Clinical trials: Cardiac Flow
Coronary Artery Disease
Angiography-Derived FFR And IVUS for Clinical Outcomes in Patients With Coronary Artery Disease
Comparison of Angiography-derived Fractional FLow Reserve And IntraVascular Ultrasound-guided Intervention Strategy for Clinical OUtcomes in Patients with CoRonary Artery Disease
- Trial name
- FLAVOUR II (NCT04397211)
- Testing
- Angiography-derived FFR, IVUS
- Where
- 23 sites in China, South Korea
- Volunteers
- 1,872 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hot Weather; Adverse Effect, Healthy
Characterization of Myocardial Blood Flow During Heat Exposure
The purpose of this study is to determine the increase in myocardial blood flow during heat exposure and how this response is affected by age and coronary artery disease.
- Conditions
- Hot Weather; Adverse Effect, Healthy, Coronary Artery Disease, Aging
- Trial name
- PET-Heat (NCT04549974)
- Testing
- Heat exposure
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Coronary Artery Disease
QUantitative Flow Ratio Or Angiography for the assessMent of nOn-culprit Lesions
The aim of this study is to study whether the use of complex 3-dimensional assessment of the severity of a stenosis improves angina and in general cardiovascular outcomes in patients who have residual intermediate coronary artery…
- Trial name
- QUOMODO (NCT04808310)
- Testing
- Quantitative flow ratio, Assessment of angiographic severity of the stenosis
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Johannes Gutenberg University Mainz
Coronary Heart Disease
Safety and Efficacy of DCB Therapy for de Novo Lesions Under the Guidance of QFR in CHD Patients (UNIQUE-DCB-I Study )
Since Gruntzig successfully performed percutaneous coronary balloon angioplasty in 1977, percutaneous coronary intervention has developed rapidly.
- Trial name
- NCT04104854
- Testing
- drug coated balloon
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Fractional Flow Reserve, Absolute Flow Measurement
Myocardial Mass Determination by FFRct and Absolute Coronary Blood Flow
The background for performing the present study is to compare the mass calculations by CT scanning and by invasive absolute blood flow measurements and thereby corroborating both methods.
- Conditions
- Fractional Flow Reserve, Absolute Flow Measurement, FFR-CT, Myocardial Mass
- Trial name
- MyoMass (NCT03393871)
- Testing
- absolute blood flow measurement
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Left Ventricular Failure, Unspecified
Daily Life Activities in Patients Treated With Continuous-Flow Left Ventricular Assist Devices
Investigation of oxygen uptake during daily life activities in HF patients with and without LVADs.
- Trial name
- Act-VAD (NCT04732039)
- Testing
- Measurement of peak oxygen uptake
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Dopamine, Protein-Losing Enteropathies
Characterizing the Effect of Dopamine on Markers of Lymph Re-circulation in Fontan-associated Protein-losing Enteropathy
Patients that have undergone a Fontan procedure (surgical correction for single ventricle congenital heart disease) may develop a complication known as protein-losing enteropathy (PLE).
- Conditions
- Dopamine, Protein-Losing Enteropathies, Lymphatic System, Lymph
- Trial name
- NCT03322345
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Michigan
Coronary Artery Disease
Correlation of FFR CT With Invasive FFR in Multi-ethnic Cohort- a Retrospective Study
This study aims to examine the correlation between Fractional Flow Reserve (FFR) FFR Computed Tomography (CT) and invasive FFR in a real-world setting using retrospective analysis of existing data, providing practical insights…
- Trial name
- NCT06790836
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- Sandwell & West Birmingham Hospitals NHS Trust
Cardiac and Hemodynamic Response, Blood Flow Distribution and Oxygen Uptake Efficiency
Effects of Aerobic Interval and Continuous Exercise Trainings in Patients With Chronic Heart Failure
Heart failure (HF) is a major and increasingly common cardiovascular syndrome, and is the end result of many cardiovascular disorders.
- Conditions
- Cardiac and Hemodynamic Response, Blood Flow Distribution and Oxygen Uptake Efficiency, Hemorheology Modulated by Erythrocyte, Atherothrombosis Modulated by Monocyte
- Trial name
- NCT01229670
- Testing
- exercise
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Chang Gung Memorial Hospital
Coronary Artery Disease
Mainz Registry of Flow-mediated Constriction
The goal of the flow-mediated constriction/ FMC-registry is to investigate whether the measurement of endothelial function using flow-mediated dilation and flow-mediated constriction provides on the presence of coronary…
- Trial name
- NCT01787370
- Where
- Germany
- Volunteers
- 750 people
- Sponsor
- Johannes Gutenberg University Mainz
Mediastinal Tumors
Echocardiographic Evaluation of the Change on Pulmonary Blood Flow and Cardiac Function Induced by Capnothorax During One Lung Ventilation
Video-assisted thoracoscopic extended thymectomy (VATET) is a minimally-invasive method for excision of mediastinal mass instead of open thymectomy.
