Clinical trials: Cerebral Blood Flows
Vertigo
A Study To Evaluate The Efficacy And Safety Of Betahistine Mesilate In The Treatment Of Patients With Vertigo Caused By Cerebral Infarction In Posterior Circulation
The purpose of this study is to determine the efficacy and safety of Betahistine Mesilate in the treatment of patients with vertigo caused by Cerebral Infarction in posterior circulation.
- Trial name
- NCT00474409
- Testing
- Merislon
- Where
- 4 sites in China
- Sponsor
- Eisai Inc.
Cerebral Oxygen Saturation,MCA Velocity,Intraoperative Neurological Symptoms During Carotid Endarterectomy
Middle Cerebral Artery Velocity and Oxygen Saturation of the Brain During Carotid Endarterectomy
The primary endpoint of our study is to determine whether neurological symptoms (aphasia, paresis, loss of consciousness, numbness) occur after clamping the internal carotid artery, and if so, changes showed by transcranial…
- Trial name
- NCT02665104
- Testing
- transcranial Doppler (TCD) and INVOS monitor
- Where
- 2 sites in Hungary
- Volunteers
- 100 people
- Sponsor
- University of Debrecen
Cerebral Blood Flow
Validation of UK Protocols to Exclude Brain Blood Flow During Normothermic Regional Perfusion (NRP)
This study aims to evaluate both Abdominal Normothermic Regional Perfusion (A-NRP) and Thoracoabdominal-NRP (TA-NRP) techniques, proving that brain blood flow is not resumed during NRP.
- Trial name
- NCT05775263
- Testing
- CT angiogram
- Volunteers
- 10 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Magnetic Resonance Imaging, Cerebrovascular Circulation
Brain Blood Vessel Responses to Changes in Blood Flow: Younger Cohort
Brain blood flow will be measured during a simulated postural change test and while breathing increased levels of carbon dioxide using magnetic resonance imaging.
- Trial name
- NCT06629090
- Testing
- MRI, Prazosin
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
COVID-19 Acute Respiratory Distress Syndrome, COVID-19 Pneumonia
Cerebral Autoregulation and COVID-19
This study aims to assess cerebral autoregulation by near-infrared spectroscopy (NIRS) in patients with severe coronavirus disease 19 (COVID-19).
- Trial name
- CA-COVID (NCT04930874)
- Testing
- NIRS (Near-Infrared Spectroscopy)
- Where
- Greece
- Volunteers
- 7 people
- Sponsor
- University of Athens
Stroke, Acute, Infarction, Middle Cerebral Artery
Autologous Bone Marrow Stem Cells in Ischemic Stroke.
The aim of the study is to determine the safety and tolerability of an autologous CD34+ subset bone marrow stem cell infusion into the middle cerebral artery in patients who have suffered acute total or partial anterior…
- Trial name
- NCT00535197
- Testing
- Infusion of autologous CD34+ stem cells into middle cerebral artery
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Imperial College London
Liver Cirrhosis, Liver Failure
Effects on Plasma Exchange on Functional Capacity of Serum Albumin, Circulatory Dysfunction, Renal and Cerebral Function in Cirrhotic Patients With "Acute-on-chronic Liver Failure"
The purpose of this study is to evaluate the effects on plasma exchange with 5% albumin on albumin functional capacity, cardiocirculatory, renal and cerebral function in cirrhotic patients with "acute-on-chronic liver failure".
- Trial name
- NCT01201720
- Testing
- Plasma exchange with albumin
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Instituto Grifols, S.A.
Ischemic Stroke
Total Posterior-circulation Infarct Volume in Basilar Artery Stroke
Preprocedural predictors of outcome in patients with acute basilar artery occlusion (ABAO) who underwent endovascular treatment (EVT) remain controversial.
- Trial name
- TPCIV-ABAO (NCT04650022)
- Testing
- Mechanical thrombectomy
- Where
- France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Montpellier
Circulatory Failure
NeoAdapt 3: Novel Biomarkers in the Evaluation of Neonatal Circulatory Insufficiency in Babies Suffering From Hypoxic Ischemic Encephalopathy
1 in 1000 babies are born suffering from a lack of oxygen. This is known as hypoxic ischemic encephalopathy (HIE). Infants with this condition can suffer multiple organ problems.
- Trial name
- NCT02051894
- Testing
- Dobutamine
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Brighton and Sussex University Hospitals NHS Trust
Ischemic Stroke
Clinical Application and Basic Study of Medicinal Fractions-based Herbal Combinations
The purpose of this study is to investigate the efficacy of fractions-based herbal combinations of clearing heat and promoting blood circulation treating acute ischemic stroke and the potential mechanism of it.
