Clinical trials: Cardiovascular Disease, Obesity
Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function.
- Trial name
- NCT06383390
- Testing
- Retatrutide
- Where
- 742 sites in United States, Argentina and 25 more
- Volunteers
- 10,000 people
- Sponsor
- Eli Lilly and Company
Cardiovascular Health, Obesity
The SI! Program Reintervention for Elementary Schools Trial
Background and objectives: The SI! Program is a multilevel school-based intervention that has been previously evaluated in different ages in three countries.
- Trial name
- PSIR (NCT06715358)
- Testing
- Reintervention, Late intervention
- Where
- Spain
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- Foundation for Science, Health and Education, Spain
Obese Patients, Production Rates of These TRL Before and After the Bariatric Surgery
Effects of Various Bariatric Surgical Procedures on Intestinal Triglyceride-rich-lipoprotein (TRL) Metabolism in Obese Patients
Morbidly obesity (body mass index 40 kg/m²), the most serious, is more and more frequent. Cardiovascular diseases are the first cause of morbidity and mortality.
- Conditions
- Obese Patients, Production Rates of These TRL Before and After the Bariatric Surgery, Cardiovascular Diseases
- Trial name
- NCT01277068
- Testing
- Surgical and medical procedures
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Cardiovascular-kidney-metabolic Syndrome, Cardiovascular Diseases
Inspire HER: Inspiring the Heart and Emotions for Radical Health
Poor heart health puts Black women at risk for a shorter life with more illness than people of any other non-indigenous racial group.
- Conditions
- Cardiovascular-kidney-metabolic Syndrome, Cardiovascular Diseases, Hypertension, Diabetes
- Trial name
- NCT06966258
- Testing
- Inspire HER Intervention
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Alabama at Birmingham
Cardiovascular Diseases, Coronary Disease
Immunogenetic Factors of Coronary Heart Disease
To assess the association of immunogenetic factors with onset of coronary heart disease and the interrelationship of these factors with standard coronary heart disease risk factors.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Hypertension
- Trial name
- NCT00005184
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Type 2 Diabetes, Hypertension
PILI 'Āina Household
Native Hawaiians' traditional lifestyles and diets ensured the mutual health and well-being of the land and its inhabitants, which stand in stark contrast to the disproportionately high prevalence of diet-related, cardiometabolic…
- Conditions
- Type 2 Diabetes, Hypertension, Dyslipidemias, Overweight and Obesity
- Trial name
- NCT06526273
- Testing
- PILI 'Āina, Control
- Where
- 2 sites in United States
- Volunteers
- 210 people
- Sponsor
- University of Hawaii
Aerobic Exercise, Strength Training
Home-Based Circuit Training in Overweight/Obese Older Adult Patients With Knee Osteoarthritis and Type 2 Diabetes
Background: Obesity and type 2 diabetes mellitus (T2DM) are considered two of the most prevalent metabolic diseases linked to the onset of knee pain caused by osteoarthritis.
- Conditions
- Aerobic Exercise, Strength Training, Glycemic Control, Blood Pressure
- Trial name
- NCT06309654
- Testing
- 12-week home-based circuit training (HBCT), Standard of care (CONT)
- Where
- Saudi Arabia
- Volunteers
- 70 people
- Sponsor
- Princess Nourah Bint Abdulrahman University
Diabetes Mellitus Risk, Obesity
Novel Intervention Linking Public Housing With Primary Care to Prevent Diabetes
(Sisters Health And Primary CarE Uniting and Preventing Diabetes; aka SHAPE UP) will consist of: 1) Neighborhood DPP Intervention: group DPP sessions and individual coaching; 2) Preventive Care Coordination to FQHC: referral…
- Conditions
- Diabetes Mellitus Risk, Obesity, Cardiovascular Risk Factor
- Trial name
- SHAPE-Up (NCT03526237)
- Testing
- 24 week community based DPP Group Lifestyle Balance Program, Wait-List Control community based DPP Group Lifestyle Balance Program
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Coronary Angiography, Obesity
Optimizing Image Quality in Obese Patients Undergoing Coronary Computed Tomography (CT) Angiography
The purpose of this cardiovascular imaging research is to look at ways to improve the way we can look at the pictures of the heart.
- Conditions
- Coronary Angiography, Obesity, Coronary Disease
- Trial name
- BMI40 (NCT00468195)
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Corewell Health East
Polyphenols, Cardiovascular Diseases
Autonomic and Cardiovascular Recovery After the Acute Use of Resveratrol in Overweight and Obesity Individuals
The aim of this study is to understand the importance of resveratrol supplementation as a possible adjuvant in improving the metabolic profile and cardiovascular autonomic recovery of individuals with overweight and grade I…
- Conditions
- Polyphenols, Cardiovascular Diseases, Autonomic Nervous System
- Trial name
- Resveratrol (NCT06020313)
- Testing
- Resveratrol Experimental
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Taisy Cinthia Ferro Cavalcante
Type 2 Diabetes Mellitus, Obesity
RCT Examining Effects of Probiotics in T2DM Individuals
Background: The connection between gut health and diabetes status is increasingly recognized. Gut microbiota composition in diabetic differs from non-diabetic individuals.
