Clinical trials: Cardiopulmonary Resuscitation (CPR)
Cardiac Arrest, Out-Of-Hospital
The REVIVE-PEEP Trial: Positive End-expiratory Pressure Versus Sham Valve/Zero End-expiratory Pressure in Cardiopulmonary Resuscitation During Manual Ventilation to Improve Neurological Outcomes at Discharge in Adult Patients Suffering an Out-of-hospital Cardiac Arrest
The goal of this clinical trial is to learn if applying positive end-expiratory pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves neurological outcome in adults with out-of-hospital cardiac arrest who receive an…
- Trial name
- REVIVE-PEEP (NCT07905482)
- Testing
- Fixed PEEP Valve
- Where
- 3 sites in Netherlands
- Volunteers
- 3,200 people
- Sponsor
- Jeroen van Eijk
Out-Of-Hospital Cardiac Arrest
Rapid Response VA-ECMO in Refractory Out-of-hospital Cardiac Arrest
A selected group of patients with refractory cardiac arrest may benefit from inhospital treatment and this may warrant transfer to the hospital with ongoing CPR.
- Trial name
- RESuSCITATe (NCT03658759)
- Testing
- Extracorporeal Cardiopulmonary Resuscitation
- Where
- Netherlands
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Cardiac Arrest
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival
A small numbers of patients (10-15%) treated with cardiopulmonary resuscitation (CPR) are discharged from hospitals with a favorable neurologic outcome.
- Trial name
- NCT04009759
- Testing
- Morphine, Ketamine Injectable Solution, Saline 0.9%
- Volunteers
- 240 people
- Sponsor
- University Hospital, Akershus
Cardiac Arrest
Improving the Quality of Cardiopulmonary Resuscitation (CPR) During Pediatric Cardiac Arrest
Our project aims to improve the delivery and assessment of cardiopulmonary resuscitation (CPR) during pediatric cardiac arrest by introducing 2 novel approaches: 1.
- Trial name
- QCPR (NCT02075450)
- Testing
- CPRcard, Just in Time Video
- Where
- 11 sites in United States, Canada and 1 more
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- KidSIM Simulation Program
Emergencies
Research on Key Technologies and System Optimization of Early Warning and Resuscitation of Cardiac Arrest
Studies have shown that early prevention and warning of cardiac arrest, rapid implementation of high-quality cardiopulmonary resuscitation, and strengthening of organ function protection after resuscitation are the keys to…
- Trial name
- NCT04955288
- Testing
- Aortic balloon assisted resuscitation, Traditional cardiopulmonary resuscitation, Esophageal cooling
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cardiopulmonary Resuscitation
Manual and Mechanical Chest Compression During In-hospital Witnessed Cardiac Arrests Using Cerebral Oximetry
Post-resuscitation neurological impairment is associated with morbidity and especially with late mortality. Thus, because good neurological outcome is vital for a successful resuscitation, it is essential to have sufficient…
- Trial name
- NCT03238287
- Testing
- Mechanical chest compression, Manuel chest compression
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Eskisehir Osmangazi University
Out-of-hospital Cardiac Arrest
The PulsePoint Randomized Controlled Trial
"Sudden cardiac arrest" occurs when someone's heart stops beating unexpectedly. Each year, more than 45,000 Canadians have a cardiac arrest.
- Trial name
- NCT01746290
- Testing
- PulsePoint notification
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Queen's University
Alpine Accident, Frostbite
10-years Nationwide Alpine Accidents in Austria
This observational study intends to analyze the characteristic of specific accidents happened in Austrian's mountainous regions.
- Conditions
- Alpine Accident, Frostbite, Cardiopulmonary Arrest With Successful Resuscitation, Lightning Injuries
- Trial name
- NCT03405467
- Testing
- general and specific data
- Where
- Austria
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Intraosseous Access, Resuscitation
Trial Comparing Proximal Tibia and Proximal Humerus Infusion Rates Using the NIO Intraosseous Device
The investigators sought to compare the intraosseous access success rates of the proximal tibia and the proximal humerus using new Intraosseous access device "NIO" in an adult cadaver model during simulated resuscitation.
- Trial name
- IOACS (NCT02700867)
- Testing
- NIO
- Where
- Poland
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Healthy Participants
Effectiveness of CPR Pillow
Pillows can be used to facilitate safe and effective learning and as a cheaper and more accessible alternative to manikins or computer-based methods for CPR training by non-healthcare professionals.
- Trial name
- NCT07160881
- Testing
- Pillow maniquin training
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Beykent
Cardiopulmonary Resuscitation, Education
Sustainable Solutions for Paediatric Basic Life Support Training in Day Care Centres
In a randomised non-inferiority trial the investigators examine two training interventions to train paediatric basic life support to laypersons: Dyad training vs Instructor led training.
