Clinical trials: Cardiopulmonary Diseases
Shock, Respiratory Failure
The Impact of Fellow-performed Cardiopulmonary Ultrasound Exams
Shock and respiratory failure are common reasons for admission to the intensive care unit (ICU) at our institution. The various causes of acute shock and respiratory failure are traditionally assessed with the use of history…
- Trial name
- NCT02186197
- Testing
- Critical Care Ultrasound
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Beth Israel Medical Center
Congenital Heart Disease, Pulmonary Hypertension
Early Postoperative Triple Targeted Therapy in Patients With CHD-PAH in the "Grey Zone"
The purpose of this study is to observe the efficacy of early application of triple targeted drug therapy, including trilostane, in patients with congenital heart disease who are in the "gray zone" of preoperative evaluation…
- Trial name
- NCT07844213
- Testing
- Control group (ambrisentan plus tadalafil or macitentan plus tadalafil), Treatment group (ambrisentan plus tadalafil plus treprostinil or macitentan plus tadalafil plus treprostinil)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- China National Center for Cardiovascular Diseases
Cardiac Arrest (CA)
V-CPR Under Special Circumstances
Out-of-hospital cardiac arrest (OHCA) remains a major cause of death globally, with bystander CPR rates varying widely (13-82%) despite public health efforts.
- Trial name
- NCT07101510
- Testing
- sV-CPR, V-CPR, T-CPR
- Where
- Hungary
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Stroke
The Effect of Backward Walking Treadmill Training on Balance in Patient With Chronic Stroke
The purpose of this research was to discuss the effect of backward walking treadmill training on balance ability, speed of walking and cardiopulmonary fitness in patients with chronic stroke.
- Trial name
- NCT02619110
- Testing
- backward walking treadmill training, conventional physical therapy
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Congenital Heart Disease, Disorder of Fetus or Newborn
Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass
Although cardiopulmonary bypass (heart-lung machine) is a necessary component of heart surgery, it is not without consequences. Cardiopulmonary bypass initiates a potent inflammatory response secondary to the body's recognition…
- Trial name
- NCT01579513
- Testing
- Methylprednisolone
- Where
- 2 sites in United States
- Volunteers
- 190 people
- Sponsor
- Medical University of South Carolina
Acute Decompensated Heart Failure
Gas Exchange for Predicting Hospital Heart Failure Readmissions
To determine whether, and if so, which gas exchange parameters measured on the Shape-HF Cardiopulmonary Exercise Testing System predict 30 and 180 day re-hospitalization in subjects discharged from hospitalization for an episode…
- Trial name
- NCT01960218
- Where
- 7 sites in United States
- Volunteers
- 120 people
- Sponsor
- Shape Medical Systems, Inc.
Chronic Obstructive Pulmonary Disease
The Difference in the Biological Characteristic Characteristics of the Heart and Lung Meridians
The association between viscera and the body surface remains obscure, but a better understanding of it will maximize its diagnostic and therapeutic values in clinical practice.
- Trial name
- NCT05690217
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Congenital Heart Disease
Efficacy of Remodulin in Adults With Congenital Heart Disease (ACHD) and Pulmonary Hypertension
The purpose of this study is to evaluate the efficacy of Remodulin in the treatment of adult patients with congenital heart disease and pulmonary hypertension.
- Trial name
- NCT01980979
- Testing
- Remodulin
- Where
- 2 sites in United States
- Sponsor
- University of California, Los Angeles
Collagen Supplementation, Whey Protein
Effects of Rehabilitation and Supplementation With Hydrolyzed Collagen vs. Whey Protein on the Cardiopulmonary, Renal, Muscular, and Immunohematological Response of COPD Patients
Chronic obstructive pulmonary disease (COPD) induces a severe loss of muscle strength and mass, in addition to reflecting significant pulmonary changes and causing cardiovascular, immunohematological, and renal alterations.
- Conditions
- Collagen Supplementation, Whey Protein, Pulmonary Rehabilitation, COPD - Chronic Obstructive Pulmonary Disease
- Trial name
- NCT07011225
- Testing
- Verisol Collagen 2,5 g/day, Peptech Collagen 2,5 g/day, Peptech Collagen 10 g/day
- Where
- Brazil
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Effects of Parent-Child Reading on Preterm Infant Stability, Parental Anxiety, and Parent-Child Attachment
Impact of Picture Book Reading on Preterm Infant Stability, Parental Anxiety, and Parent-Child Attachment
This study investigates the effects of a parent-child picture book reading intervention on the cardiopulmonary stability of preterm infants, parental anxiety, and parent-child attachment.
- Trial name
- NCT06854549
- Testing
- Parental Reading Picture-book
- Where
- Taiwan
- Volunteers
- 88 people
- Sponsor
- National Yang Ming Chiao Tung University
Exercise Capacity
Cocoa Flavanols and Exercise Capacity
The purpose of this study is to characterize the potential improvement of cocoa flavanols on exercise capacity in highly trained cyclist.
