Clinical trials: Chronic Brain Injury, open to volunteers
Infant Development, Perinatal Stroke
Behavioral Assessment Method Index
The overall goal of this study is to develop and improve assessment methods for children with and without perinatal arterial ischemic stroke (PAS)/hemiparetic cerebral palsy (HCP).
- Conditions
- Infant Development, Perinatal Stroke, Hemiparesis, Cerebral Palsy
- Trial name
- BAM (NCT07291479)
- Testing
- Non interventional study
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Cerebral Palsy, Hemiparesis; Poststroke/CVA
Characterization of Muscle Activity During a Surface EMG-controlled Rehabilitation Game
The aim of this pilot study is to evaluate muscular activity during a single session of surface electromyography controlled exergame (muscle activation, number of contraction…) in cerebral palsy kids, hemiparetic adults and…
- Conditions
- Cerebral Palsy, Hemiparesis; Poststroke/CVA, Healthy (Controls)
- Trial name
- CONTRACTIV-1S (NCT07838688)
- Testing
- Surface electromyography (sEMG)-controlled rehabilitation game
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Cerebral Palsy, Brain Injury
Validation of a 3D Instrumented Serious Game to Evaluate Upper Limb Impairments in Children With Neuromotor Disorders
The goal of this clinical trial is to validate an instrumented 3D serious game to assess upper limb impairments in children with neuromotor disorders.
- Conditions
- Cerebral Palsy, Brain Injury, Neurological; Disorder, Nervous System
- Trial name
- Play2BEAPI (NCT06774456)
- Testing
- instrumented 3D serious game (BE API 3.0)
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Cerebral Palsy, Muscle
How Are the Muscles Affected in Cerebral Palsy? A Study of Muscle Biopsies Taken During Orthopaedic Surgery.
Cerebral palsy (CP) is a motor disorder caused by an injury to the immature brain. Even though the brain damage does not change, children with CP will have progressively weaker, shorter and stiffer muscles that will lead to…
- Conditions
- Cerebral Palsy, Muscle, Muscle Contracture, Muscle Spasticity
- Trial name
- CPTDBiopsy (NCT05506228)
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Eva Ponten
Cerebral Palsy, Prematurity
Best Practices Fo Early Diagnosis of Cerebral Palsy
In this research, the investigators are using an implementation science approach to enhance the uptake of a clinical practice guideline for earlier diagnosis of cerebral palsy (i.e.
- Trial name
- CP (NCT06537622)
- Testing
- Implementation group, Standard of care
- Where
- Canada
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Traumatic Brain Injury
Treating Traumatic Brain Injury With Transcranial Direct Current Stimulation
Traumatic Brain Injury (TBI) often results in a wide array of cognitive impairments, which can significantly diminish quality of life for affected individuals.
- Trial name
- NCT06989970
- Testing
- Active tDCS on the DLPFC + Cognitive Intervention(s)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Spastic Cerebral Palsy, Acquired Brain Injury
Evaluation of Macroscopic Muscle Growth in Infants and Young Children With Spastic Cerebral Palsy
A mixed longitudinal design study will be carried out to explore the onset and time course of morphological muscle changes on a macroscopic level in children with spastic cerebral palsy (SCP).
- Trial name
- 3D-MMAP (NCT05197764)
- Where
- Belgium
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Traumatic Encephalopathy
Post-Concussion Syndrome in Professional Athletes: A Multidisciplinary Study
to examine the relationship between repeated concussions and late decline of brain function. In addition, all participants agreeing to participate in the study will be asked to will their brains to The Krembil Neuroscience Centre…
- Trial name
- NCT03218332
- Testing
- Biomarkers for detecting possible CTE invivo
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Cerebral Palsy, Typically Developing Children
Repetitive Transcranial Magnetic Stimulation on Motor Function and Meta-Plasticity in Cerebral Palsy: TMS-EEG Study
This project examines the use of repetitive transcranial magnetic stimulation (rTMS) as a therapeutic approach to improve motor function in children with cerebral palsy (CP).
