Clinical trials: Chromoendoscopy
Colorectal Neoplasms
Comparative Efficacy of Water & Indigo Carmine vs. Water or Air Method on Adenoma Detection Rate (ADR) - a Randomized Controlled Trial (RCT)
Adenoma detection rate (ADR) is a quality indicator of colonoscopy performed for colorectal cancer screening. Population studies have shown that traditional air colonoscopy fails to eliminate post screening colonoscopy cancers or…
- Trial name
- NCT01607255
- Testing
- Indigo carmine, water (exchange) method, water (exchange) plus dye method
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Inflammatory Bowel Diseases
Chromoendoscopy of the Colon After Oral Administration of Indigo Carmine
The purpose of this study is to examine whether oral administration of Indigo Carmine together with Polyethylene Glycol (PEG), the usual colon preparatory solution, can be used instead of staining during the examination itself.
- Trial name
- NCT01914445
- Testing
- Indigo Carmine
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Hillel Yaffe Medical Center
Chromoendoscopy
Chromocolonoscopy With Food-grade Dyes
Previous with methylene blue suggested that oral administration may be superior to conventional spray catheters. The main advantages claimed were better staining due to longer exposure to the dye, more uniform staining due to…
- Trial name
- NCT02631798
- Testing
- Food grade dye mucosal staining
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Suspected or Known Squamous Cell Neoplasia, Prior History of Squamous Cell Dysplasia and /or Neoplasia
Effectiveness and Performance of an Optical Biopsy Technology for Esophageal Cancer in Brazil and the United States
In a previous clinical trial in China and the United States (US), the investigators developed and validated a mobile, high-resolution microendoscope (mHRME) for screening and surveillance of esophageal squamous cell neoplasia…
- Trial name
- NCT06435286
- Testing
- Proflavine Hemisulfate, Artificial Intelligence Mobile High-Resolution Microendoscope
- Where
- 4 sites in United States, Brazil
- Volunteers
- 200 people
- Sponsor
- Baylor College of Medicine
Gastric Intestinal Metaplasia
Confocal Endomicroscopy Detection of Gastric Preneoplasia and Neoplasia
This is a prospective randomised study investigating the use of chromoendoscopy and confocal laser endomicroscopy for the detection of preneoplastic neoplasm in patients at high-risk of gastric cancer.
- Trial name
- R-CE-GCEP (NCT01384201)
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- National University Hospital, Singapore
IBD
Texture and Colour Enhancement Imaging (TXI) Versus Dye Chromoendoscopy for Dysplasia Detection in IBD Surveillance.
In individuals with inflammatory bowel disease (IBD), bowel cancer can develop from abnormal cell changes (dysplasia). Regular colonoscopies are recommended to identify these early changes, which can be difficult to detect…
- Trial name
- TXIorDyE (NCT07208214)
- Testing
- TXI
- Volunteers
- 242 people
- Sponsor
- London North West Healthcare NHS Trust
FRENCH STUDY
Narrow-Band Imaging (NBI) Versus Lugol Chromoendoscopy in the Detection of Oesophagus Squamous Cell Carcinoma in High Risk Population
Narrow-Band Imaging (NBI) is as sensitive as Lugol chromoendoscopy to detect oesophageal squamous cell carcinoma (SCC) and appears more specific than Lugol chromoendoscopy in expert centres but its specificity in current practice…
- Trial name
- NCT04224896
- Testing
- UPPER ENDOSCOPY
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- Hôpital Edouard Herriot
Lichen Planus
Incidence of Esophageal Lichen Planus in Patients With Known Oral Lichen Planus
The lichen planus is a mucocutaneous disease of unknown etiology with an incidence of 1-2%, that affects in 30-70% of cases either the mucosa of the mouth, or partly in combination with infection of the skin, the oral with his…
- Trial name
- NCT02532166
- Testing
- Esophageal lichen planus
- Where
- 2 sites in Germany
- Volunteers
- 50 people
- Sponsor
- Ruhr University of Bochum
Colonic Adenoma
High Definition Endoscopy and Virtual Chromoendoscopy Versus Standard Resolution Endoscopy in Detection of Colon Polyps
Over the last years a number of new endoscopic imaging modalities have been introduced (high-definition and virtual chromoendoscopy).
