Clinical trials: Cerebral Disorder
Migraine Disorders
Impact of Migraine on Work Productivity in Patients Treated With a Combination Product Containing Sumatriptan and Naproxen Sodium or Triptan Monotherapy
Migraine headaches lead to absenteeism and can restrict on-the-job productivity (presenteeism) for employed migraine sufferers. Effective migraine treatments should reduce migraine-associated productivity losses and return…
- Trial name
- NCT01381497
- Testing
- Combination therapy of sumatriptan and naproxen sodium (SumaRT/Nap), Triptan monotherapy
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Brain and Central Nervous System Tumors, Long-term Effects Secondary to Cancer Therapy in Children
Proton Beam Radiation Therapy in Treating Young Patients Who Have Undergone Biopsy or Surgery for Medulloblastoma or Pineoblastoma
RATIONALE: Specialized radiation therapy that delivers radiation directly to the area where a tumor was surgically removed may kill any remaining tumor cells and cause less damage to normal tissue.
- Trial name
- NCT00105560
- Testing
- radiation therapy
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Massachusetts General Hospital
Epilepsy, Adverse Effects
Exploration of Genotype Based Personalized Prescription of Valproate Sodium in Anti-epileptic Treatment
The purpose of this study is to investigate the relationship between the side effects of valproate sodium in the treatment of epilepsy in Han Chinese and the genetic polymorphisms of drug metabolizing enzymes and pharmacokinetics…
- Trial name
- EGBPPVPA (NCT01172626)
- Testing
- valproate sodium, Polymorphism Analysis, Pharmacokinetic analysis
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sun Yat-sen University
Autism Spectrum Disorder, Executive Dysfunction
Non-invasive Brain Stimulation in Children With Autism
Although many children diagnosed with autism spectrum disorder (ASD) make significant progress in learning and their cognitive skills improve with applied behavior analysis (ABA), there are a significant number of children who…
- Conditions
- Autism Spectrum Disorder, Executive Dysfunction, Child Autism
- Trial name
- NCT05105126
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Sponsor
- Rutgers, The State University of New Jersey
Moyamoya Disease, Ischemic Cerebral Infarction
NBP in Patients With Moyamoya Disease of High Risk for Ischemic Cerebrovascular Events
An extracranial-to-intracranial (EC-IC) revascularization is the most widely used treatment to improve cerebral perfusion in patients with moyamoya disease (MMD), and it has been shown to reduce the risk of subsequent stroke and…
- Conditions
- Moyamoya Disease, Ischemic Cerebral Infarction, Ischemic Stroke, Ischemic Cerebrovascular Accident
- Trial name
- NICE-MMD (NCT04205578)
- Testing
- dl-3-n-butylphthalide (NBP), Normal Saline 0.9% Infusion Solution
- Where
- 2 sites in China
- Volunteers
- 450 people
- Sponsor
- yuanli Zhao
Traumatic Brain Injury, Depression
Treatment of Post-TBI Depression
Randomized clinical trial that compares the effects of cognitive behavioral therapy (CBT) and supportive psychotherapy for depression.
- Trial name
- NCT00211835
- Testing
- Cognitive behavioral therapy, Supportive psychotherapy
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Muscle Spasticity, Stroke
OnabotulinumtoxinA Treatment in Adult Patients With Upper Limb Spasticity
This is a safety and efficacy study of onabotulinumtoxinA in poststroke patients with upper limb spasticity.
- Trial name
- NCT02145676
- Testing
- onabotulinumtoxinA
- Where
- 2 sites in United States, Canada
- Volunteers
- 53 people
- Sponsor
- Allergan
Alzheimer Disease (AD)
The Co-Production and Evaluation of the Computerised Cognitive Assessment for Preclinical Alzheimer's Disease (CoCoA-PAD)
Background. Healthcare professionals can now diagnose the earliest stages of Alzheimer's disease (early-AD) and new drugs are effective at slowing the disease.
- Trial name
- CoCoA-PAD (NCT07598617)
- Where
- 3 sites in United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Plymouth
Plexus Choroideus, Metabolic Syndrome
Choroid Plexus Dysfunction in Neurological Diseases
Cerebral folate deficiency (CFD), a partially treatable condition defined by a low folate cerebrospinal fluid (CSF) concentration, can be linked to genetic defects of folate metabolism or be secondary to various diseases without…
- Trial name
- PLEXFOLD (NCT06403189)
- Testing
- Biologic samples and MRI
- Where
- 2 sites in France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obsessive Compulsive Disorder, Healthy
Cortical Excitability in Obsessive-Compulsive and Related Disorders
This study will use transcranial magnetic stimulation (TMS) to study the function of the cerebral cortex (outer layer of the brain) in people with obsessive compulsive disorder (OCD) and related disorders.
