Clinical trials: Chronic Obstr Lung Disease
Chronic Obstructive Pulmonary Disease
PRagmatic EVAluation of a Quality Improvement Program for People Living With Modifiable High-risk COPD.
A 3-year cluster randomized controlled trial of the impact of a quality improvement and clinical decision support package versus usual care for patients with modifiable high-risk chronic obstructive pulmonary disease with or…
- Trial name
- PREVAIL (NCT05306743)
- Testing
- CONQUEST Quality Improvement Program
- Where
- 3 sites in United States
- Volunteers
- 126 people
- Sponsor
- Observational and Pragmatic Research Institute
Chronic Obstructive Pulmonary Disease, Pulmonary Rehabilitation
Comparison of the Cardiopulmonary and Gaz-exchange Response Between the Six-minute Stepper Test and the Incremental Cardiopulmonary Exercise Testing in Patients With Chronicle Obstructive Pulmonary Disease
Chronicle obstructive pulmonary disease is a worldwide cause of mortality and morbidity. This systemic disease progressively leads to dyspnea, muscle wasting and exercise capacity impairment.
- Conditions
- Chronic Obstructive Pulmonary Disease, Pulmonary Rehabilitation, 6-minute Stepper Test
- Trial name
- PH-6MST (NCT04008615)
- Testing
- 2 times : 6-minute stepper test with cardiorespiratory parameters and gaz exchange monitoring (with a rest of 20min between each test).
- Where
- 3 sites in France
- Volunteers
- 65 people
- Sponsor
- ADIR Association
Chronic Obstructive Pulmonary Disease
Eosinophilic Cationic Protein as a Biomarker in Diagnosis of Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease is a type of obstructive lung disease characterized by long-term breathing problems and poor airflow.
- Trial name
- NCT04008017
- Testing
- Eosinophilic Cationic Protein biomarker
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Assiut University
Chronic Obstructive Pulmonary Disease
This is a Non-interventional, Study to Assess Demographic Characteristics and Patient Reported Outcomes in China Patients With SEA Treated With Benralizumab
The objective of this study is to collect empirical data that elucidates the clinical profile and therapeutic efficacy of benralizumab among the patients aged 12 years and above, with severe eosinophilic asthma.
- Trial name
- SPEED (NCT06862206)
- Testing
- benralizumab
- Where
- 36 sites in China
- Volunteers
- 1,000 people
- Sponsor
- AstraZeneca
COPD
Efficacy of AZD3199 in Chronic Obstructive Pulmonary Disease (COPD) Patients
The purpose of this study is to investigate the efficacy, safety and tolerability of 4 weeks treatment with AZD3199 in moderate to severe COPD.
- Trial name
- GLAD (NCT00929708)
- Testing
- AZD3199, formoterol
- Where
- 38 sites in Bulgaria, Canada and 3 more
- Volunteers
- 329 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
Nursing-Driven Primary Palliative Care for Urban-Dwelling African Americans With Chronic Lung Disease
In prior work, this research team developed a telehealth primary care model (TIPC), designed in close partnership with patients and clinicians to address a widespread increase in telehealth use during the COVID-19 pandemic.
- Trial name
- Hillman (NCT05611125)
- Testing
- Telehealth Integrated Primary Care (TIPC)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Thomas Jefferson University
Asthma, Chronic Obstructive Pulmonary Disease
Analysis of Inhaled Corticoid Prescriptions in General Medicine
Chronic obstructive pulmonary disease (COPD) and asthma are frequent and disabling pathologies. The general practitioner is often at the front line vis-a-vis screening, diagnosis and treatment of these pathologies.
- Trial name
- COMEGE (NCT03179826)
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Montpellier
Chronic Obstructive Airway Disease, Neutrophil Function Disorder
Exercise and Neutrophil Function in COPD
Exercise is a cornerstone of pulmonary rehabilitation in the treatment of Chronic Obstructive Pulmonary Disease (COPD). Although researchers have shown numerous benefits with exercise in COPD patients, most studies have only…
- Trial name
- NCT02124343
- Testing
- Interval Exercise
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hywel Dda Health Board
Chronic Obstructive Pulmonary Disease
Ig PRx in AECOPD: Pilot Study
This study will look at immunoglobulin (Ig) treatment in hospitalized chronic obstructive lung disease (COPD) patients with frequent exacerbations.
- Trial name
- NCT02690038
- Testing
- Intravenous immunoglobulin (IVIG), Normal Saline
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Ottawa Hospital Research Institute
Pulmonary Disease, Chronic Obstructive
A Randomised, Double-blind, Crossover Study of Ba679BR Respimat in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The objective of this trial is to compare the efficacy and the safety of Ba 679 BR Respimat 5 ug once daily to tiotropium inhalation capsule 18 ug (Spiriva inhalation capsule) in a crossover study of 4-week treatment periods in…
- Trial name
- NCT00292448
- Testing
- Ba 679 BR Respimat, Tiotropium (Spiriva) inhalation capsule 18 ug
- Where
- 27 sites in Japan
- Volunteers
- 157 people
- Sponsor
- Boehringer Ingelheim
Emphysema
A Prospective Multicenter Clinical Study to Evaluate the Safety and Effectiveness of the OL-BF-001 for Severe Emphysema
This is a multicenter,single-arm,open-label study designed to evaluate improvement of lung function and safety after treatment with OL-BF-001 for severe emphysema.