- Trial name
- NCT03243669
- Testing
- High-definition, Virtual chromoendoscopy, Standard
- Where
- Belgium
- Volunteers
- 2,146 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Colonic Polyps, Adenomatous Polyps
Linked-Color Imaging Versus Indigo Carmine Pump Spraying on the Colorectal Adenoma Detection Rate
Detection and removal of polyps during colonoscopy is crucial for the prevention of colorectal cancer. Indigo carmine spraying up to the colonic mucosa could probably increase the adenoma detection rate, but considering the long…
- Conditions
- Colonic Polyps, Adenomatous Polyps, Adenoma Detection Rate, Chromoendoscopy
- Trial name
- NCT06961149
- Testing
- Chromoendoscopy with indigo carmine solution spray, Linked-color imaging endoscopy
- Where
- China
- Volunteers
- 352 people
- Sponsor
- Shandong University
Crohn Disease
AI-enabled Endoscopic Prediction of Post-operative Recurrence in Crohn's Disease
This is a multicentre prospective international observational study. This study aims to introduce a novel multidimensional approach to precision imaging, enabling the identification and stratification of high-risk patients who…
- Trial name
- PROSPER (NCT06505304)
- Testing
- Colonoscopy, Intestinal biopsies, Confocal laser endomicroscopy
- Where
- 15 sites in Belgium, Canada and 4 more
- Volunteers
- 225 people
- Sponsor
- University College Cork
Esophageal Squamous Intraepithelial Neoplasia
Detection of Early Esophageal Squamous Neoplasia
The aim of the present study： 1. To investigate the diagnosing value of pCLE for early esophageal squamous neoplasia. 2. To assess the detection rate of early esophageal squamous neoplasia by virtual chromoendoscopy
- Trial name
- NCT01909518
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shandong University
Lynch Syndrome
Chromoendoscopy to Decrease the Risk of Colorectal Neoplasia in Lynch Syndrome
Lynch syndrome (LS), or hereditary nonpolyposis colorectal cancer (HNPCC), is a hereditary disorder predisposing for colorectal cancer. To reduce the risk of colorectal cancer, patients undergo colonoscopy every 1-2 years.
- Trial name
- ChromoLynch (NCT00905710)
- Testing
- Chromoendoscopy
- Where
- Netherlands
- Volunteers
- 240 people
- Sponsor
- University Medical Center Groningen
Inflammatory Bowel Disease, Colorectal Cancer
Usefulness of Chromoendoscopy for the Early Detection of Colorectal Cancer Associated With Inflammatory Bowel Disease
To assess the feasibility and effectiveness of a program in L-IBD patients using CE targeted biopsies
- Trial name
- CE (NCT02543762)
- Testing
- Chromoendoscopy
- Where
- 15 sites in Spain
- Volunteers
- 350 people
- Sponsor
- Hospital Clinic of Barcelona
Barrett's Esophagus
"Acetic Acid Chromoendoscopy in Barrett's Esophagus Surveillance
Neoplasia in Barrett's esophagus could be missed during routine random biopsies. We propose a study using chromoendoscopy with Acetic Acid to increase the yield of biopsies in detecting neoplasia.
- Trial name
- NCT02614703
- Testing
- Chromoendoscopy using Acetic Acid 2.5%, Standard random esophageal biopsies
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- DHR Health Institute for Research and Development
Esophageal Squamous Cell Carcinoma
High-concentration Small-volume Versus Low-concentration Large-volume Iodine Solution for Esophageal Chromoendoscopy
This clinical trial aims to test the participants' tolerance for different concentration iodine solutions during esophageal chromoendoscopy.
- Trial name
- NCT06063941
- Testing
- 1% Lugol's iodine solution, 5% Lugol's iodine solution
- Where
- 5 sites in China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Barrett Esophagus
Methylene Blue Chromoendoscopy in Barrett's Esophagus
This study is being done to: Determine if a temporary dye applied to the esophagus identifies areas of dysplasia (pre-cancer). Determine if certain dye patterns indicate specific grades of dysplasia.
- Trial name
- NCT00587652
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Colorectal Cancer, Colorectal Polyp
Accuracy for Predicting Deep Submucosal Invasion
The main aim of this study is to determine whether the assessment of the invasive pattern based on NBI with dual focus/magnification or BLI with magnification ± chromoendoscopy (NBI+CE) for predicting deep invasion is…
- Trial name
- NBIBLI (NCT03748667)
- Testing
- White light endoscopy (WLE), NBI/BLI +/- chromoendoscopy (NBIBLI +/- CE)
- Where
- 14 sites in United States, Japan and 1 more
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Esophageal Neoplasms
Pronase Improves Efficacy of Chromoendoscopy Screening on Esophageal Cancer
Lugol's solution staining was regarded as a gold standard to detect early superficial lesion during esophageal cancer screening using endoscopy.
- Trial name
- NCT02030769
- Testing
- Pronase, Control
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Inflammatory Bowel Disease
Virtual Chromoendoscopy for Colitis Surveillance: A Feasibility Study
Patients with colitis require regular 'surveillance' colonoscopy as their risk of developing colon cancer is at least 2.5 times that of the general population.
- Trial name
- NCT02543021
- Testing
- Virtual chromoendoscopy, Conventional chromoendoscopy
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- King's College Hospital NHS Trust