Clinical trials: Central Venous Catheters
Patients With Uncomplicated Long-term Central Venous Catheter-related Biofilm-related Infection
Conservative Treatment of Catheter - Related Injections With Gentamicine/EDTA
Catheter-related infections are frequent. Treatment without catheter removal is difficult because of the presence of biofilm. The association of gentamicin and EDTA is active in vitro and in vivo against biofilms formed by Gram…
- Trial name
- CATH-GE (NCT04789928)
- Testing
- Gentamicins-EDTA
- Where
- 6 sites in France
- Volunteers
- 8 people
- Sponsor
- Institut Pasteur
Central Venous Catheter, Infant
Optimal Insertion Depth of Left Internal Jugular Vein Catheter in Infants
We previously performed a study to create formula for the optimal insertion depth of left internal jugular vein catheter in infant, which was registered at cris.nih.go.kr.
- Trial name
- NCT03025178
- Testing
- 4Fr central venous catheter insertion
- Where
- South Korea
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Central Venous Catheter Thrombosis
Early Detection of PICC-related Deep Vein Thrombosis by US Surveillance: an Effective Approach for Secondary Prevention?
Background: PICC-related thrombosis have shown a slightly different pattern of frequency and risk factors, compared with traditional CVC; because of the increasing diffusion of PICCs, they are becoming a somehow independent…
- Trial name
- NCT01779999
- Testing
- PICC-carrying patients
- Volunteers
- 150 people
- Sponsor
- University of Turin, Italy
Infection
Antimicrobial Catheter Lock Solution for the Treatment of Central Line Associated Bloodstream Infection (CLABSI)
A CVC is a sterile flexible tube that allows a drug to flow from a bottle or bag directly into a patient's bloodstream. CVCs may cause infections when bacteria gets into the catheter and enters the bloodstream.
- Trial name
- NCT01539343
- Testing
- Antimicrobial Solution
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- M.D. Anderson Cancer Center
Catheter Related Infection
Ethanol in the Prevention of Central Venous Catheter Infections
In recent years, several new methods for treatment of catheter-related bloodstream infections (CRBSI) such as antibiotic or antiseptic lock-therapy have been developed with variable success [1-10].
- Trial name
- NCT01229592
- Testing
- Ethanol, Heparine
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Bacteremia, Neoplasms
Taurolidine Lock Solution in the Prevention of Catheter Related Bacteremia
Children with cancer need a long term tunnelled central venous catheter (TCVC) for the entire duration of their treatment. TCVCs are locked with heparin when not in use.
- Trial name
- NCT00735813
- Testing
- Taurolock, Heparin
- Where
- Denmark
- Volunteers
- 129 people
- Sponsor
- Aarhus University Hospital
Hemodialysis Catheter Infection
Evaluation of the Efficacy of Prophylactic Topical Gentamicin in Tunnelled Catheters for Hemodialysis
Chronic kidney disease (CKD) is a major public health problem worldwide, with a significant increase in the number of patients treated with dialysis and renal transplantation.
- Trial name
- NCT04967859
- Testing
- 0.1% gentamicin
- Where
- Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Heart Defects, Congenital
Mixed Venous Oxygen Saturation From Central Venous Line, Venous Side of Heart Lung Machine and the Pulmonary Artery
This study was designed to examine if venous saturations from the central venous line and from the venous side of the heart lung machine are interchangeable or not with mixed venous saturation from the pulmonary artery in…
- Trial name
- NCT02498626
- Testing
- venous saturations
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Infection
Prevention of Catheter-Related Bloodstream Infection in Patients With Hemato-Oncological Disease
The aim of this prospective randomised controlled trial is to compare the incidence of catheter-related bloodstream infection in 2 groups of patients with hemato-oncological disease: Group A: heparin-coated central venous…
- Trial name
- NCT00413738
- Testing
- Antiseptic-coated central venous catheters
- Sponsor
- Centre National de Greffe de Moelle Osseuse
Sepsis, Bacteremia
Safety and Efficacy of MBI 226 for the Prevention of Central Venous Catheter-Related Bloodstream Infections
Central venous catheters (CVCs) are used in patient care for such purposes as the administration of medication, fluids, blood products and for functions such as hemodialysis and plasmapheresis.
- Conditions
- Sepsis, Bacteremia, Fungemia
- Trial name
- NCT00027248
- Testing
- MBI 226
- Where
- United States
- Volunteers
- 1,400 people
- Sponsor
- BioWest Therapeutics Inc
Patients Requiring Urgent Vascular Access
Observation of Intraosseous Vascular Access in the Emergency Department
The purpose of this study is to evaluate the use of powered intraosseous vascular access (EZ-IO by Vidacare) in the emergency department for patients requiring urgent vascular access.