- Trial name
- NCT02470052
- Testing
- OL-BF-001
- Where
- 10 sites in Japan
- Volunteers
- 38 people
- Sponsor
- Olympus Corporation
Chronic Obstructive Pulmonary Disease
Study to Evaluate the Effect of Megestrol Acetate in Severe Chronic Obstructive Pulmonary Disease With Loss of Weight
The purpose of this trial is to study the effect of megestrol acetate in the gain of body weight in patients with severe Chronic obstructive pulmonary disease in order to improve the survival of the patients.
- Trial name
- NCT00507949
- Testing
- Megestrol acetate
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Rottapharm Spain
Chronic Obstructive Pulmonary Disease
A Phase 2 Study of MP-376 to Prevent Acute Exacerbations in Chronic Obstructive Pulmonary Disease (COPD) Patients
Patients with Chronic Obstructive Pulmonary Disease (COPD) suffer from frequent and recurrent acute exacerbations (AECB) which are associated with enormous healthcare expenditures and significant morbidity, specifically an…
- Trial name
- NCT00739648
- Testing
- MP-376
- Where
- 39 sites in United States
- Volunteers
- 322 people
- Sponsor
- Amgen
COPD
Study of Chronic Obstructive Pulmonary Disease (COPD) Exacerbations In Spain
ECOS is a cross-sectional, observational, longitudinal, multicenter study enrolling 100-200 patients during a COPD exacerbation.
- Trial name
- ECOS (NCT01750658)
- Where
- Spain
- Volunteers
- 99 people
- Sponsor
- Cimera
Chronic Obstructive Pulmonary Disease
The Impact of Pulmonary Rehabilitation on Dyspnea in Chronic Obstructive Pulmonary Disease
Dyspnea (respiratory discomfort) and activity limitation are the most common symptoms of chronic obstructive pulmonary disease (COPD) and contribute importantly to a perceived poor quality of life.
- Trial name
- NCT01513616
- Testing
- Pulmonary rehabilitation, Usual care
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Queen's University
Pulmonary Disease, Chronic Obstructive
Tiotropium (18 Mcg) Once Daily Via the HandiHaler® in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The primary objective of this trial is to determine whether treatment with tiotropium (18 mcg) capsule once daily via the HandiHaler reduces the proportion of patients with COPD experiencing an exacerbation and the proportion of…
- Trial name
- NCT00274547
- Testing
- Tiotropium
- Where
- 26 sites in United States
- Volunteers
- 1,829 people
- Sponsor
- Boehringer Ingelheim
Chronic Obstructive Pulmonary Disease
Pharmacokinetic Study to Compare Itepekimab Exposure When Administered With an Autoinjector Versus Prefilled Syringe
This Phase 1, single-center study will be conducted in an open-label, randomized, parallel design. Healthy male and female participants aged 18 to 65 years will receive a single dose of itepekimab subcutaneous (SC) administered…
- Trial name
- NCT06114238
- Testing
- Itepekimab AI, Itepekimab PFS
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sanofi
Chronic Obstructive Pulmonary Disease
Assessing the Utility of Peak Inspiratory Flow as a Predictor for COPD Exacerbations
This is an international, mulitcentre, observational, prospective study into Peak Inspiratory Flow in COPD patients that aims to: A) Determine the prevalence of suboptimal Peak Inspiratory Flow (PIF) and inadequate inhaler choice…
- Trial name
- NCT04360226
- Testing
- Non-interventional
- Where
- 13 sites in Italy, Malta and 4 more
- Volunteers
- 400 people
- Sponsor
- Respiratory Effectiveness Group
Hypoxia Altitude Simulation Test, High Altitude
Hypoxia-altitude Testing to Predict Altitude Related Adverse Health Effects in Chronic Obstructive Pulmonary Disease (COPD) Patients
The predictive value of the hypoxia altitude simulation test (HAST) or other baseline values to predict altitude-related adverse health effects (ARAHE) is not established.
- Trial name
- NCT04915378
- Testing
- hypoxia altitude simulation test (HAST) at 760m, High Altitude (3100m)
- Where
- Kyrgyzstan
- Volunteers
- 75 people
- Sponsor
- University of Zurich
COPD, COPD (Chronic Obstructive Pulmonary Disease)
Impact of Home Non Invasive Ventilation in Patients With Chronic Obstructive Pulmonary Disease Discharged From Assiut University Hospital
This study aims to evaluate the impact of long-term home non-invasive ventilation (NIV) on patients with COPD
- Conditions
- COPD, COPD (Chronic Obstructive Pulmonary Disease), Ventilation Therapy, Non Invasive Ventilation (NIV)
- Trial name
- NCT07198880
- Testing
- BiPAP device (non invasive ventilation), Optimal Medical Management ( long acting beta agonist , long acting muscarinic antagonist and inhaled corticosteroids)
- Volunteers
- 40 people
- Sponsor
- Assiut University
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