Clinical trials: Chest CT Scan
Pulmonary Embolism
Evaluation of the PERC Score and the YEARS Algorithm in the Diagnosis of Pulmonary Embolism in the Emergency Department
The current diagnostic strategy for pulmonary embolism relies on clinical evaluation, followed by D-dimer testing and chest CT angiography. However, this approach leads to overuse of CT angiography.
- Trial name
- EP (NCT07313501)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
Coronary Artery Disease, Coronary Artery Stenosis Stent
Deep Learning CAD Screening on Chest CT
Coronary artery disease (CAD) is one of the leading causes of death worldwide. Many people have early atherosclerosis without symptoms, and some may develop significant coronary stenosis before any warning signs appear.
- Trial name
- CAD-AI (NCT07181512)
- Testing
- Deep Learning Analysis of Non-contrast Chest CT
- Where
- 2 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yifan Guo
Lung Cancer
Early Lung Cancer Detection Using Computed Tomography
Early detection of lung cancer may improve treatment outcomes. Risk factors have been identified, suggesting a population which might benefit from regular screening.
- Trial name
- NCT00188734
- Where
- Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Osteoporosis, Interstitial Lung Disease
Opportunistic Screening for Osteoporotic Vertebral Fractures in Patients With Diffuse Interstitial Lung Disease
It is well known that some chronic respiratory pathologies such as asthma or chronic obstructive pulmonary disease (COPD) are associated with an increased risk of osteoporosis, due to the pathology itself and the therapies…
- Conditions
- Osteoporosis, Interstitial Lung Disease, Vertebral Fracture
- Trial name
- NCT05714787
- Testing
- Chest CT Scan examination
- Where
- France
- Volunteers
- 202 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Lung Cancer
Respiratory Adaptive Computed Tomography: Feasibility Study on Real-Time Gated 4DCT for Lung Cancer Radiotherapy
This study does not involve a therapeutic intervention as standard radiation therapy treatment will be prescribed. This study involves one additional 4DCT scan (i.e.
- Trial name
- REACT (NCT05030207)
- Testing
- Real-time Gated 4DCT, Conventional 4DCT
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- University of Sydney
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
Evaluate the Utility of the ProLung China Test in the Diagnosis of Lung Cancer
A Study to evaluate the utility of the ProLung China Test as an adjunct to CT scan in the diagnosis of lung cancer.
- Trial name
- ProLung (NCT02726633)
- Where
- 3 sites in China
- Volunteers
- 500 people
- Sponsor
- Chinese Alliance Against Lung Cancer
NSCLC
Pathological and Nuclear Medicine Factors for Prognosis in Lung Carcinoma
Retrospective study in patients with therapy-naive non small cell lung carcinoma correlating presurgical F18-FDG-PET/CT imaging texture analysis data with postsurgical molecular pathology data and clinical patient outcome.
- Trial name
- PANU (NCT04276025)
- Testing
- Clinical routine F18-FDG-PET/CT, molecular pathology and clinical outcome
- Volunteers
- 2,000 people
- Sponsor
- Klinikum Bayreuth GmbH
Lung Cancer, Lung Cancer Stage III
Radiomic Signature as Predictive Marker of Response to Chemoradiation and Durvalumab in Stage III NSCLC.
The introduction of maintenance immunotherapy with the anti PD-L1 inhibitor durvalumab opened a new therapeutic window for stage III NSCLC patients who achieve at least stable disease after chemo-radiation, as shown by the…
- Trial name
- NCT04364776
- Testing
- Durvalumab
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Lung Cancer
Involvement of General Practitioners in Lung Cancer Screening
The main objective is to evaluate the adherence of smoking patients to lung cancer screening by low-dose CT scan, when proposed by the general practitioner.
