Clinical trials: Cervical Ripening and Induction of Labor
Post Date, Induction of Labor
Use of Single Versus Double Foley's Catheter in Pre-induction Cervical Ripening
Cervical ripening should be present before labor induction, which can generally be divided into two categories: pharmacological and mechanical
- Trial name
- NCT05511727
- Testing
- single versus double Foley's catheter in pre-induction cervical ripening
- Where
- Egypt
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Egymedicalpedia
Induction of Labor
Comparing Outpatient and Inpatient Use of a Cervical Balloon for Starting Labor in Low-Risk Pregnancies.
Why was this study done? About 20-30% of pregnancies involve labor being started artificially, known as induction. One way to do this is with a balloon catheter placed in the cervix, which helps prepare the body for labor.
- Trial name
- Cook (NCT06983535)
- Testing
- cervical balloon catheter
- Where
- 4 sites in Belgium
- Volunteers
- 358 people
- Sponsor
- Ziekenhuis Oost-Limburg
Pregnancy
Labour Induction With Misoprostol, Dinoprostone and Bard Catheter
This is a randomised study aimed at comparing the currently most frequently used prostaglandin dinoprostone to two other methods, the cheaper and perhaps more effective prostaglandin misoprostol and a transcervical catheter.
- Trial name
- LI (NCT00602095)
- Testing
- misoprostol, dinoprostone, Bard Catheter (balloon catheter)
- Volunteers
- 592 people
- Sponsor
- Karolinska University Hospital
Induction of Labor Affected Fetus / Newborn
Castor Oil Ingestion and Balloon Catheter for Labor Induction in Nulliparous
The goal of this randomized controlled trial is to examine the efficacy of combining castor oil ingestion with extra-amniotic single balloon catheter for cervical ripening on time from induction to delivery in nulliparous women.
- Trial name
- NCT06325007
- Testing
- Induction of labor
- Where
- 2 sites in Israel
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Nazareth, Israel
Hypnosis, Labor Pain
Pain Management With Virtual Reality Hypnosis
The latency phase corresponds to the first phase of the first stage of labour, during which the parturient feels regular, rhythmic uterine contractions that are often painful, with or without changes of the cervix.
- Conditions
- Hypnosis, Labor Pain, Virtual Reality, Labor Induction
- Trial name
- PreVR (NCT06502457)
- Testing
- painkiller, hypnosis group
- Where
- France
- Volunteers
- 142 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Cervical Ripening, Labor, Induced
Safety/Efficacy Study Comparing the Misoprostol Vaginal Insert to Cervidil for Cervical Ripening and Induction of Labor
The purpose of this study is to determine whether the misoprostol vaginal insert (50 mcg and 100 mcg) can safely and effectively speed time to vaginal delivery compared to Cervidil (R) in women who need to have cervical ripneing…
- Trial name
- NCT00308711
- Testing
- Misoprostol vaginal insert 100 mcg, Misoprostol vaginal insert 50 mcg, Dinoprostone vaginal insert (Cervidil)
- Where
- 52 sites in United States, Canada
- Volunteers
- 1,308 people
- Sponsor
- Ferring Pharmaceuticals
Labor Onset and Length Abnormalities, Induced; Birth
Comparison of Misoprostol Ripening Efficacy With Dilapan
The purpose of this study is to find out if Dilapan works as well as Misoprostol for preparing the mouth of the uterus (cervix) for inducing labor in women who need to undergo this procedure.
- Trial name
- COMRED (NCT03670836)
- Testing
- Dilapan, Misoprostol
- Where
- 2 sites in United States
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- Columbia University
Induction of Birth, Cervical Ripening
Open, Randomized Feasibility Trial on the Safety and Performance of the INGA Catheter for Labor Induction
This study investigates the safety and usability of the new INGA catheter for labor induction. Labor induction is common, with about one in three births being induced.
- Conditions
- Induction of Birth, Cervical Ripening, Cervical Ripening and Induction of Labor
- Trial name
- INGA-RCT (NCT07214948)
- Testing
- INGA Catheter, Currently used single balloon catheter
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Aalto University
PROM (Premature Rupture Of Foetal Membrane)
Cook Balloon Versus Propess After 12 Hours of Rupture of Membranes
The objective is to demonstrate the superiority of the strategy of labor induction by Cook® cervical ripening balloon between recommended strategy by dinoprostone (propess®) on the reduction of the time between cervical ripening…
- Trial name
- RUBAPRO (NCT03310333)
- Testing
- Propess® (dinoprostone), cook cervical pipening balloon
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cervical Ripening, Induction of Labor
Foley Catheter Compared to the Foley Catheter Alone for Cervical Ripening
In term women presenting for labor induction, combined use of the controlled release dinoprostone vaginal insert and Foley catheter for cervical ripening will decrease the median time from induction to vaginal delivery by at…
- Trial name
- NCT03111316
- Testing
- Cervidil 10 MG Vaginal Insert, Foley Catheter
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Oklahoma
Vaginal Delivery, Cesarean Section
Open Label Comparative Trial of Dinoprostone Plus or Minus Oxytocin Versus Oxytocin Alone in Cervical Ripening for Labor Induction
This is a comparative trial between oxytocin alone and dinoprostone for cervical ripening in unfavorable cervix pregnant women with 38 or more weeks of gestational age.
