Clinical trials: Cardiovascular Condition
Arterial Occlusive Diseases
Safety/Tolerability and Pharmacokinetic Study of SID142
A randomized, open-label, oral multiple dosing, two-part, two-way crossover clinical trial to evaluate the safety/tolerability and pharmacokinetic profiles of SID142 in healthy volunteers
- Trial name
- NCT02625714
- Testing
- Renexin®, SID142
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- SK Chemicals Co., Ltd.
Trisomy 21, Trisomy 18
Development of Non-invasive Prenatal Screening Test for Microdeletions Based on Fetal DNA Isolated From Maternal Blood
The purpose of this study is to collect maternal blood samples from pregnant women carrying a fetus with a confirmed diagnosis of chromosomal abnormality or genetic disorder including microdeletions in order to further develop a…
- Conditions
- Trisomy 21, Trisomy 18, Trisomy 13, Sex Chromosome Abnormalities
- Trial name
- MAPS (NCT01852708)
- Where
- 9 sites in United States, Spain and 1 more
- Volunteers
- 1,059 people, healthy volunteers welcome
- Sponsor
- Natera, Inc.
Vascular Function
Effect of Woodsmoke on Vascular Function
Exposure to air pollution is a well established risk factor for the development of heart disease. Firefighters are exposed to excess air pollution in the form of wood smoke during the extinguishing of forest or woodland fires.
- Trial name
- FIREWOOD (NCT01495325)
- Testing
- Forearm Vascular Study, Badimon Chamber
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Stroke, Hemiparesis
Error Enhancement of the Velocity Component
The purpose of this pilot study was to explore the impact of enhancement of the velocity component error in the course of reaching movements of the impaired/hemiparetic limb in an acute stroke subject.
- Trial name
- NCT02017093
- Testing
- Error Enhancement, control treatment
- Where
- Israel
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Subarachnoid Hemorrhage, Aneurysmal
Investigate the Relationship Between Inflammatory and Coagulation in SAH CSF
Investigate the role of inflammasome and blood coagulation response in human cerebrospinal fluid after subarachnoid hemorrhage.
- Trial name
- NCT04938414
- Testing
- Lumbar puncture
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Type 2 Diabetes Mellitus
Carotid Wall Texture as a Cardiovascular Risk Biomarker in Type 2 Diabetes Mellitus
This study aims to compare carotid intima-media thickness (CIMT) and layer-specific texture characteristics of the carotid wall between individuals with Type 2 diabetes mellitus (T2DM) and normoglycemic controls, to assess the…
- Trial name
- NCT07373938
- Testing
- SCORE2, SCORE2-Diabetes, Ultrasound Assessment
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cardenal Herrera University
Obesity, Smoking
Africa and Middle East Cardiovascular Epidemiological Study
This is a cross-sectional, epidemiological study to determine the prevalence of cardiovascular risk factors such as obesity, smoking, dyslipidemia, diabetes mellitus and hypertension in patients attending General Practice clinics…
- Conditions
- Obesity, Smoking, Dyslipidemia, Diabetes Mellitus
- Trial name
- ACE (NCT01243138)
- Where
- 73 sites in Algeria, Cameroon and 12 more
- Volunteers
- 4,386 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Aging, Cardiovascular Disease
Passive Limb Movement: A Tool to Assess Vascular Health and Guide Rehabilitation
Brief Summary: Current U.S. Veteran demographics reveal an aging population with significant cardiovascular dysfunction. This ultimately manifests as mobility limitation, inactivity, and a subsequent worsening of cardiovascular…
- Trial name
- NCT03625349
- Testing
- NG-Monomethyl-L-Arginine
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Premature Ventricular Beats, Premature Ventricular Complexes
Flecainide in Idiopathic Premature Ventricular Contractions and Related Cardiomyopathy
The UNIFLECA study is a prospective, single-arm, observational cohort evaluating the efficacy, safety, and tolerability of flecainide (in the form of Sanocard) in adults with frequent idiopathic premature ventricular contractions…
- Conditions
- Premature Ventricular Beats, Premature Ventricular Complexes, Premature Ventricular Contraction (PVC), Arrhythmia Ventricular
- Trial name
- UNIFLECA (NCT06949748)
- Testing
- Flecainide (monotherapy)
- Where
- 6 sites in Greece
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Athens
Pacemaker Complication, Arrhythmias, Cardiac
Association of Obesity and Cardiovascular Outcomes in Patients With Pacemaker
In this study, the investigators evaluated the association between various measures of adiposity [BMI and waist circumference (WC)] and clinical outcomes in Asian patients who underwent pacemaker insertion, using a nationwide…
- Conditions
- Pacemaker Complication, Arrhythmias, Cardiac, Obesity, Cardiovascular Morbidity
- Trial name
- Paradox (NCT05645978)
- Testing
- Pacemaker insertion
- Where
- South Korea
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Ajou University School of Medicine
Hypertension Induced by Pregnancy, Pre-Eclampsia
Placental Growth and Adverse Pregnancy Outcomes
The purpose of this study to determine if measurement of maternal serum biomarkers and evaluation of the placenta by ultrasound can improve prediction of adverse pregnancy outcomes.
