Clinical trials: Cerebral Vascular Accident (CVA)
Stroke
Efficacy and Safety of MRI-based Thrombolysis in Wake-up Stroke
WAKE-UP is an investigator initiated European multicenter randomized controlled clinical trial of MRI based thrombolysis in acute stroke patients with unknown time of symptom onset, e.g.
- Trial name
- WAKE-UP (NCT01525290)
- Testing
- Alteplase
- Where
- 7 sites in Belgium, Denmark and 4 more
- Volunteers
- 501 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Atrial Fibrillation, Stroke
Anticoagulation With Rivaroxaban in Cardioversion -The ARC Study
The purpose of this study is to determine that a new drug called "Rivaroxaban®" is effective in preventing patients from forming clots after their heart rhythm has been reset by the cardiologist with an electrical device.
- Conditions
- Atrial Fibrillation, Stroke, Thrombo-embolism, Bleeding
- Trial name
- ARC (NCT01747746)
- Testing
- Rivaroxaban, Warfarin and Enoxaparin
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Cook County Health
Alzheimer's Disease, Amyotrophic Lateral Sclerosis (ALS)
PRISM Registry: Pseudobulbar Affect Registry Series
PBA is a neurologic condition that is estimated to impact over a million patients and their families in the United States. PBA occurs secondary to an otherwise unrelated neurologic disease or injury, and manifests as involuntary…
- Conditions
- Alzheimer's Disease, Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), Parkinson's Disease
- Trial name
- NCT01366027
- Where
- United States
- Volunteers
- 5,290 people
- Sponsor
- Avanir Pharmaceuticals
Stroke, Cardiovascular Diseases
Evaluation of Effectiveness of Nutritional Counseling in Patients After Stroke
Stroke is the leading cause of disability worldwide and the leading cause of death in Brazil. It is estimated that about 18 million people will have a stroke in 2015 and approximately one third of these resulting in death.
- Trial name
- NCT01517542
- Testing
- Nutritional Counseling
- Sponsor
- Hospital de Clinicas de Porto Alegre
Primary Prevention of Atherosclerotic Cardiovascular Disease
A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.
CKJX839D12302 is a pivotal Phase III study designed to test the hypothesis that treatment with inclisiran sodium 300 milligram (mg) subcutaneous (s.c.) administered on Day 1, Day 90, and every 6 months thereafter in patients at…
- Trial name
- NCT05739383
- Testing
- Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL
- Where
- 983 sites in United States, Argentina and 40 more
- Volunteers
- 14,012 people
- Sponsor
- Novartis Pharmaceuticals
Stroke, Ischemic, Stroke Hemorrhagic
Multicenter Study on the Efficacy of Transcranial Direct Current Stimulation (tDCS) in Post-stroke Motor Recovery
Several previous studies have used tDCS as a neuromodulation tool, showing improvements in several diseases (Lefaucheur et al., 2017).
- Trial name
- NCT04166968
- Testing
- Anodal transcranial direct current stimulation (A-tDCS), Cathodal transcranial direct current stimulation (C-tDCS), Neuromotor training
- Where
- Italy
- Volunteers
- 162 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Spasticity
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.
The purpose of the study is to assess the safety and efficacy of increasing doses of Corabotase (also known as IPN10200) with the aim to evaluate the Pharmacodynamics (PD) profile of Corabotase and to establish the total…
- Trial name
- LANTIMA (NCT04752774)
- Testing
- Corabotase, Dysport
- Where
- 81 sites in United States, Austria and 12 more
- Volunteers
- 240 people
- Sponsor
- Ipsen
Stroke, Intracranial Atherosclerosis
PCSK9 Inhibition in Patients With Symptomatic Intracranial Atherosclerosis
This will be a randomized double blind placebo-controlled pilot study using a repeated measures design in which participants with acute ischemic stroke and intracranial atherosclerotic disease are randomized to either drug or…
- Conditions
- Stroke, Intracranial Atherosclerosis, Intraplaque Hemorrhage
- Trial name
- PINNACLE (NCT03507374)
- Testing
- Alirocumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Stroke
New Model of Stroke Education
The main goal of this study is to reorganize how stroke educational materials are given to patients from written delivery of information to using verbal delivery of information.