- Trial name
- NCT01259739
- Testing
- Cocoa
- Where
- Germany
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Heart Failure, Heart Failure With Reduced Ejection Fraction
Effects of Dapagliflozin on Cardiorespiratory Parameters in Heart Failure
Dapagliflozin is a molecule belonging to the class of sodium-glucose transporter type 2 (SGLT2-i) inhibitors. This type of drug, initially used in the treatment of diabetes mellitus, has in recent years demonstrated significant…
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Left Ventricle Remodeling, Sleep Apnea
- Trial name
- NCT05770167
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Centro Cardiologico Monzino
Congenital Heart Disease in Children, Neuroprotection
Cerebrum and Cardiac Protection With Allopurinol in Neonates With Critical Congenital Heart Disease Requiring Cardiac Surgery With Cardiopulmonary Bypass
Neurodevelopmental impairment due to delayed brain development and brain injury is a fundamental problem in children with critical congenital heart disease (CCHD).
- Trial name
- CRUCIAL (NCT04217421)
- Testing
- Allopurinol, Mannitol
- Where
- 4 sites in Netherlands
- Volunteers
- 236 people
- Sponsor
- dr. M.J.N.L. Benders
Ventricular Septal Defect
Cardiopulmonary Function in Adults Born With a Ventricular Septal Defect
The overall objective for this study is to evaluate the cardiopulmonary function of VSD-patients compared with healthy age- and gender-matched controls.
- Trial name
- NCT03684161
- Testing
- Cardiopulmonary function
- Where
- Denmark
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Pulmonary Arterial Hypertension, Cardiovascular Diseases
Effects of Different Types of Physical Training in Patients With Pulmonary Arterial Hypertension.
Although there has been some progress in pharmacological management of PAH, limited functional capacity and low survival still persist, but there is evidence that exercise training can be accomplished without adverse effects or…
- Conditions
- Pulmonary Arterial Hypertension, Cardiovascular Diseases, Respiratory Disease, Hypertension, Pulmonary
- Trial name
- PAH (NCT03476629)
- Testing
- Physical activity
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- University of Nove de Julho
Aortic Aneurysm, Aortic Dissection
Freestyle Prosthesis for Aortic Root-replacement With and Without Hemiarch Replacement
The Freestyle® prosthesis (Medtronic plc, Dublin, Ireland) is a biological, porcine aortic root implanted in various combinations and techniques since the 1990s.
- Conditions
- Aortic Aneurysm, Aortic Dissection, Endocarditis, Root Abscess
- Trial name
- NCT04068337
- Testing
- Aortic root replacement with Freestyle biological prosthesis with and without hemiarch replacement
- Where
- Switzerland
- Volunteers
- 278 people
- Sponsor
- Triemli Hospital
Quality of Cardio-pulmonary Resuscitation
Manikin Study on Different Protocols of CPR (MANI-CPR)
The aim of the study is to verify whether the inclusion of breaks of different frequency and duration during the hands-only cardio-pulmonary resuscitation (CPR) could increase chest compressions quality during an 8-minutes…
- Trial name
- MANI-CPR (NCT02632500)
- Testing
- Quality of chest compressions
- Where
- 8 sites in Italy, Switzerland
- Volunteers
- 576 people, healthy volunteers welcome
- Sponsor
- Pavia nel Cuore
Cardiopulmonary Arrest, Cardiopulmonary Resuscitation
Plethysmographic Waveform for Monitoring the Quality of Cardiopulmonary Resuscitation
Cardiopulmonary resuscitation(CPR) is the key to success for high-quality early cardiopulmonary resuscitation, and its success in the restoration of spontaneous circulation (ROSC), therefore, monitoring the quality of…
- Conditions
- Cardiopulmonary Arrest, Cardiopulmonary Resuscitation, Return of Spontaneous Circulation, Pulse Oximeter Plethysmographic Waveform
- Trial name
- PWMQC (NCT01987245)
- Where
- China
- Volunteers
- 617 people
- Sponsor
- Jun Xu
Congenital Heart Disease
Antithrombin III in Infants With Cardiopulmonary Bypass (CPB)
The purpose of this study is to discern whether supplementation of Antithrombin III will decrease coagulation and inflammation associated with cardiopulmonary bypass in infants undergoing cardiac surgery.
- Trial name
- NCT01698567
- Testing
- Antithrombin III
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Rochester
Thrombosis
Risk of Developing Antibodies to Heparin-PF4 After Heart Surgery
Heparin is a drug that is widely used to prevent and treat blood clotting. Individuals undergoing cardiopulmonary bypass surgery are administered high doses of heparin, and some of them develop antibodies to the drug.
- Trial name
- HIT (NCT00237328)
- Testing
- Heparin
- Where
- 4 sites in United States
- Volunteers
- 1,015 people
- Sponsor
- Duke University
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