Clinical trials: Cell Invasion
Non-small Cell Lung Cancer, Spread Through Air Space
Deep Learning Signature for Predicting Aggressive Histological Pattern in Resected Non-small Cell Lung Cancer
The purpose of this study is to evaluate the performance of a PET/ CT-based deep learning signature for predicting aggressive histological pattern in resected non-small cell lung cancer based on a multicenter prospective cohort.
- Conditions
- Non-small Cell Lung Cancer, Spread Through Air Space, Visceral Pleural Invasion, Lymphovascular Invasion
- Trial name
- NCT05925738
- Testing
- PET/CT-based Deep Learning Signature
- Where
- 3 sites in China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Pregnancy, Polycystic Ovary Syndrome
Metformin and Folate in Pregnant Polycystic Ovary Syndrome(PCOS) Women
A more recent prospective nonrandomized placebo-controlled double-blind clinical study demonstrated that metformin exerts a slight but significant deleterious effect on serum homocysteine (Hcy) levels in patients with PCOS, and…
- Trial name
- NCT01115140
- Testing
- Metformin plus folic acid
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
Advanced Hepatocellular Carcinoma
Concurrent Nivolumab and External Beam Radiation Therapy for Patients With Advanced HCC
To investigate the efficacy and safety of nivolumab for patients with advanced HCC undergoing EBRT
- Trial name
- Nextrah (NCT04611165)
- Testing
- Nivolumab
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Colonic Lesions
Prospective Image Collection of Colorectal Polyps.
It concerns a study in which we wish to collect images and corresponding histological information (microscopic characteristics) in a prospective manner in various European and non-European centers (multicentric).
- Trial name
- NCT07401264
- Where
- Belgium
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pancreatic Cancer
Detection of Cancer-Specific Active Proteases in Blood Via Fluorescence
The primary objective is to develop a rapid in vitro screening assay for detection of pancreatic cancer biomarkers in blood of patients with pancreatic cancer.
- Trial name
- NCT01707758
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Kansas
Healthy
Inflammation, Intracellular Invasion and Colonization of the Nasal Mucosa by Staphylococcus Aureus
An inflammatory state of the nasal cells (very close to keratinocytes) could favour the internalization of Staphylococcus aureus and thus constitute a persistent reservoir for the carriage of this bacterium.
- Trial name
- I3COSa (NCT04469348)
- Testing
- nasal swab
- Where
- France
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Breast Cancer, HER2-negative Breast Cancer
Clinical Study of Breast Conserving Surgery Combined With Intraoperative Radiotherapy for Early Breast Cancer
A Single-center, open, prospective study，for analyzing the local recurrence rate, the incidence of incision complications and the aesthetic effect of intraoperative radiotherapy in early breast cancer patients after…
- Trial name
- NCT06375798
- Testing
- radiotherapy
- Where
- China
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- Hebei Medical University Fourth Hospital
Preeclampsia
Maternal Serum Stathmin-1 Levels in Preeclampsia
The goal of this observational study is to investigate maternal serum Stathmin-1 levels in pregnancies affected by preeclampsia compared to healthy gestations. The main questions it aims to answer are: 1.
- Trial name
- MSSLP (NCT06481683)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Burak Yücel Special Clinic
Thyroid Cancer
SREBP1 as a Potential Biomarker Promotes Cell Proliferation and Invasion in Thyroid Cancer
In this study, the investigators detected the expression of SREBP1 in thyroid cancer tissues, explored the biological functions of SREBP1 in thyroid cancer cells.
- Trial name
- NCT04072731
- Testing
- pathologic
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- People's Hospital of Zhengzhou University
Placenta Previa
Management Of Placenta Previa Cases And Determination Of Hospitalization Criteria
Placenta previa cases are one of the difficult groups of patients to manage in modern obstetrics. When the literature is evaluated extensively, no clear information can be seen especially in terms of hospitalization time.
- Trial name
- NCT04264234
- Testing
- Vaginal Ultrasonography, Magnetic Resonance Imaging
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Ege University
Placebo Effect, Physical Performance
Effects of Conditioning Activities in Female Athletes
This study will investigate how different warm-up strategies affect physical performance in female athletes who practice invasion sports (e.g., soccer, handball, and basketball).
- Conditions
- Placebo Effect, Physical Performance, Countermovement Jump
- Trial name
- NCT07542119
- Testing
- post-activation performance enhancement (PAPE) protocol
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Triangulo Mineiro
Oral Cancer, Oral Cavity Cancer
WORST PATTERN OF INVASION IN ORAL SQUAMOUS CELL CARCINOMA
Cancer of the oral mucosa, also known as oral squamous cell carcinoma (OSCC), occurs as an ulceroproliferative lesion that can develop at any site in the mouth, from the lips to oropharynx.