- Trial name
- NCT05614882
- Testing
- Written Stroke Education, Verbal Stroke Education
- Where
- United States
- Sponsor
- Yale University
Stroke
Comparing ESWT Doses for Post-Stroke Ankle Spasticity Treatment
Post-stroke spasticity is a common complication affecting the neurological recovery, self-care daily activities and patients' quality of life.
- Trial name
- NCT05878223
- Testing
- Extracorporeal shock waves
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Stroke, Hemiparesis
Retraining the Walking Pattern After Stroke
The purpose of the study is to determine the effects of pairing gait training with different forms of visual feedback about leg movements in individual post-stroke to modify/normalize their gait pattern over time.
- Trial name
- NCT03813342
- Testing
- Gait training with visual feedback of joint kinematics
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Stroke, Chronic Disease
AR Training Platform at Home
Video Communications, like ZOOM, have been widely used in the time of this epidemic. But how about to design an AR / VR communication system with coaching from clinician to facilitate training at home in this time of epidemic.
- Trial name
- NCT05627050
- Testing
- An Online Augmented Reality (AR) Training Platform
- Where
- Hong Kong
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Intracranial Atherosclerosis
Predicting Stroke Risk in ICAD With Novel MRI
The cerebral and spinal vasculature possesses several unique properties: it is composed of relatively small vessels, it has a highly connected network architecture, and, due to the confined space around the brain, disruptions in…
- Trial name
- NCT05515874
- Testing
- Feraheme
- Where
- United States
- Sponsor
- Northwestern University
Stroke
Dry Needling in Patients Who Had Experience Stroke
Individuals who had experience a stroke usually suffer from spasticity at medium and long-terms. The presence of spasticity in the lower extremity implies several impairments for standing and walking inducing high disability.
- Trial name
- NCT02579291
- Testing
- Dry needling, Bobath
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad Rey Juan Carlos
Stroke
A Cognitive-Augmented Mobility Program
This project will combine best-evidence gait and mobility training with best evidence cognitive strategy training to produce a new cognitive-augmented mobility intervention that is expected to optimize long-term functional…
- Trial name
- CAMP (NCT03683160)
- Testing
- Cognitive Augmented Mobility Program
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
Stroke (CVA) or TIA
Functional Electrical Stimulation Versus Whole-Body Vibration in Post-Stroke Rehabilitation
This study will compare the effects of Functional Electrical Stimulation (FES) and Whole Body Vibration Training (WBVT) on lower limb motor control, balance, and physical performance in post-stroke patients.
- Trial name
- NCT07629882
- Testing
- Functional Electrical Stimulation, Whole Body Vibration Training
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Patients in Minimally Conscious State After a Severe Brain Injury
tDCS on Precuneus in MCS: Repeated Stimulations
In this study researchers will apply transcranial direct current stimulation (tDCS) for 5 consecutive days in chronic patients in minimally conscious state (MCS).
- Trial name
- NCT02702362
- Testing
- transcranial direct current stimulation
- Volunteers
- 33 people
- Sponsor
- Hangzhou Normal University
Non-valvular Atrial Fibrillation
Safety and Effectiveness of Apixaban in Very Elderly Patients With Non-valvular Atrial Fibrillation (NVAF) Compared to Warfarin Using Administrative Claims Data
The objective of this study is to investigate safety and effectiveness of apixaban compared to warfarin in very elderly patients with Non-valvular atrial fibrillation (NVAF).
- Trial name
- NCT05438888
- Testing
- Warfarin, Apixaban
- Where
- Japan
- Volunteers
- 77,814 people
- Sponsor
- Pfizer
Cerebral Infarction
Contrast Enhanced Ultrasound of Carotid Plaque in Acute Ischemic Stroke
This is a biomedical, single-center, and prospective study of a consecutive patients cohort in acute ischemic stroke with carotid plaque.
- Trial name
- CUSCAS (NCT03115242)
- Testing
- Contrast injection Sonovue®
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Versailles Hospital
Stroke, Attention Disorder
Virtual-reality Exercises for Alleviating Attention Deficits in Patients With Acquired Brain Injury
Stroke is the leading cause of long-term disability with an increasing incidence, especially in young adults. Among the cognitive difficulties following brain damage, deficits in attention are frequent and pervasive, affecting…
- Trial name
- NCT05728840
- Testing
- Immersive virtual reality gamified cognitive activities, Double neuropsychological standard activities
- Where
- Switzerland
- Volunteers
- 135 people
- Sponsor
- Mindmaze SA
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