- Trial name
- SOFTNES (NCT01190163)
- Testing
- Dinoprostone, Oxytocin
- Where
- 4 sites in Brazil
- Volunteers
- 170 people
- Sponsor
- Ferring Pharmaceuticals
Induction of Labor, Cervical Ripening
Balloon + Oxytocin Versus Oral Misoprostol to Induce Labor in Case of PROM (RUBAPRO2)
Premature rupture of membranes (PROM) at term complicates 6 to 22% of singleton pregnancies. Spontaneous labour occurs in 60-67% of these patients within 24h.
- Conditions
- Induction of Labor, Cervical Ripening, Premature Rupture of Fetal Membranes, Nulliparous
- Trial name
- RUBAPRO2 (NCT05568745)
- Testing
- Balloon for cervical ripening (Teleflex French Dufour catheter CH20 reference 174000), Oxytocin, Misoprostol Oral Tablet
- Where
- 5 sites in France
- Volunteers
- 152 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cervical Ripening, Induction of Labor
Safety and Efficacy Study of Vaginal Misoprostol for Cervical Ripening and Induction of Labor
The purpose of this study is to estimate the efficacy and safety of the 25mcg vaginal misoprostol for cervical ripening and induction of labour.
- Trial name
- NCT01428037
- Testing
- Misoprostol vaginal Tablet 25 mcg
- Where
- 6 sites in China
- Volunteers
- 225 people
- Sponsor
- Regenex Pharmaceutical, China
Labour Onset and Length Abnormalities, Labor; Forced or Induced, Affecting Fetus or Newborn
Dilapan-S/Dilasoft E-Registry in Induction of Labor
International Observational E-Registry on the use of DILAPAN-S® osmotic dilator / DILASOFT® osmotic dilator for cervical ripening prior to labour induction.
- Trial name
- DSREGISTRYIL (NCT02318173)
- Testing
- Dilapan-S
- Where
- 11 sites in United States, Czechia and 5 more
- Volunteers
- 444 people
- Sponsor
- Medicem International CR s.r.o.
Post Term Pregnancy, Premature Rupture of Membrane
Dilapan-S®: A Multicenter US E-registry
Objective of this registry is to collect a representative set of real world data on the use of Dilapan-S® for pre-induction cervical ripening in daily clinical practice.
- Conditions
- Post Term Pregnancy, Premature Rupture of Membrane, Fetal Growth Retardation, Oligohydramnios
- Trial name
- NCT04451109
- Testing
- Dilapan-S
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Medicem Technology s.r.o.
Premature Rupture of Fetal Membranes
Evaluation of CRB in PROM Patients
The CRB study is designed to study the safety and effectiveness of the Cook Cervical Ripening Balloon (CRB) for the induction of labor in term and near-term patients with premature rupture of membranes (PROM).
- Trial name
- NCT01736852
- Testing
- CRB, Pitocin
- Where
- 4 sites in United States
- Volunteers
- 129 people
- Sponsor
- Cook Group Incorporated
Uterine Cervical Incompetence
Dilapan-S Osmotic Dilator in Pre-induction of Labor
Non-interventional prospective data collection designed to evaluate clinical outcome on the efficacy of the use of Dilapan-S in the indication of labor pre-induction in women with/without a history of Caesarean section.
- Trial name
- NCT02098382
- Testing
- Dilapan-S
- Where
- Czechia
- Volunteers
- 125 people
- Sponsor
- Medicem International CR s.r.o.
Premature Rupture of Fetal Membranes, Labor, Induced
PGE2 Followed by Oxytocin vs Oxytocin in Term PROM (POXY-PROM)
This study is being done to learn more about the best way to start labor for pregnant women whose water breaks at term before labor begins, a condition called term prelabor rupture of membranes (term PROM).
- Conditions
- Premature Rupture of Fetal Membranes, Labor, Induced, Cervical Ripening
- Trial name
- POXY-PROM (NCT07366359)
- Testing
- Sequential Induction: Dinoprostone Followed by Oxytocin, Immediate Oxytocin Induction
- Where
- Vietnam
- Volunteers
- 450 people
- Sponsor
- National Hospital of Obstetrics and Gynecology
Cervical Ripening, Outpatient
Outpatient Cervical Preparation to Reduce Induction Duration in NTSV Women
This study is to compare 2 groups in nulliparous women undergoing cervical ripening for induction of labor. The study hypothesis is that outpatient cervical preparation with a foley catheter can reduce the induction of labor…
- Conditions
- Cervical Ripening, Outpatient, Patient Satisfaction, Nulliparous
- Trial name
- OCPRID (NCT03934918)
- Testing
- Treatment
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Davis
Induced; Birth, Pregnancy
Comparison of Patient Satisfaction With Home Induction and In-patient Induction.
Induced labour is a medical intervention designed to initiate or accelerate the childbirth process when clinically indicated. Induced labour concerns 25.8% of pregnant women in France, according to the latest National Perinatal…
- Trial name
- NCT06272591
- Testing
- Preliminary search in the patient's file, A posteriori research in the patient's file, First questionnaire : choice of induction method reason for choice
- Where
- France
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne