Clinical trials: Chemoradiotherapy
Locally Advanced Rectal Cancer (LARC)
XELOX Plus DoSTARlimab Versus XELOX Alone as Consolidation Treatment After Standard Chemoradiation in pMMR/MSS or MSI-Low Locally Advanced Rectal Cancer (LARC) Patients
This is a phase II, multicenter, randomized (2:1) controlled, clinical trial to evaluate the preliminary efficacy and safety of consolidation chemotherapy (XELOX) plus dostarlimab after standard long-course CRT (ARM A) compared…
- Trial name
- IMMUNOSTAR (NCT07381777)
- Testing
- XELOX (Capecitabine and Oxaliplatin), Dostarlimab
- Where
- 30 sites in Italy
- Volunteers
- 270 people
- Sponsor
- Gruppo Oncologico Italiano di Ricerca Clinica
Pancreatic Cancer
Adjuvant Gemcitabine and Cisplatin Followed by Chemoradiation for Resected Pancreatic Cancer
This is a phase Ⅱ Trial of Postoperative Adjuvant Gemcitabine and Cisplatin Chemotherapy Followed by Chemoradiation With Gemcitabine in Patients With Resected Pancreatic Cancer.
- Trial name
- NCT01396681
- Testing
- gemcitabine and cisplatin
- Where
- 2 sites in South Korea
- Volunteers
- 70 people
- Sponsor
- Seoul National University Hospital
Non-small Cell Lung Cancer Stage III
A Study of Envafolimab in Subjects With Stage III Non-Small Cell Lung Cancer
This is a prospective, single arm, phase II study to evaluate the efficacy and safety of Envafolimab in subjects with locally advanced/unresectable (Stage III) non-small cell lung cancer that has not progressed after prior…
- Trial name
- NCT05414630
- Testing
- Envafolimab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Anhui Provincial Cancer Hospital
Non-small Cell Lung Cancer
Neoadjuvant Immunotherapy With Durvalumab (MEDI4736) in Non-Surgical Early Stage or Locally Advanced Non-Small Cell Lung Cancer (NSCLC) Followed by Radical Radiotherapy or Chemoradiotherapy
This study proposes to evaluate the safety and efficacy of an anti-PD-L1 (durvalumab) agent as neoadjuvant therapy in patients diagnosed with localized NSCLC who are planned to undergo radical RT or CRT.
- Trial name
- IDEAR (NCT05267392)
- Testing
- Durvalumab, standard of care RT/RCT
- Where
- Portugal
- Volunteers
- 30 people
- Sponsor
- Instituto Portugues de Oncologia, Francisco Gentil, Porto
Stage III Lung Cancer AJCC v8, Stage III Lung Non-Small Cell Cancer AJCC v7
Local Consolidative Therapy and Durvalumab for Oligoprogressive and Polyprogressive Stage III NSCLC After Chemoradiation and Anti-PD-L1 Therapy
This phase II trial finds out the effect of local consolidative therapy and durvalumab in treating patients with stage III non-small cell lung cancer that has 3 or fewer lesions of progression (oligoprogressive) and greater than…
- Conditions
- Stage III Lung Cancer AJCC v8, Stage III Lung Non-Small Cell Cancer AJCC v7, Stage IIIA Lung Cancer AJCC v8, Stage IIIA Lung Non-Small Cell Cancer AJCC v7
- Trial name
- NCT04892953
- Testing
- Carboplatin, Durvalumab, Gemcitabine
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- M.D. Anderson Cancer Center
Glioma, Malignant
HSRT and IMRT Chemoradiotherapy for Newly Diagnosed GBM
This study aims to evaluate the safety and effectiveness of the combination of 30Gy/5fx HSRT and 20Gy/10fx IMRT adjuvant therapy.