- Trial name
- NCT01235078
- Testing
- EZ-IO
- Where
- 6 sites in United States
- Volunteers
- 105 people
- Sponsor
- Vidacare Corporation
Septic Thrombophlebitis
Description of Septic Thrombophlebitis on Central Venous Catheter and Midline
Central venous catheters improve the tolerability and feasibility of patient care in the hospital setting by allowing the administration of hyper-osmotic, vesicant and venotoxic fluids.
- Trial name
- THROMBOSEP (NCT05743738)
- Testing
- Doppler ultrasound
- Where
- 2 sites in France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier le Mans
Education, Simulation
Observer Tool Use and Learning Outcomes for Central Venous Catheter Insertion Training
Learning to insert a central venous catheter (CVC) is essential in anesthesiology and the use of simulation is recommended. Since 2017, this training has been integrated into the curriculum for incoming first year anesthesia…
- Trial name
- NCT05134818
- Testing
- observer tool
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Université Paris-Sud
Dysfunctional Central Venous Access Catheters
A Study of Tenecteplase for Restoration of Function in Dysfunctional Central Venous Catheters
This was a Phase III, randomized, double-blind, placebo-controlled study that was conducted at 24 centers in the United States and Canada.
- Trial name
- TROPICS 1 (NCT00395876)
- Testing
- tenecteplase
- Volunteers
- 100 people
- Sponsor
- Genentech, Inc.
Bacterial Infections
Frequence of Dressing Change and Bacterial Colonization in Pediatric Intensive Care Unit
This study is non-inferiority trial design.The relationship between whether dressing change 24hrs after CVC (central venous catheter) catheterization and bacterial colonization of the skin.
- Trial name
- NCT04806776
- Testing
- 24hrs dressings change, 7days dressings change
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Children's Hospital of Fudan University
Occluded Totally Implanted Central Venous Catheter
Determining the Safe Dosage of Ascorbic Acid Used in the Treatment of Occluded Totally Implanted Central Venous Catheter
The hypothesis of the study is to evaluate whether ascorbic acid is able to clear totally implanted central venous catheter
- Trial name
- NCT01270152
- Testing
- Ascorbic Acid
- Where
- Brazil
- Volunteers
- 21 people
- Sponsor
- University of Sao Paulo
Catheter-related Infections
Mino-Lok Therapy (MLT) for the Treatment of CRBSI/CLABSI
This is a Phase 3, multi-center, randomized, open-label, assess-blind study to determine the efficacy and safety of MLT, a novel antibiotic lock therapy that combines minocycline with edetate disodium in 25% ethanol solution as…
- Trial name
- NCT02901717
- Testing
- Mino-Lok, Antibiotic lock
- Where
- 22 sites in United States, Puerto Rico
- Volunteers
- 144 people
- Sponsor
- Leonard-Meron Biosciences, Inc.
CLABSI - Central Line Associated Bloodstream Infection
Efficacy & Cost Effectiveness of Antimicrobial-impregnated CVCs in CLABSI Prevention in a Malaysia Adult ICU
Central venous catheters (CVCs) are indispensable in modern critical care. However, CVC usage is associated with complications, including central line-associated bloodstream infections (CLABSIs), which in turn, is translated to…
- Trial name
- NCT05959018
- Testing
- Arrow Three-Lumen Central Venous Catheter, Arrowg+ard Blue Plus® Three-Lumen Central Venous Catheter
- Where
- Malaysia
- Volunteers
- 110 people
- Sponsor
- University of Malaya
Hemodialysis Access Failure, Kidney Disease, End-Stage
Low-Dose Apixaban Added to Standard Heparin Lock Versus Heparin Lock Alone to Prevent Tunneled Hemodialysis Catheters Dysfunction (APICATH-HD)
This randomized, single-center, PROBE trial evaluates whether adding low-dose apixaban (2.5 mg orally every 12 hours) to standard intraluminal heparin lock prolongs primary functional patency of tunneled hemodialysis catheters…
- Conditions
- Hemodialysis Access Failure, Kidney Disease, End-Stage, Hemodialysis Catheter
- Trial name
- APICATH-HD (NCT07404345)
- Testing
- Apixaban, Heparin sodium lock solution
- Where
- Mexico
- Volunteers
- 54 people
- Sponsor
- Hospital Civil de Guadalajara
Bleeding, Central Line Complication
Bleeding Events Before vs After Lowering Departmental Platelet Transfusion Trigger
Central venous catheters are essential when administering treatment for hematological conditions. Many patients have a decreased platelet count which increases the risk for bleeding complications. Baarle et al.
- Conditions
- Bleeding, Central Line Complication, Thrombocytopenia, Hematologic Diseases
- Trial name
- OBS-PLATE (NCT06187831)
- Where
- Sweden
- Volunteers
- 927 people
- Sponsor
- Thomas Kander