- Trial name
- NCT01636154
- Testing
- Ixeris of sonchifolia Hance, Panax notoginseng saponins, Ixeris of sonchifolia Hance combined with Panax notoginseng saponins
- Where
- 3 sites in China
- Volunteers
- 120 people
- Sponsor
- Yunling Zhang
Heart-Assist Devices, Heart Failure
Individual Blood Pressure Optimization Based on Cerebral Autoregulation After Implantation of Continuous-flow LVAD
This study will collect retrospective and prospective clinical data regarding the Principal Investigator's patient population to allow for data analysis seeking basic trends and to prepare academic reports, including journal…
- Trial name
- NIRS (NCT03093012)
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Baylor College of Medicine
Type A Aortic Dissection, Circulatory Arrest
Antegrade Cerebral Perfusion and Retrograde Inferior Vena Caval Perfusion for Total Aortic Arch Replacement
This study is designed as a multicenter, randomized, assessor- blinded clinical trial.The primary aim of this trial is to assess whether retrograde inferior venal caval perfusion combined selective antegrade cerebral…
- Conditions
- Type A Aortic Dissection, Circulatory Arrest, Hypothermia
- Trial name
- CARTAR (NCT03607786)
- Testing
- Retrograde Inferior Vena Caval Perfusion, Select antegrade cerebral perfusion
- Where
- China
- Volunteers
- 600 people
- Sponsor
- West China Hospital
Effect on Cerebrovascular Reactivity
The Effect of a Deep-fried Chocolate Bar or Porridge on Cerebral Blood Flow
The deep fried chocolate bar is a snack that the international community strongly associates with Scotland. It has previously been cited as being "a symbol of all that is wrong with the high-fat, high-sugar Scottish diet".
- Trial name
- NCT01918137
- Testing
- chocolate bar, Porridge
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Acute Ischemic Stroke
Study of Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients With a Large Infarct Core
Endovascular therapy (EVT) was recommended as the primary treatment for patients with acute large vascular occlusion (LVO) in anterior circulation.
- Trial name
- ANGEL-ASPECT (NCT04551664)
- Testing
- Best medical management, Endovascular therapy
- Where
- China
- Volunteers
- 456 people
- Sponsor
- Beijing Tiantan Hospital
Healthy
Evaluating Q-Collar Effects on Brain Blood Flow Control During Exercise
The goal of this clinical trial is to learn how the FDA-cleared Q-Collar device affects brain blood flow regulation during rest and exercise in healthy adults. The main questions this study aims to answer are: 1.
- Trial name
- NCT06826781
- Testing
- Q30 Q-Collar, Not wearing Q-Collar
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Brain Injuries, Traumatic, Cerebrovascular Circulation
CPPopt Guided Therapy: Assessment of Target Effectiveness
Despite improvements in management, mortality in severe traumatic brain injury (TBI) remains 25% and only 40% of patients survive without major handicap.
- Conditions
- Brain Injuries, Traumatic, Cerebrovascular Circulation, Homeostasis
- Trial name
- COGITATE (NCT02982122)
- Testing
- For both groups, CPP targets will be achieved first by ICP control if this is raised and then by ABP support by titration (up or down) of vasopressors and fluids according to local protocols.
- Where
- 2 sites in Belgium, United Kingdom
- Volunteers
- 60 people
- Sponsor
- Maastricht University Medical Center
Cerebrovascular Disorders
Identification of microRNAs Involved in Cerebral Collateral Regulation
Patients >18 years of age presenting to Ohio State Wexner Medical Center Emergency department with stroke symptoms, within 6 hours of last know well and found to have acute anterior circulation large vessel occlusion (LVO) will…
- Trial name
- microRNA (NCT03905434)
- Testing
- miRNA sampling
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Preeclampsia
A Study of Cerebral-circulatory Response to Intravenous Antihypertensive Treatment in Women With Serious Preeclampsia
The purpose of this study is a systematical registration of hemodynamic measurements (cardiac output, blood pressure and systemic vascular resistance) in women with serious preeclampsia.
- Trial name
- NCT00403572
- Volunteers
- 8 people
- Sponsor
- Oslo University Hospital
Ischemic Stroke
Bolus of Saline in Stroke
This study is a non-randomized, Phase 2 clinical trial designed to assess optical cerebral blood flow (CBF) response to bolus normal saline. Subjects will have had an ischemic stroke within 96 hours of enrollment.
- Trial name
- BOSS (NCT01971463)
- Testing
- Normal saline
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Pennsylvania
Long COVID
Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog
This study aims to assess the effects of both acute and chronic exposures to hypoxia and hypercapnia in patients with Long COVID syndrome.
- Trial name
- NCT06614309
- Testing
- Acute Progressive Carbon Dioxide, Acute Intermittent Hypoxia, Training: Progressive Carbon Dioxide Ramping
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Mayo Clinic