Clinical trials: Chronic Aphasia
Alzheimer Disease
Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Alzheimer Disease
Impaired verbal communication is a cardinal symptom of Alzheimer Disease (AD) and the source of enormous distress and disability. Effective therapies for this deficit are lacking.
- Trial name
- NCT04482179
- Testing
- Active TMS, CILT
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Pennsylvania
Aphasia
Speeded Anomia Treatment in Chronic Post-stroke Aphasia
The main aim of the study is to investigate the effect of a novel, speeded anomia therapy (Conroy et al., 2018) in a large population of patients with chronic post-stroke aphasia.
- Trial name
- NCT05512884
- Testing
- Speeded anomia therapy
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Cambridge
Chronic Aphasia
Computerised Therapy in Chronic Stroke
The few studies looking systematically into the neurophysiological and neuropsychological components of available therapies for chronic aphasia are highly heterogeneous in nature.
- Trial name
- CATChES (NCT01928602)
- Testing
- TherAppy Language App, Mind-Games
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Aphasia, Stroke
Improvement of Language Disturbances After Stroke by Intensive Training and Electrical Brain Stimulation
The study aims to identify if intensive language training, consisting mainly of computer-based object naming, together with electrical brain stimulation, will lead to an improvement of language functions in patients that suffer…
- Trial name
- NCT00822068
- Testing
- anodal tDCS, cathodal tDCS
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Muenster
Aphasia Following Cerebral Infarction, Aphasia Following Nontraumatic Intracerebral Hemorrhage
TDCS and Aphasia Therapy in the Chronic Phase After Stroke
This study evaluates the neuromodulatory effect of combined tDCS and aphasia therapy in patients in the chronic phase after stroke.
- Trial name
- NCT03305614
- Testing
- tDCS, Aphasia therapy
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- University Hospital, Ghent
Aphasia
Classical Conditioning Training for Aphasia. A Telemedicine Approach.
This study aimed at investigating the suitability of a classical conditioning for the treatment of anomic disorder. In this study 12 patients suffering from pure anomia in the chronic stage of the disease underwent a word…
- Trial name
- NCT03381313
- Testing
- Conditioned word repetition training
- Volunteers
- 12 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Aphasia, Stroke
Memantine and Intensive Speech-Language Therapy in Aphasia
Aphasia, the loss or impairment of language caused by brain damage, is one of the most devastating cognitive impairments of stroke. Aphasia can be treated with combination of speech-language therapy and drugs.
- Trial name
- NCT00640198
- Testing
- memantine, constraint-induced language therapy (CIAT)
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Gabinete Berthier y Martínez
Stroke
Transcranial Direct Current Stimulation for Post-Stroke Aphasia
This is a randomized, crossover design trial that will compare how anodal transcranial direct current stimulation (tDCS) versus sham tDCS administered during multiple sessions of scripting therapy affects the acquisition and…
- Trial name
- NCT02461355
- Testing
- Aphasia therapy, Anodal tDCS
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Columbia University
Aphasia, Stroke
Levetiracetam (Keppra) to Improve Chronic Aphasia in Post-stroke Patients.
The study investigates the possibility that levetiracetam may improve the symptoms of chronic post-stroke aphasia.
- Trial name
- NCT00227461
- Testing
- Wait first, then levetiracetam, Levetiracetam first, then wait
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Kessler Foundation
Aphasia, Anomia (Word-Finding Impairment)
Chronic Aphasia - Improved by Intensive Training and Electrical Brain Stimulation (CATS)
The purpose of this study is to determine if non-invasive electrical brain stimulation can enhance the outcome of intensive language therapy in chronic aphasia.
- Trial name
- NCT01924702
- Testing
- Intensive language therapy, transcranial direct current stimulation
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Charité Neurocure AG Flöel
Aphasia, Chronic Stroke
Transcutaneous Vagus Nerve Stimulation in Aphasia After Stroke
Aphasia is an acquired language disorder. Stroke is the most common cause of aphasia, which affects 30% of stroke survivors. Speech and Language Therapy (SLT) can help people with aphasia but it may not be provided at the…
- Trial name
- TRANSLATE (NCT06403475)
- Testing
- Transcutaneous Vagus Nerve Stimulation, Computer Based Speech and Language Therapy (Step by Step)
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Aphasia, Stroke
Transcranial Direct Current Stimulation (tDCS) With Verb Network Strengthening Treatment (VNeST) in Chronic Aphasia
The purpose of this study is to assess changes in language abilities of participants with chronic, post-stroke aphasia following an 8-week therapy period combined with brain stimulation.
