrial Fibrillation Paroxysmal, Catheter Ablation
Randomized Trial: High Power Short Duration Versus Ablation Index
The single procedure success rates of durable pulmonary vein isolation (PVI) for paroxysmal atrial fibrillation (PAF) varies between 80 and 90 %.
- Trial name
- NCT05251545
- Testing
- Pulmonary vein isolation
- Where
- Germany
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Robert Bosch Medical Center
Visceral Obesity, Atherosclerosis
Abdominal Fat and Imaging Measurements of Heart Disease
Although it is frequently mentioned in the media that overweight and obesity have reached epidemic proportions worldwide and in this country, some Canadians are perplexed and sometimes confused about the role of obesity in…
- Conditions
- Visceral Obesity, Atherosclerosis, Metabolic Syndrome
- Trial name
- NCT01447745
- Where
- Canada
- Volunteers
- 357 people, healthy volunteers welcome
- Sponsor
- Laval University
Orphan Cholestatic Liver Diseases, Progressive Familial Intrahepatic Cholestasis
An Open Label, Single-dose, Single Period ADME Study of A4250 in Healthy Subjects
The primary objectives of the study are to assess the mass balance recovery after a single dose of carbon-14 [14C]-A4250 as a capsule and to provide plasma, urine and faecal samples for metabolite profiling and structural…
- Conditions
- Orphan Cholestatic Liver Diseases, Progressive Familial Intrahepatic Cholestasis, Alagille Syndrome, Primary Biliary Cirrhosis
- Trial name
- NCT03082937
- Testing
- 3 mg [14C]-A4250 capsule
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Albireo
Persistent Atrial Fibrillation
Liner Ablation Using Contact-force in Atrial Fibrillation
Linear ablation is frequently used in the procedure for persistent atrial fibrillation. However, it has a limitation because of technical difficulty. Incomplete block is common and an important cause of atrial tachycardia.
- Trial name
- LIBCAAF (NCT03091972)
- Testing
- Pulmonary vein isolation, Contact force assisted left atrial linear ablation, left atrial linear ablation without contact force monitoring
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Hypotension, Tachycardia
Processing and Effects of Cannabis
The purpose of this study is to investigate the processing of cannabis, and to investigate the occurrence of effects of cannabis on the cardiovascular system and the central nervous system; at higher levels of exposure.
- Trial name
- NCT00225407
- Testing
- Smoking of cannabis cigarettes (different strength)
- Where
- Netherlands
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Atrial Fibrillation
An Interaction Study With Digoxin and AZD1305
The primary purpose of this study is to learn more about how digoxin is handled by the body, i.e. absorption, distribution, metabolism and excretion, when administered alone and in combination with AZD1305.
- Trial name
- NCT00712465
- Testing
- AZD1305, Digoxin
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Sepsis, Septic Shock
The Role of Serotonin in Intensive Care Patients
Sepsis, cardiac arrest and multiple trauma are potentially life-threatening conditions and common reasons for intensive care unit (ICU) admission.
- Conditions
- Sepsis, Septic Shock, Cardiac Arrest With Successful Resuscitation, Multiple Trauma
- Trial name
- SERO-22 (NCT05386199)
- Where
- Norway
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Acute Coronary Syndrome, Myocardial Infarction
Hepatocyte Growth Factor (HGF) Concentration in Myocardial Infarction
This is the continuation of previous study (registration number: NCT00844987) which revealed that hepatocyte growth factor (HGF) is a very early, good marker of myocardial injury and prognostic factor for post myocardial…
- Trial name
- NCT01233336
- Where
- Poland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Atrial Fibrillation
Assessment of the Clinical Efficacy of the Heart Spectrum Blood Pressure Monitor for Diagnosis of Atrial Fibrillation
Question: Is 12-lead electrocardiography (ECG) the most accurate and convenient diagnostic method for atrial fibrillation (AF)? Findings: The Heart Spectrum Blood Pressure Monitor can be used at home, and is capable of…
- Trial name
- NCT03095131
- Testing
- Heart Spectrum Blood Pressure Monitor
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Ostar Meditech Corp
Heart Failure, Atrial Fibrillation
Exercise Training in Patients With Heart Failure and Permanent Atrial Fibrillation
The positive effect of physical training in patients with heart failure (HF) has been increasingly established. However, the presence of atrial fibrillation (AF), mainly in its permanent form, makes the clinical condition of the…
- Trial name
- NCT03550872
- Testing
- Physical Training
- Where
- Brazil
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Healthy
A Study to Evaluate the Pharmacokinetics and the Effect on Cardiac Repolarization of Odalasvir Administered as a Single Dose Tablet Under Fed Conditions in Healthy Participants
The purpose of this study is to determine the relationship between the plasma concentrations of odalasvir and changes in the QT interval / QTc interval (QT corrected for heart rate) using exposure-response (ER) analysis.
