Clinical trials: Cerebral Blood Flows
Brain Vascular Function, Cerebral Blood Flow
Soy and Brain Vascular Function
Cognitive performance is negatively related to an impaired glucose metabolism, possibly due to impairments in brain vascular function.
- Conditions
- Brain Vascular Function, Cerebral Blood Flow, Glucose Metabolism, Cognitive Performance
- Trial name
- NCT03627637
- Testing
- Soy nuts
- Where
- Netherlands
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy Brain Perfusion
Improving Human Cerebrovascular Function Using Acute Intermittent Hypoxia
This study uses magnetic resonance imaging to determine whether 3 weeks of repeated exposure to Acute Intermittent Hypoxia can improve brain blood flow or blood flow regulation in healthy adults.
- Trial name
- NCT05164705
- Testing
- Acute Intermittent Hypoxia
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Effect on Cerebrovascular Reactivity
The Effect of a Deep-fried Chocolate Bar or Porridge on Cerebral Blood Flow
The deep fried chocolate bar is a snack that the international community strongly associates with Scotland. It has previously been cited as being "a symbol of all that is wrong with the high-fat, high-sugar Scottish diet".
- Trial name
- NCT01918137
- Testing
- chocolate bar, Porridge
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Obstructive Sleep Apnea of Adult, Hypoxia, Brain
Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia
A prospective double blind, placebo-controlled, randomized cross-over trial to evaluate the effect of lowering cerebral blood flow on the ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses).
- Conditions
- Obstructive Sleep Apnea of Adult, Hypoxia, Brain, Sleep Apnea, Sleep Disorder
- Trial name
- NCT03255408
- Testing
- Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep, Drug Lowering CBF and Intermittent Hypoxia Sleep
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Cardiovascular Diseases, Hypertension
Peanuts and Neurocognitive / Cardiovascular Health in Black Individuals
The overall research objective of this proposal is to determine the impact of increased daily peanut consumption on indices of neurocognitive and physiological health in BL individuals
- Conditions
- Cardiovascular Diseases, Hypertension, Cognitive Decline, Diet
- Trial name
- NCT06318377
- Testing
- Peanut group
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Caffeine
Effects of a Cocoa Shot on the Human Brain 2
The Hershey Company is interested in investigating the effects of various chocolate beverages on brain physiology and cognitive function.
- Trial name
- NCT02080845
- Testing
- no caffeine, high caffeine, no theobromine
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Fat Processing in the Brain
How Fat Influences the Brain
The aim of the current study was to investigate the effect of a high versus a low fat meal (operationalized by high and low fat yoghurt) on homeostatic and gustatory brain regions.
- Trial name
- NCT01516021
- Testing
- intake of high or low fat yoghurt
- Where
- Germany
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Brain Vascular Disorders, Coronary Artery Disease
Detection of Ultrasound Contrast Signals in the Cerebral Circulation
To Determine whether transcranial ultrasound can detect the presence of intravenously injected microbubbles used routinely for dobutamine stress echocardiography.
- Trial name
- NCT00579241
- Testing
- Ultrasound on Temporal Bone
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Healthy, Brain Insulin Sensitivity
Long-Term Effects of Walnut Consumption on Brain Function
Rationale: Healthy foods, including mixed nuts, may improve brain function, which is essential for cognitive and metabolic health, and may contribute to improved food intake regulation.
- Conditions
- Healthy, Brain Insulin Sensitivity, Cerebral Blood Flow, Brain Vascular Function
- Trial name
- WalBrain (NCT07422220)
- Testing
- Walnuts
- Where
- Netherlands
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Caffeine, Flavonoids
Effects of a Cocoa Shot on the Human Brain
The Hershey Company is interested in investigating the effects of various chocolate beverages on brain physiology and cognitive function.
- Trial name
- NCT01924481
- Testing
- High Caffeine, Low caffeine, High theobromine
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Dementia
BOLD Functional Magnetic Resonance Imaging (fMRI) and Cerebral Blood Flow Measurements as Biomarkers for Cognition Enhancing Drugs (3134-006)
This study will evaluate functional magnetic resonance imaging (fMRI) and methods for measuring drug induced changes in cerebral blood flow as biomarkers for attention-improving drugs.