- Conditions
- Cardiopulmonary Resuscitation, Education, Medical Emergencies
- Trial name
- NCT03469154
- Testing
- Dyad training method, Instructor led training method
- Volunteers
- 569 people, healthy volunteers welcome
- Sponsor
- Copenhagen Academy for Medical Education and Simulation
Cardiopulmonary Resuscitation
Cardiopulmonary Resuscitation Training Program Based on Quality Control
In a prospective, non-randomized study, all of the basic and advanced cardiopulmonary resuscitations would be analyzed. All resuscitation are planned to be performed by the above mentioned devices according to the recent…
- Trial name
- NCT03112460
- Testing
- cardiopulmonary resuscitation with Zoll R Series defibrillator and defibrillator pads with a real-time CPR feedback option and CodeReview case analysis software
- Volunteers
- 20 people
- Sponsor
- Hungarian Institute of Cardiology
Congestive Heart Failure, Infections
Does Detailed Informed Consent for Cardiopulmonary Resuscitation and Mechanical Ventilation Impact Patients' Decisions and Outcomes?
There is evidence to suggest that patients make different end-of-life decisions if they understand the risks, benefits and alternatives of CPR and mechanical ventilation.
- Conditions
- Congestive Heart Failure, Infections, Sepsis, Acute Renal Failure
- Trial name
- NCT01878968
- Testing
- Script and CPR/Mechanical ventilation video.
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Jewish Hospital, Cincinnati, Ohio
Carrying Naloxone/Narcan on Their Person or in Their Vehicle, Being Trained to Respond to an Opioid Overdose
The Feasibility of Using the PulsePoint to Facilitate Overdose Education and Naloxone Distribution
This study is a feasibility trial to assess whether, in a random sample of 180 agencies where PulsePoint is already active, revised procedures (hereinafter PulsePoint-OD) to facilitate opioid overdose and naloxone distribution…
- Trial name
- PP-OD (NCT06523985)
- Testing
- Push messages (standard), Push messages (customized)
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Indiana University
Cardiac Arrest, Cardiopulmonary Resuscitation
Evaluation of eCPR Survivors
A cardiac arrest event has severe impact on the patient´s health-related quality of life. Survival of cardiac arrest does not innately translate to favorable quality of life.
- Conditions
- Cardiac Arrest, Cardiopulmonary Resuscitation, Extracorporeal Membrane Oxygenation Complication, Myocardial Infarction
- Trial name
- NCT05339854
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Charite University, Berlin, Germany
In-hospital Cardiac Arrest
Poor Theoretical Knowledge and Self-assessed Ability of Cardiopulmonary Resuscitation Among In-hospital Healthcare Professionals: a Cross Sectional Study With Questionnaires.
Theoretical knowledge of cardiopulmonary resuscitation (CPR) is the foundation of being able to perform CPR in a cardiac arrest situation.
- Trial name
- NCT03498508
- Where
- 4 sites in Sweden
- Volunteers
- 3,044 people
- Sponsor
- Dalarna County Council, Sweden
Cardiac Arrest, Heart Arrest
Rehabilitation for Survivors of Out-of-hospital Cardiac Arrest
This study is a parallel group multicentre investigator-initiated clinical randomised controlled superiority trial that will include a total of 214 survivors of OHCA.
- Conditions
- Cardiac Arrest, Heart Arrest, Cardiopulmonary Resuscitation, Return to Work
- Trial name
- NCT05173740
- Testing
- Individually tailored rehabilitation intervention, Usual care
- Where
- Denmark
- Volunteers
- 214 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Out-of-Hospital Cardiac Arrest
AMCPR (Augmented-Medication CardioPulmonary Resuscitation) Trial for OHCA
The investigators aimed to evaluate the effect of AMCPR (Augmented-Medication CardioPulmonary Resuscitation: administration of additional vasopressin to titrate to arterial diastolic blood pressure over 20 mmHg) on…
- Trial name
- NCT03191240
- Testing
- Vasopressins, Normal saline
- Where
- 2 sites in South Korea
- Volunteers
- 110 people
- Sponsor
- Asan Medical Center
Cardiac Arrest (CA)
V-CPR Under Special Circumstances
Out-of-hospital cardiac arrest (OHCA) remains a major cause of death globally, with bystander CPR rates varying widely (13-82%) despite public health efforts.
- Trial name
- NCT07101510
- Testing
- sV-CPR, V-CPR, T-CPR
- Where
- Hungary
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Cardiac Arrest (CA), Pediatric Cardiac Arrest (Simulated)
Augmented Reality-Cardiopulmonary Resuscitation Support for Pediatric Resuscitation
This study evaluates whether an augmented reality cardiopulmonary resuscitation feedback system (AR-CPR) can support health care providers in delivering high-quality chest compressions during pediatric cardiac arrest.
- Conditions
- Cardiac Arrest (CA), Pediatric Cardiac Arrest (Simulated), Cardiopulmonary Resuscitation (CPR)
- Trial name
- AR-CPR (NCT07778823)
- Testing
- AR-CPR
- Where
- 8 sites in United States, Canada
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University