- Trial name
- HSCK-010 (NCT04547621)
- Testing
- Radiation, Temozolomide
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Huashan Hospital
Gall Bladder Cancers
Perioperative Therapy Preoperative Chemotherapy Versus Chemoradiotherapy in Locally Advanced Gall Bladder Cancers
Locally advanced Gall bladders cancers not amenable for curative resection are often treated with chemotherapy alone which is the current standard of care.
- Trial name
- POLCAGB (NCT02867865)
- Testing
- Gemcitabine, Cisplatin, Chemoradiation
- Where
- India
- Volunteers
- 124 people
- Sponsor
- Tata Memorial Hospital
Neoadjuvant Therapy in Rectal Cancer, Radiotherapy, FOLFOX
Neoadjuvant Therapy vs Standard Therapy in Locally Advanced Rectal Cancer
Phase II, Multicenter, Open-label, Randomized Study evaluating neoadjuvant chemotherapy (FOLFOX4) in patients with stage II and III colorectal cancer with standard chemoradiation Defined by Magnetic Resonance Imaging
- Trial name
- RECTUM2015 (NCT05378919)
- Testing
- Radiotherapy 50 Gy, Fluorouracil/folic acid, Chemotherapy in regimen with Oxaliplatin, fluorouracil, folinic acid (FOLFOX4)
- Where
- Lithuania
- Volunteers
- 250 people
- Sponsor
- Lithuanian University of Health Sciences
Carcinoma Cervix
Study on Early Stage Bulky Cervical Cancers
The aim of this study is to establish the role of neoadjuvant chemotherapy and chemo irradiation in carcinoma cervix and to compare its results with the concurrent chemo irradiation in terms of overall survival, disease free…
- Trial name
- NCT01917695
- Testing
- Chemotherapy, External Beam Radiotherapy, Brachytherapy
- Where
- India
- Volunteers
- 180 people
- Sponsor
- Rajkumar Kottayasamy Seenivasagam
Alveolar Soft Part Sarcoma, Angiomatoid Fibrous Histiocytoma
Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery
This randomized phase II/III trial studies how well pazopanib, when combined with chemotherapy and radiation therapy or radiation therapy alone, work in the treatment of patients with newly diagnosed non-rhabdomyosarcoma soft…
- Conditions
- Alveolar Soft Part Sarcoma, Angiomatoid Fibrous Histiocytoma, Atypical Fibroxanthoma, Clear Cell Sarcoma of Soft Tissue
- Trial name
- NCT02180867
- Testing
- Doxorubicin, Doxorubicin Hydrochloride, Ifosfamide
- Where
- 381 sites in United States, Canada and 1 more
- Volunteers
- 140 people
- Sponsor
- National Cancer Institute (NCI)
Stage III NSCLC
Adjuvant Chemotherapy +/- Cemiplimab and Sequential Hypofractionated Radiotherapy in Unfit or Elderly Patients With Stage III Lung Cancer
The use of neoadjuvant immuno-chemotherapy could improve survival outcomes of patients eligible for sequential radio-chemotherapy comparing to the benefit already obtained with maintenance immunotherapy.