- Trial name
- NCT04142866
- Testing
- Anodal transcranial direct current stimulation, Speech-Language Therapy (SLT)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- City University of New York
Chronic Aphasia
Effects of tDCS Versus HD-tDCS for Stroke Rehabilitation
The purpose of this study is to assess the changes in language processing of patients with chronic aphasia after receiving non-invasive brain stimulation.Previous research using traditional transcranial direct current stimulation…
- Trial name
- tDCS- Aphasia (NCT01651884)
- Testing
- HD-tDCS (Soterix), Transcranial Direct Current Stimulation (Neuroconn)
- Sponsor
- Soterix Medical
Ischaemic Stroke, Hemorrhagic Stroke
Exploratory Study on the Potential Cross-System Effects of BCI-FES Hand Therapy on Dysphagia and Aphasia in Chronic Stroke Patients
The goal of this neurorehabilitation explorative study is to investigate how a closed-loop Brain-Computer Interface Functional Electrical Stimulation (BCI-FES) therapy, used within the intended purpose for hand rehabilitation…
- Trial name
- c-STEPS (NCT06940635)
- Testing
- closed-loop BCI-FES device
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- VASCage GmbH
Aphasia, Chronic Stroke
A Trial Investigating Telerehabilitation as an add-on to Face-to-face Speech and Language Therapy in Post-stroke Aphasia.
The aim of this study is to investigate the effects of high-frequency short duration tablet-based speech and language therapy (teleSLT) mixed with cognitive training (teleCT) in chronic stroke patients.
- Conditions
- Aphasia, Chronic Stroke, Post Stroke Seizure
- Trial name
- NCT03228264
- Testing
- teleSLT, teleCT
- Where
- 2 sites in Switzerland
- Volunteers
- 21 people
- Sponsor
- University of Bern
Aphasia
Learning to Communicate Successfully Approach for Urdu Speaking Patients With Chronic Aphasia
This study aims to develop and validate the Learning to Communicate Successfully Approach (LCSA), a culturally sensitive communication intervention manual for Urdu-speaking adults with chronic aphasia.
- Trial name
- LCSA (NCT07889778)
- Testing
- Learning to Communicate Successfully Approach (LCSA)
- Where
- 2 sites in Pakistan
- Volunteers
- 30 people
- Sponsor
- University of Lahore
Aphasia
Effect of Anodal Transcranial Direct Current Stimulation (tDCS) Over the Right-hemisphere on Picture Naming in Chronic Aphasia
There are two opposing hypotheses, namely the interference and laterality-shift hypotheses, regarding the role of the right hemisphere (RH) in language recovery following a left hemisphere damage.
- Trial name
- NCT05471570
- Testing
- tDCS stimulation
- Volunteers
- 4 people
- Sponsor
- The University of Hong Kong
Aphasia, Language
tDCS as an Adjuvant to Intensive Speech Therapy for Chronic Post Stroke Aphasia
The purpose of this study is to determine if transcranial direct current stimulation (tDCS) in conjunction with intensive speech therapy will improve sentence production and word retrieval in individuals with chronic post stroke…
- Trial name
- NCT02801864
- Testing
- Real tDCS, Intensive Speech Therapy
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Austin Speech Labs
Post-Stroke Chronic Aphasia
Ecological Momentary Intervention for Post-Stroke Anomia
Anomia (i.e., impaired word retrieval) is one of the most common and debilitating deficits experienced by stroke survivors with aphasia, an acquired disorder characterized by impaired language.
- Trial name
- NCT07739875
- Testing
- Semantic Feature Ecological Momentary Intervention
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Northeastern University
Non-fluent Aphasia
Combined Intervention Program for Non-fluent Aphasia Based on Neuroplasticity
Sequentially applying Melodic Intonation Therapy (MIT) during the subacute phase, followed by Constraint-Induced Aphasia Therapy (CIAT) during the chronic phase
- Trial name
- CIPAN (NCT07759375)
- Testing
- CIPAN = MIT + CIAT, MIT + MIT, CIAT + CIAT
- Volunteers
- 48 people
- Sponsor
- Universidad de Granada