Clinical trials: Central Apnea
Obstructive Sleep Apnea, Dementia
The Effect of OSA on Brain Waste Clearance
Recent ground-breaking research has shown that clearance of toxic neuro-metabolites from the brain including the proteins β-Amyloid (Aβ) and tau that form dementia causing plaques and tangles is markedly impaired when sleep is…
- Conditions
- Obstructive Sleep Apnea, Dementia, Cognitive Impairment
- Trial name
- NCT05606991
- Testing
- CPAP Withdrawal
- Where
- Australia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Woolcock Institute of Medical Research
Sleep Disordered Breathing, Sleep Apnea, Central
Evaluation of Software Enhancements to the Respironics BiPAP Auto Servo Ventilation (AutoSV) Device
This study is being undertaken to collect data from Respironics Inc's BiPAP Auto Servo Ventilation 3 (autoSV3) and compare with data from Respironics, Inc's BiPAP autoSV2, to confirm that the algorithms in the BiPAP autoSV3…
- Trial name
- AUTOSV3 (NCT00720213)
- Testing
- Respironics BiPAP autoSV2, Respironics BiPAP autoSV3
- Where
- 5 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Philips Respironics
Spinal Cord Injury, Sleep Apnea, Obstructive
Sleep-Disordered Breathing in Chronic SCI
The purpose of this study is to examine impact of Sleep Disordered Breathing (SDB) treatment in persons with chronic Spinal Cord Injury (SCI).
- Trial name
- NCT02176928
- Testing
- AutoPAP
- Where
- 4 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Miami
Sleep-disordered Breathing
Sleep and Breathing in the General Population - Chemical Stimuli
Central sleep apnea (CSA) is a common condition and its treatment remains elusive. The focus of this proposal is to identify the role of the physiologic path involving cortical arousals in CSA by decreasing arousal frequency…
- Trial name
- NCT04720547
- Testing
- Zolpidem, No Treatment
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Wayne State University
OSA
Assessment of Knowledge and Attitude Toward Obstructive Sleep Apnea in Medical Teams
Obstructive sleep apnea (OSA) is a serious and often underreported condition, despite its highly prevalent distribution. Medical teams play an integral role in screening and managing patients with a high risk of developing OSA.
- Trial name
- NCT05990777
- Where
- 2 sites in Egypt
- Volunteers
- 377 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sleep Apnea, Obstructive, Sleep Apnea, Central
DreamKit Respiratory Effort Signal Validation
This study has been developed in order to demonstrate the validity of the DreamKit respiratory effort signal.
- Trial name
- NCT04926077
- Testing
- DreamKit
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Philips Clinical & Medical Affairs Global
Alzheimer Disease, Sleep Apnea
Sleep Aging and Risk for Alzheimer's 2.0
Age-related sleep changes and common sleep disorders like obstructive sleep apnea (OSA) may increase amyloid burden and represent risk factors for cognitive decline in the elderly.
- Trial name
- SARA (NCT03278119)
- Testing
- PET Scan and nocturnal polysomnography
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Sleep Apnea, Central, Heart Failure
Phrenic Nerve Stimulation for Treatment of Central Sleep Apnea
The study objectives are to demonstrate the ease and safety of bilateral cervically implanted phrenic nerve stimulators for Central Sleep Apnea in patients with Heart Failure.
- Trial name
- STIMULATE-CSA (NCT03238937)
- Testing
- Phrenic nerve stimulator
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Healthy
Autonomic Nervous System Activity, Aging and Sleep Apnea/Hypopnea
The regulatory effects of the autonomic nervous system (ANS) concern almost all organs which permanently feed information back to this global biological vigilance system controlling allostasis.
- Trial name
- SYNAPSE (NCT00766584)
- Testing
- Sleep apnea/hypopnea detection
- Where
- France
- Volunteers
- 852 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Hypertension, Chronic Kidneys Disease
Nocturnal Blood Pressure and Hypertension - Central and Peripheral 24-h Blood Pressure.
A new study have shown that high night time blood pressure (BP) and/or non-dipping (lack of fall in BP during night time) is a strong predictor for the risk of cardiovascular disease and mortality in patients with hypertension.
- Conditions
- Hypertension, Chronic Kidneys Disease, Obstructive Sleep Apnea
- Trial name
- HOSA (NCT02078765)
- Where
- Denmark
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Erling Bjerregaard Pedersen
Sleep Apnea, Obstructive
Prescision Medicine in Obstructive Sleep Apnea, Cardiovascular and Cerebrovascular Disease: AI Electrocardiogram Patch Does it All
Obstructive Sleep apnea(OSA) is a disease with multiple causes, and treatments are very diverse. Patients and doctors have a lot of choices.