- Trial name
- SPORADIC (NCT06656598)
- Testing
- Carboplatin, Paclitaxel, Cemiplimab
- Where
- 25 sites in France
- Volunteers
- 152 people
- Sponsor
- Intergroupe Francophone de Cancerologie Thoracique
Glioblastoma
Efficiency of Vaccination with Lysate-loaded Dendritic Cells in Patients with Newly Diagnosed Glioblastoma
The primary objective of the study is to determine whether overall survival of newly diagnosed glioblastoma patients treated with lysate-loaded, mature dendritic cell vaccines as add-on to the standard of care consisting of…
- Trial name
- GlioVax (NCT03395587)
- Testing
- Autologous, tumor lysate-loaded, mature dendritic cells (DC), standard therapy
- Where
- 6 sites in Germany
- Volunteers
- 136 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Rectal Cancer Stage III
Short RT Versus RCT,Followed by Chemo and Organ Preservation for Interm and High-risk Rectal Cancer Patients
The hereby proposed ACO/ARO/AIO-18.1 randomized trial aims to directly compare the newly established TNT concepts applying either short-course RT according to RAPIDO, or CRT according to CAO/ARO/AIO-04/-12, both followed by…
- Trial name
- NCT04246684
- Testing
- Oxaliplatin, 85 mg/m2, 5FU; 2400 mg/m2, 5FU, 250 mg/m2
- Where
- 75 sites in Germany
- Volunteers
- 702 people
- Sponsor
- Prof. Dr. med. Claus Rödel
Head and Neck Cancer, Oral Mucositis
Edible Plant Exosome Ability to Prevent Oral Mucositis Associated With Chemoradiation Treatment of Head and Neck Cancer
This study will evaluate the ability of grape exosomes, given to the subject as grape powder, as an important anti-inflammatory agent to reduce the incidence of oral mucositis during radiation and chemotherapy treatment for head…
- Trial name
- NCT01668849
- Testing
- Grape extract, Lortab, Fentanyl patch, mouthwash
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Louisville
CERVICAL NEOPLASMS
Concurrent Chemoradiation With Cisplatin Every 3 Week in Advanced Cervical Cancer
Concurrent chemoradiation (CCRT) is the standard therapy for locally advanced cervical cancer. However, the most effective chemotherapy regimen is controversial.
- Trial name
- NCT00916500
- Testing
- CONCURRENT CHEMORADIATION (CISPLATIN)
- Where
- South Korea
- Volunteers
- 71 people
- Sponsor
- Korea Cancer Center Hospital
Stomach Neoplasms
Study of Adjuvant Radiochemotherapy for Gastric Cancer
In 1991, the South West Oncology Group (SWOG) conducted a randomized study of adjuvant chemotherapy (5-fluorouracil and folinic acid) with concurrent radiation (4500 cGy/25 fractions) versus surgery alone for patients with…
- Trial name
- NCT00188266
- Testing
- cisplatinum combined with infusional fluorouracil (5 FU)
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- University Health Network, Toronto
Extrahepatic Bile Duct Cancer, Nausea
Aprepitant in Preventing Nausea and Vomiting in Patients Undergoing Chemotherapy and Radiation Therapy for Pancreatic Cancer
This pilot clinical trial is studying how well aprepitant works in preventing nausea and vomiting in patients undergoing chemotherapy and radiation therapy for pancreatic cancer.
- Conditions
- Extrahepatic Bile Duct Cancer, Nausea, Vomiting, Stage II Pancreatic Cancer
- Trial name
- NCT01534637
- Testing
- aprepitant, gemcitabine hydrochloride, capecitabine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Wake Forest University Health Sciences
Endometrial Cancer
Phase I Trial Testing the Safety and Tolerability of Chemoradiation Followed by Chemotherapy + Dostarlimab for Stage IIIC, Node Positive, Endometrial Cancer
To learn if chemotherapy given in combination with radiation therapy, followed by maintenance therapy, can help to control endometrial cancer. The safety and effects of this study treatment will also be studied
- Trial name
- NCT05819892
- Testing
- Paclitaxel, Carboplatin, Dostarlimab
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- M.D. Anderson Cancer Center
Head and Neck Cancer
Reduced Radiotherapy With Pac/Cis vs Standard Radiotherapy With 5-FU/Cis in Locally Advanced Head and Neck Cancer
Reduced RT with Pac/Cis vs. standard RCT with 5-FU/Cis
- Trial name
- Paccis-RCT (NCT01126216)
- Testing
- Paclitaxel/Cisplatin, Reduced RT, 5-FU/Cisplatin
- Where
- 13 sites in Germany
- Volunteers
- 221 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Lung Cancer
SWOG-9416: Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Stage III Non-small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to kill tumor cells.
- Trial name
- NCT00002642
- Testing
- cisplatin, etoposide, conventional surgery
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- SWOG Cancer Research Network
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