- Trial name
- NCT07567053
- Testing
- MRI, HD-EEG Recording, rTMS
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cook Children's Health Care System
Cervical Spinal Cord Plasticity
Cervical Spinal Cord Associative Plasticity
Associative plasticity has been used to promote functional recovery from conditions affecting movement. Prior work from the Carmel laboratory has shown that paired associative stimulation protocols timed to converge in the…
- Trial name
- NCT07539025
- Testing
- SCAP, MagPro X100, Digitimer DS8R
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Columbia University
Fatigue Symptom, Fatigue Intensity
Monitoring Fatigue In Daily Life In Adults With Cerebral Palsy or Acquired Brain Injury
The goal of this observational study is to learn about levels and patterns of fatigue in adults with cerebral palsy (CP) and acquired brain injury (ABI) in daily life.
- Conditions
- Fatigue Symptom, Fatigue Intensity, Cerebral Palsy (CP), Acquired Brain Injury Including Stroke
- Trial name
- NCT07135791
- Testing
- Real-time monitoring
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Traumatic Chronic Encephalopathy
Cerebral and Cognitive Impact of Professional Soccer Practice
The objective of this study is to evaluate, using MRI, the microstructural consequences and the onset of any cognitive impairment in professional soccer players at the end of their career, who have experienced repeated minor head…
- Trial name
- TC-FOOT (NCT04903015)
- Testing
- MRI
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Stair Climbing, Instrumentation
Implementation and Validation of Instrumented Stair Climb Test
The aim of this study is to design an instrumented test for the evaluation of the climb of stairs. In particular, the main purpose is to characterize and compare the performance of subjects, both pediatrics and adults, with…
- Conditions
- Stair Climbing, Instrumentation, Test
- Trial name
- SCTS (NCT06999850)
- Testing
- Instrumented Stair Climb Test, Walk Test, Repaeted Instrumented Stair Climb Test
- Where
- 3 sites in Italy
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Traumatic Brain Injury, Stroke
Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function
This study aims to recruit patients already implanted with Deep Brain Stimulation (DBS) for movement disorders to complete tasks assessing parameters of motor output, speech, and swallowing functions, both with and without…
- Conditions
- Traumatic Brain Injury, Stroke, Brain Disease, Movement Disorders (Incl Parkinsonism)
- Trial name
- NCT07056348
- Testing
- Deep Brain Stimulation (DBS) of the Motor Thalamus
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jorge Gonzalez-Martinez
Healthy Volunteers, Spinal Cord Injury
Chronic Transcutaneous Stimulation to Promote Motor Function and Recovery in Individuals With Paralysis or Paresis
This is an early feasibility trial to determine whether transcutaneous neuromuscular electrical stimulation, with or without transcutaneous spinal cord stimulation, using an investigational neurostimulation device improves…
- Conditions
- Healthy Volunteers, Spinal Cord Injury, Stroke, Paralysis
- Trial name
- NCT04755699
- Testing
- Transcutaneous Electrical Stimulation
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Spinal Cord Injury, Traumatic Brain Injury
The National Center for Testing Treatments in Chronic Spinal Cord and Traumatic Brain Injury
The NCTT is a prospective, multicenter, observational research network for subjects with chronic spinal cord and/or chronic traumatic brain injury.
- Trial name
- NCTT (NCT02769416)
- Testing
- Data and sample repository
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Alzheimer Disease, Chronic Traumatic Encephalopathy
Visualizing Brain Proteinopathies Using [F-18]Flornaptitril-PET in the Prediction of Clinical Progression of Mild Cognitive Impairment With Either Suspected Chronic Traumatic Encephalopathy or Alzheimer's Disease
CMK-0301 is a multi-site, randomized clinical trial to evaluate the safety and efficacy of [F-18]Flornaptitril-PET (F-18 FNT-PET) for the prediction of clinical progression of Mild Cognitive Impairment (MCI) with either Suspected…
- Trial name
- NCT06254469
- Testing
- [F-18]Flornaptitril
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- CereMark Pharma, LLC
Cerebral Palsy
Investigating New Methods to Study Movement in Children and Young Adults With Movement Disorders.
Background: Cerebral palsy (CP) is the most common motor disorder that affects children. People with CP have weak muscles; they may have trouble controlling the movements of their arms and legs.
- Trial name
- NCT06498596
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Cerebral Palsy (CP), Spasticity
Predictors of Motor İmagery Performance in Cerebral Palsy
There are very few studies in the literature examining the effect of age on motor imagery ability in children with cerebral palsy. To our knowledge, no studies have investigated the impact of other related factors.
- Conditions
- Cerebral Palsy (CP), Spasticity, Motor Learning
- Trial name
- NCT07002567
- Testing
- Implicit motor imagery, Explicit motor imagery
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative