Clinical trials: Carotid Artery Plaques
Carotid Artery Stenosis
The Correlation Between the Enzyme Paraoxigenase 1 (PON1) to Carotid Artery Atheromatous Plaque
The objective of the research, is to examine the hypothesis, that the enzyme paraoxygenase 1 ( PON1) can influence carotid artery's atherosclerotic plaque content and stability, and its relation to plasma's enzyme concentration.
- Trial name
- NCT01440036
- Testing
- Carotid endarterectomy
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Ziv Hospital
Carotid Artery Plaque
Carotid Plaque Assessment Using 18Fluorine (18F) -Sodium Fluoride Positron Emission Tomography (PET) /MR
Carotid plaque can lead to ischemic stroke. Treatment of asymptomatic carotid plaque, based on degree stenosis, is still controversial.
- Trial name
- CARTIS (NCT02726984)
- Testing
- 18F-sodium fluoride PET/MR
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Hospices Civils de Lyon
Coronary Arteriosclerosis
Association Between Carotid Plaque Length and Cardiovascular Events
This multicenter study involved 5 hospitals (Changhai Hospital; Yueyang Hospital of Shanghai University of Traditional Chinese Medicine; Gongli Hospital; Putuo Hospital of Shanghai University of Traditional Chinese Medicine; No.
- Trial name
- NCT05159804
- Where
- 5 sites in China
- Volunteers
- 3,637 people
- Sponsor
- Changhai Hospital
Carotid Artery Stenosis, Atherosclerosis
Contrast-enhanced Ultrasound (CE-US) and Magnetic Resonance Imaging (MRI): Evaluating Plaque Neovascularisation
The first goal of this study is to investigate whether CE-US is able to accurately identify and quantify neovascularisation in carotid artery plaques.
- Trial name
- NCT00677963
- Testing
- sulphur hexafluoride, gadopentate dimeglumine
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- Maastricht University Medical Center
Carotid Artery Diseases, Peripheral Arterial Disease
Study to Image Inflammatory Activity of a Fluorescence Imaging Agent in Excised Human Artery Plaques
Active inflammation plays a key role in causing Coronary Artery Disease (CAD) and Peripheral Arterial Disease (PAD). Since inflammation is so important in how these diseases start, are diagnosed, and treated, being able to see it…
- Trial name
- NCT06957821
- Testing
- Pegulicianine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Atherosclerosis, Carotid Artery Disease
Morphological and Serological Criteria of Plaque Vulnerability: Risk Assessment for Symptomatic and Asymptomatic Carotid Artery Stenosis
The aim of this study is to investigate the association of sonographic and histological features of the plaque among each other and with biomarkers of cardiovascular risk.
- Trial name
- VUCAP (NCT02124928)
- Testing
- Carotid endarterectomy
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Prim PD Dr Afshin Assadian
Atherosclerosis, Stroke
3D/4D Ultrasound Contrast Enhanced Imaging (CEUS) for Carotid Plaque Vulnerability
Contrast enhanced 3D/4D (3 dimension/4 dimension) ultrasound (CEUS) provides visualization of the dynamic vascular features of the plaques, in a unique spatial format using three orthogonal planes and angiogram-like images.
- Trial name
- CEUS carotid (NCT02259257)
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Diana Gaitini MD.
Atherosclerotic Disease, Plaque, Atherosclerotic
Natural History of Carotid Plaque as Determined by 3D Ultrasound
This proposed follow-up study aims to recruit participants from the original BioImage cohort for a one-time follow-up examination.
- Conditions
- Atherosclerotic Disease, Plaque, Atherosclerotic, Heart Diseases, Stroke
- Trial name
- BioImage2 (NCT03314818)
- Testing
- Ultrasound 3D Imaging
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Pieter Muntendam
Carotid Artery Stenosis, Carotid Artery Stenosis Asymptomatic
The VANGAS-Trial. The Value of Neurofilament Light Chain and Glial Fibrillary Acid Protein in the Blood of Patients With Asymptomatic Carotid Artery Stenosis
Stroke is the second leading cause of death and the third leading cause of disability worldwide. The cause is usually either a blockage or a severe narrowing of a cerebral artery.
- Conditions
- Carotid Artery Stenosis, Carotid Artery Stenosis Asymptomatic, Carotid Artery Diseases, Carotid Artery Plaque
- Trial name
- VANGAS (NCT06211725)
- Where
- 2 sites in Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Carotid Artery Diseases
OPTIMAl Endovascular Exclusion of Consecutive Patient High-risk Carotid Plaque Using the MicroNet Covered Stent
Prospective, multicentric, multispecialty, international, open-label, single arm study using per-protocol intravascular ultrasound [IVUS, 20MHz electronic phase-array transducer] to document the procedure result of an effective…
- Trial name
- OPTIMA (NCT04234854)
- Testing
- Intravascular Utrasound (IVUS) of Carotid Artery after implantation of CGuard stent
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- John Paul II Hospital, Krakow
Carotid Stenosis, Carotid Artery Diseases
The ENROUTE Transcarotid Neuroprotection System (ENROUTE Transcarotid NPS) DW-MRI Study
The goal of this study is to evaluate the incidence of post procedure DW-MRI lesions (relative to baseline) and debris captured in the ENROUTE Transcarotid NPS inline filter during a transcarotid stenting procedure.