- Trial name
- GEDEPIST (NCT06956040)
- Testing
- Low-dose computed tomography of the chest
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pleural Effusion, Transudative Pleural Effusion
Evaluation of Transthoracic Ultrasonography in Differentiating Pleural Effusions
Pleural effusion is a condition where excess fluid builds up in the space between the lungs and the chest wall. To properly treat this condition, doctors must determine if the fluid is a "transudate" (usually resulting from…
- Conditions
- Pleural Effusion, Transudative Pleural Effusion, Exudative Pleural Effusion
- Trial name
- NCT07513909
- Volunteers
- 90 people
- Sponsor
- Assiut University
Pneumonia, Viral, COVID-19 Pneumonia
AI-based System for Assessing Suspected Viral Pneumonia Related Lung Changes
The AI-based system designed to process chest computed tomography (CT) aims to 1) detect the presence of pathologic patterns associated with interstitial changes in pneumonia; 2) highlight areas on the images with the probable…
- Trial name
- NCT06501599
- Testing
- Medical software (AI-based system)
- Where
- Russia
- Volunteers
- 563 people, healthy volunteers welcome
- Sponsor
- Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department
Lung Cancer
Positron Emission Tomography (PET)/Computed Tomography (CT) and Roentgen in Lung Cancer: Evaluation of Patients in General Practice
The prognosis of lung cancer depends much on the stage of the disease at the time of diagnosis. Only 16 % of lung cancer can be offered curative intended surgery.
- Trial name
- PROLOG (NCT00675168)
- Testing
- PET/CT (low-dose)
- Where
- 3 sites in Denmark
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Coronary Artery Disease
Dual Source CT Angiography for Detection of Coronary Artery Stenoses
The trial will investigate the accuracy of Dual Source CT coronary angiography to detect coronary artery stenoses in patients with chest pain who have, based on clinical criteria, an intermediate likelihood for the presence of…
- Trial name
- MEDIC (NCT01190579)
- Where
- 8 sites in Denmark, Germany and 3 more
- Volunteers
- 398 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Thoracic Neoplasms
Comparison of Ultrasound, CT, and Classical Methods for Selecting Sizes and Placement of Left-Sided Double-Lumen Tubes
Investigators aimed to compare anatomical measurements obtained using ultrasound and computed tomography with classical methods to select the appropriate size of double-lumen tubes more quickly and easily and to determine the…
- Trial name
- NCT06731517
- Testing
- intubation
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Coronary Artery Disease
Cardiac Pathologies in Standard Thoracic CT Imaging
Modern high-end CT scanners with faster scan acquisition times now allow for routine assessment of cardiac pathologies, which could result in numerous incidental cardiac findings on standard thoracic CT angiography (CTA) scans.
- Trial name
- CaPaCT (NCT02904239)
- Where
- Netherlands
- Volunteers
- 221 people
- Sponsor
- Maastricht University Medical Center
Lung Cancer
Implementing Low-dose ct Lung Cancer Screening in France.
The main objective is to estimate the detection rate of lung cancer in the population screened by low-dose chest CT scans.
- Trial name
- IMPULSION (NCT07513818)
- Testing
- Low-dose computed tomography of the chest
- Where
- 2 sites in France
- Volunteers
- 20,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postoperative Pulmonary Atelectasis
Diagnostic Values of Lung Ultrasound for Perioperative Atelectasis
Lung ultrasound offers a novel, reliable and radiation-free tool for diagnosing perioperative atelectasis and evaluating its severity in adult patients undergoing general anesthesia in the operating room.
- Trial name
- NCT02355405
- Testing
- lung ultrasound, thoracic computed tomography
- Where
- 2 sites in China
- Volunteers
- 46 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Small Airways Diseases, Vaping
The Canadian Lung Outcomes in Users of Vaping Devices Study
Vaping is increasingly popular with both adolescent and adult Canadians, but the long-term health impacts remain unknown. We believe that the tools we currently have to detect lung disease in people who vape may be insufficient…
- Conditions
- Small Airways Diseases, Vaping, Vaping Related Disorder, Vaping Teens
- Trial name
- CLOUD (NCT06819969)
- Where
- 8 sites in Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Coronary Artery Disease (CAD), Stable Angina Pectoris
Identification of Lesion Characteristics in Coronary Plaques Using Multimodality Intravascular Imaging and Novel Photon-counting CT in Stable Angina
Coronary artery disease, caused by the furring up of the heart arteries by atherosclerosis, is a major cause of death in the UK.
- Conditions
- Coronary Artery Disease (CAD), Stable Angina Pectoris, Ischaemic Heart Disease (IHD)
- Trial name
- ILUMINA (NCT07864025)
- Testing
- observational study
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Queen Mary University of London
Volunteer
Clinical Study of Spectral CT
This study will prospective enroll 80 subjects to evaluate the comparison of image quality, proportion of high-quality images, and image noise between the Spectral Precise Image (SPI) intelligent denoising for low-dose scans on…
- Trial name
- NCT07759050
- Testing
- CT Radiation Scan
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Philips Clinical & Medical Affairs Global