Clinical trials: Cardiac Surgery
Death, Stroke
Postoperative Atrial Fibrillation and Long-term Survival
The aim of the investigators trial was to evaluate association between new onset postoperative atrial fibrillation (POAF) and late cardiovascular morbidity and mortality.
- Conditions
- Death, Stroke, Myocardial Infarction
- Trial name
- POAF (NCT02349269)
- Volunteers
- 519 people, healthy volunteers welcome
- Sponsor
- Kuopio University Hospital
Ketamine-Induced Mood Disorder
The Role of Ketamine and Dexmedetomidine in Opioid-Sparing Analgesia
Optimal multimodal opioid-sparing analgesic technique is considered as one of the most important Enhanced recovery pathways (ERPs) or enhanced recovery after surgery (ERAS) interventions that mitigate the undesirable effects of…
- Trial name
- NCT05474183
- Testing
- Ketamine
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fayoum University Hospital
Analgesia
Bilateral Transversus Thoracic Muscle Plane Block as Analgesic in Open Heart Surgeries by US.
OPEN CARDIAC SURGERY may cause severe postoperative pain and promote a high risk of chronic pain if not treated adequately, that is caused by multiple factors; sternotomy, costotransverse and costovertebral joint distensions…
- Trial name
- NCT04116554
- Testing
- 0.25% bupivacaine., 0.9%saline
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Artificial; Complications, Heart
Stroke Volume Variations and Pulse Pressure Variations Undergoing Artificial Pneumothorax Surgery
Stroke volume variation (SVV) and pulse pressure variation (PPV) have been thought to be sensitive predictors of fluid responsiveness in mechanically ventilated participants.
- Trial name
- NCT05644405
- Testing
- FloTrac Vigileo
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Rigid Plate Fixation, Median Sternotomy
A Prospective, Single Center, Observational Study to Assess the Rapid Recovery After Cardiac Surgery Using SternaLock XP
The primary objective of this study is to evaluate the post-operative rapid recovery in patients treated with SternaLock XP for rigid sternal fixation with sternal precautions less restrictive than standard of care.
- Trial name
- RACE XP (NCT05578651)
- Testing
- SternaLock XP
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Pain, Postoperative, Respiratory Complication
Thoracic Epidural Analgesia and Bilateral Erector Spinae Plane Block on Postoperative Pain in Open Heart Surgeries
Postoperative pain negatively effects respiratory functions in open heart surgeries. The aim of the study is to compare the effects of thoracic epidural analgesia (TEA) and erector spinae plane block (ESPB) on postoperative pain…
- Trial name
- NCT06098859
- Testing
- Thoracic epidural analgesia, Erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Perioperative/Postoperative Complications, Surgery
Validity of Aortic Pulse Wave Velocity in Predicting the 6- Minute Walking Test Before Major Non-cardiac Surgery
Methods: Prospective observational study in adult patients requiring preoperative evaluation Objectives: To determine the correlation between the aortic pulse wave velocity (AoPWV) and the distance walked in the 6-minute walk…
- Conditions
- Perioperative/Postoperative Complications, Surgery, Exercise Tolerance
- Trial name
- 6WAVE (NCT03866915)
- Testing
- Aortic pulse wave velocity measurement, 6 minutes walking test
- Where
- 3 sites in Spain
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Grupo Español de Rehabilitación Multimodal
Cardiac Surgery
Efficacy of Ultrasound Guided PIFB Versus Lidocaine Infusion on Postoperative Pain After Sternotomy
Chronic pain is a common complication after cardiothoracic surgery. The prevalence of post-sternoyomy pain syndrome (PSPS) ranges from 33% to 91%.
- Trial name
- NCT05885230
- Testing
- pecto intercostal fascial block using bupivacaine 0.25%, lidocaine infusion
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Coronary Artery Disease, Sleep Disorder
The Effect of Eye Mask Applied on Patients Undergoing Coronary Artery Bypass Graft Surgery
Introduction: Coronary Artery Bypass Graft (CABG) performed with open heart surgery technique is a successful operation in the treatment of cardiovascular diseases.
- Conditions
- Coronary Artery Disease, Sleep Disorder, Pain, Postoperative
- Trial name
- NCT06010498
- Testing
- eye mask, standart care
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Vasoplegic Syndrome of Cardiac Surgery
Inotropic Effects of Vasopressin Versus Noradrenaline In Patients With Vasoplegic Syndrome After Cardiac Surgery
This is a randomized, double-blind clinical trial designed to compare the inotropic effects of vasopressin versus norepinephrine in patients who develop vasoplegic syndrome in the immediate postoperative period following cardiac…
- Trial name
- INVASC (NCT06934798)
- Testing
- Vasopressin intravenous infusion, Norepinephrine intravenous infusion
- Where
- Brazil
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Heart Disease, Mitral Regurgitation
Using Beta Blockers to Treat Mitral Regurgitation
The purpose of this study tests whether beta-blocker will benefit asymptomatic patients with chronic primary mitral regurgitation.
