Clinical trials: Cardiovascular Outcomes
Cerebral Desaturation, Cerebral Ischemia
Assessment of Cerebral Blood Flow Asymmetry in Cardiac Surgery Patients Undergoing Hypothermic Circulatory Arrest
Cerebral oxygen desaturation during cardiac surgery measured using near infrared spectroscopy (NIRS) derived cerebral oximetry has been associated with significant postoperative morbidity.
- Trial name
- COASTLINE (NCT03215589)
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Hypertension
The Feasibility of a Web-based Application to Monitor Home Blood Pressure
Control of hypertension remains one of the most important interventions available to clinicians to reduce risk of cardiovascular disease, kidney disease and stroke.
- Trial name
- NCT03116815
- Testing
- Direct input of home blood pressure readings via MyChart
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Loyola University
Monoclonal B-Cell Lymphocytosis, Chronic Lymphocytic Leukemia
Risk and Clinical Consequences of Low Count Monoclonal B-cell Lymphocytosis (LC MBL)
The aim of this proposal is to identify immune biomarkers, genetic risk, and the clinical consequences of low count monoclonal B-cell lymphocytosis (LC MBL), a common premalignant condition affecting up to 17% of European adults…
- Conditions
- Monoclonal B-Cell Lymphocytosis, Chronic Lymphocytic Leukemia, Infections, Cancers
- Trial name
- MBL RiskConseq (NCT06416267)
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Heart Valve Disease
D-Dimer Determined Anticoagulation INTENSITY in Patients With Mechanical Valve Replacement
The optimal intensity of oral anticoagulation in China patients undergoing mechanical valve replacements is still controversial due to the different risk profiles of thrombophilia and bleeding in Chinese patients.
- Trial name
- 3D-INTENSITY (NCT01996657)
- Testing
- Warfarin
- Where
- 2 sites in China
- Volunteers
- 772 people, healthy volunteers welcome
- Sponsor
- Wuhan Asia Heart Hospital
COVID-19 Respiratory Infection
Cardiovascular Disease and Outcomes Among Patients With SARS-CoV-2 Infection (COVID-19)
The coronavirus disease of 2019 (COVID-19) has affected over 2.4 million individuals worldwide and has resulted in >171,000 deaths. Cardiovascular disease (CVD) is an important contributor to death in these patients.
- Trial name
- NCT05085262
- Testing
- Bloodwork, Echocardiogram, PET/MRI, Bloodwork, Echocardiogram, MRI
- Where
- Canada
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Sleep, Atrial Fibrillation
Impact of Sleep Quality on Outcomes After Cardiac Surgery
Sleep is a basic human need and is essential for good quality of life, good health. In fact, humans spend one third of their life time in sleeping or attempting to do so.
- Conditions
- Sleep, Atrial Fibrillation, Delirium, Postoperative, Complications, Postoperative
- Trial name
- NCT06527105
- Testing
- Eye masks and ear plugs
- Where
- India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Amrita Institute of Medical Sciences & Research Center
Orthopedic Disorder, Neurologic Disorder
Safety and Clinical Outcomes With Amniotic and Umbilical Cord Tissue Therapy for Numerous Medical Conditions
To determine the safety and efficacy of Amniotic and Umbilical Cord Tissue for the treatment of the following condition categories: Orthopedic, Neurologic, Urologic, Autoimmune, Renal, Cardiac and Pulmonary Conditions.
- Conditions
- Orthopedic Disorder, Neurologic Disorder, Urologic Diseases, Erectile Dysfunction
- Trial name
- NCT03899298
- Testing
- Amniotic and Umbilical Cord Tissue Procedure
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- R3 Stem Cell
Gestational Hypertension, Mild Pre-eclampsia
Labor Characteristics and Outcomes in Women With Gestational Hypertension or Preeclampsia Who Underwent Labor Induction
Comparison of Labor Characteristics and Maternal-Neonatal Outcomes in Induced Labor Between Women with Gestational Hypertension/Mild Preeclampsia and Normotensive Controls
- Trial name
- NCT06907576
- Where
- China
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
DVT - Deep Vein Thrombosis, PE - Pulmonary Thromboembolism
Outcomes Study in Patients Receiving Aspirin With Mechanical Compression Devices Versus Aspirin Alone Following Knee and Hip Arthroplasty
The Purpose is to compare the safety and efficacy of the use of aspirin(ASA) with medical compression devices versus aspirin alone for venous thromboprophylaxis following knee and hip arthroplasty.