- Trial name
- NCT00029068
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Stroke
The Relationship of Trunk Control With Lower Extremity Sense, Balance and Gait in Stroke
Cerebrovascular accident is the third leading cause of death in developed countries after heart disease and cancer. In adults, it ranks first among neurological diseases in terms of causing death and disability.
- Trial name
- NCT05244850
- Testing
- Test
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Parkinsonism
Efficacy and Safety of Astragalus for Non-motor Symptoms of α-Synucleinopathy
α-Synucleinopathy is a cluster of neurodegenerative disease with motor and non-motor symptom. However, there is still a lack of research on the treatment for non-motor symptoms of α-synucleinopathy, especially autonomic…
- Trial name
- NCT05506891
- Testing
- Physical therapy group, Astragalus
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fujian Medical University Union Hospital
Brain Tumors
Integrated Pulmonary Index and Opioid Based Patient Controlled Analgesia
An optimal analgesic therapy is very important for postoperative recovery. In recent years, several studies showed that the prevalence of the moderate to severe pain after craniotomy ranged from 69 to 87% of patients.
- Trial name
- NCT04313374
- Testing
- Morphine PCA 1 mg, Morphine PCA 0,5 mg
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Dementia
Going Down Memory Lane: A Technological Intervention
Over 90% of people living with dementia (PLWD) experience behavioural and psychological symptoms of dementia, including apathy, depression, sleep disruptions, wandering, repetitive behaviours and anxiety.
- Trial name
- NCT04131374
- Testing
- Reminiscence Therapy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Epilepsy
Open-label Long-term Study of Adjunctive Brivaracetam in Pediatric Subjects With Epilepsy
This study will evaluate the safety and tolerability of brivaracetam in pediatric subjects with epilepsy.
- Trial name
- NCT01364597
- Testing
- Brivaracetam (BRV)
- Where
- 56 sites in United States, Belgium and 10 more
- Volunteers
- 257 people
- Sponsor
- UCB Pharma SA
Cognitive Impairment
Development and Application of Portable Multisensory Stimulation Device
This is a study to develop the vibroacustic devices, and to compare the effects between vibroacustic device therapy and music therapy in adults with dementia or with neck pain.
- Trial name
- NCT04005313
- Testing
- vibroacoustic device
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Buddhist Tzu Chi General Hospital
Stroke, Acute
The Effectiveness of Waiting Room Posters for Stroke Education
The purpose of this study is to determine the effectiveness of posters in improving patient awareness and knowledge of the signs and symptoms of stroke. The control group study will be conducted in the first two weeks.
- Trial name
- NCT03391713
- Testing
- Poster
- Where
- Malaysia
- Volunteers
- 1,064 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Dementia, Alzheimer Disease
Translating a Dementia Caregiver Intervention Into a Mobile Application
The overall goal of this development project is to combine elements of two efficacious interventions into a mobile health (mHealth) App for informal dementia caregivers.
- Conditions
- Dementia, Alzheimer Disease, Caregiver Burnout
- Trial name
- NCT04330482
- Testing
- CARE-Well App, Internet Links
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
West Nile Fever
High-Titer Neutralizing Plasma for West Nile Fever in Hospitalized Patients
This study will test whether plasma containing high levels of neturalizing antibodies against West Nile virus (WNV) can help people hospitalized with severe West Nile fever recover faster and avoid serious complications.
- Trial name
- NCT07094724
- Testing
- Plasma
- Where
- Israel
- Volunteers
- 37 people
- Sponsor
- Gili Regev-Yochay MD
Kidney Cancer, Melanoma (Skin)
Radiation Therapy in Treating Patients With Newly Diagnosed Brain Metastases From Kidney Cancer, Melanoma, or Sarcoma
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. PURPOSE: Phase II trial to study the effectiveness of radiation therapy in treating patients with newly diagnosed brain metastases from kidney cancer…
- Conditions
- Kidney Cancer, Melanoma (Skin), Metastatic Cancer, Ovarian Cancer
- Trial name
- NCT00003308
- Testing
- stereotactic radiosurgery
- Where
- 14 sites in United States, Australia and 2 more
- Sponsor
- Eastern Cooperative Oncology Group
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