- Trial name
- NCT02889367
- Testing
- Odalasvir 100 mg, Odalasvir 500 mg, Odalasvir (Up to maximum 1000 mg)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Atrial Fibrillation, Hypertension, Pulmonary
Safety Procedure Pulmonary Artery Denervation in Addition to Pulmonary Vein Isolation Combined With Ganglionated Plexi Ablation in Patients With Persistent Atrial Fibrillation and Pulmonary Hypertension
Some patients with a long history of AF develops PH "reactive" type with an increase in pulmonary vascular resistance due to vasoconstriction or structural changes of the vascular wall.
- Conditions
- Atrial Fibrillation, Hypertension, Pulmonary, Heart Diseases, Arrhythmias, Cardiac
- Trial name
- NCT02298244
- Testing
- PV isolation + GP Ablation, PV isolation + GP ablation + Pulmonary GP ablation
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Krasnoyarsk Regional Hospital
Pain Management
Effectiveness of Bupivacaine, Ketorolac, Ketamine, vs Bupivacaine Alone in Reducing Postoperative Pocket Pain
Bupivacaine is the most widely used local anesthetic agent across majority of the Cardiac Implantable Electronic device (CIED) implant procedures in the United States.
- Trial name
- NCT05575999
- Testing
- Bupivacaine alone OR Bupivacaine-Ketorolac-Ketamine (BKK) Combination
- Where
- 3 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Arrhythmias, Cardiac, Tachycardia, Ventricular
Cardiac Arrhythmias at Extreme Altitude
Background: Exposure to high altitudes has been associated with an increased risk of cardiac arrhythmias in healthy subjects and an increased risk of sudden cardiac death.
- Conditions
- Arrhythmias, Cardiac, Tachycardia, Ventricular, Tachycardia, Supraventricular, Bradycardia
- Trial name
- SUMMIT (NCT05676398)
- Testing
- Ambulatory rhythm recording
- Where
- Nepal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Postoperative Cardiorespiratory Failure
Hypertonic Saline-hetastarch in Cardiac Surgery
Cardiopulmonary bypass(CPB) is associated with increased fluid extravasation and edema formation. A continuous infusion of a mixture of hypertonic saline/hydroxyethyl starch (HSH)during CPB reduced fluid extravasation and total…
- Trial name
- HH (NCT00469716)
- Testing
- Hypertonic saline (7.2%) hetastarch (6 %)(200/0.5)
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Long QT Syndrome
Long QT Syndrome Screening in Newborns
The purpose of this project is to test a new, very compact, 12-lead ECG device as a way to detect long QT syndrome (LQTS) in infants. The device -- called QTScreen -- was developed in Phase I of this project.
- Trial name
- NCT02412709
- Testing
- QTScreen ECG Recorder
- Where
- 3 sites in United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- QT Medical, Inc.
Pregnancy, Labor Pain
Association Between Fluid Administration, Oxytocin Administration, and Fetal Heart Rate Changes
Fetal heart rate patterns are an important parameter in the diagnosis of non-reassuring fetal status. Combined-spinal epidural analgesia is a method of initiating labor analgesia used by approximately 90% of the parturients at…
- Trial name
- NCT02121184
- Testing
- Routine oxytocin, Half-dose oxytocin
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Northwestern University
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