- Trial name
- NCT05566860
- Testing
- Positional Therapy, Intraoral Negative Pressure Therapy, Oral Appliances
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Obese, Sleep Apnea, Obstructive
Eval EarlySense Bet Lowenstein Sleeplab
The study objective is to collect heart rate, respiration rate and motion data of patients admitted to sleep lab and to determine the accuracy level of the EarlySense system vs.
- Conditions
- Obese, Sleep Apnea, Obstructive, Central Apnea, Sleep Disorders
- Trial name
- NCT01978340
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- EarlySense Ltd.
Chronic Kidney Disease, Obstructive Sleep Apnea
Nocturnal Blood Pressure - Central and Peripheral 24-h Blood Pressure in Chronic Kidney Disease.
A new study have shown that high nighttime blood pressure (BP) and/or non-dipping (lack of fall in blood pressure during nighttime) is a strong predictor for the risk of cardiovascular disease and mortality in patients with…
- Trial name
- NOSA (NCT01951196)
- Where
- Denmark
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Erling Bjerregaard Pedersen
Sleep Apnea
The Efficacy of the 4-channel Sequential NMES for the Treatment of Sleep Apnea
In the treatment of obstructive sleep apnea, by using sequential 4-channel electrical stimulation treatment, unlike conventional positive pressure devices, it can be done more effectively by improving the strength of the biceps…
- Trial name
- NCT05135611
- Testing
- 4 channel Electrical Stimulation Device
- Where
- South Korea
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Sleep Disordered Breathing (SDB), Sleep Apnea
Sleep Disordered Breathing and Multimorbidity: The Xiangya SDB Cohort Study
Sleep disordered breathing (SDB) is one of the most common sleep disorders, including obstructive sleep apnea (OSA), central sleep apnea (CSA), sleep-related hypoventilation, hypoxemia, etc., with OSA being the most prevalent.
- Conditions
- Sleep Disordered Breathing (SDB), Sleep Apnea, Cardiometabolic Diseases, Multimorbidity
- Trial name
- NCT06755840
- Where
- China
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Sleep Apnea, Spinal Cord Injury
Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury
This study will investigate potential therapeutic approaches for sleep-disordered breathing (SDB) in patients with chronic cervical spine injury (>6 months post-injury).
- Trial name
- NCT02922894
- Testing
- Acute episodic hypoxia, Supplemental oxygen, Trazodone
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- John D. Dingell VA Medical Center
Insomnia, Hypersomnia
Sleep Disorders and Their Cardiovascular Correlates in Atahualpa.
Little is known on the prevalence of sleep disorders and their role in the increased prevalence of cardiovascular diseases in the developing world.
- Conditions
- Insomnia, Hypersomnia, Sleep-disordered Breathing, Stroke
- Trial name
- NCT01877616
- Testing
- diagnostic test
- Where
- Ecuador
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Hospital Clínica Kennedy
Asthma, Atrial Fibrillation
Improving Quality by Maintaining Accurate Problems in the EHR
The overall goal of the IQ-MAPLE project is to improve the quality of care provided to patients with several heart, lung and blood conditions by facilitating more accurate and complete problem list documentation.
- Conditions
- Asthma, Atrial Fibrillation, Chronic Obstructive Pulmonary Disease, Coronary Artery Disease
- Trial name
- IQ-MAPLE (NCT02596087)
- Testing
- Problem List Suggestion
- Where
- 4 sites in United States
- Volunteers
- 2,386 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sudden Unexplained Infant Death, Apnea of Newborn
Advanced Wireless Sensors for Neonatal Care in the Delivery Room
The goals of this observational study is to assess whether a new advanced wireless skin sensor vital sign monitoring system can effectively monitor the vital signs of healthy newborn infants (≥ 35 weeks gestational age).
- Conditions
- Sudden Unexplained Infant Death, Apnea of Newborn, Newborn Morbidity, Newborn Asphyxia
- Trial name
- AWARD (NCT06693817)
- Testing
- Wireless skin sensors vital sign monitoring system, Wired vital sign monitoring system
- Where
- 5 sites in Brazil, Canada and 2 more
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Guilherme Sant'Anna, MD
Spinal Cord Injury, Sleep Disordered Breathing
Role of Enhancing Serotonin Receptors Activity for Sleep Apnea Treatment in Patients With SCI
The purpose of this study is to look at the effect of exciting using drugs to target a specific pathway in the body, that relies on a natural chemical the body produces called 'serotonin', in patients with spinal cord injury…
- Trial name
- REST-SCI (NCT02458469)
- Testing
- Buspirone, Trazodone
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development