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Hypertension, Hyperlipidemia
- Trial name
- NCT01752803
- Testing
- Probiotic
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Diabetes, Prediabetes
Meta-analyses of the Effect of Dietary Pulses on Acute Postprandial Metabolic Control
Dietary pulses (beans, peas, chickpeas, and lentils), more commonly known as "legumes", are generally recognized as healthy components of the diet.
- Conditions
- Diabetes, Prediabetes, Dysglycemia, Overweight
- Trial name
- NCT01605422
- Testing
- Dietary pulses
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
Physical Activity, Overweight
Intervention Centered on Adolescents' Physical Activity and Sedentary Behavior (ICAPS)
Physical activity is thought to be a key element in preventing the obesity epidemic and the associated cardiovascular and metabolic diseases.
- Conditions
- Physical Activity, Overweight, Cardiovascular Disease
- Trial name
- ICAPS (NCT00498459)
- Testing
- Physical activity
- Where
- France
- Volunteers
- 954 people, healthy volunteers welcome
- Sponsor
- Louis Pasteur University, Strasbourg
Cardiovascular Diseases, Prevention
Cardiovascular Health Promotion Among African-Americans by FAITH!
Given the importance of healthy lifestyle practices to cardiovascular disease (CVD) prevention and the utility of church-based interventions in African-American adults, the investigators developed a theory-informed…
- Conditions
- Cardiovascular Diseases, Prevention, Physical Activity, Diet Modification
- Trial name
- FAITH! (NCT03084822)
- Testing
- FAITH! App digital intervention
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Gastrointestinal Diseases, Cardiovascular Diseases
Determining the Potential of Wholegrain Wheat and Rye to Improve Gut HealTh
A dietary intervention study designed as a randomized, controlled, parallel intervention of 6-weeks duration. A total of 75 participants will be included in the study and randomly allocated to one of three interventions (refined…
- Conditions
- Gastrointestinal Diseases, Cardiovascular Diseases, Obesity
- Trial name
- RIGHT (NCT02358122)
- Testing
- Wholegrain rye, Wholegrain wheat, Refined wheat
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Obesity, Cardiovascular Disease
BNP Pharmacodynamics and Effects on Metabolism in Lean and Obese Subjects
The purpose of this study is to collect data to help researchers better understand the various causes of obesity, which may lead to the development of new obesity treatment options.
- Conditions
- Obesity, Cardiovascular Disease, Hypertension, Diabetes
- Trial name
- NCT01977859
- Testing
- Nesiritide, Saline
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Hypertension, Hypertension (HTN)
FIM+DASH: Food is Medicine Intervention to Promote Healthy Eating and Blood Pressure Control
The goal of this clinical trial is to treat both hypertension and obesity in adults using a food is medicine framework. Participants will be randomized 1:1 to FIM+DASH or usual-care control.
- Conditions
- Hypertension, Hypertension (HTN), Obesity & Overweight
- Trial name
- FIM+DASH (NCT07332741)
- Testing
- FIM intervention arm, FIM Usual Care Arm
- Where
- 4 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Illinois Chicago
Diabetes Mellitus, Cardiovascular Diseases
Estudo Longitudinal de Saúde do Adulto (Brazilian Longitudinal Study of Adult Health )
The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) aims to contribute with relevant information regarding the development and progression of clinical and subclinical chronic diseases, particularly cardiovascular…
- Trial name
- ELSA-Brasil (NCT02320461)
- Volunteers
- 15,105 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Obesity, Hypertension
Feasibility of Integrating Indirect Calorimetry (IC) Technology in Primary Care
The purpose of this study is to evaluate the feasibility of using indirect calorimetry (IC) within a comprehensive weight reduction program.
- Trial name
- NCT00750022
- Testing
- Individualized IC treatment, Usual Care
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Colorado Center for Chronic Care Innovations, Inc.
Hypertension, Obesity
DUCS-DHD Determinants of Hypertension in Tanzania
The aim of the Dar es Salaam Urban Cohort Hypertension Study (DUCS-HTN) was to determine the current prevalence, risk factors, and barriers to diagnosis and treatment for hypertension in Dar es Salaam, Tanzania.
- Trial name
- DUCS-HTN (NCT03250702)
- Volunteers
- 2,290 people
- Sponsor
- Harvard School of Public Health (HSPH)
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