- Conditions
- Oral Cancer, Oral Cavity Cancer, Oral Squamous Cell Carcinoma
- Trial name
- NCT05927220
- Testing
- Biopsy Specimens Histopathology
- Where
- Pakistan
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Armed Forces Institute of Pathology Rawalpindi
Colorectal Cancer, Colorectal Polyp
Accuracy for Predicting Deep Submucosal Invasion
The main aim of this study is to determine whether the assessment of the invasive pattern based on NBI with dual focus/magnification or BLI with magnification ± chromoendoscopy (NBI+CE) for predicting deep invasion is…
- Trial name
- NBIBLI (NCT03748667)
- Testing
- White light endoscopy (WLE), NBI/BLI +/- chromoendoscopy (NBIBLI +/- CE)
- Where
- 14 sites in United States, Japan and 1 more
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Miscarriage, Recurrent, Premature Labor
PAR Family Polymorphisms and Placental Invasion Disorders
The present study will be undertaken to establish whether genetic variations of PAR1 could be involved in the occurrence of any of the "placental syndromes" of preterm delivery, preeclampsia, and/or small for gestational age…
- Trial name
- NCT00425867
- Testing
- PAR1 polymoprhisms and placental invasion
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Early Gastric Cancer, Gastric Adenoma
Magnifying Endoscopy With Narrow Band Imaging Versus Endoscopic Ultrasonography for Prediction of Tumor Invasion Depth in Early Gastric Cancer: A Prospective Comparative Study
The treatment of early gastric cancer can be divided into endoscopic resection and surgery, and the precise staging of early gastric cancer is very important to prevent unnecessary surgery or additional surgery after the…
- Conditions
- Early Gastric Cancer, Gastric Adenoma, Gastric Dysplasia
- Trial name
- NCT03546257
- Testing
- magnifying endoscopy with narrow band imaging (ME-NBI)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Placenta Accreta, Placenta Previa
Placenta Accreta New Detection Procedure by Rapid Assessment of Serum BNP
The placenta accreta is defined as a placenta that is abnormally adherent to the myometrium. It can thus invade the entire thickness of the myometrium (placenta increta) or even exceed the serosa and invade neighboring organs…
- Conditions
- Placenta Accreta, Placenta Previa, Normal Pregnancy
- Trial name
- PANDORA (NCT04215484)
- Testing
- serum BNP assessment
- Where
- Tunisia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ben marzouk Sofiene
Cell Migration, Cell Invasion
This Repeated Measures Parallel-group Investigation Will Examine the Influence of Short-term Melatonin Supplementation (5mg, 3 x Day for 72 Hours) on Cellular Responses, Functional Performance and Recovery Following an Acute Bout of Dynamic Resistance Exercise in Resistance Trained Men and Women
Oral Melatonin is a commercially available product available alone and as a constituent in a number of supplements. Previous research suggests that short-term supplementation with oral melatonin may amplify the recovery response…
- Conditions
- Cell Migration, Cell Invasion, Exercise Recovery
- Trial name
- NCT06617351
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Visual Impairment, Ocular Illness
Pupillometry and Locus Coeruleus Activation (PuLCA)
This project will apply non-invasive, trans-cutaneous vagal nerve stimulation using various stimulation parameters to young, healthy adults to find the optimal set of parameters to elicit pupil response.
- Trial name
- PuLCA (NCT04579653)
- Testing
- transcutaneous electrical nerve stimulation devices
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Placenta Accreta Spectrum, Cesarean Hysterectomy
Early vs Late Bladder Dissection During CS Hysterectomy in Patients With PAS With Bladder Invasion
Thirty-six singleton pregnant women with PAS and bladder invasion; total anterior or anterolateral invasion, who were scheduled for cesarean hysterectomy were randomly assigned into two equal groups Group 1: included 18 pregnant…
- Trial name
- NCT05752513
- Testing
- Late bladder dissection, early bladder dissection
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Malaria
Molecular Basis of Erythrocyte Invasion by Plasmodium Vivax Into Duffy-Negative Erythrocytes in Mali
Background: Malaria is caused by parasites carried by some mosquitos. When the mosquitos bite people, the parasites can infect them. One of these parasites is Plasmodium vivax (P. vivax). Some children have P.
- Trial name
- NCT03304691
- Where
- 2 sites in Mali
- Volunteers
- 667 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)