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Carotid Atherosclerosis, Carotid Artery Plaque
- Trial name
- DW-MRI OUS (NCT03985774)
- Testing
- Transcarotid revascularization
- Where
- 3 sites in Belgium, Germany and 1 more
- Volunteers
- 31 people
- Sponsor
- Silk Road Medical
Carotid Artery Diseases
Biomarkers and Unstable Carotid Plaque
This prospective study investigated associations between circulating miRNAs and symptomatic and asymptomatic ICAS, carotid plaque morphology and future cardiovascular events.
- Trial name
- NCT06887894
- Testing
- Carotid endarterectomy
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Atherosclerosis Cardiovascular Disease, Atherosclerosis of Artery
Oral Microbiome in Carotid Atherosclerosis
The goal of this observational study, called OMICA (Oral Microbiome in Carotid Atherosclerosis), is to learn how bacteria living in the mouth may influence the development and stability of plaques in the carotid arteries, which…
- Conditions
- Atherosclerosis Cardiovascular Disease, Atherosclerosis of Artery, Carotid Artery Plaque, Periodontitis
- Trial name
- OMICA (NCT07296965)
- Testing
- Sample Collection
- Where
- Hungary
- Volunteers
- 200 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Carotid Artery Stenosis
Optimization Strategy of Carotid Artery Stenosis
The goal of this observational study is to learn about how to utilize multiple evaluation techniques in carotid artery stenosis patients for optimizing assessment of diagnosis and treatment strategy.
- Trial name
- COAS-CAS (NCT05629000)
- Testing
- Carotid revascularization, MRI-PWI, CTA
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Acute Myocardial Infarction, Severe Periodontitis
Impact of Treating Severe Periodontitis on Inflammatory Activity of Atheromatous Plaques in Patients With Acute Myocardial Infarction (AMI)
Multicenter randomized clinical trial with two arms in patients hospitalized for an AMI nested in the Frenchie registry. Periodontal therapy is performed by periodontists in the intervention group versus treatment by dental…
- Conditions
- Acute Myocardial Infarction, Severe Periodontitis, Carotid Atherosclerosis
- Trial name
- PAROCARD (NCT04046237)
- Testing
- Periodontal treatment
- Where
- France
- Volunteers
- 210 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Carotid Stenosis, Carotid Artery Diseases
Embolic Signals Detection Study (Esds) in Candidates for Surgical Carotid Revascularisation
About 20% of strokes are caused by emboli deriving from a carotid plaque. In symptomatic patients with carotid stenosis grater than 70% the Carotid Endarterectomy (CEA) reduces stroke risk by about 75% and is generally accepted…
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Carotid Atherosclerosis, Carotid Artery Plaque
- Trial name
- NCT05134493
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Atherosclerosis, Carotid Artery Plaque
New Technologies to Determine Carotid Plaque Vulnerability
Hypothesis: Identification of vulnerable atherosclerotic plaques (with or without neovascularization) using carotid CEUS is an independent predictor of MACE (over clinical risk factors, stress echo wall motion results, and…
- Trial name
- CEUS (NCT02224339)
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Mayo Clinic
Carotid Stenosis, Carotid Artery Plaque
CARotid Mri of Atherosclerosis
In the entire world most people die from cardiovascular disease. Death is primarily from myocardial infarction (MI) and stroke which are most often caused by rupture of atherosclerotic plaques. Patients with high-grade, i.e.
- Conditions
- Carotid Stenosis, Carotid Artery Plaque, Carotid Atherosclerosis
- Trial name
- CARMA (NCT04835571)
- Testing
- Optimization of cardiovascular risk management
- Volunteers
- 52 people
- Sponsor
- Linkoeping University
Carotid Artery Plaque, Ultrasonic Diagnosis
Identification of Carotid Plague Vulnerability by Contrast Enhanced Ultrasound: Correlation With Plague Histopathology
OBJECTIVE/BACKGROUND: Intraplaque neovascularization is one of the most important risk factors for unstable carotid plaque. This study was designed to evaluate whether carotid intraplaque neovascularization (IPN) can be…
- Trial name
- NCT02820207
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Atherosclerosis
Study to Determine the Effect of 14 Days Dosing With Darapladib (SB-480848) on Carotid Plague Composition in Patients With Planned Carotid Endarterectomy
The primary objective is to determine Lp-PLA2 activity in atherosclerotic carotid plaques after 14 (+/-4) days treatment with darapladib, compared to placebo.
- Trial name
- NCT01916720
- Testing
- SB-480848 40 mg, SB-480848 80 mg
- Volunteers
- 103 people
- Sponsor
- GlaxoSmithKline