- Trial name
- NCT00887601
- Testing
- MK3134, Donepezil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
High Altitude Hypoxia, Exercise
Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise
The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral…
- Trial name
- NCT07063732
- Testing
- Ketone Monoester (KME)
- Where
- 2 sites in United States, Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- McMaster University
Obstructive Sleep Apnea (OSA)
Heart and Brain Blood Flow in Obstructive Sleep Apnea
Obstructive sleep apnea causes repeated pauses in breathing during sleep. Breathing efforts against an occluded airway may change how blood flows through the heart and how blood drains from the brain.
- Trial name
- OSA4DFlow (NCT07913269)
- Where
- 2 sites in Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cognitive Function and Mood, Cerebral Blood Flow
The Effects of Resveratrol Supplementation on Cognition, Cerebral Blood Flow, Microbiota and Systemic Inflammation.
Previous research shows that a diet high in fat has harmful effects on gut health. This increases the chance of developing obesity-related diseases (such as type 2 diabetes) and disrupts cognition and mood.
- Conditions
- Cognitive Function and Mood, Cerebral Blood Flow, Systemic Inflammation, Gut Microbiota
- Trial name
- NCT03448094
- Testing
- Resveratrol
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Healthy Males, Neuromuscular Function
Cerebral Blood Flow and PETCO2 on Neuromuscular Function During Environmental Stress
Environmental stress, such as low oxygen availability (hypoxia), has been associated with impaired neuromuscular performance; however, the mechanisms associated with these performance decrements remain unclear.
- Trial name
- NCT01830335
- Testing
- Indomethacin
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Brock University
Anesthesia, Cerebral Blood Flow
Hypertension and Cerebrovascular Hemodynamics in General Anaesthesia
During anesthesia, blood pressure-raising medications are often required to achieve an adequate blood pressure level. However, there is limited knowledge about what constitutes an adequate blood pressure to ensure sufficient…
- Conditions
- Anesthesia, Cerebral Blood Flow, Regional Cerebral Oxygen Saturation, Blood Pressure
- Trial name
- NCT06855407
- Testing
- Blood pressure elevation
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Umeå University
Subarachnoid Hemorrhage, Aneurysmal
Investigate the Relationship Between Inflammatory and Coagulation in SAH CSF
Investigate the role of inflammasome and blood coagulation response in human cerebrospinal fluid after subarachnoid hemorrhage.
- Trial name
- NCT04938414
- Testing
- Lumbar puncture
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cerebral Hypoperfusion, Cerebral Occlusion
Evaluation of Cerebral Blood Flow and Cerebral Oxygenation With Transcranial Doppler and NIRS in Laparoscopic Cholecystectomy Cases
The goal of this clinical trial is to test intracranial blood flow and cerebral oxygenisation changes in patients who have pneumoperitoneum in laparoscopic cholecystectomy procedure.
- Conditions
- Cerebral Hypoperfusion, Cerebral Occlusion, Cholecystitis; Gallstone, Cholecystitis/Cholelithiasis
- Trial name
- NIRS L/C (NCT06036498)
- Testing
- Near Infrared Spectrophotometry Device, Transcranial Doppler Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Uludag University
Preterm Children
Neonatal Cerebral Blood Flow and the Neurobehavioral and Handedness Outcomes in Term and Preterm Adolescents
The results will provide insightful information to understand the process of neural development and the predictive value of early cerebral blood flow measures on longitudinal neurodevelopment and handedness outcomes in preterm…
- Trial name
- NCT04708652
- Testing
- No intervention
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cognitive and Cerebral Blood Flow Effects of Resveratrol
The Cognitive and Cerebral Blood Flow Effects of Resveratrol
Research shows that resveratrol is able to induce vasodilation (and therefore blood flow) by interacting with nitric oxide (NO).
- Trial name
- NCT01010009
- Testing
- Trans- resveratrol
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northumbria University