- Trial name
- PDAS (NCT03027167)
- Testing
- Aspirin, (Post- discharge) Mechanical Compression Device
- Volunteers
- healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health
Ambient air temperatures in Asian, Latin American, African, and Pacific climate hotspots have broken record highs in 2024, driven by man-made climate change. Solutions are needed to reduce heat exposure in communities.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- REFLECT (NCT06579950)
- Testing
- Cool roof
- Where
- 5 sites in Burkina Faso, Fiji and 3 more
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Cardiovascular Diseases, Cancer
Relationship Between Dietary Protein Intake and Fatal and Non-fatal Health Outcomes
The aim of the current study was to clarify the relationship between protein intake and health by using a very large, general population cohort study, UK Biobank, to study the associations between reported protein intake…
- Conditions
- Cardiovascular Diseases, Cancer, All-cause Mortality
- Trial name
- NCT03243578
- Testing
- None as this is an observational study
- Volunteers
- 502,628 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Atrium; Fibrillation, Lipid Metabolism Disorders
The Atherogenic Index of Plasma（AIP） in Patients With Atrial Fibrillation
The goal of this observational study is to learn about The Atherogenic Index of Plasma(AIP) in patients with atrial fibrillation(AF).
- Conditions
- Atrium; Fibrillation, Lipid Metabolism Disorders, Cardiovascular Diseases, Event, Cardiac
- Trial name
- NCT05973474
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Heart Failure, ICD
Comparing Rate Response With CLS Versus Accelerometer ICD Settings in Heart Failure Patients With BIOTRONIK CRT-Ds
Dr. Jonathan Hsu and Dr. Eric Adler are conducting a research study to find out more about how implantable cardiac defibrillator (ICD) settings can be adjusted to improve patient cardiovascular health and quality of life.
- Conditions
- Heart Failure, ICD, Chronotropic Incompetence
- Trial name
- CLASS (NCT02693262)
- Testing
- CLS Mode on Biotronik CRT-D, Accelerometer Mode on Biotronik CRT-D
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Post-stroke Depression
SCED - Wisdom Enhancement for Post-Stroke Depression
One-third of stroke survivors experience post-stroke depression, but there are currently no official guidelines for supporting them.
- Trial name
- WE-PSD (NCT06451965)
- Testing
- Timeline Intervention
- Where
- United Kingdom
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Normal Weight
Impact of the Timing of Pasta Consumption on Health
To date, the optimal timing for pasta consumption remains uncertain. Based on recent evidence in the field of chrono-nutrition, it is speculated that eating pasta at dinner may have a negative impact on cardio-metabolic health.
- Trial name
- NCT06185634
- Testing
- Dietary intervention - Pasta at dinner, Dietary intervention - Pasta at lunch
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Postoperative Complications (Cardiopulmonary)
Preoperative Exercise Testing and Perioperative Outcomes
The goal of this observational study is to learn whether results from a brief exercise test done before surgery can help identify adults who may be more likely to have problems after moderate- to high-risk noncardiac surgery.
- Trial name
- SAMPO (NCT07519733)
- Testing
- Recruited participants receive preoperative rapid submaximal cardiopulmonary exercise testing within the current risk assessment framework of the pre-surgical evaluation clinic
- Where
- United States
- Volunteers
- 992 people, healthy volunteers welcome
- Sponsor
- Yale University
Heart Rate, All-day Steps
Assessing the Effect of Cool Roofs on Health Using Smartwatches
Ambient air temperatures in Asian, Latin American, African, and Pacific climate hotspots have broken record highs in 2024. Solutions are needed to build heat resilience in communities and adapt to increasing heat from climate…
- Conditions
- Heart Rate, All-day Steps, Distance Walked, Active Minutes
- Trial name
- REFLECT (NCT06579963)
- Testing
- Cool roof
- Where
- 4 sites in Burkina Faso, India and 2 more
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Implantable Defibrillator User, Arrhythmias, Cardiac
Association of Obesity and Cardiovascular Outcomes in Patients With Implantable Cardioverter-defibrillator (ICD)
In this study, the investigators evaluated the association between various measures of adiposity [BMI and waist circumference (WC)] and clinical outcomes in Asian patients who underwent Implantable Cardioverter-defibrillator…
- Conditions
- Implantable Defibrillator User, Arrhythmias, Cardiac, Obesity, Cardiovascular Morbidity
- Trial name
- Paradox (NCT05645965)
- Testing
- ICD insertion
- Where
- South Korea
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Ajou University School of Medicine
Stroke
The Effect of Transitional Care Model-Based Interventions for Stroke Patients and Their Caregivers
Stroke affects both the patient's and the caregiver's whole life by creating permanent damages. Patients and their families need further information and support in the transition from hospital to home.
- Trial name
- TEMpEST (NCT03708835)
- Testing
- Transitional care model
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- The Scientific and Technological Research Council of Turkey
Sleep Apnea, Insufficient Sleep Syndrome
Improving Outcomes for Patients With SDB and Insufficient Sleep
The purpose of this study is to look at how sleep disordered breathing (SDB) and not getting enough sleep each night contribute to daytime sleepiness.
- Conditions
- Sleep Apnea, Insufficient Sleep Syndrome, Sleep, Hypertension
- Trial name
- RESTORE (NCT04279834)
- Testing
- PAP Treatment, Sleep Education I
- Where
- United States
- Volunteers
- 561 people, healthy volunteers welcome
- Sponsor
- Wayne State University