- Trial name
- NCT02220231
- Testing
- capnothorax
- Volunteers
- 25 people
- Sponsor
- Yonsei University
Cardiovascular Disease, Heart Failure
Effects of Urocortins on Forearm Arterial Blood Flow in Healthy Volunteers - Protocol 4
Impairment of the heart's pumping capacity (heart failure) remains a major clinical problem with a poor prognosis and the search for novel treatments remains an important area of research.
- Trial name
- NCT01296607
- Testing
- Urocortin 2, Urocortin 3
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Microvascular Obstruction (MVO), Multivessel Coronary Artery Disease
For Patients With Myocardial Infarction and Multiple Vessel: Testing if Ultrasound (UFR) Can Guide All Needed Treatment in One Procedure, Avoiding a Return Hospital Visit for a Second Operation.
Brief Summary The Purpose of the Study : The purpose of this study is to find a safe and reliable "one-stop" solution for treating heart attack patients who have multiple blocked arteries.
- Conditions
- Microvascular Obstruction (MVO), Multivessel Coronary Artery Disease, ACS (Acute Coronary Syndrome), ST Elevation Myocardial Infarction (STEMI)
- Trial name
- ACT-EVOLVE (NCT07264881)
- Testing
- IVUS-based Fractional Flow Reserve (UFR), Invasive Coronary Physiology Measurement (FFR/RFR/IMR), Cardiac Magnetic Resonance (CMR)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Anzhen Hospital
Cardiac Arrest (CA)
Effect of AED-optimized Telephone-assisted CPR Instructions on No-flow Time and Chest Compression Fraction
Out-of-hospital cardiac arrest (OHCA) remains a leading cause of mortality worldwide, with survival highly dependent on the immediate initiation of bystander cardiopulmonary resuscitation (CPR).
- Trial name
- NCT07520877
- Testing
- T-CPR, AED-optimized T-CPR
- Where
- Hungary
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Atrial Fibrillation, Thrombosis
Association of Genetic Polymorphisms With Atrial Fibrosis and Thrombogenic Substrate in Patients With Non-valvular Atrial Fibrillation
Atrial fibrillation (AF) is the most frequently encountered cardiac arrhythmia. Emerging data suggests that common genetic variants are associated with the development of AF.
- Conditions
- Atrial Fibrillation, Thrombosis, Stroke, Genetic Predisposition
- Trial name
- ANATOLI-AF (NCT03560219)
- Testing
- Biomarkers, Cardiac Magnetic Resonance Imaging, Echocardiography, Flow Mediated Dilatation, Genetic Analysis
- Volunteers
- 225 people
- Sponsor
- Memorial Ankara Hospital
Computer Simulation, Energy Expenditure
Modelling of Energy Expenditure From Heart Rate, Accelerometry and Other Physiological Parameters
At this time, 24h energy expenditure is rarely assessed under free-living conditions for specific individuals because of the lack of cheap and accurate software/materials to record the energy expenditure.
- Conditions
- Computer Simulation, Energy Expenditure, Energy Metabolism
- Trial name
- Modelheart (NCT01209572)
- Testing
- calorimetric chamber, Free living conditions
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Acute Respiratory Failure, Cancer
Oxygenation Methods and Non-invasive Ventilation in Patients With Acute Respiratory Failure and a do Not Intubate Order
ICU care of patients considered "palliative" but without contraindications to admission to intensive care, for whom a do-not intubate order decision was made upon admission represents a particular target for non-invasive…
- Conditions
- Acute Respiratory Failure, Cancer, Hematologic Malignancy, Cardiac Insufficiency
- Trial name
- OXYPAL (NCT03673631)
- Testing
- NIV, NFHC-O2
- Where
- France
- Volunteers
- 330 people
- Sponsor
- Poitiers University Hospital
Coronary Artery Disease
Influence of Lipid Lowering on Impaired Coronary Flow
This study assess in patients with stable chest pain and coronary artery disease (CAD) determined by coronary CTA whether cholesterol lowering with regression of coronary adverse plaque characteristics is associated with recovery…
- Trial name
- NCT05368545
- Testing
- High intensity lipid lowering
- Where
- Denmark
- Volunteers
- 109 people
- Sponsor
- Aarhus University Hospital
Single-ventricle, Pulmonary Vascular Resistance Abnormality
ET1 Concentration, Metabolic Pathway Activation, and Pulmonary Blood Flow in Infants Undergoing Superior Cavo-Pulmonary Anastomosis
This is a novel preliminary study of biomarkers of pathologic pre-operative pulmonary vascular development, elevated pre-operative Pulmonary Vascular Resistance Index (PVRi), and complications associated with decreased…
- Conditions
- Single-ventricle, Pulmonary Vascular Resistance Abnormality, Superior Cavo-Pulmonary Anastomosis, Endothelin
- Trial name
- NCT03404258
- Testing
- Research Blood Sampling
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Cardiac Remodeling, Ventricular
Intracardiac Flow Remodeling in Athletes
The uncertainty concerning the onset and the extent of cardiac remodeling in response to intensive training hinders medical evaluation by physician.
- Trial name
- INFINITE (NCT03076788)
- Testing
- electrocardiogram and echocardiography
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
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