Clinical trials: Cardiovascular System
Stroke, Stroke, Acute
Phase 1 Study to Assess AER-271
The objective of this Phase 1 trial is to assess the safety, tolerability and pharmacokinetics of AER-271 in health subjects.
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic
- Trial name
- NCT03804476
- Testing
- AER-271
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aeromics, Inc.
Elderly
Effect of Muay Thai vs. Circuit Training on the Cardiovascular Health of Elderly
The elderly will be recruited, after meeting the inclusion criteria, will be submitted to data collection, all necessary assessments for the study and after 12 weeks, the same data will be collected, so that the elderly are…
- Trial name
- NCT03919968
- Testing
- Martial Arts, Functional Training
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Bradycardia
Clinical Investigation of ENO/TEO/OTO Pacing System Under MRI Environment
The interest of the CAPRI study is to confirm the safety and the efficacy of the ENO/TEO/OTO pacing system when used under 1.5 or 3 Tesla MRI environment and in accordance with the MRI solutions guideline.
- Trial name
- CAPRI (NCT03811691)
- Testing
- MRI exam
- Where
- France
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- MicroPort CRM
Heart Valve Diseases
Effect Of Power Breath Device On Arterial Blood Gases And Diaphragmatic Excursion After Valve Surgery
The aim of this study is to evaluate the effect of power breath device on arterial blood gases, diaphragmatic excursion and the 6 min walk test after cardiac valve surgery.
- Trial name
- NCT06012474
- Testing
- Power breath plus, Incrementing the training load, Diaphragmatic breathing exercises
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Diabetes Mellitus Type 2, Breast Neoplasms
AI-Based Phenome Data Analysis for Predicting the Onset of Major Diseases
This study aims to develop and validate an artificial intelligence (AI)-based predictive model to estimate the risk of incident onset of five major diseases or conditions: cardiovascular disease, type 2 diabetes mellitus, breast…
- Conditions
- Diabetes Mellitus Type 2, Breast Neoplasms, Low Back Pain, Osteoarthritis
- Trial name
- NCT07595718
- Where
- South Korea
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Jae Yong Jeon, MD
Psychopathology
Virtual Mom Power With High-Adversity Mothers and Children (MPHAMC)
This study is a randomized controlled confirmatory efficacy trial of virtual Mom Power (MP), a group-based, relationship-focused multifamily preventive intervention.
- Trial name
- NCT05129397
- Testing
- Mom Power, Mom Power Informational Mailing
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Tulane University
Single-ventricle, Fontan Circulation
Venous Compression in Fontan
The aim of this study is to investigate whether venous compression garments increase exercise stroke volume in patients with Fontan circulation. To address this aim, we will test the following hypotheses: 1.
- Trial name
- NCT07220226
- Testing
- Lower extremity compression garments, Without compression garments
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Multiple Myeloma in Relapse, Multiple Myeloma, Refractory
Early Palliative Care for Patients With Multiple Myeloma and Aggressive Lymphoma
Patients with multiple myeloma experience a wide range of physical and psychological symptoms from the time of their diagnosis. Meanwhile, patients with aggressive lymphomas undergo unpredictable illness courses, resulting in…
- Conditions
- Multiple Myeloma in Relapse, Multiple Myeloma, Refractory, Multiple Myeloma Stage III, Multiple Myeloma Progression
- Trial name
- EPC-MM+L (NCT06485076)
- Testing
- Early Palliative Care
- Where
- Canada
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Healthy Volunteers
A Single Oral Dose Study to Evaluate Four Different Formulations of AZD9977 and the Effect of Food in Healthy Male Subjects
This study will evaluate pharmacokinetics (PK) of four different formulations with different release profiles of AZD9977 (PART A) in the fasted state, and one of the formulation will be selected for further development (Part B).
- Trial name
- NCT03450759
- Testing
- AZD9977 Oral suspension (reference), AZD9977 capsule, AZD9977 ER capsule (fastvrate)
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Traumatic Brain Injury, Stroke
Neural Dynamics and Connectivity in Response Inhibition and Traumatic Brain Injury
Background: Previous research has shown that certain parts of the brain are involved in voluntarily stopping an ongoing motor response (movement); however, it is not known whether this same network is also involved in suppressing…
- Conditions
- Traumatic Brain Injury, Stroke, Headache, PTSD
- Trial name
- NCT01194661
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Oral Lichen Planus, Thyroid Disease
Association Between Oral Lichen Planus and Thyroid Disease
The goal of this observational study is to determine the prevalence of thyroid disease in adults with oral lichen planus (OLP) treated at the Dental Hospital of the University of Barcelona (HOUB), and to evaluate the association…
- Trial name
- NCT06550154
- Testing
- Data collection
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Hypertension
Expanding Health Systems Research to Optimize Hypertension Care Cascade in HIV-Infected Individuals in Mozambique
Undiagnosed and untreated hypertension is a main driver of cardiovascular disease, affecting disproportionately low and middle-income countries, where guidelines to screen and manage hypertension are poorly used.