- Conditions
- Heart Disease, Mitral Regurgitation, Heart Valve Disease, Mitral Valve Insufficiency
- Trial name
- REGURG (NCT00700947)
- Testing
- Beta-blocker therapy (TOPROL-XL® )
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Cardiovascular Diseases, Cardiovascular Complication
Colchicine in Patients at Cardiac Risk Undergoing Major Non-Cardiac Surgery
Perioperative myocardial injury and major adverse cardiovascular events (MACE) are common causes of morbidity and mortality in patients at increased cardiovascular risk undergoing non-cardiac surgery.
- Conditions
- Cardiovascular Diseases, Cardiovascular Complication, Perioperative Complication, Myocardial Injury
- Trial name
- COLCAT (NCT06279000)
- Testing
- Colchicine
- Where
- Switzerland
- Volunteers
- 880 people, healthy volunteers welcome
- Sponsor
- Cantonal Hospital of St. Gallen
Septoplasty Surgeries
Cold Dissection vs Electrocautry on TCR in Septoplasty
This study aims to address these gaps by comparing the incidence of TCR during septoplasty performed using cold dissection versus electrocautery, while also incorporating a novel assessment of surgical force.
- Trial name
- TCR (NCT07425834)
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fatmaelzahraa Omar Mahmoud Bahr
Effect of Sedation on Heart Rate Variability
EFFECT OF DEXMEDETOMİDİNE AND MİDAZOLAM SEDATİON ON HEART RATE VARİABİLİTY AFTER CORONARY ARTERY BYPASS GRAFT SURGERY
The parasympathetic tone reduction and sympathetic tone enhancement, which are components of the autonomic nervous system (ANS) activity, increase the likelihood of malignant arrhythmias leading to ventricular fibrillation.
- Trial name
- NCT03601091
- Testing
- Precedex 200 MCG in 2 ML Injection, DORMICUM 5MG/5 ML
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Cardiac Pacemaker, Artificial
The Potential Interference of Magnets From a Surgical Magnetic Drape With Cardiac Pacemakers
Magnetic fields may interfere with the function of cardiac pacemakers. A magnetic drape to hold surgical instruments is widely used in surgery. The use of this drape on pacemaker patients has not yet been tested.
- Trial name
- NCT01009320
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Maisonneuve-Rosemont Hospital
Oxidative Stress, Cardiac Surgery
The Comparison of Oxidative Stress Between Inhalation Anesthetics
Oxidative stress is an unavoidable event during cardiac surgery. Isoprostanes have been demonstrated to be a reliable biomarker for the evaluation of oxidative stress in vivo.The aims of this study are(1)to develop an accurate…
- Trial name
- NCT00965445
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Thoracic Surgery
Electrical Impedance Tomography in Evaluating the Effects of Noninvasive Ventilation in Post-Operative Cardiac Surgery
NTRODUCTION: cardiac surgery can lead to pulmonary complications such as hypoxemia and atelectasis. Noninvasive ventilation has been used to prevent and treat such complications.
- Trial name
- NCT03371628
- Testing
- Non invasive ventilation
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Postoperative Cognitive Dysfunction
Comparison of Postoperative Outcome After Sevoflurane and Propofol Anaesthesia
As the investigators know, postoperative cognitive dysfunction (POCD) is a fairly well-documented clinical phenomenon, which affect patients' short-term and long-term outcome.
- Trial name
- NCT02931877
- Testing
- sevoflurane, propofol
- Where
- 3 sites in China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Xinqiao Hospital of Chongqing
Frail Elderly, Coronary Artery Disease
Off-pump Versus On-pump Coronary Artery Bypass Grafting in Frail Patients
Frailty is defined as a geriatric syndrome of impaired resiliency to stressors (such as cardiac surgery) that has been delineated recently in the cardiovascular literature.
- Trial name
- FRAGILE (NCT02338947)
- Testing
- Off-pump coronary-artery bypass grafting, On-pump coronary-artery bypass grafting
- Where
- 7 sites in United States, Brazil
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Low Cardiac Output
Hemodynamic Survey Cardiac Surgical Scenarios
The purpose of this study is to find out the Lidco Rapid ( monitoring tool gives cardiac output) is as equivalent in determining the hemodynamic assessment in cardiac surgical scenarios as the most often used pulmonary artery…
- Trial name
- NCT02529033
- Testing
- LIDCO Rapid, Pulmonary artery catheter
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Iowa