- Conditions
- Hypertension Induced by Pregnancy, Pre-Eclampsia, IUGR
- Trial name
- NCT01669525
- Where
- United States
- Volunteers
- 1,043 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Rheumatic Heart Disease
Rheumatic Heart Disease School Project
Acute rheumatic Fever (ARF) results from an autoimmune response due to molecular mimicry between the M-protein on the group A β-hemolytic streptococci (GABHS) cell membrane and cardiac myosin, and may lead through recurrent or…
- Trial name
- NCT01550068
- Testing
- Echocardiography
- Where
- Nepal
- Volunteers
- 8,519 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cardiovascular Diseases, Vascular Diseases
Influence of Age, Weight and Ethnic Background on Blood Pressure
Hypertension, also known as high blood pressure, is a chronic medical condition, in which the blood pressure is elevated. This is a common condition, which can lead to severe complications such as cardiovascular disease, heart…
- Conditions
- Cardiovascular Diseases, Vascular Diseases, Hypertension
- Trial name
- AWE (NCT03014791)
- Testing
- Brief lifestyle/medical history questionnaire, Anthropometric measures, Blood pressure and arterial stiffness
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Pulmonary Hypertension
Evaluation of a New 6 Minute Walk Test Smartphone App in Patients With Pulmonary Hypertension
Comparison of standard 6 minute walk test with 6 minute walk test smartphone app.
- Trial name
- 6-APP (NCT04633538)
- Testing
- 6MWT smartphone app
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Circulatory Collapse, Circulatory Failure
Suspension Syndrome
Suspension syndrome refers to a potentially life-threatening condition that can occur in unconscious persons after prolonged suspension in a harness.
- Conditions
- Circulatory Collapse, Circulatory Failure, Syncope, Vasovagal, Neurally-Mediated, Orthostatic Hypotension
- Trial name
- NCT02726776
- Testing
- Suspension in a harness, Climbing
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Institute of Mountain Emergency Medicine
Heart Failure, Periodontitis
Periodontitis Treatment and Heart Failure
Heart failure (HF) is a rapidly growing public health issue affecting more than 40 million individuals globally; while gum disease with bone loss affects 50% of people in general.
- Trial name
- NCT07036289
- Testing
- Mechanical Treatment
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Taubate
Hyperlipidemia, Diabetes
Point-of-Care Testing (POCT) Detection and Management of Metabolic Syndrome in Patients With Mental Illness
The study was a 12-month, multi-centered, quasi-experimental design to assess point-of-care (POCT) screening/monitoring of subjects on antipsychotic agents for metabolic syndrome.
- Conditions
- Hyperlipidemia, Diabetes, Hypertension
- Trial name
- NCT02029989
- Testing
- Glucose and lipids, Glycosylated Hemoglobin A1c, Blood Pressure and Heart Rate
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Vasodilation, Arterial Stiffness
Targeting ER Stress in Vascular Dysfunction
Aging and obesity are both risk factors for cardiovascular disease (CVD). One process that links both of these conditions to CVD is vascular dysfunction.
- Trial name
- NCT04001647
- Testing
- Acetylcholine, Sodium Nitroprusside, Ascorbic Acid
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Posterior Fossa Hemorrhage, Lung Cancer
Pilot Study of Model Based Iterative Reconstruction Using 64-Slice
This study is being performed to confirm that the new technique, Model-Based Iterative Reconstruction (MBIR) with reduced radiation dose can deliver equivalent image quality for CT scans compared to current techniques (Filtered…
- Conditions
- Posterior Fossa Hemorrhage, Lung Cancer, Flank Pain, Urolithiasis
- Trial name
- MBIR (NCT01431378)
- Where
- 3 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
CPR, Cardiac Arrest (CA)
Effect of an Educational Intervention on CPR Knowledge and Skills in Schoolchildren
This study aims to evaluate the effectiveness of a CPR intervention for children aged 7 and 8. Given the high prevalence of out-of-hospital cardiac arrests (OHCA) and the proven benefits of early CPR training, the study seeks to…
- Trial name
- NCT06929715
- Testing
- Intervention for Teaching the First Link in the Chain of Survival to 7- and 8-Year-Old Children
- Where
- Colombia
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Colombia
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