- Trial name
- SCALESAIAHTN (NCT05002322)
- Testing
- Systems Analysis and Improvement Approach
- Where
- 6 sites in Mozambique
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Eduardo Mondlane University
Vascular Stiffness, Inflammation
Anthocyanin-rich Blackcurrant and Vascular Function
Regular consumption of fruits and vegetables may improve human health and reduce the risk of chronic diseases, such as heart disease, certain cancers and type 2 diabetes, but the active components and the underlying mechanisms…
- Trial name
- NCT02459756
- Testing
- Beverage: Spray dried blackcurrant powder dissolved in water
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Reading
Obstructive Sleep Apnea
Obstructive Sleep Apnea (OSA), Hypertension , β1 Subunit of Maxi-k+ Channel and Cardiovascular Risk
To describe the relationship between OSA and clinical Hypertension (performing ABPM), endothelial dysfunction (performing flowmetry), and its relation at the basic research (determining the β1 subunit in Peripheral Leukocytes in…
- Trial name
- OSAS (NCT01791270)
- Testing
- Continuous positive airway pressure (CPAP) therapy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Angeles Sanchez Armengol
Varicose Veins, Wound Infection
A Randomised Study to Assess Betadine in the Groin Wound of Patients Undergoing Primary Varicose Vein Surgery
To investigate whether Betadine can reduce infection rates and recurrence rates following varicose veins surgery in a randomized double blind placebo controlled study.
- Conditions
- Varicose Veins, Wound Infection, Recurrence
- Trial name
- NCT00500669
- Testing
- Betadine
- Where
- Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Royal Hobart Hospital
Atherosclerosis, Cardiovascular Diseases
Risk Burden of Lipoprotein Metabolic Gene Haplotypes
To investigate the role in coronary heart disease (CHD) of intragenic variation in a network of six genes affecting lipoprotein transport and metabolism.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Coronary Disease, Heart Diseases
- Trial name
- NCT00090441
- Volunteers
- 4,303 people, healthy volunteers welcome
- Sponsor
- Intermountain Health Care, Inc.
Hypertension
Approaches to Reduce Clinical Inertia in Hypertension in the Dominican Republic
The purpose of this cluster randomized control trial is to test whether a multimodality strategy that includes an educational on-line course and performance feedback reports is effective to reduce clinical inertia in the…
- Trial name
- ARCH DR (NCT03954951)
- Testing
- Multimodality behavioral strategy
- Where
- Dominican Republic
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Diabetic Retinopathy
A Study of PER-001 in Participants With Diabetic Retinopathy
This is a Phase 2a, randomized, single-masked (participant), sham controlled clinical study.
- Trial name
- NCT06003751
- Testing
- PER-001 Intravitreal Implant - Low Dose, PER-001 Intravitreal Implant - High Dose
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Perfuse Therapeutics, Inc.
Metabolic Syndrome, Insulin Sensitivity
Effect of Phosphorus Additives on the Metabolome in Healthy Adults
This study evaluates the effect of phosphorus supplementation on the human metabolome. The investigators will do so by conducting a cross-over study in healthy adults consuming a study diet (normal diet supplemented by neutral…
- Conditions
- Metabolic Syndrome, Insulin Sensitivity, Cardiovascular Diseases
- Trial name
- NCT03841786
- Testing
- Phosphorus-supplemented study diet, Control Diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Stroke, Cerebral Palsy
Design of an Affordable Gym for Post Stroke Rehabilitation
Rehab in a Crate is a therapy gym designed to be affordable, compact and easily transportable. The purpose of this particular study is to gain feedback on the initial design of the Rehab in a Crate system.
- Conditions
- Stroke, Cerebral Palsy, Healthy
- Trial name
- RehabCares (NCT02820480)
- Testing
- Rehab in a Crate System
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
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